Strain Name:
C57BL/6J-MtgxR6495Btlr/Mmmh
Stock Number:
044627-MU
Citation ID:
RRID:MMRRC_044627-MU
Other Names:
R6495 (G1)
Major Collection:

Strain Information

Cacybp
Name: calcyclin binding protein
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12301
Homologene: 7649
Zfp706
Name: zinc finger protein 706
Synonyms: C77232, 3110006P09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68036
VEGA: 15
Homologene: 128235
Cyp39a1
Name: cytochrome P450, family 39, subfamily a, polypeptide 1
Synonyms: oxysterol 7-alpha-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56050
VEGA: 17
Homologene: 9580
Shroom3
Name: shroom family member 3
Synonyms: Shrm3, Shrm, D5Ertd287e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27428
Homologene: 9263
Tut7
Name: terminal uridylyl transferase 7
Synonyms: Tent3b, 6030448M23Rik, Zcchc6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 214290
VEGA: 13
Homologene: 51941
Rfc1
Name: replication factor C (activator 1) 1
Synonyms: Alp145, RFC140, 140kDa, Recc1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19687
HGNC: HGNC:9969
Homologene: 2187
Tnks
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Synonyms: Parp5a, TANK1, 4930554K12Rik, tankyrase 1, D130072O21Rik, mTNKS1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21951
Homologene: 18405
Eif3c
Name: eukaryotic translation initiation factor 3, subunit C
Synonyms: 3230401O13Rik, Xsl, Eif3s8, 110kDa, NIPIL(A3), Xs
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56347
Homologene: 2781
Rapsn
Name: receptor-associated protein of the synapse
Synonyms: rapsyn, Raps, Nraps, 43kDa acetylcholine receptor-associated protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19400
HGNC: HGNC:9863
Homologene: 3708
Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
Synonyms: MLTKalpha, Zak, MLTKbeta, B230120H23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65964
Homologene: 32331
Rims2
Name: regulating synaptic membrane exocytosis 2
Synonyms: Syt3-rs, 2810036I15Rik, RIM2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 116838
VEGA: 15
Homologene: 81639
Stt3b
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
Synonyms: 1300006C19Rik, Simp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68292
VEGA: 9
Homologene: 7387
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12032
Homologene: 7244
Dusp3
Name: dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
Synonyms: T-DSP11, 5031436O03Rik, 2210015O03Rik, VHR
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72349
HGNC: HGNC:3069
Homologene: 20870
Onecut1
Name: one cut domain, family member 1
Synonyms: OC-1, Hfh12, D9Ertd423e, Oc1, HNF6, Hnf6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15379
HGNC: HGNC:8138
Homologene: 3309
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268878
Homologene: 77451
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: TRPP2, PC2, polycystin-2, C030034P18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Pwp2
Name: PWP2 periodic tryptophan protein homolog (yeast)
Synonyms: 6530411D08Rik, Pwp2, Pwp2h
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110816
VEGA: 10
HGNC: HGNC:9711
Homologene: 3702
Exosc10
Name: exosome component 10
Synonyms: PM/Scl-100, p3, RRP6, p2, p4, Pmscl2, PM-Scl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50912
HGNC: HGNC:9138
Homologene: 31105
Tbc1d19
Name: TBC1 domain family, member 19
Synonyms: 2810453K03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67249
Homologene: 10130
Rbm19
Name: RNA binding motif protein 19
Synonyms: 1200009A02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74111
Homologene: 7158
Asap3
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Synonyms: 9430088F20Rik, UPLC1, Ddefl1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230837
Homologene: 41190
Cd82
Name: CD82 antigen
Synonyms: C33, Tspan27, Kai1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12521
HGNC: HGNC:6210
Homologene: 20512
Wdr19
Name: WD repeat domain 19
Synonyms: C330027H04Rik, Ift144, DYF2, D330023L08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 213081
Homologene: 11842
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: 2810027M23Rik, auxilin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72685
Homologene: 8865
Galns
Name: galactosamine (N-acetyl)-6-sulfatase
Synonyms: N-acetylgalactosamine-6-sulfate sulfatase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50917
HGNC: HGNC:4122
Homologene: 55468
Uba7
Name: ubiquitin-like modifier activating enzyme 7
Synonyms: Ube1l, 1300004C08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74153
Homologene: 2502
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: EG638102, V2Rp4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 638102
Homologene: 86604
Ahnak2
Name: AHNAK nucleoprotein 2
Synonyms: LOC382643
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100041194
Homologene: 131081
S100a16
Name: S100 calcium binding protein A16
Synonyms: 2300002L21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67860
Homologene: 12201
Zkscan3
Name: zinc finger with KRAB and SCAN domains 3
Synonyms: 2810435N07Rik, Zfp306, Zfp307, Skz1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72739
Homologene: 130732
Vmn2r75
Name: vomeronasal 2, receptor 75
Synonyms: EG546981
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546981
Homologene: 115466
