Strain Name:
C57BL/6J-MtgxR6496Btlr/Mmmh
Stock Number:
044628-MU
Citation ID:
RRID:MMRRC_044628-MU
Other Names:
R6496 (G1)
Major Collection:

Strain Information

Slc1a3
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3
Synonyms: Gmt1, Eaat1, B430115D02Rik, MGluT1, GLAST
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20512
Homologene: 20882
Kera
Name: keratocan
Synonyms: CNA2, SLRR2B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16545
VEGA: 10
HGNC: HGNC:6309
Homologene: 5106
Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
Thoc7
Name: THO complex 7
Synonyms: 1500006O09Rik, 9230101K24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66231
VEGA: 14
Homologene: 11821
Patj
Name: PATJ, crumbs cell polarity complex component
Synonyms: Inadl, Cipp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12695
Homologene: 72199
Atp2b1
Name: ATPase, Ca++ transporting, plasma membrane 1
Synonyms: PMCA1, 2810442I22Rik, E130111D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67972
VEGA: 10
HGNC: HGNC:814
Homologene: 55597
Nsd2
Name: nuclear receptor binding SET domain protein 2
Synonyms: 9430010A17Rik, 5830445G22Rik, Whsc1, D030027O06Rik, C130020C13Rik, D930023B08Rik, Whsc1l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 107823
Homologene: 26175
Edaradd
Name: EDAR associated via death domain
Synonyms: 1810032E07Rik, EDAR (ectodysplasin-A receptor)-associated death domain, 5830469M23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171211
VEGA: 13
Homologene: 15430
Tfap2a
Name: transcription factor AP-2, alpha
Synonyms: AP-2 alpha, Tcfap2a, Ap2tf, Ap2, AP2alpha, Ap-2 (a)
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21418
VEGA: 13
Homologene: 2421
Casp8ap2
Name: caspase 8 associated protein 2
Synonyms: D4Ertd659e, FLASH
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26885
HGNC: HGNC:1510
Homologene: 8066
Usp42
Name: ubiquitin specific peptidase 42
Synonyms: 2410140K03Rik, D5Ertd591e, A630018G05Rik, 3110031A07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76800
Homologene: 35425
Zfp874a
Name: zinc finger protein 874a
Synonyms: Rslcan15, C330011K17Rik, Zfp874
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238692
Homologene: 135597
Jtb
Name: jumping translocation breakpoint
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23922
HGNC: HGNC:6201
Homologene: 4870
Ndst3
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
Synonyms: 4930511P15Rik, 4921531K01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83398
HGNC: HGNC:7682
Homologene: 3513
Psd
Name: pleckstrin and Sec7 domain containing
Synonyms: Psdl, Efa6, Efa6a, 1110007H17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73728
VEGA: 19
HGNC: HGNC:9507
Homologene: 31115
Klhl1
Name: kelch-like 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93688
HGNC: HGNC:6352
Homologene: 56903
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: 1700016D22Rik, F77
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56523
Homologene: 23182
Pls1
Name: plastin 1 (I-isoform)
Synonyms: I-fimbrin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102502
HGNC: HGNC:9090
Homologene: 68270
Col4a2
Name: collagen, type IV, alpha 2
Synonyms: Col4a-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12827
HGNC: HGNC:2203
Homologene: 1390
Atp8b5
Name: ATPase, class I, type 8B, member 5
Synonyms: FetA, 4930417M19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320571
Homologene: 99882
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244668
Homologene: 18956
Spata22
Name: spermatogenesis associated 22
Synonyms: LOC380709
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380709
Homologene: 13076
Slc34a1
Name: solute carrier family 34 (sodium phosphate), member 1
Synonyms: Na/Pi cotransporter, Slc17a2, Npt2, NaPi-IIa, renal Na+/Pi transporter
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20505
