Strain Name:
C57BL/6J-MtgxR6488Btlr/Mmmh
Stock Number:
044620-MU
Citation ID:
RRID:MMRRC_044620-MU
Other Names:
R6488 (G1)
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: PTPbeta, DSD-1-PG, Rptpbeta, phosphacan, Ptpz, Ptprz, RPTPz, PTPzeta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: Tkrb, trkB, C030027L06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Col3a1
Name: collagen, type III, alpha 1
Synonyms: Tsk-2, Tsk2, Col3a-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Mga
Name: MAX gene associated
Synonyms: C130042M01Rik, Mad5, D030062C11Rik, Mga
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: 1110005P14Rik, D1Ertd101e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
2610021A01Rik
Name: RIKEN cDNA 2610021A01 gene
Type: Gene
Species: Mouse
Chromosome: 7
Ap2a2
Name: adaptor-related protein complex 2, alpha 2 subunit
Synonyms: Adtab, alpha-C adaptin, alpha-adaptin C, L25, 2410074K14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11772
HGNC: HGNC:562
Homologene: 5335
Eif4b
Name: eukaryotic translation initiation factor 4B
Synonyms: 2310046H11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75705
VEGA: 15
HGNC: HGNC:3285
Homologene: 83162
Glod4
Name: glyoxalase domain containing 4
Synonyms: 1700082G03Rik, 2700085E05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67201
Homologene: 9376
Kifbp
Name: kinesin family binding protein
Synonyms: 2510003E04Rik, Kif1bp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72320
Homologene: 9223
Nup214
Name: nucleoporin 214
Synonyms: CAN, D2H9S46E
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Hnf1a
Name: HNF1 homeobox A
Synonyms: HNF1[a], LFB1, Hnf1alpha, Tcf1, HNF1, HNF1-alpha, hepatocyte nuclear factor 1, Hnf-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21405
Homologene: 459
Rraga
Name: Ras-related GTP binding A
Synonyms: 1300010C19Rik, FIP-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68441
Homologene: 68522
Fam83h
Name: family with sequence similarity 83, member H
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105732
VEGA: 15
Homologene: 15890
Lrpprc
Name: leucine-rich PPR-motif containing
Synonyms: 3110001K13Rik, Lrp130
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72416
Homologene: 32695
Npas4
Name: neuronal PAS domain protein 4
Synonyms: Nxf, LE-PAS, Npas4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225872
VEGA: 19
Homologene: 15333
St6galnac3
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Synonyms: Siat7c, ST6GalNAc III
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20447
Homologene: 7938
Zdhhc20
Name: zinc finger, DHHC domain containing 20
Synonyms: B230110O18Rik, 4930542A17Rik, 5033406L14Rik, ENSMUSG00000055956
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75965
VEGA: 14
Homologene: 57105
Rab37
Name: RAB37, member RAS oncogene family
Synonyms: B230354I04Rik, B230331O03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 58222
Homologene: 23303
Tpbg
Name: trophoblast glycoprotein
Synonyms: 5T4 oncofetal antigen, 5T4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21983
Homologene: 4859
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319262
Homologene: 14127
Gpc6
Name: glypican 6
Synonyms: 6720429C22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 23888
HGNC: HGNC:4454
Homologene: 55922
Lman1l
Name: lectin, mannose-binding 1 like
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235416
HGNC: HGNC:6632
Homologene: 11047
Pbx1
Name: pre B cell leukemia homeobox 1
Synonyms: D230003C07Rik, Pbx1a, Pbx-1, 2310056B04Rik, Pbx1b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18514
HGNC: HGNC:8632
Homologene: 20574
Ext2
Name: exostosin glycosyltransferase 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14043
HGNC: HGNC:3513
Homologene: 345
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: MUPP1, B930003D11Rik, multiple PDZ domain protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Mtus1
Name: mitochondrial tumor suppressor 1
Synonyms: MD44, B430305I03Rik, Atip1, MTSG1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102103
Homologene: 100292
Thsd1
Name: thrombospondin, type I, domain 1
Synonyms: 4833423O18Rik, Tmtsp
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56229
Homologene: 10264
Mgat4f
Name: MGAT4 family, member F
