Strain Name:
C57BL/6J-MtgxR6465Btlr/Mmmh
Stock Number:
044598-MU
Citation ID:
RRID:MMRRC_044598-MU
Other Names:
R6465 (G1)
Major Collection:

Strain Information

Pzp
Name: PZP, alpha-2-macroglobulin like
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11287
Homologene: 104112
Get3
Name: guided entry of tail-anchored proteins factor 3, ATPase
Synonyms: ArsA, Asna1, 1810048H22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56495
HGNC: HGNC:752
Homologene: 31513
Rtel1
Name: regulator of telomere elongation helicase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269400
Homologene: 13168
Ylpm1
Name: YLP motif containing 1
Synonyms: Zap3, A930013E17Rik, ZAP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56531
Homologene: 87707
Adam23
Name: a disintegrin and metallopeptidase domain 23
Synonyms: MDC3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23792
HGNC: HGNC:202
Homologene: 2826
Tm9sf2
Name: transmembrane 9 superfamily member 2
Synonyms: P76, D14Ertd64e, 1500001N15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68059
Homologene: 21004
Nedd4l
Name: neural precursor cell expressed, developmentally down-regulated gene 4-like
Synonyms: Nedd4b, 1300012C07Rik, Nedd4-2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 83814
VEGA: 18
HGNC: HGNC:7728
Homologene: 86986
Rad17
Name: RAD17 checkpoint clamp loader component
Synonyms: 9430035O09Rik, MmRad24
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19356
VEGA: 13
HGNC: HGNC:9807
Homologene: 32117
Zfp719
Name: zinc finger protein 719
Synonyms: 9430094P17Rik, mszf6, C630016O21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210105
Inpp5j
Name: inositol polyphosphate 5-phosphatase J
Synonyms: Pib5pa, Pipp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170835
HGNC: HGNC:8956
Homologene: 8682
Cytl1
Name: cytokine-like 1
Synonyms: 4930443F05Rik, C17
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231162
Homologene: 10254
Isoc1
Name: isochorismatase domain containing 1
Synonyms: 2610034N03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66307
VEGA: 18
Homologene: 9361
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: CED-5, MBC, Hch
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Myo7a
Name: myosin VIIA
Synonyms: nmf371, polka, Myo7, Hdb, USH1B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: Piezo2, Fam38b, 9030411M15Rik, Fam38b2, 9430028L06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 667742
Homologene: 49695
Ttc8
Name: tetratricopeptide repeat domain 8
Synonyms: 0610012F22Rik, BBS8
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76260
Homologene: 14988
Zc3hav1
Name: zinc finger CCCH type, antiviral 1
Synonyms: 1200014N16Rik, 9130009D18Rik, 9830115L13Rik, ZAP, 2900058M19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78781
Homologene: 10585
Ints10
Name: integrator complex subunit 10
Synonyms: 4921521J11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70885
Homologene: 10029
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Pwwp2b
Name: PWWP domain containing 2B
Synonyms: D930023J19Rik, D7Ertd517e, Pwwp2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101631
Homologene: 19056
Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20663
Homologene: 38253
Parvg
Name: parvin, gamma
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 64099
Homologene: 11151
A2ml1
Name: alpha-2-macroglobulin like 1
Synonyms: Ovos2, BC048546
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232400
Homologene: 45969
Zcchc4
Name: zinc finger, CCHC domain containing 4
Synonyms: 4930449I23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78796
Homologene: 14632
Ptprn2
Name: protein tyrosine phosphatase receptor type N polypeptide 2
Synonyms: IA-2beta, IA-2 beta, 4930425H11Rik, phogrin, PTP-NP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19276
HGNC: HGNC:9677
Homologene: 2134
Nsun7
Name: NOL1/NOP2/Sun domain family, member 7
Synonyms: 4921525L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70918
Homologene: 11653
Or6b6
Name: olfactory receptor family 6 subfamily B member 6
Synonyms: MOR103-4, Olfr711, GA_x6K02T2PBJ9-9352783-9351839
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259037
Homologene: 128111
Bfsp1
Name: beaded filament structural protein 1, in lens-CP94
Synonyms: filensin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12075