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: B230399N07Rik, 4930532L22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269610
Homologene: 56712
Nt5dc1
Name: 5'-nucleotidase domain containing 1
Synonyms: Nt5c2l1, 6030401B09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319638
Homologene: 16281
Arfgef3
Name: ARFGEF family member 3
Synonyms: D10Bwg1379e, BIG3, B930094H20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215821
VEGA: 10
Homologene: 41366
Pramel15
Name: PRAME like 15
Synonyms: EG627009, Pramef20, Gm13125
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 627009
Homologene: 133194
Nubp2
Name: nucleotide binding protein 2
Synonyms: D17Wsu11e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26426
VEGA: 17
HGNC: HGNC:8042
Homologene: 8057
Or5b116
Name: olfactory receptor family 5 subfamily B member 116
Synonyms: MOR202-47_p, MOR202-38, Olfr1471, GA_x6K02T2RE5P-3777626-3778570
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258231
Homologene: 79417
Cpb2
Name: carboxypeptidase B2
Synonyms: CPU, 4930405E17Rik, carboxypeptidase R, CPR, TAFI, 1110032P04Rik, carboxypeptidase U, thrombin-activatable fibrinolysis inhibitor
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56373
VEGA: 14
HGNC: HGNC:2300
Homologene: 55610
Zdhhc7
Name: zinc finger, DHHC domain containing 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102193
Homologene: 41193
Pcdhb17
Name: protocadherin beta 17
Synonyms: PcdhbQ, Pcdhb16
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93888
Homologene: 81881
Apbb1ip
Name: amyloid beta precursor protein binding family B member 1 interacting protein
Synonyms: Prp48, proline-rich protein 48, 9930118P07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54519
Homologene: 32434
Tas2r129
Name: taste receptor, type 2, member 129
Synonyms: T2R29, Tas2r29, mGR29, mt2r60
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387354
Homologene: 130074
Ttc29
Name: tetratricopeptide repeat domain 29
Synonyms: 1700031F13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73301
Homologene: 12918
Zbtb22
Name: zinc finger and BTB domain containing 22
Synonyms: 1110008J20Rik, Bing1, Zfp297
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81630
Homologene: 3982
Tnip3
Name: TNFAIP3 interacting protein 3
Synonyms: 9030611K07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 414084
Homologene: 47979
Taar8b
Name: trace amine-associated receptor 8B
Synonyms: LOC382348
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 382348
Homologene: 77586
Hadha
Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Synonyms: Mtpa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 97212
HGNC: HGNC:4801
Homologene: 152
Tas2r119
Name: taste receptor, type 2, member 119
Synonyms: Tas2r19, mt2r19, mGR19, T2R19
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 57254
Homologene: 10480
Krtap10-21
Name: keratin associated protein 10-21
Synonyms: Gm3233
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100041250
VEGA: 10
Homologene: 115744
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 160,208,523 bp
  • T to A, chromosome 2 at 22,853,120 bp
  • T to C, chromosome 2 at 72,368,419 bp
  • A to T, chromosome 2 at 91,036,628 bp
  • A to G, chromosome 2 at 93,430,012 bp
  • C to A, chromosome 3 at 87,996,597 bp
  • C to T, chromosome 3 at 90,542,428 bp
  • C to T, chromosome 4 at 101,635,065 bp
  • T to A, chromosome 4 at 136,228,479 bp
  • T to C, chromosome 4 at 144,376,839 bp
  • C to T, chromosome 4 at 148,562,872 bp
  • C to T, chromosome 4 at 152,367,372 bp
  • A to T, chromosome 5 at 30,120,050 bp
  • T to G, chromosome 5 at 53,889,213 bp
  • A to T, chromosome 5 at 65,258,123 bp
  • G to A, chromosome 5 at 65,273,815 bp
  • T to C, chromosome 5 at 92,942,069 bp
  • T to A, chromosome 5 at 104,489,293 bp
  • A to G, chromosome 5 at 120,119,680 bp
  • A to T, chromosome 6 at 65,605,862 bp
  • A to G, chromosome 6 at 132,951,165 bp
  • A to T, chromosome 7 at 86,164,079 bp
  • A to T, chromosome 7 at 126,547,500 bp
  • A to T, chromosome 8 at 34,839,966 bp
  • T to C, chromosome 8 at 78,282,334 bp
  • A to G, chromosome 8 at 120,086,656 bp
  • C to T, chromosome 8 at 122,600,610 bp
  • C to T, chromosome 9 at 74,863,215 bp
  • T to A, chromosome 9 at 107,977,014 bp
  • T to A, chromosome 9 at 115,267,320 bp
  • A to G, chromosome 10 at 18,611,202 bp
  • A to G, chromosome 10 at 24,091,262 bp
  • A to G, chromosome 10 at 34,324,369 bp
  • A to T, chromosome 10 at 77,759,052 bp
  • A to T, chromosome 10 at 78,177,127 bp
  • T to C, chromosome 11 at 101,981,827 bp
  • A to G, chromosome 12 at 7,990,394 bp
  • T to A, chromosome 12 at 112,773,714 bp
  • G to A, chromosome 13 at 21,387,905 bp
  • T to C, chromosome 13 at 59,799,939 bp
  • T to C, chromosome 14 at 75,275,079 bp
  • G to A, chromosome 15 at 32,177,530 bp
  • T to C, chromosome 15 at 37,003,801 bp
  • T to A, chromosome 15 at 39,517,812 bp
  • C to T, chromosome 16 at 29,321,622 bp
  • A to T, chromosome 17 at 23,359,598 bp
  • A to T, chromosome 17 at 24,885,603 bp
  • A to G, chromosome 17 at 33,917,250 bp
  • T to C, chromosome 17 at 43,691,694 bp
  • A to G, chromosome 18 at 37,485,667 bp
  • T to A, chromosome 19 at 13,445,625 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6495 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044627-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.