Strain Name:
C57BL/6J-MtgxR6470Btlr/Mmmh
Stock Number:
044603-MU
Citation ID:
RRID:MMRRC_044603-MU
Other Names:
R6470 (G1)
Major Collection:

Strain Information

Gba1
Name: glucosylceramidase beta 1
Synonyms: GCase, betaGC, GBA1, Gba, glucocerebrosidase, GC
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14466
HGNC: HGNC:4177
Homologene: 68040
Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Plin2
Name: perilipin 2
Synonyms: adipophilin, ADPH, Adrp, Adfp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11520
HGNC: HGNC:248
Homologene: 872
Dst
Name: dystonin
Synonyms: Bpag, Macf2, A830042E19Rik, nmf339, 2310001O04Rik, BPAG1, BPAG1-n, bullous pemphigoid antigen 1, bullous pemphigoid antigen 1, athetoid, nmf203, Bpag1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur-4, Gluralpha4, Glur4, spkw1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Kif1b
Name: kinesin family member 1B
Synonyms: N-3 kinesin, D4Mil1e, KIF1Bp204, KIF1Bp130, A530096N05Rik, Kif1b alpha, Kif1b beta
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Srrt
Name: serrate RNA effector molecule homolog (Arabidopsis)
Synonyms: Asr2, 2810019G02Rik, Ars2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83701
Homologene: 9298
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 9030205D12Rik, AD013, A330063D19Rik, 1810014J18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109151
Homologene: 11844
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Qrich1
Name: glutamine-rich 1
Synonyms: 2610028H07Rik, b2b2404Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69232
Homologene: 9803
Scaf4
Name: SR-related CTD-associated factor 4
Synonyms: Sfrs15, Sra4, Srsf15
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224432
VEGA: 16
Homologene: 16227
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, Zfp650, 1110059H15Rik, A130030D10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Sptb
Name: spectrin beta, erythrocytic
Synonyms: Spnb1, brain erythroid spectrin (235E), D330027P03Rik, LOC383567, Spnb-1, spectrin R
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20741
Homologene: 295
Pianp
Name: PILR alpha associated neural protein
Synonyms: C530028O21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319352
Homologene: 17799
Cd300lg
Name: CD300 molecule like family member G
Synonyms: nepmucin, D11Ertd736e, Clm9, 2310016B05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52685
Homologene: 17059
Dpy19l2
Name: dpy-19 like 2
Synonyms: 4932443J21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320752
VEGA: 9
Homologene: 77569
Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase 5
Synonyms: D17Abb1e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83965
Homologene: 23313
Il17rb
Name: interleukin 17 receptor B
Synonyms: IL-17Rh1, IL-17ER, Evi27, IL17RH1, Il17br
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50905
Homologene: 10287
Smap2
Name: small ArfGAP 2
Synonyms: Smap2, 1810031K02Rik, Smap1l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69780
Homologene: 41489
Tlr3
Name: toll-like receptor 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 142980
Homologene: 20696
Cubn
Name: cubilin
Synonyms: intrinsic factor-cobalamin receptor, D2Wsu88e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Slc35d1
Name: solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
Synonyms: UGTREL7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242585
Homologene: 22870
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Itga9
Name: integrin alpha 9
Synonyms: D9Ertd428e, 2610002H11Rik, 6720458D17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 104099
HGNC: HGNC:6145
Homologene: 1664
Gm9936
Name: predicted gene 9936
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 791292
VEGA: 5
Brinp3
Name: bone morphogenetic protein/retinoic acid inducible neural specific 3
Synonyms: B830045N13Rik, Fam5c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215378
Homologene: 17786
Clca3a2
Name: chloride channel accessory 3A2
Synonyms: Clca2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80797