HGNC: HGNC:1040
Homologene: 922
Or5m12
Name: olfactory receptor family 5 subfamily M member 12
Synonyms: MOR197-1, Olfr1024, GA_x6K02T2Q125-47384320-47383337
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257900
Homologene: 128271
Klhl18
Name: kelch-like 18
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270201
Homologene: 14805
Pou2f3
Name: POU domain, class 2, transcription factor 3
Synonyms: Skin, Skn-li, Epoc-1, Otf-11, Skin-1a, Otf11, Oct11, Oct-11a, Skn-1a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18988
Homologene: 7898
Acvr2b
Name: activin receptor IIB
Synonyms: ActRIIB
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11481
VEGA: 9
HGNC: HGNC:174
Homologene: 863
Apol8
Name: apolipoprotein L 8
Synonyms: 9830006J20Rik, Apol2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239552
VEGA: 15
Homologene: 12785
Gcm1
Name: glial cells missing homolog 1
Synonyms: glial cell deficient, Gcm 1, Gcm a, Gcm1-rs1, glide, GCMa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14531
VEGA: 9
HGNC: HGNC:4197
Homologene: 2702
Wfikkn1
Name: WAP, FS, Ig, KU, and NTR-containing protein 1
Synonyms: Gasp2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 215001
Homologene: 14244
Unc93a2
Name: unc-93 homolog A2
Synonyms: Gm9992
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 667055
VEGA: 17
Homologene: 10356
Krtap2-4
Name: keratin associated protein 2-4
Synonyms: 5530401P19Rik, KAP2.4, KRTAP2.4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71453
Homologene: 41961
Fxyd5
Name: FXYD domain-containing ion transport regulator 5
Synonyms: dysadherin, EF-8, Oit2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18301
HGNC: HGNC:4029
Homologene: 7458
Pate13
Name: prostate and testis expressed 13
Synonyms: 9230113P08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77908
Haghl
Name: hydroxyacylglutathione hydrolase-like
Synonyms: 2810014I23Rik, C330022E15Rik, 1500017E18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68977
Homologene: 57062
Tdpoz6
Name: TD and POZ domain containing 6
Synonyms: Gm37596, Gm9107
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 668325
Krtap3-1
Name: keratin associated protein 3-1
Synonyms: KRTAP3.1, 2310003K17Rik, KAP3.1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69473
Homologene: 84874
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 63,566,668 bp
  • GCCC to GC, chromosome 1 at 88,232,257 bp
  • A to T, chromosome 2 at 85,904,539 bp
  • A to C, chromosome 2 at 143,858,055 bp
  • T to A, chromosome 2 at 181,335,940 bp
  • A to G, chromosome 3 at 93,692,996 bp
  • T to C, chromosome 5 at 37,737,670 bp
  • T to A, chromosome 5 at 52,819,276 bp
  • T to C, chromosome 5 at 66,295,586 bp
  • T to C, chromosome 6 at 38,331,849 bp
  • A to G, chromosome 6 at 128,491,619 bp
  • G to A, chromosome 6 at 128,541,078 bp
  • G to T, chromosome 7 at 31,037,880 bp
  • C to A, chromosome 7 at 43,590,684 bp
  • A to G, chromosome 7 at 98,062,680 bp
  • A to T, chromosome 7 at 106,972,212 bp
  • T to C, chromosome 7 at 139,256,035 bp
  • A to G, chromosome 8 at 68,807,536 bp
  • A to T, chromosome 8 at 85,018,565 bp
  • A to T, chromosome 9 at 35,908,625 bp
  • A to C, chromosome 9 at 43,139,867 bp
  • A to G, chromosome 9 at 78,064,869 bp
  • A to G, chromosome 9 at 110,428,920 bp
  • T to A, chromosome 9 at 119,433,303 bp
  • C to A, chromosome 11 at 3,502,293 bp
  • A to T, chromosome 11 at 34,503,413 bp
  • G to A, chromosome 11 at 99,566,451 bp
  • A to G, chromosome 11 at 99,614,759 bp
  • T to C, chromosome 12 at 69,596,775 bp
  • T to A, chromosome 12 at 85,049,802 bp
  • A to G, chromosome 12 at 98,964,570 bp
  • T to C, chromosome 12 at 117,269,589 bp
  • T to A, chromosome 13 at 100,637,080 bp
  • A to G, chromosome 14 at 122,141,207 bp
  • T to G, chromosome 15 at 77,749,948 bp
  • A to G, chromosome 15 at 84,328,940 bp
  • G to T, chromosome 17 at 7,374,443 bp
  • T to C, chromosome 17 at 25,783,819 bp
  • A to G, chromosome 17 at 25,878,718 bp
  • T to A, chromosome 18 at 58,671,256 bp
  • T to A, chromosome 18 at 63,041,663 bp
  • T to A, chromosome 18 at 65,155,264 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6465 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044598-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.