Strain Name:
C57BL/6J-MtgxR6453Btlr/Mmmh
Stock Number:
044589-MU
Citation ID:
RRID:MMRRC_044589-MU
Other Names:
R6453 (G1)
Major Collection:

Strain Information

Gria2
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: GluR2, Glur-2, GluR-B, Glur2, GluA2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14800
HGNC: HGNC:4572
Homologene: 20225
Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk-2, Tsk2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Gldc
Name: glycine decarboxylase
Synonyms: D030049L12Rik, D19Wsu57e, b2b2679Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104174
VEGA: 19
HGNC: HGNC:4313
Homologene: 141
Pik3cd
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Synonyms: p110delta, 2610208K16Rik, 2410099E07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18707
HGNC: HGNC:8977
Homologene: 3686
Gpatch4
Name: G patch domain containing 4
Synonyms: Gpatc4, 2610029K21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66614
Homologene: 9203
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Rnf169
Name: ring finger protein 169
Synonyms: 2900057K09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108937
Homologene: 47510
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, XAP8, Hbxap, C030033M12Rik, p325
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, Garnl1, Tulip1, 2310003F20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Garem1
Name: GRB2 associated regulator of MAPK1 subtype 1
Synonyms: Fam59a, LOC381126, Garem
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381126
VEGA: 18
Homologene: 11237
Slc30a5
Name: solute carrier family 30 (zinc transporter), member 5
Synonyms: ZTL1, Znt5, ZnT-5, Zntl1, 1810010K08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69048
VEGA: 13
Homologene: 41503
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyes2, heb, eyem02Jus, crf11, QBRICK
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Dennd1b
Name: DENN domain containing 1B
Synonyms: F730008N07Rik, 4632404N19Rik, 6820401H01Rik, 4930467M19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329260
Homologene: 11739
Msh6
Name: mutS homolog 6
Synonyms: GTBP, Gtmbp, Msh6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17688
VEGA: 17
HGNC: HGNC:7329
Homologene: 149
Macrod2
Name: mono-ADP ribosylhydrolase 2
Synonyms: 2610107G07Rik, 2900006F19Rik, 1110033L15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72899
Homologene: 85987
Dnajc14
Name: DnaJ heat shock protein family (Hsp40) member C14
Synonyms: LIP6, HDJ3, DRIP78, 5730551F12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74330
VEGA: 10
Homologene: 12553
2300002M23Rik
Name: RIKEN cDNA 2300002M23 gene
Synonyms: emprin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69542
Homologene: 49368
Mcm4
Name: minichromosome maintenance complex component 4
Synonyms: 19G, Mcmd4, Cdc21, mCdc21
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17217
VEGA: 16
HGNC: HGNC:6947
Homologene: 40496
Sptbn2
Name: spectrin beta, non-erythrocytic 2
Synonyms: Spnb3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20743
VEGA: 19
Homologene: 48482
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Slc9a2
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 2
Synonyms: 4932415O19Rik, 2210416H12Rik, NHE2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226999
Homologene: 20661
Qrfprl
Name: pyroglutamylated RFamide peptide receptor like
Synonyms: C130060K24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243407
Homologene: 135976
Myo7a
Name: myosin VIIA
Synonyms: polka, nmf371, Myo7, Hdb, USH1B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Hormad1
Name: HORMA domain containing 1
Synonyms: Nohma, 4921522K05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67981
Homologene: 69415
Acta2
Name: actin alpha 2, smooth muscle, aorta
Synonyms: SMAalpha, alphaSMA, Actvs, SMalphaA, 0610041G09Rik, a-SMA
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11475
VEGA: 19
HGNC: HGNC:130
Homologene: 133938
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Fat2
Name: FAT atypical cadherin 2
Synonyms: Fath2, EMI2, LOC245827, mKIAA0811
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
Or8b1c
Name: olfactory receptor family 8 subfamily B member 1C
Synonyms: GA_x6K02T2PVTD-32165709-32166641, Olfr905, MOR167-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258800
VEGA: 9
Homologene: 110524
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Chd7, 2600010P09Rik, Mi-2 alpha, Prp7, Prp9-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Flt1
Name: FMS-like tyrosine kinase 1
Synonyms: vascular endothelial growth factor receptor-1, VEGFR-1, Flt-1, VEGFR1, sFlt1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14254
HGNC: HGNC:3763
Homologene: 134179
Exoc7
Name: exocyst complex component 7
Synonyms: 70kDa, sec70, Exo70
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53413
Homologene: 41019
Parvg
Name: parvin, gamma
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 64099
Homologene: 11151
Kif14
Name: kinesin family member 14
Synonyms: D1Ertd367e, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381293
Homologene: 8916
Sgsm3
Name: small G protein signaling modulator 3
Synonyms: CIP85, Rutbc3, 1810012I01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105835
Homologene: 9249
Speg
Name: SPEG complex locus
Synonyms: SPEGbeta, SPEG, Apeg1, BPEG, SPEGalpha, D1Bwg1450e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Slc13a3
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Synonyms: NaDC-3, NaDC3, SDCT2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 114644
Homologene: 11266
H2-Q2
Name: histocompatibility 2, Q region locus 2
Synonyms: Gm11132, H-2Q2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15013
Homologene: 128352
