Strain Name:
C57BL/6J-MtgxR6480Btlr/Mmmh
Stock Number:
044612-MU
Citation ID:
RRID:MMRRC_044612-MU
Other Names:
R6480 (G1)
Major Collection:

Strain Information

Drd4
Name: dopamine receptor D4
Synonyms: Drd-4, D4R
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13491
HGNC: HGNC:3025
Homologene: 20215
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66860
Homologene: 18946
Utp20
Name: UTP20 small subunit processome component
Synonyms: mDRIM, DRIM, 3830408P06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Plcd3
Name: phospholipase C, delta 3
Synonyms: 2610205J15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72469
HGNC: HGNC:9061
Homologene: 14858
Pipox
Name: pipecolic acid oxidase
Synonyms: Pso
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19193
Homologene: 40640
Arl8b
Name: ADP-ribosylation factor-like 8B
Synonyms: 3100002J04Rik, 2610313E07Rik, Arl10c
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67166
Homologene: 10056
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: ASC1p200, B630009I04Rik, Helic1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Mical3
Name: microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms: MICAL-3, C130040D16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194401
Homologene: 85288
Tcof1
Name: treacle ribosome biogenesis factor 1
Synonyms: treacle
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21453
Homologene: 68049
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Wbp1l
Name: WW domain binding protein 1 like
Synonyms: D19Wsu162e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226178
Homologene: 9839
Thbs1
Name: thrombospondin 1
Synonyms: TSP1, TSP-1, Thbs-1, tbsp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21825
Homologene: 31142
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: C530005A01Rik, 6030465E24Rik, spastic paraplegia 11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214585
Homologene: 41614
Glg1
Name: golgi apparatus protein 1
Synonyms: ESL-1, CFR, MG-160, MG160, CFR-1, Selel
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20340
HGNC: HGNC:4316
Homologene: 7533
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Tbc1d10b
Name: TBC1 domain family, member 10b
Synonyms: 1110003P22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68449
Homologene: 9177
Cul2
Name: cullin 2
Synonyms: 1300003D18Rik, 4932411N15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71745
HGNC: HGNC:2552
Homologene: 2662
Dhx29
Name: DExH-box helicase 29
Synonyms: E130202M19Rik, DEAH (Asp-Glu-Ala-His) box polypeptide 29
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218629
VEGA: 13
Homologene: 10387
Nepro
Name: nucleolus and neural progenitor protein
Synonyms: BC027231
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212547
Homologene: 9127
Fam169b
Name: family with sequence similarity 169, member B
Synonyms: EG434197
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434197
Homologene: 79038
Lct
Name: lactase
Synonyms: LOC226413, Lphl, LPH
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: 3110001A05Rik, 1810064L21Rik, 3110027P15Rik, A230065J02Rik, Ugcgl2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66435
Homologene: 56875
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
Clk4
Name: CDC like kinase 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12750
Homologene: 56895
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna-1, erythroid, ihj, Spna1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Hdhc3, HL-19, DLP12, HL19, DHC3, LOC380889, 4921531P07Rik, Dnahc7l, Dnahc12
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Art3
Name: ADP-ribosyltransferase 3
Synonyms: 4930569O04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 109979
HGNC: HGNC:725
Homologene: 911
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Per2
Name: period circadian clock 2
Synonyms: mPer2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18627
HGNC: HGNC:8846
Homologene: 7885
Mmp23
Name: matrix metallopeptidase 23
Synonyms: cysteine array matrix metalloproteinase, CA-MMP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26561
HGNC: HGNC:7171
Homologene: 3424
Stk35
Name: serine/threonine kinase 35
Synonyms: CLP-36 interacting kinase, CLIK1, 1700054C12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67333
Homologene: 15441
Or5b105
Name: olfactory receptor family 5 subfamily B member 105
Synonyms: GA_x6K02T2RE5P-3430689-3429787, MOR202-24, EG667271, Olfr1458
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667271
HGNC: HGNC:8324
Zpr1
Name: ZPR1 zinc finger
Synonyms: ZPR1, Zfp259
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22687
Homologene: 2900
Tlr11
Name: toll-like receptor 11
Synonyms: LOC239081
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239081
Homologene: 77905
Dlec1
Name: deleted in lung and esophageal cancer 1
Synonyms: D630005C06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320256
HGNC: HGNC:2899
Homologene: 84733
Slc13a3
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Synonyms: SDCT2, NaDC3, NaDC-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 114644
Homologene: 11266
Slc14a2
Name: solute carrier family 14 (urea transporter), member 2
Synonyms: UT-A3, UT-A5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 27411
VEGA: 18
Homologene: 5183
Rwdd3
Name: RWD domain containing 3
Synonyms: 3110037C01Rik, 2510027J23Rik, RSUME
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66568
Homologene: 22899
Pgbd1
Name: piggyBac transposable element derived 1
