Strain Name:
C57BL/6J-MtgxR6471Btlr/Mmmh
Stock Number:
044604-MU
Citation ID:
RRID:MMRRC_044604-MU
Other Names:
R6471 (G1)
Major Collection:

Strain Information

Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, C030018K18Rik, Pdzgef2, RA-GEF-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Kif1b
Name: kinesin family member 1B
Synonyms: A530096N05Rik, KIF1Bp130, KIF1Bp204, N-3 kinesin, D4Mil1e, Kif1b alpha, Kif1b beta
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Glod4
Name: glyoxalase domain containing 4
Synonyms: 2700085E05Rik, 1700082G03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67201
Homologene: 9376
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Plcg1
Name: phospholipase C, gamma 1
Synonyms: Plc-gamma1, Plc-1, Plcg-1, Cded
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18803
HGNC: HGNC:9065
Homologene: 1997
Zfp318
Name: zinc finger protein 318
Synonyms: TZF, D530032D06Rik, 2610034E08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57908
Homologene: 22808
Slc6a3
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Synonyms: Dat1, DAT
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13162
VEGA: 13
Homologene: 55547
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: Mtmr15, 6030441H18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
Tuba1b
Name: tubulin, alpha 1B
Synonyms: Tuba2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22143
Homologene: 134527
Car9
Name: carbonic anhydrase 9
Synonyms: CAIX, MN/CA9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230099
HGNC: HGNC:1383
Homologene: 20325
Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase 5
Synonyms: D17Abb1e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83965
Homologene: 23313
Peak1
Name: pseudopodium-enriched atypical kinase 1
Synonyms: 1110049L02Rik, C230081A13Rik, NKF3 kinase family member
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244895
Homologene: 18259
Tex15
Name: testis expressed gene 15 meiosis and synapsis associated
Synonyms: 2210014E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104271
Homologene: 12837
Pak5
Name: p21 (RAC1) activated kinase 5
Synonyms: Pak5, Pak7, 2900083L08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241656
Homologene: 22211
Lrrc37
Name: leucine rich repeat containing 37
Synonyms: Gm884, LOC380730
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380730
Homologene: 134511
Exoc3l
Name: exocyst complex component 3-like
Synonyms: C730015A04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 277978
Homologene: 18629
Fam227b
Name: family with sequence similarity 227, member B
Synonyms: 4930525F21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75823
Homologene: 27384
Zfp93
Name: zinc finger protein 93
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22755
Homologene: 117959
Map3k19
Name: mitogen-activated protein kinase kinase kinase 19
Synonyms: Ysk4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22625
Homologene: 19318
Ttbk1
Name: tau tubulin kinase 1
Synonyms: C330008L01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106763
VEGA: 17
Homologene: 50342
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: cytoplasmic linker protein 50, restin, Clip 170, Clip50, Rsn, 4631429H07Rik, 1110007I12Rik, CLIP-170
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56430
Homologene: 74455
Usp9y
Name: ubiquitin specific peptidase 9, Y chromosome
Synonyms: Dffry, Fafl2
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 107868
Homologene: 68408
Cobll1
Name: Cobl-like 1
Synonyms: D430044D16Rik, Coblr1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319876
Homologene: 8933
Birc3
Name: baculoviral IAP repeat-containing 3
Synonyms: RNF49, Api2, cIAP2, MIAP2, MIHC, HIAP2, IAP2, cIAP-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11796
HGNC: HGNC:591
Homologene: 899
Vmn2r51
Name: vomeronasal 2, receptor 51
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042921
Homologene: 113703
Gdap1
Name: ganglioside-induced differentiation-associated-protein 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14545
Homologene: 40713
Vmn1r169
Name: vomeronasal 1 receptor 169
Synonyms: Gm4232
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043103
Homologene: 128341
Cideb
Name: cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
Synonyms: CIDE-B, 1110030C18Rik, DFFA-like B
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12684
HGNC: HGNC:1977
Homologene: 7666
Rnft1
Name: ring finger protein, transmembrane 1
Synonyms: 0610013E23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76892
Homologene: 41110
Ciao2a
Name: cytosolic iron-sulfur assembly component 2A
Synonyms: Fam96a, 5730536A07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68250
Homologene: 12252
Ccdc86
Name: coiled-coil domain containing 86
Synonyms: D19Ertd678e, cyclon, 4933411H20Rik, 6720480F16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 108673
Homologene: 41531
Rbfa
Name: ribosome binding factor A
Synonyms: 1110032A13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68731
VEGA: 18
Homologene: 11725
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 17,160,025 bp
  • C to T, chromosome 1 at 127,817,254 bp
  • A to G, chromosome 2 at 65,107,884 bp
  • A to T, chromosome 2 at 126,121,065 bp
  • A to T, chromosome 2 at 136,116,190 bp
  • A to G, chromosome 2 at 160,753,710 bp
  • T to C, chromosome 4 at 43,511,938 bp
  • T to C, chromosome 4 at 149,192,596 bp
  • A to G, chromosome 5 at 123,640,549 bp
  • A to C, chromosome 7 at 10,102,583 bp
  • A to G, chromosome 7 at 23,577,545 bp
  • T to C, chromosome 7 at 24,273,329 bp
  • T to A, chromosome 7 at 64,372,486 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,914 bp
  • G to T, chromosome 8 at 33,581,734 bp
  • A to G, chromosome 8 at 105,290,534 bp
  • A to G, chromosome 9 at 7,857,420 bp
  • A to G, chromosome 9 at 56,258,259 bp
  • T to A, chromosome 9 at 66,126,857 bp
  • A to G, chromosome 11 at 54,691,737 bp
  • A to T, chromosome 11 at 76,233,918 bp
  • T to C, chromosome 11 at 86,491,682 bp
  • T to A, chromosome 11 at 103,619,622 bp
  • G to A, chromosome 13 at 73,544,884 bp
  • T to C, chromosome 14 at 55,757,952 bp
  • T to C, chromosome 15 at 98,932,447 bp
  • G to A, chromosome 17 at 44,085,264 bp
  • A to G, chromosome 17 at 46,399,505 bp
  • A to G, chromosome 17 at 46,467,277 bp
  • G to T, chromosome 18 at 80,200,458 bp
  • A to G, chromosome 19 at 10,948,879 bp
  • A to G, chromosome Y at 1,384,511 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6471 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044604-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.