Strain Name:
C57BL/6J-MtgxR6459Btlr/Mmmh
Stock Number:
044594-MU
Citation ID:
RRID:MMRRC_044594-MU
Other Names:
R6459 (G1)
Major Collection:

Strain Information

Nefh
Name: neurofilament, heavy polypeptide
Synonyms: NF200, NEFH, NF-H
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380684
HGNC: HGNC:7737
Homologene: 40755
Pak1
Name: p21 (RAC1) activated kinase 1
Synonyms: Paka, PAK-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18479
HGNC: HGNC:8590
Homologene: 1936
Atl3
Name: atlastin GTPase 3
Synonyms: 5730596K20Rik, 4633402C03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109168
VEGA: 19
Homologene: 9149
Epop
Name: elongin BC and polycomb repressive complex 2 associated protein
Synonyms: E13, E130012A19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103551
Homologene: 82351
Lrrc41
Name: leucine rich repeat containing 41
Synonyms: D630045E04Rik, D730026A16Rik, MUF1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230654
Homologene: 4645
Pcm1
Name: pericentriolar material 1
Synonyms: C030044G17Rik, 9430077F19Rik, 2600002H09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18536
HGNC: HGNC:8727
Homologene: 4518
Specc1l
Name: sperm antigen with calponin homology and coiled-coil domains 1-like
Synonyms: 4932439K10Rik, Specc1l, 4930470P14Rik, 9530057A13Rik, Cytsa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74392
VEGA: 10
Homologene: 15610
Ipo11
Name: importin 11
Synonyms: E330021B14Rik, 1700081H05Rik, Ranbp11, 2510001A17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76582
Homologene: 7089
Proser1
Name: proline and serine rich 1
Synonyms: 2810046L04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 212127
Homologene: 13463
Trappc8
Name: trafficking protein particle complex 8
Synonyms: 5033403J15Rik, Trs85, D030074E01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75964
VEGA: 18
Homologene: 40993
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227648
Homologene: 10533
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, AnkG, 2900054D09Rik, Ankyrin-3, Ankyrin-G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 2810487N22Rik, B130055D15Rik, 4632407J06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Slc25a16
Name: solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16
Synonyms: 3110021G18Rik, ML7, HGT.1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73132
Homologene: 21858
Abr
Name: active BCR-related gene
Synonyms: 6330400K15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 109934
HGNC: HGNC:81
Homologene: 11081
Cftr
Name: cystic fibrosis transmembrane conductance regulator
Synonyms: Abcc7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12638
HGNC: HGNC:1884
Homologene: 55465
Grhl3
Name: grainyhead like transcription factor 3
Synonyms: Get1, ct, Som
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230824
Homologene: 18864
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, D330038K10Rik, 4930516E05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+K+-transporting alpha 1, H+/K+-ATPase alpha
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Mgat4c
Name: MGAT4 family, member C
Synonyms: 9130411I17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67569
Homologene: 8297
Il16
Name: interleukin 16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16170
HGNC: HGNC:5980
Homologene: 18157
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, skrr, calcium release channel isoform 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Frmd4b
Name: FERM domain containing 4B
Synonyms: GRSP1, 6030440G05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232288
Homologene: 14916
Kng2
Name: kininogen 2
Synonyms: Kininogen-II
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385643
HGNC: HGNC:6383
Homologene: 88343
Ccdc88b
Name: coiled-coil domain containing 88B
Synonyms: 2610041P08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78317
VEGA: 19
Homologene: 49992
Prg4
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms: SZP, MSF, DOL54, lubricin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 96875
HGNC: HGNC:9364
Homologene: 137352
Acss1
Name: acyl-CoA synthetase short-chain family member 1
Synonyms: Acas2, 1110032O15Rik, AceCS2, Acas2l
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68738
Homologene: 56037
Zc3h7a
Name: zinc finger CCCH type containing 7 A
Synonyms: Zc3h7, A430104C18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106205
Homologene: 8563
Fhl2
Name: four and a half LIM domains 2
Synonyms: SLIM3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14200
HGNC: HGNC:3703
Homologene: 20372
Or8d23
Name: olfactory receptor family 8 subfamily D member 23
Synonyms: MOR171-46, Olfr930, GA_x6K02T2PVTD-32626123-32627049
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258269
VEGA: 9
HGNC: HGNC:8481
Homologene: 138304
Atp9a
Name: ATPase, class II, type 9A
Synonyms: Class II, IIa
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11981
Homologene: 69194
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244668
Homologene: 18956
Tsen54
Name: tRNA splicing endonuclease subunit 54
Synonyms: 0610034P02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76265
Homologene: 35476
Vwa5b2
Name: von Willebrand factor A domain containing 5B2
Synonyms: EG328644
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328643
Homologene: 28056
Or8k41
Name: olfactory receptor family 8 subfamily K member 41
