Strain Name:
C57BL/6J-MtgxR6479Btlr/Mmmh
Stock Number:
044611-MU
Citation ID:
RRID:MMRRC_044611-MU
Other Names:
R6479 (G1)
Major Collection:

Strain Information

Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: 1110006F08Rik, Dicer1, D12Ertd7e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Jarid2
Name: jumonji and AT-rich interaction domain containing 2
Synonyms: Jmj, jumonji
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16468
HGNC: HGNC:6196
Homologene: 31279
Cops3
Name: COP9 signalosome subunit 3
Synonyms: COP9 complex S3, Csn3, Sgn3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 26572
HGNC: HGNC:2239
Homologene: 2710
Pepd
Name: peptidase D
Synonyms: peptidase D, Pep-4, Pep4, dal
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18624
HGNC: HGNC:8840
Homologene: 239
Slc37a1
Name: solute carrier family 37 (glycerol-3-phosphate transporter), member 1
Synonyms: G3PP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224674
VEGA: 17
Homologene: 70486
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: Frap1, RAPT1, RAFT1, flat, 2610315D21Rik, FKBP-rapamycin-associated protein FRAP, mechanistic target of rapamycin (serine/threonine kinase)
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: D5Ertd66e, 2610509D04Rik, Ggtb3, Bwf1, Alfy, Bchs
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72145
Homologene: 22855
Kif13b
Name: kinesin family member 13B
Synonyms: C130021D12Rik, N-3 kinesin, GAKIN, 5330429L19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16554
VEGA: 14
Homologene: 9073
Banp
Name: BTG3 associated nuclear protein
Synonyms: SMAR1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 53325
Homologene: 9635
Nedd4l
Name: neural precursor cell expressed, developmentally down-regulated gene 4-like
Synonyms: Nedd4-2, Nedd4b, 1300012C07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 83814
VEGA: 18
HGNC: HGNC:7728
Homologene: 86986
Anapc2
Name: anaphase promoting complex subunit 2
Synonyms: 9230107K09Rik, Imi4, APC2, expressed during mesenchymal induction 4, Emi4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99152
Homologene: 8359
Dock4
Name: dedicator of cytokinesis 4
Synonyms: EST N28122, 6330411N01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238130
VEGA: 12
Homologene: 56680
Tead1
Name: TEA domain family member 1
Synonyms: mTEF-1, Tcf13, Gtrgeo5, TEAD-1, TEF-1, B230114H05Rik, 2610024B07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21676
Homologene: 2418
Gab1
Name: growth factor receptor bound protein 2-associated protein 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14388
HGNC: HGNC:4066
Homologene: 1542
Atp6v1a
Name: ATPase, H+ transporting, lysosomal V1 subunit A
Synonyms: lysosomal 70kDa, VPP2, VA68, Atp6a1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11964
HGNC: HGNC:851
Homologene: 123934
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, C130039F11Rik, A330049M09Rik, enaptin165, nesprin-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Camsap1
Name: calmodulin regulated spectrin-associated protein 1
Synonyms: 9530003A05Rik, PRO2405
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227634
Homologene: 19202
Erap1
Name: endoplasmic reticulum aminopeptidase 1
Synonyms: ERAAP, PILSAP, Arts1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 80898
VEGA: 13
Homologene: 56754
Slit2
Name: slit guidance ligand 2
Synonyms: Drad-1, b2b1200.1Clo, E130320P19Rik, Slil3, E030015M03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20563
Homologene: 3516
Dennd1b
Name: DENN domain containing 1B
Synonyms: 4632404N19Rik, F730008N07Rik, 4930467M19Rik, 6820401H01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329260
Homologene: 11739
Med13
Name: mediator complex subunit 13
Synonyms: Trap240, 1110067M05Rik, Thrap1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327987