Synonyms: 4933406M09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240755
Homologene: 128441
Siglec1
Name: sialic acid binding Ig-like lectin 1, sialoadhesin
Synonyms: Sn, CD169, Siglec-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20612
Homologene: 124458
Ptpro
Name: protein tyrosine phosphatase receptor type O
Synonyms: Ptpn15, PTP-BK, PTP-phi, PTPROt, PTP-U2, PTP-oc, D28, GLEPP1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Rb1cc1
Name: RB1-inducible coiled-coil 1
Synonyms: Fip200, 2900055E04Rik, Cc1, LaXp180, 5930404L04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12421
Homologene: 7659
Ppp6r2
Name: protein phosphatase 6, regulatory subunit 2
Synonyms: Pp6r2, 1110033O10Rik, B230107H12Rik, 8430411H09Rik, Saps2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71474
VEGA: 15
Homologene: 36455
Pabpc6
Name: poly(A) binding protein, cytoplasmic 6
Synonyms: 4932702K14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67543
VEGA: 17
Homologene: 129776
Zfp941
Name: zinc finger protein 941
Synonyms: BC066028
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 407812
Adamts7
Name: ADAM metallopeptidase with thrombospondin type 1 motif 7
Synonyms: ADAM-TS7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 108153
HGNC: HGNC:223
Homologene: 22803
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319695
Homologene: 85163
Ptprn2
Name: protein tyrosine phosphatase receptor type N polypeptide 2
Synonyms: IA-2beta, 4930425H11Rik, PTP-NP, phogrin, IA-2 beta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19276
HGNC: HGNC:9677
Homologene: 2134
Glis3
Name: GLIS family zinc finger 3
Synonyms: E330013K21Rik, 4833409N03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226075
Homologene: 34989
Serpinf2
Name: serine (or cysteine) peptidase inhibitor, clade F, member 2
Synonyms: Pli, alpha 2 antiplasmin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18816
HGNC: HGNC:9075
Homologene: 719
Kif26b
Name: kinesin family member 26B
Synonyms: D230039L06Rik, N-11 kinesin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269152
Homologene: 18623
Oas2
Name: 2'-5' oligoadenylate synthetase 2
Synonyms: Oasl11, 2'-5' oligoadenylate synthetase-like 11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246728
HGNC: HGNC:8087
Homologene: 49478
Lrrc49
Name: leucine rich repeat containing 49
Synonyms: D430025H09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102747
Homologene: 9782
Pcyt1a
Name: phosphate cytidylyltransferase 1, choline, alpha isoform
Synonyms: Cctalpha, Ctpct, Cttalpha, CTalpha, CTP:phosphocholine cytidylyltransferase alpha
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13026
HGNC: HGNC:8754
Homologene: 3680
Or5b118
Name: olfactory receptor family 5 subfamily B member 118
Synonyms: Olfr1474, MOR202-42, MOR202-26P, GA_x6K02T2RE5P-3803583-3804527
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258123
Homologene: 79417
Rad51ap2
Name: RAD51 associated protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209550
VEGA: 12
Homologene: 85245
Fndc7
Name: fibronectin type III domain containing 7
Synonyms: E230011A21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320181
Homologene: 18551
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Mpv17l
Name: Mpv17 transgene, kidney disease mutant-like
Synonyms: M-LP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 93734
Homologene: 13547
Cxcr5
Name: C-X-C motif chemokine receptor 5
Synonyms: Blr1, Gpcr6, CXCR-5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12145
VEGA: 9
HGNC: HGNC:1060
Homologene: 1298
Pogk
Name: pogo transposable element with KRAB domain
Synonyms: 9130401E23Rik, BASS2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71592
Homologene: 32346
Klra9
Name: killer cell lectin-like receptor subfamily A, member 9
Synonyms: LY49I1, Ly49I
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16640
Homologene: 110821
Kcnc3
Name: potassium voltage gated channel, Shaw-related subfamily, member 3
Synonyms: Kcr2-3, KShIIID, Kv3.3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16504
HGNC: HGNC:6235
Homologene: 3650
Vmn2r50
Name: vomeronasal 2, receptor 50
Synonyms: EG434117
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434117
Homologene: 113703
Mettl22
Name: methyltransferase 22, Kin17 lysine
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239706