Synonyms: 4921509E05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319207
Homologene: 130030
Or1q1
Name: olfactory receptor family 1 subfamily Q member 1
Synonyms: GA_x6K02T2NLDC-33688556-33689482, MOR138-3, Olfr357
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258616
HGNC: HGNC:8223
Homologene: 17320
Lilra6
Name: leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
Synonyms: 7M1, Pira3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18726
Homologene: 134028
Muc17
Name: mucin 17, cell surface associated
Synonyms: Muc3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 666339
Homologene: 141159
Or2a7
Name: olfactory receptor family 2 subfamily A member 7
Synonyms: MOR261-6, GA_x6K02T2P3E9-4384160-4383228, Olfr13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18310
Homologene: 27232
Slc25a24
Name: solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24
Synonyms: 2610016M12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229731
Homologene: 92693
Itgax
Name: integrin alpha X
Synonyms: CD11C (p150) alpha polypeptide, Cd11c, CR4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16411
HGNC: HGNC:6152
Homologene: 55493
Cdc14b
Name: CDC14 cell division cycle 14B
Synonyms: 2810432N10Rik, A530086E13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218294
VEGA: 13
Homologene: 104197
Nsmce1
Name: NSE1 homolog, SMC5-SMC6 complex component
Synonyms: 2510027N19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67711
Homologene: 41672
Nlrp6
Name: NLR family, pyrin domain containing 6
Synonyms: Nalp6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101613
Homologene: 15881
Zfp865
Name: zinc finger protein 865
Synonyms: 6430526N21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319748
Homologene: 19652
Ndufs2
Name: NADH:ubiquinone oxidoreductase core subunit S2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226646
HGNC: HGNC:7708
Homologene: 56659
Or6c3
Name: olfactory receptor family 6 subfamily C member 3
Synonyms: GA_x6K02T2PULF-11151514-11152449, MOR111-4, Olfr788
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258544
Homologene: 74200
Ccne1
Name: cyclin E1
Synonyms: cyclin E, CycE1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12447
HGNC: HGNC:1589
Homologene: 14452
Rcor2
Name: REST corepressor 2
Synonyms: CoREST, 1A13
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104383
Homologene: 14280
Gjb6
Name: gap junction protein, beta 6
Synonyms: connexin 30, Cx30, D14Bwg0506e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14623
HGNC: HGNC:4288
Homologene: 4936
Igkv5-48
Name: immunoglobulin kappa variable 5-48
Synonyms: ENSMUSG00000029975, Gm10881
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 619846
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 91,429,382 bp
  • G to A, chromosome 1 at 128,294,320 bp
  • A to G, chromosome 1 at 171,236,698 bp
  • A to T, chromosome 1 at 174,187,148 bp
  • T to C, chromosome 2 at 36,996,995 bp
  • T to C, chromosome 2 at 59,807,642 bp
  • A to G, chromosome 2 at 82,990,086 bp
  • T to C, chromosome 2 at 118,119,117 bp
  • T to C, chromosome 2 at 122,092,305 bp
  • T to A, chromosome 2 at 125,335,418 bp
  • C to A, chromosome 2 at 129,810,687 bp
  • T to C, chromosome 2 at 165,408,898 bp
  • G to T, chromosome 3 at 109,136,301 bp
  • T to C, chromosome 3 at 121,156,452 bp
  • T to A, chromosome 4 at 155,652,341 bp
  • T to C, chromosome 5 at 92,392,817 bp
  • T to C, chromosome 5 at 137,142,390 bp
  • T to C, chromosome 6 at 43,174,066 bp
  • A to G, chromosome 6 at 69,726,826 bp
  • T to A, chromosome 6 at 108,815,049 bp
  • T to C, chromosome 6 at 121,034,275 bp
  • T to C, chromosome 6 at 139,730,469 bp
  • G to A, chromosome 7 at 3,912,933 bp
  • A to G, chromosome 7 at 5,029,783 bp
  • T to A, chromosome 7 at 25,519,989 bp
  • G to A, chromosome 7 at 38,106,854 bp
  • T to A, chromosome 7 at 68,353,718 bp
  • A to G, chromosome 7 at 125,491,418 bp
  • T to C, chromosome 7 at 127,198,878 bp
  • C to A, chromosome 7 at 128,148,599 bp
  • A to G, chromosome 7 at 140,927,443 bp
  • A to T, chromosome 7 at 141,294,793 bp
  • C to T, chromosome 8 at 109,638,387 bp
  • T to C, chromosome 8 at 111,197,706 bp
  • A to G, chromosome 9 at 46,274,711 bp
  • T to C, chromosome 9 at 119,147,690 bp
  • T to A, chromosome 10 at 50,710,953 bp
  • T to A, chromosome 10 at 81,720,244 bp
  • A to G, chromosome 10 at 88,755,186 bp
  • A to T, chromosome 10 at 129,472,721 bp
  • T to A, chromosome 11 at 51,270,546 bp
  • A to G, chromosome 11 at 77,882,648 bp
  • A to G, chromosome 11 at 103,074,931 bp
  • T to C, chromosome 13 at 21,423,476 bp
  • T to C, chromosome 13 at 64,225,650 bp
  • A to C, chromosome 13 at 100,162,041 bp
  • A to T, chromosome 13 at 112,953,788 bp
  • A to G, chromosome 14 at 26,872,455 bp
  • A to G, chromosome 14 at 50,363,055 bp
  • T to C, chromosome 14 at 57,124,442 bp
  • T to A, chromosome 14 at 119,057,564 bp
  • T to A, chromosome 15 at 66,671,311 bp
  • T to C, chromosome 16 at 44,727,075 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • A to C, chromosome 18 at 3,417,561 bp
  • A to T, chromosome 18 at 60,814,780 bp
  • A to T, chromosome 18 at 78,159,082 bp
  • T to G, chromosome 19 at 7,271,046 bp
  • T to A, chromosome 19 at 13,102,474 bp
  • T to A, chromosome 19 at 46,654,319 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6480 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044612-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.