VEGA: 13
Homologene: 20663
Lgmn
Name: legumain
Synonyms: preprolegumain, Prsc1, AEP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19141
HGNC: HGNC:9472
Homologene: 38075
Cdh26
Name: cadherin-like 26
Synonyms: LOC381409
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381409
Homologene: 18643
Spata31f1a
Name: spermatogenesis associated 31 subfamily F member 1A
Synonyms: Fam205a1, Gm12429
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433698
Homologene: 79022
Fam217a
Name: family with sequence similarity 217, member A
Synonyms: 1700026J04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71864
VEGA: 13
Homologene: 82344
Plcd1
Name: phospholipase C, delta 1
Synonyms: PLC-delta 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18799
VEGA: 9
HGNC: HGNC:9060
Homologene: 21252
Or6c33
Name: olfactory receptor family 6 subfamily C member 33
Synonyms: MOR116-1, GA_x6K02T2PULF-11688441-11689379, Olfr820
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258670
Homologene: 17337
Or10ag59
Name: olfactory receptor family 10 subfamily AG member 59
Synonyms: GA_x6K02T2Q125-49078087-49079031, Olfr1129, MOR264-23, MOR264-9P
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258111
Homologene: 133705
Dsn1
Name: DSN1 homolog, MIS12 kinetochore complex component
Synonyms: 1700022L09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66934
Homologene: 49806
4921504E06Rik
Name: RIKEN cDNA 4921504E06 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70909
Homologene: 87049
Potefam1
Name: POTE ankyrin domain family member 1
Synonyms: Potea, Pote1, A26c3, 4930430A15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67575
Homologene: 69410
B3gnt4
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
Synonyms: 1010001G17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231727
Homologene: 81939
Gm17175
Name: predicted gene 17175
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 102641463
Pcdha7
Name: protocadherin alpha 7
Synonyms: Crnr4, Cnr4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12939
HGNC: HGNC:8673
Homologene: 117962
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 2 at 19,540,406 bp
  • A to C, chromosome 2 at 87,575,116 bp
  • T to A, chromosome 2 at 111,164,472 bp
  • T to C, chromosome 2 at 156,533,796 bp
  • A to G, chromosome 2 at 157,005,267 bp
  • G to A, chromosome 2 at 178,449,861 bp
  • T to C, chromosome 3 at 90,233,957 bp
  • A to G, chromosome 3 at 123,552,552 bp
  • A to C, chromosome 4 at 32,641,553 bp
  • G to T, chromosome 4 at 42,848,424 bp
  • T to C, chromosome 4 at 43,371,003 bp
  • C to A, chromosome 4 at 98,416,752 bp
  • A to G, chromosome 5 at 33,843,513 bp
  • G to A, chromosome 5 at 123,511,591 bp
  • T to C, chromosome 5 at 143,715,103 bp
  • G to T, chromosome 8 at 11,402,993 bp
  • G to T, chromosome 8 at 11,402,994 bp
  • A to G, chromosome 8 at 109,532,157 bp
  • T to C, chromosome 8 at 125,449,894 bp
  • A to G, chromosome 9 at 95,754,745 bp
  • A to G, chromosome 9 at 119,072,641 bp
  • T to A, chromosome 10 at 97,612,810 bp
  • T to A, chromosome 10 at 99,003,337 bp
  • T to A, chromosome 10 at 130,017,579 bp
  • G to A, chromosome 11 at 73,340,363 bp
  • T to C, chromosome 12 at 102,398,239 bp
  • T to A, chromosome 13 at 12,478,442 bp
  • G to A, chromosome 13 at 34,910,802 bp
  • T to C, chromosome 13 at 40,728,775 bp
  • T to C, chromosome 13 at 55,402,682 bp
  • A to G, chromosome 13 at 67,442,575 bp
  • T to C, chromosome 14 at 13,954,593 bp
  • A to G, chromosome 14 at 51,573,077 bp
  • T to C, chromosome 14 at 96,240,216 bp
  • T to A, chromosome 15 at 8,649,581 bp
  • A to G, chromosome 18 at 36,974,585 bp
  • G to A, chromosome 19 at 46,320,314 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6496 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044628-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.