Synonyms: Olfr1071, GA_x6K02T2Q125-47962802-47962551, MOR189-3, Olfr228, GA_x6K02T0101M-139-669
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258400
Homologene: 17233
Aoah
Name: acyloxyacyl hydrolase
Synonyms: 4930433E13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27052
VEGA: 13
HGNC: HGNC:548
Homologene: 1238
Scg2
Name: secretogranin II
Synonyms: SgII, Chgc
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20254
Homologene: 2591
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329679
Homologene: 46417
Or5b97
Name: olfactory receptor family 5 subfamily B member 97
Synonyms: Olfr1447, GA_x6K02T2RE5P-3231251-3230331, MOR202-3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258698
HGNC: HGNC:8324
Homologene: 74233
Cldn13
Name: claudin 13
Synonyms: 2500004B14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57255
HGNC: HGNC:2046
Or5m11
Name: olfactory receptor family 5 subfamily M member 11
Synonyms: Olfr1028, GA_x6K02T2Q125-47430129-47431103, MOR198-3P, MOR198-3P, MOR198-6_p, Olfr1534-ps1, MOR198-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257936
Homologene: 73972
Rftn1
Name: raftlin lipid raft linker 1
Synonyms: 2310015N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76438
Homologene: 18745
Slc10a2
Name: solute carrier family 10, member 2
Synonyms: ASBT, 9130221J18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20494
Homologene: 390
Ston1
Name: stonin 1
Synonyms: 4921524J06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 77057
Homologene: 122152
Cnksr3
Name: Cnksr family member 3
Synonyms: Magi1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215748
Homologene: 18192
Cyb5r2
Name: cytochrome b5 reductase 2
Synonyms: D630003K02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320635
Homologene: 6182
Or5ac17
Name: olfactory receptor family 5 subfamily AC member 17
Synonyms: Olfr199, GA_x54KRFPKG5P-55430495-55429569, MOR182-14
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 404310
Homologene: 37011
Nipa1
Name: non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human)
Synonyms: A830014A18Rik, 1110027G09Rik, Spg6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233280
Homologene: 42327
Mrps28
Name: mitochondrial ribosomal protein S28
Synonyms: 1500012D08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66230
Homologene: 8519
Maneal
Name: mannosidase, endo-alpha-like
Synonyms: LOC215090
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 215090
Homologene: 17597
Tarbp2
Name: TARBP2, RISC loading complex RNA binding subunit
Synonyms: TRBP, Prbp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21357
Homologene: 7562
Zfp994
Name: zinc finger protein 994
Synonyms: Gm4944
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240038
VEGA: 17
Homologene: 133246
Igkv14-111
Name: immunoglobulin kappa variable 14-111
Synonyms: Gm16939
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 545847
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 43,123,653 bp
  • T to A, chromosome 1 at 79,436,290 bp
  • T to C, chromosome 1 at 150,454,301 bp
  • C to A, chromosome 2 at 26,423,500 bp
  • G to T, chromosome 2 at 85,951,518 bp
  • T to A, chromosome 2 at 86,483,229 bp
  • A to G, chromosome 2 at 150,667,920 bp
  • G to A, chromosome 2 at 168,668,013 bp
  • A to G, chromosome 3 at 8,899,980 bp
  • C to T, chromosome 3 at 53,478,329 bp
  • T to C, chromosome 3 at 79,481,634 bp
  • T to C, chromosome 4 at 116,088,780 bp
  • C to T, chromosome 4 at 124,856,842 bp
  • T to C, chromosome 4 at 135,557,433 bp
  • T to C, chromosome 5 at 134,914,915 bp
  • T to C, chromosome 6 at 18,258,236 bp
  • A to T, chromosome 6 at 68,256,741 bp
  • A to G, chromosome 6 at 97,487,640 bp
  • T to C, chromosome 7 at 29,015,654 bp
  • A to G, chromosome 7 at 30,712,462 bp
  • A to G, chromosome 7 at 55,979,606 bp
  • A to T, chromosome 7 at 83,722,321 bp
  • C to A, chromosome 7 at 83,722,328 bp
  • A to G, chromosome 7 at 97,907,881 bp
  • T to C, chromosome 7 at 107,753,255 bp
  • A to C, chromosome 8 at 5,098,581 bp
  • G to A, chromosome 8 at 41,261,036 bp
  • A to G, chromosome 8 at 125,444,484 bp
  • A to G, chromosome 9 at 27,051,755 bp
  • A to G, chromosome 9 at 38,930,665 bp
  • T to C, chromosome 10 at 7,126,820 bp
  • C to T, chromosome 10 at 62,937,477 bp
  • C to T, chromosome 10 at 69,991,747 bp
  • T to C, chromosome 10 at 75,246,167 bp
  • T to A, chromosome 10 at 102,385,127 bp
  • T to C, chromosome 11 at 4,939,551 bp
  • C to A, chromosome 11 at 76,424,989 bp
  • T to C, chromosome 11 at 97,628,507 bp
  • T to C, chromosome 11 at 115,821,680 bp
  • A to G, chromosome 13 at 20,999,942 bp
  • T to C, chromosome 13 at 106,865,769 bp
  • A to G, chromosome 15 at 102,518,479 bp
  • A to G, chromosome 16 at 11,153,161 bp
  • A to G, chromosome 16 at 20,594,679 bp
  • A to G, chromosome 16 at 23,012,115 bp
  • C to T, chromosome 16 at 59,216,020 bp
  • T to A, chromosome 17 at 22,200,546 bp
  • T to C, chromosome 17 at 50,047,306 bp
  • T to C, chromosome 17 at 88,636,468 bp
  • C to T, chromosome 18 at 20,836,868 bp
  • A to T, chromosome 19 at 6,854,878 bp
  • A to T, chromosome 19 at 7,520,798 bp
  • G to T, chromosome 19 at 12,901,005 bp
  • A to T, chromosome 19 at 16,664,018 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6459 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044594-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.