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330222
Homologene: 27395
Rbbp9
Name: retinoblastoma binding protein 9, serine hydrolase
Synonyms: Bog
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26450
HGNC: HGNC:9892
Homologene: 4816
Ttll6
Name: tubulin tyrosine ligase-like family, member 6
Synonyms: t8130b59, 4932418K24Rik, D11Moh43e, D11Moh44e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237930
Homologene: 18229
A830018L16Rik
Name: RIKEN cDNA A830018L16 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320492
Homologene: 14194
Cimip1
Name: ciliary microtubule inner protein 1
Synonyms: 1700021F07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72221
Homologene: 82371
Ankrd44
Name: ankyrin repeat domain 44
Synonyms: E130014H08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329154
Homologene: 27547
Slc7a15
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 15
Synonyms: Arpat, 2010001P20Rik, 9030221C07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328059
Homologene: 77627
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: 5033413D22Rik, Gm6976, Gm29096
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75973
Homologene: 136355
Cers6
Name: ceramide synthase 6
Synonyms: 4732462C07Rik, similar to TRH1, CerS6, T1L, Lass6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241447
Homologene: 72228
Sostdc1
Name: sclerostin domain containing 1
Synonyms: Wise, ectodin, USAG-1, Sostl
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66042
VEGA: 12
Homologene: 9154
Rangrf
Name: RAN guanine nucleotide release factor
Synonyms: Rangnrf, 2400006H24Rik, Mog1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57785
Homologene: 41138
Adgra1
Name: adhesion G protein-coupled receptor A1
Synonyms: 2900059M17Rik, D7Ertd680e, Gpr123
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52389
Homologene: 18582
Spg7
Name: SPG7, paraplegin matrix AAA peptidase subunit
Synonyms: paraplegin, spastic paraplegia 7 homolog (human), Cmar
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234847
Homologene: 31133
Lmcd1
Name: LIM and cysteine-rich domains 1
Synonyms: dyxin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30937
HGNC: HGNC:6633
Homologene: 22823
Nipa2
Name: non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human)
Synonyms: 3830408P04Rik, 2600017P10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 93790
Homologene: 11368
Gm15922
Name: predicted gene 15922
Type: Gene
Species: Mouse
Chromosome: 7
Trem6l
Name: triggering receptor expressed on myeloid cells-like 6
Synonyms: B430306N03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320148
Homologene: 138443
Slc46a3
Name: solute carrier family 46, member 3
Synonyms: 1200006F02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71706
Homologene: 41733
Qpctl
Name: glutaminyl-peptide cyclotransferase-like
Synonyms: 1810019P04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67369
Homologene: 9765
Cyb5d2
Name: cytochrome b5 domain containing 2
Synonyms: 9330151E16Rik, neuferricin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192986
Homologene: 14701
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 11,798,558 bp
  • A to T, chromosome 1 at 40,742,621 bp
  • G to A, chromosome 1 at 45,339,378 bp
  • A to T, chromosome 1 at 54,657,704 bp
  • A to G, chromosome 1 at 75,417,972 bp
  • A to G, chromosome 1 at 136,482,304 bp
  • A to G, chromosome 1 at 139,143,948 bp
  • C to T, chromosome 2 at 69,047,169 bp
  • A to G, chromosome 2 at 142,176,625 bp
  • G to T, chromosome 2 at 144,549,134 bp
  • C to T, chromosome 2 at 165,411,947 bp
  • A to G, chromosome 2 at 173,528,259 bp
  • A to G, chromosome 3 at 80,740,974 bp
  • A to G, chromosome 3 at 88,055,005 bp
  • A to G, chromosome 3 at 95,578,257 bp
  • G to T, chromosome 4 at 82,914,825 bp
  • A to G, chromosome 4 at 149,652,302 bp
  • T to A, chromosome 5 at 14,676,789 bp
  • G to A, chromosome 5 at 121,350,592 bp
  • A to G, chromosome 5 at 142,096,921 bp
  • T to C, chromosome 5 at 147,683,941 bp
  • A to G, chromosome 5 at 147,886,390 bp
  • G to A, chromosome 6 at 65,453,030 bp
  • A to G, chromosome 6 at 112,315,828 bp
  • C to G, chromosome 7 at 3,737,320 bp
  • C to T, chromosome 7 at 19,141,297 bp
  • A to T, chromosome 7 at 55,935,821 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,917 bp
  • C to T, chromosome 7 at 98,073,167 bp
  • C to T, chromosome 7 at 99,935,227 bp
  • T to A, chromosome 7 at 139,875,427 bp
  • A to G, chromosome 8 at 123,079,423 bp
  • T to C, chromosome 9 at 38,473,575 bp
  • A to T, chromosome 10 at 41,550,825 bp
  • A to G, chromosome 10 at 128,807,490 bp
  • A to G, chromosome 11 at 55,282,216 bp
  • A to G, chromosome 11 at 68,973,552 bp
  • T to A, chromosome 11 at 69,350,112 bp
  • T to G, chromosome 11 at 72,782,760 bp
  • G to A, chromosome 11 at 96,158,727 bp
  • T to C, chromosome 11 at 116,293,969 bp
  • T to C, chromosome 12 at 8,534,490 bp
  • C to A, chromosome 12 at 36,314,408 bp
  • A to G, chromosome 12 at 55,738,319 bp
  • A to T, chromosome 13 at 100,814,689 bp
  • T to A, chromosome 15 at 81,011,314 bp
  • A to T, chromosome 15 at 84,328,925 bp
  • A to T, chromosome 16 at 15,630,409 bp
  • C to T, chromosome 17 at 35,344,895 bp
  • C to T, chromosome 17 at 35,568,212 bp
  • T to A, chromosome 17 at 48,316,736 bp
  • T to C, chromosome 17 at 84,416,323 bp
  • T to A, chromosome 17 at 87,985,739 bp
  • T to A, chromosome 18 at 21,148,739 bp
  • A to T, chromosome 19 at 4,744,180 bp
  • G to A, chromosome 19 at 18,829,990 bp
  • A to T, chromosome 19 at 30,116,517 bp
  • G to A, chromosome 19 at 34,246,657 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6453 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044589-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.