Homologene: 21067
Pdp1
Name: pyruvate dehydrogenase phosphatase catalytic subunit 1
Synonyms: LOC381511, Ppm2c
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381511
HGNC: HGNC:9279
Homologene: 31928
Casz1
Name: castor zinc finger 1
Synonyms: castor, 2410019P08Rik, D4Ertd432e, Cst
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69743
Homologene: 9824
Strip2
Name: striatin interacting protein 2
Synonyms: Fam40b, D330017J20Rik, Myoscape
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320609
Homologene: 66198
Adam18
Name: a disintegrin and metallopeptidase domain 18
Synonyms: Dtgn3, Adam27
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13524
HGNC: HGNC:196
Homologene: 74941
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Trim37
Name: tripartite motif-containing 37
Synonyms: TEF3, 2810004E07Rik, MUL, 1110032A10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68729
HGNC: HGNC:7523
Homologene: 9084
Nrde2
Name: nrde-2 necessary for RNA interference, domain containing
Synonyms: BC002230, 6720454P05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217827
VEGA: 12
Homologene: 41213
Akap6
Name: A kinase anchor protein 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Irak2
Name: interleukin-1 receptor-associated kinase 2
Synonyms: 6330415L08Rik, IRAK-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108960
HGNC: HGNC:6113
Homologene: 1207
Mroh7
Name: maestro heat-like repeat family member 7
Synonyms: Heatr8, Gm1027, LOC381538
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381538
Homologene: 19633
Hmcn1
Name: hemicentin 1
Synonyms: EG545370, LOC240793
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Stxbp4
Name: syntaxin binding protein 4
Synonyms: Synip, 6030470M02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20913
Homologene: 7963
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Alox15
Name: arachidonate 15-lipoxygenase
Synonyms: L-12LO, Alox12l, 12-LO
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11687
HGNC: HGNC:433
Homologene: 44935
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Megf10
Name: multiple EGF-like-domains 10
Synonyms: 3000002B06Rik, LOC240312
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70417
Homologene: 23771
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: Megf7, mdig, 6430526J12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Pcdha1
Name: protocadherin alpha 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 116731
HGNC: HGNC:8663
Homologene: 75093
Syne4
Name: spectrin repeat containing, nuclear envelope family member 4
Synonyms: AI428936, nesprin-4, 0610012K07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233066
Homologene: 17716
Osgepl1
Name: O-sialoglycoprotein endopeptidase-like 1
Synonyms: MGC13061, 2610001M19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72085
Homologene: 5561
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Or52n4
Name: olfactory receptor family 52 subfamily N member 4
Synonyms: Olfr658, MOR34-5, GA_x6K02T2PBJ9-7273558-7272587
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259051
Homologene: 105161
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Cxcl15
Name: C-X-C motif chemokine ligand 15
Synonyms: Scyb15, weche, Il8, lungkine
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20309
Rhot2
Name: ras homolog family member T2
Synonyms: Miro2, Arht2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 214952
Homologene: 56038
Gm10309
Name: predicted gene 10309
Type: Gene
Species: Mouse
Chromosome: 17
Hsd3b9
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 9
Synonyms: Gm4450
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100043461
Homologene: 104115
Cts7
Name: cathepsin 7
Synonyms: Epcs24, CTS1, Epcs71
