Strain Name:
C57BL/6J-MtgxR6472Btlr/Mmmh
Stock Number:
044605-MU
Citation ID:
RRID:MMRRC_044605-MU
Other Names:
R6472 (G1)
Major Collection:

Strain Information

Wnt3
Name: wingless-type MMTV integration site family, member 3
Synonyms: Int-4, Wnt-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22415
Homologene: 22527
Gsn
Name: gelsolin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227753
HGNC: HGNC:4620
Homologene: 147
Kif16b
Name: kinesin family member 16B
Synonyms: N-3 kinesin, 8430434E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16558
Homologene: 135708
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: B630009I04Rik, Helic1, ASC1p200
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Kif1b
Name: kinesin family member 1B
Synonyms: Kif1b beta, A530096N05Rik, N-3 kinesin, D4Mil1e, KIF1Bp204, KIF1Bp130, Kif1b alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Abca1
Name: ATP-binding cassette, sub-family A member 1
Synonyms: ABC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Snrpb2
Name: U2 small nuclear ribonucleoprotein B
Synonyms: 2810052G09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20639
Homologene: 37728
Ccn3
Name: cellular communication network factor 3
Synonyms: CCN3, C130088N23Rik, Nov
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18133
HGNC: HGNC:7885
Homologene: 1884
Il2ra
Name: interleukin 2 receptor, alpha chain
Synonyms: Ly-43, Il2r, IL-2R alpha chain, CD25
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16184
HGNC: HGNC:6008
Homologene: 360
Smap2
Name: small ArfGAP 2
Synonyms: Smap1l, 1810031K02Rik, Smap2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69780
Homologene: 41489
Sis
Name: sucrase isomaltase
Synonyms: sucrase-isomaltase, 2010204N08Rik, Si-s
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69983
Homologene: 37424
Fbxo30
Name: F-box protein 30
Synonyms: 1700026A16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71865
Homologene: 12959
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 1300010F03Rik, 4932416F07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Pappa2
Name: pappalysin 2
Synonyms: pregnancy-associated plasma protein-E, pregnancy-associated plasma preproprotein-A2, placenta-specific 3, PLAC3, PAPP-A2, Pappe
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23850
Homologene: 10661
Epcip
Name: exosomal polycystin 1 interacting protein
Synonyms: 4932438H23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74387
HGNC: HGNC:1305
Homologene: 49594
Syt10
Name: synaptotagmin X
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54526
Homologene: 10303
Tmem163
Name: transmembrane protein 163
Synonyms: 2610024A01Rik, SV31
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72160
Homologene: 12798
Or8k41
Name: olfactory receptor family 8 subfamily K member 41
Synonyms: Olfr1071, GA_x6K02T2Q125-47962802-47962551, MOR189-3, Olfr228, GA_x6K02T0101M-139-669
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258400
Homologene: 17233
Cdadc1
Name: cytidine and dCMP deaminase domain containing 1
Synonyms: NYD-SP15, 2310010M10Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71891
VEGA: 14
Homologene: 12794
Or2a20
Name: olfactory receptor family 2 subfamily A member 2
Synonyms: Olfr434, MOR261-10, GA_x6K02T2P3E9-4341246-4340281
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258366
Homologene: 133700
Odr4
Name: odr4 GPCR localization factor homolog
Synonyms: BC003331, 1810053E15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226499
Homologene: 41202
Cyp2f2
Name: cytochrome P450, family 2, subfamily f, polypeptide 2
Synonyms: Cyp2f
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13107
Homologene: 73898
Vmn1r237
Name: vomeronasal 1 receptor 237
Synonyms: V1rf3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171234
Homologene: 64475
Fads6
Name: fatty acid desaturase domain family, member 6
Synonyms: BC050213, OTTMUSG00000021749
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 328035
Homologene: 18646
Csrp3
Name: cysteine and glycine-rich protein 3
Synonyms: MLP, CRP3, muscle LIM protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13009
HGNC: HGNC:2472
Homologene: 20742
Or7g22
Name: olfactory receptor family 7 subfamily G member 22
Synonyms: GA_x6K02T2PVTD-12873838-12874776, Olfr837, MOR152-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258558
HGNC: HGNC:8466
Homologene: 115507
Pcp4l1
Name: Purkinje cell protein 4-like 1
Synonyms: 1500036F01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66425
Homologene: 136091
Or2aa1
Name: olfactory receptor family 2 subfamily AA member 1
Synonyms: Olfr223, MOR256-30, GA_x6K02T000SA-78-1037
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258421
Homologene: 73917
Trav3-1
Name: T cell receptor alpha variable 3-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 667441
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 127,495,734 bp
  • C to T, chromosome 1 at 150,381,522 bp
  • T to C, chromosome 1 at 158,834,799 bp
  • A to T, chromosome 1 at 171,174,435 bp
  • G to A, chromosome 2 at 11,681,969 bp
  • A to G, chromosome 2 at 35,290,451 bp
  • A to T, chromosome 2 at 86,483,190 bp
  • G to T, chromosome 2 at 142,699,948 bp
  • A to G, chromosome 2 at 143,068,301 bp
  • C to T, chromosome 3 at 72,938,734 bp
  • A to G, chromosome 4 at 53,085,991 bp
  • GACTCTAC to GAC, chromosome 4 at 120,973,085 bp
  • T to C, chromosome 4 at 149,192,596 bp
  • A to G, chromosome 6 at 43,217,359 bp
  • G to A, chromosome 7 at 27,129,224 bp
  • G to A, chromosome 7 at 48,835,608 bp
  • T to A, chromosome 9 at 19,137,415 bp
  • T to C, chromosome 10 at 11,291,231 bp
  • T to C, chromosome 10 at 50,720,687 bp
  • G to A, chromosome 11 at 59,589,756 bp
  • G to A, chromosome 11 at 103,808,274 bp
  • T to C, chromosome 11 at 115,286,136 bp
  • A to G, chromosome 13 at 12,434,230 bp
  • G to T, chromosome 14 at 52,581,050 bp
  • T to C, chromosome 14 at 59,586,042 bp
  • T to C, chromosome 14 at 79,009,170 bp
  • A to T, chromosome 15 at 54,749,272 bp
  • T to G, chromosome 15 at 89,814,558 bp
  • A to T, chromosome 16 at 91,056,003 bp
  • G to A, chromosome 17 at 21,314,354 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6472 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044605-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.