HGNC: HGNC:2017
Homologene: 77224
Cyp2b10
Name: cytochrome P450, family 2, subfamily b, polypeptide 10
Synonyms: Cyp2b, Cyp2b20, phenobarbitol inducible, type b, p16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13088
HGNC: HGNC:2615
Homologene: 73894
Ros1
Name: Ros1 proto-oncogene
Synonyms: c-ros, Ros-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19886
Homologene: 2207
Phlpp2
Name: PH domain and leucine rich repeat protein phosphatase 2
Synonyms: C130044A18Rik, Phlppl
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244650
Homologene: 71015
Garin5b
Name: golgi associated RAB2 interactor family member 5B
Synonyms: 4930401F20Rik, Fam71e2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243822
Homologene: 89225
Ces3b
Name: carboxylesterase 3B
Synonyms: Gm4738, ES31L
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13909
HGNC: HGNC:1865
Homologene: 84407
Sardh
Name: sarcosine dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192166
Homologene: 5149
Sh3rf3
Name: SH3 domain containing ring finger 3
Synonyms: 4831416G18Rik, Sh3md4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237353
Homologene: 77551
Or10a4
Name: olfactory receptor family 10 subfamily A member 4
Synonyms: MOR263-5, P2, Olfr17, GA_x6K02T2PBJ9-9470146-9471093
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18314
Homologene: 23241
Cyp4v3
Name: cytochrome P450, family 4, subfamily v, polypeptide 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102294
Homologene: 133054
Carns1
Name: carnosine synthase 1
Synonyms: Atpgd1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107239
VEGA: 19
Homologene: 26439
Nat8l
Name: N-acetyltransferase 8-like
Synonyms: Shati, 1110038O08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269642
Homologene: 19546
4933402J07Rik
Name: RIKEN cDNA 4933402J07 gene
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330820
Homologene: 51633
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 34,295,237 bp
  • A to G, chromosome 1 at 146,901,906 bp
  • G to T, chromosome 2 at 13,322,993 bp
  • C to T, chromosome 2 at 27,244,372 bp
  • T to A, chromosome 2 at 69,965,460 bp
  • A to T, chromosome 2 at 119,753,035 bp
  • C to T, chromosome 3 at 89,204,081 bp
  • T to A, chromosome 3 at 144,804,263 bp
  • G to T, chromosome 4 at 86,668,370 bp
  • T to C, chromosome 4 at 88,683,514 bp
  • A to G, chromosome 4 at 103,189,822 bp
  • GACTCTAC to GAC, chromosome 4 at 120,973,085 bp
  • T to C, chromosome 4 at 149,192,596 bp
  • C to T, chromosome 5 at 33,998,492 bp
  • T to C, chromosome 5 at 114,857,421 bp
  • T to C, chromosome 5 at 137,302,656 bp
  • A to G, chromosome 6 at 30,102,200 bp
  • T to A, chromosome 6 at 73,074,586 bp
  • A to G, chromosome 6 at 84,066,944 bp
  • T to A, chromosome 6 at 124,999,269 bp
  • T to C, chromosome 7 at 4,757,851 bp
  • T to C, chromosome 7 at 25,911,656 bp
  • T to C, chromosome 7 at 107,097,744 bp
  • C to T, chromosome 8 at 45,317,736 bp
  • T to C, chromosome 8 at 45,397,385 bp
  • G to T, chromosome 8 at 87,564,028 bp
  • A to G, chromosome 8 at 90,932,798 bp
  • A to T, chromosome 8 at 105,088,653 bp
  • A to G, chromosome 8 at 109,937,194 bp
  • A to G, chromosome 9 at 4,503,680 bp
  • A to T, chromosome 9 at 24,660,743 bp
  • T to C, chromosome 9 at 108,534,518 bp
  • A to T, chromosome 9 at 118,897,267 bp
  • G to T, chromosome 10 at 11,171,937 bp
  • A to G, chromosome 10 at 52,166,044 bp
  • A to G, chromosome 10 at 58,983,969 bp
  • A to G, chromosome 11 at 95,511,093 bp
  • A to G, chromosome 11 at 102,050,505 bp
  • A to G, chromosome 11 at 107,072,767 bp
  • A to G, chromosome 12 at 76,612,829 bp
  • A to G, chromosome 14 at 30,002,909 bp
  • T to C, chromosome 15 at 89,792,601 bp
  • C to T, chromosome 16 at 90,229,638 bp
  • G to A, chromosome 17 at 44,085,264 bp
  • T to C, chromosome 19 at 4,171,783 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6470 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044603-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.