Strain Name:
C57BL/6J-MtgxR6487Btlr/Mmmh
Stock Number:
044619-MU
Citation ID:
RRID:MMRRC_044619-MU
Other Names:
R6487 (G1)
Major Collection:

Strain Information

U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67958
Homologene: 13964
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Wapl
Name: WAPL cohesin release factor
Synonyms: Wapal, A530089A20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218914
Homologene: 41002
Atp13a1
Name: ATPase type 13A1
Synonyms: catp, Cgi152, Atp13a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170759
VEGA: 8
Homologene: 5791
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: 2700017A04Rik, C730024G01Rik, Brctd1, Brctx, Ankrd32
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105377
Homologene: 13000
Med13
Name: mediator complex subunit 13
Synonyms: 1110067M05Rik, Trap240, Thrap1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327987
Homologene: 21067
Tpst2
Name: protein-tyrosine sulfotransferase 2
Synonyms: grt, grm, Tango13b, D5Ucla3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22022
Homologene: 2666
Cntrl
Name: centriolin
Synonyms: Cep110, b2b1468Clo, IB3/5, Ma2a8, 6720467O09Rik, Cep1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Rsrc1
Name: arginine/serine-rich coiled-coil 1
Synonyms: 1200013F24Rik, SRrp53
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66880
Homologene: 41147
Abca3
Name: ATP-binding cassette, sub-family A member 3
Synonyms: ABC-C, Abc3, 1810036E22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27410
HGNC: HGNC:33
Homologene: 37437
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Or8b54
Name: olfactory receptor family 8 subfamily B member 54
Synonyms: MOR165-8, Olfr921, GA_x6K02T2PVTD-32478047-32478988
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258778
VEGA: 9
Homologene: 128138
Vmn2r102
Name: vomeronasal 2, receptor 102
Synonyms: EG224572
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224572
Homologene: 115024
Or4c35
Name: olfactory receptor family 4 subfamily C member 35
Synonyms: GA_x6K02T2Q125-51409740-51410672, MOR232-2, Olfr1260
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258983
Homologene: 17455
Xab2
Name: XPA binding protein 2
Synonyms: 0610041O14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67439
Homologene: 5738
Npepl1
Name: aminopeptidase-like 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228961
Homologene: 11647
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225638
Homologene: 50475
Rims4
Name: regulating synaptic membrane exocytosis 4
Synonyms: Rim4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241770
Homologene: 18123
Cyp2c37
Name: cytochrome P450, family 2. subfamily c, polypeptide 37
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13096
Homologene: 137231
Or5d41
Name: olfactory receptor family 5 subfamily D member 41
Synonyms: MOR174-12, Olfr1170, GA_x6K02T2Q125-49709783-49708833
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258525
Homologene: 138307
Shisa9
Name: shisa family member 9
Synonyms: 2700045P11Rik, CKAMP44
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72555
Homologene: 109462
Or5h26
Name: olfactory receptor family 5 subfamily H member 26
Synonyms: MOR183-1, GA_x54KRFPKG5P-55389051-55388122, Olfr196
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258775
Homologene: 74113
Kics2
Name: KICSTOR subunit 2
Synonyms: BC048403
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270802
Homologene: 17580
Vmn1r17
Name: vomeronasal 1 receptor 17
Synonyms: V1rc16
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171189
Homologene: 115643
Irgm1
Name: immunity-related GTPase family M member 1
Synonyms: LRG-47, Iigp3, Irgm, Ifi1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15944
Homologene: 134089
Oog2
Name: oogenesin 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381570
Homologene: 77858
Or4k38
Name: olfactory receptor family 4 subfamily K member 38
Synonyms: GA_x6K02T2Q125-72387537-72386620, Olfr1557, MOR248-2, Olfr1282, MOR248-16
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258909
Homologene: 73992
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Cops5
Name: COP9 signalosome subunit 5
Synonyms: CSN5, COP9 complex S5, Jab1, JUN activation binding protein, Sgn5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26754
HGNC: HGNC:2240
Homologene: 55992
Vmn1r55
Name: vomeronasal 1 receptor 55
Synonyms: LOC384522, V1rd5, LOC236535
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384522
Homologene: 41799
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 10,037,779 bp
  • T to C, chromosome 1 at 46,769,124 bp
  • A to T, chromosome 2 at 35,122,682 bp
  • A to G, chromosome 2 at 88,224,526 bp
  • A to T, chromosome 2 at 89,977,838 bp
  • T to C, chromosome 2 at 111,335,667 bp
  • A to T, chromosome 2 at 163,864,897 bp
  • A to G, chromosome 2 at 174,111,732 bp
  • C to T, chromosome 3 at 66,994,649 bp
  • A to T, chromosome 4 at 88,827,506 bp
  • A to G, chromosome 4 at 144,196,485 bp
  • T to C, chromosome 5 at 112,308,123 bp
  • A to T, chromosome 6 at 57,361,224 bp
  • A to G, chromosome 7 at 5,146,555 bp
  • T to C, chromosome 8 at 3,613,879 bp
  • T to C, chromosome 8 at 69,799,878 bp
  • A to G, chromosome 9 at 38,775,435 bp
  • A to T, chromosome 9 at 95,477,512 bp
  • T to C, chromosome 10 at 58,485,741 bp
  • T to C, chromosome 10 at 121,745,541 bp
  • C to A, chromosome 11 at 48,865,950 bp
  • T to C, chromosome 11 at 86,331,150 bp
  • C to T, chromosome 11 at 107,077,726 bp
  • A to T, chromosome 13 at 77,066,617 bp
  • T to A, chromosome 14 at 34,692,292 bp
  • G to T, chromosome 15 at 4,947,239 bp
  • C to T, chromosome 16 at 12,244,611 bp
  • A to T, chromosome 16 at 59,168,173 bp
  • G to A, chromosome 17 at 19,677,907 bp
  • T to C, chromosome 17 at 24,397,472 bp
  • T to C, chromosome 18 at 65,266,183 bp
  • A to T, chromosome 19 at 39,994,581 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6487 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044619-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.