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56092
VEGA: 13
Homologene: 75110
Meltf
Name: melanotransferrin
Synonyms: MTf, Mfi2, melanotransferrin, CD228
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 30060
VEGA: 16
HGNC: HGNC:7037
Homologene: 4335
Wdr81
Name: WD repeat domain 81
Synonyms: shakey 5, MGC32441, nur5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192652
Homologene: 13983
Spint4
Name: serine protease inhibitor, Kunitz type 4
Synonyms: Spint4, 9230105I15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78239
Homologene: 49932
Zfp1002
Name: zinc finger protein 1002
Synonyms: Gm21994
Type: Gene
Species: Mouse
Chromosome: 2
Rbp7
Name: retinol binding protein 7, cellular
Synonyms: 1110002J23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 63954
Homologene: 32521
Ccl5
Name: C-C motif chemokine ligand 5
Synonyms: TCP228, SISd, MuRantes, Scya5, RANTES
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20304
Homologene: 2244
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 53,321,543 bp
  • C to T, chromosome 1 at 139,041,960 bp
  • G to A, chromosome 1 at 150,677,302 bp
  • T to C, chromosome 2 at 22,577,865 bp
  • A to G, chromosome 2 at 25,285,395 bp
  • A to G, chromosome 2 at 25,935,862 bp
  • A to G, chromosome 2 at 31,425,468 bp
  • A to T, chromosome 2 at 31,887,401 bp
  • A to G, chromosome 2 at 82,990,086 bp
  • C to T, chromosome 2 at 91,487,084 bp
  • C to T, chromosome 2 at 150,254,591 bp
  • C to A, chromosome 2 at 164,700,844 bp
  • T to C, chromosome 3 at 63,744,510 bp
  • T to A, chromosome 3 at 98,446,841 bp
  • T to C, chromosome 4 at 11,961,327 bp
  • A to G, chromosome 4 at 106,703,188 bp
  • T to C, chromosome 4 at 148,551,000 bp
  • C to A, chromosome 4 at 148,937,078 bp
  • T to C, chromosome 4 at 149,449,890 bp
  • T to A, chromosome 5 at 48,231,989 bp
  • A to T, chromosome 5 at 90,795,245 bp
  • A to C, chromosome 5 at 101,913,179 bp
  • G to A, chromosome 5 at 134,661,519 bp
  • G to T, chromosome 6 at 29,944,497 bp
  • A to T, chromosome 6 at 113,686,941 bp
  • G to T, chromosome 7 at 30,316,915 bp
  • A to G, chromosome 7 at 35,040,722 bp
  • A to T, chromosome 7 at 41,040,787 bp
  • A to G, chromosome 7 at 104,645,126 bp
  • T to C, chromosome 7 at 112,861,465 bp
  • A to C, chromosome 8 at 24,629,665 bp
  • C to A, chromosome 8 at 80,788,597 bp
  • A to G, chromosome 8 at 121,991,437 bp
  • C to A, chromosome 9 at 109,111,665 bp
  • G to A, chromosome 10 at 5,231,679 bp
  • A to T, chromosome 10 at 5,456,826 bp
  • A to T, chromosome 11 at 59,833,072 bp
  • A to G, chromosome 11 at 70,345,185 bp
  • A to G, chromosome 11 at 75,452,105 bp
  • A to G, chromosome 11 at 83,530,386 bp
  • G to A, chromosome 11 at 86,357,527 bp
  • G to T, chromosome 11 at 87,216,487 bp
  • T to C, chromosome 11 at 90,619,187 bp
  • A to G, chromosome 12 at 40,828,955 bp
  • T to G, chromosome 12 at 53,141,169 bp
  • T to C, chromosome 12 at 100,143,948 bp
  • T to C, chromosome 12 at 104,696,723 bp
  • G to A, chromosome 13 at 44,848,289 bp
  • A to G, chromosome 13 at 61,355,641 bp
  • A to G, chromosome 13 at 74,663,493 bp
  • A to G, chromosome 14 at 64,751,525 bp
  • T to A, chromosome 16 at 31,881,882 bp
  • T to C, chromosome 16 at 44,098,758 bp
  • A to T, chromosome 17 at 25,841,080 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • A to G, chromosome 17 at 31,338,990 bp
  • A to T, chromosome 17 at 86,504,579 bp
  • C to T, chromosome 18 at 36,931,456 bp
  • T to C, chromosome 18 at 57,246,570 bp
  • G to A, chromosome 18 at 65,209,681 bp
  • T to C, chromosome 18 at 74,617,015 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6479 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044611-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.