Homologene: 16619
Vmn1r219
Name: vomeronasal 1 receptor 219
Synonyms: V1rh13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171272
Homologene: 110880
Arhgef37
Name: Rho guanine nucleotide exchange factor 37
Synonyms: 4933429F08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328967
VEGA: 18
Homologene: 28467
Or52z15
Name: olfactory receptor family 52 subfamily Z member 15
Synonyms: GA_x6K02T2PBJ9-6416276-6417237, Olfr625, MOR31-15P
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258169
Krtap4-1
Name: keratin associated protein 4-1
Synonyms: A030010K20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 665891
Abhd15
Name: abhydrolase domain containing 15
Synonyms: 1300007F04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67477
Homologene: 12142
Slc35e4
Name: solute carrier family 35, member E4
Synonyms: A330108F03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103710
Homologene: 37409
Trav16n
Name: T cell receptor alpha variable 16n
Synonyms: Gm16837
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100126459
Pramel51
Name: PRAME like 51
Synonyms: Gm10436
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100039315
VEGA: 12
Homologene: 103830
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 6,270,727 bp
  • C to A, chromosome 1 at 45,331,534 bp
  • A to G, chromosome 1 at 72,681,808 bp
  • T to C, chromosome 1 at 93,428,224 bp
  • T to A, chromosome 1 at 134,390,888 bp
  • T to C, chromosome 1 at 166,399,422 bp
  • T to A, chromosome 1 at 168,191,395 bp
  • T to C, chromosome 1 at 178,529,573 bp
  • T to C, chromosome 2 at 28,078,289 bp
  • T to A, chromosome 2 at 31,991,372 bp
  • A to G, chromosome 2 at 93,806,085 bp
  • T to A, chromosome 2 at 119,960,907 bp
  • T to C, chromosome 2 at 131,081,307 bp
  • A to G, chromosome 2 at 168,935,209 bp
  • T to C, chromosome 3 at 55,717,843 bp
  • T to C, chromosome 3 at 108,870,575 bp
  • C to T, chromosome 3 at 153,411,757 bp
  • G to T, chromosome 4 at 81,287,733 bp
  • G to A, chromosome 4 at 86,576,328 bp
  • T to C, chromosome 5 at 114,955,961 bp
  • A to G, chromosome 5 at 120,738,363 bp
  • T to A, chromosome 6 at 23,001,517 bp
  • G to T, chromosome 6 at 130,179,032 bp
  • T to G, chromosome 6 at 137,393,675 bp
  • T to C, chromosome 7 at 10,037,717 bp
  • A to G, chromosome 7 at 28,093,538 bp
  • C to T, chromosome 7 at 41,625,874 bp
  • T to C, chromosome 7 at 44,595,182 bp
  • G to C, chromosome 7 at 80,730,326 bp
  • T to C, chromosome 7 at 103,683,078 bp
  • C to T, chromosome 7 at 140,812,750 bp
  • T to C, chromosome 7 at 141,602,307 bp
  • T to C, chromosome 8 at 22,243,717 bp
  • G to A, chromosome 8 at 41,041,508 bp
  • A to G, chromosome 9 at 44,513,979 bp
  • A to G, chromosome 9 at 57,620,643 bp
  • A to T, chromosome 9 at 60,602,633 bp
  • T to A, chromosome 9 at 85,844,485 bp
  • A to G, chromosome 9 at 90,171,482 bp
  • C to A, chromosome 10 at 62,559,658 bp
  • T to C, chromosome 11 at 3,912,602 bp
  • A to T, chromosome 11 at 60,478,487 bp
  • A to G, chromosome 11 at 75,437,503 bp
  • A to G, chromosome 11 at 76,237,785 bp
  • T to C, chromosome 11 at 77,516,022 bp
  • G to T, chromosome 11 at 99,628,077 bp
  • A to G, chromosome 11 at 115,157,963 bp
  • T to G, chromosome 12 at 11,458,160 bp
  • T to C, chromosome 12 at 88,177,587 bp
  • T to A, chromosome 12 at 116,872,038 bp
  • T to C, chromosome 13 at 23,162,965 bp
  • T to A, chromosome 13 at 58,861,356 bp
  • A to G, chromosome 14 at 53,351,585 bp
  • C to T, chromosome 14 at 57,840,832 bp
  • T to C, chromosome 14 at 117,964,713 bp
  • T to C, chromosome 15 at 76,002,053 bp
  • T to C, chromosome 15 at 89,268,538 bp
  • T to A, chromosome 15 at 102,092,987 bp
  • T to C, chromosome 16 at 8,487,361 bp
  • G to A, chromosome 16 at 13,946,588 bp
  • T to C, chromosome 16 at 32,467,081 bp
  • A to G, chromosome 17 at 9,669,599 bp
  • T to C, chromosome 17 at 84,751,353 bp
  • T to C, chromosome 18 at 37,967,268 bp
  • G to A, chromosome 18 at 61,518,052 bp
  • A to G, chromosome 19 at 4,985,983 bp
  • T to C, chromosome 19 at 13,471,617 bp
  • T to C, chromosome 19 at 28,298,853 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6488 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044620-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.