Strain Name:
C57BL/6J-MtgxR6522Btlr/Mmmh
Stock Number:
044648-MU
Citation ID:
RRID:MMRRC_044648-MU
Other Names:
R6522 (G1)
Major Collection:

Strain Information

Ptprcap
Name: protein tyrosine phosphatase receptor type C polypeptide-associated protein
Synonyms: LSM-1, CD-45-AP
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19265
HGNC: HGNC:9667
Homologene: 48358
Lamb3
Name: laminin, beta 3
Synonyms: nicein, 125kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16780
HGNC: HGNC:6490
Homologene: 191
Nap1l1
Name: nucleosome assembly protein 1-like 1
Synonyms: D10Ertd68e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 53605
VEGA: 10
HGNC: HGNC:7637
Homologene: 129218
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208440
Homologene: 40996
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Naa15
Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms: 5730450D16Rik, Narg1, Tbdn-1, tubedown, mNAT1, ASTBDN
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74838
Homologene: 14211
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: Ascc3l1, U5-200KD, HELIC2, A330064G03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320632
Homologene: 5859
Tmem104
Name: transmembrane protein 104
Synonyms: C630005D06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320534
Homologene: 9802
Opa1
Name: OPA1, mitochondrial dynamin like GTPase
Synonyms: optic atrophy 1, 1200011N24Rik, lilr3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74143
HGNC: HGNC:8140
Homologene: 14618
Nav2
Name: neuron navigator 2
Synonyms: 5330421F07Rik, RAINB2, POMFIL2, HELAD1, Unc53H2, Rainb1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78286
Homologene: 52330
Bicd1
Name: BICD cargo adaptor 1
Synonyms: B830009D06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12121
HGNC: HGNC:1049
Homologene: 37518
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Loa, MAP1C, Dnec1, Swl, dynein heavy chain, retrograde transport, 9930018I23Rik, Dnchc1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: Itpr-1, Ip3r, Pcp1, InsP3R type I, P400, wblo, Pcp-1, IP3R1, opt
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Ccnk
Name: cyclin K
Synonyms: CycK, CPR4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12454
VEGA: 12
HGNC: HGNC:1596
Homologene: 14748
Scfd1
Name: Sec1 family domain containing 1
Synonyms: RA410, 3110021P21Rik, STXBP1L2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76983
VEGA: 12
Homologene: 5650
Vps8
Name: VPS8 CORVET complex subunit
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 209018
Homologene: 44592
Plxnb2
Name: plexin B2
Synonyms: Debt, 1110007H23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 140570
HGNC: HGNC:9104
Homologene: 66630
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l7Rn3, ELM2, Odz4, Doc4, Ten-m4, l(7)-3Rn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Clec4g
Name: C-type lectin domain family 4, member g
Synonyms: 4930572L20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75863
Homologene: 18879
Adgrg5
Name: adhesion G protein-coupled receptor G5
Synonyms: Gpr114, LOC382045, PGR27
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382045
Homologene: 17828
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: perlecan, per, Pcn, Plc
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Anxa5
Name: annexin A5
Synonyms: annexin V, Anx5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11747
HGNC: HGNC:543
Homologene: 20312
Dpf2
Name: double PHD fingers 2
Synonyms: requiem, 2210010M07Rik, ubi-d4, Baf45d, Req
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19708
HGNC: HGNC:9964
Homologene: 21265
Csnk1d
Name: casein kinase 1, delta
Synonyms: 1200006A05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104318
HGNC: HGNC:2452
Homologene: 74841
Kdm2a
Name: lysine (K)-specific demethylase 2A
Synonyms: Fbl7, Gm4560, Jhdm1a, Cxxc8, 5530401A10Rik, Fbxl11, lalina
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225876
Homologene: 56564
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Phf10
Name: PHD finger protein 10
Synonyms: 1810055P05Rik, Baf45a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72057
Homologene: 10112
Mst1r
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Synonyms: PTK8, CDw136, Fv2, STK, Fv-2, friend virus susceptibility 2, Ron
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19882
HGNC: HGNC:7381
Homologene: 1835
Tfeb
Name: transcription factor EB
Synonyms: Tcfeb, bHLHe35, TFEB
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21425
Homologene: 5182
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Vwf
Name: Von Willebrand factor
Synonyms: 6820430P06Rik, B130011O06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22371
Homologene: 466
Fbxl13
Name: F-box and leucine-rich repeat protein 13
Synonyms: 4921539K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320118
Homologene: 27057
Plce1
Name: phospholipase C, epsilon 1
Synonyms: 4933403A21Rik, PLCepsilon
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74055
Homologene: 9478
Flad1
Name: flavin adenine dinucleotide synthetase 1
Synonyms: A930017E24Rik, Pp591
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319945
Homologene: 115598
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215772
Homologene: 100289
Map3k6
Name: mitogen-activated protein kinase kinase kinase 6
Synonyms: MEKK6, MAPKKK6, Ask2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 53608
HGNC: HGNC:6858
Homologene: 3435
Slco1b2
Name: solute carrier organic anion transporter family, member 1b2
Synonyms: Oatp1b2, Slc21a10, mlst-1, Slc21a6, 7330442B20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28253
Homologene: 75119
Tmem132d
Name: transmembrane protein 132D
Synonyms: C630028F04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243274
Homologene: 71684
Trim12c
Name: tripartite motif-containing 12C
Synonyms: 9230105E10Rik, Trim12-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319236
Homologene: 75345
Ccdc42
Name: coiled-coil domain containing 42
Synonyms: A530001H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276920
Homologene: 44902
Kif19a
Name: kinesin family member 19A
Synonyms: N-8 kinesin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 286942
Homologene: 17709
Pcdhb15
Name: protocadherin beta 15
Synonyms: Pcdhb7, PcdhbO
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93886
HGNC: HGNC:8692
Homologene: 32429
Tfb2m
Name: transcription factor B2, mitochondrial
Synonyms: Hkp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15278
Homologene: 7362
Or4c104
Name: olfactory receptor family 4 subfamily C member 104
Synonyms: GA_x6K02T2Q125-50231574-50230642, MOR230-8, Olfr1199
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258450
Homologene: 128092
Galnt6
Name: polypeptide N-acetylgalactosaminyltransferase 6
Synonyms: GalNAc-T6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207839
HGNC: HGNC:4128
Homologene: 5218
Prss51
Name: serine protease 51
Synonyms: 1700007N14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100504162
Homologene: 131540
Clec2i
Name: C-type lectin domain family 2, member i
Synonyms: Clr-g, OCILrP2, Clrg, Dcl1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93675
Homologene: 136309
Or52n4b
Name: olfactory receptor family 52 subfamily N member 4B
Synonyms: GA_x6K02T2PBJ9-10874315-10875286, MOR34-12, Olfr503, MOR34-8P, MOR34-9, MOR34-9, Olfr1548
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259143
Homologene: 121509
Ncf2
Name: neutrophil cytosolic factor 2
Synonyms: NOXA2, NADPH oxidase subunit (67kDa), p67phox, Ncf-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17970
HGNC: HGNC:7661
Homologene: 374
Prh1
Name: proline rich protein HaeIII subfamily 1
Synonyms: Prp, A-type, MP2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19131
Bnip1
Name: BCL2/adenovirus E1B interacting protein 1
Synonyms: 2010005M06Rik, 5930429G21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224630
HGNC: HGNC:1082
Homologene: 930
Anks1b
Name: ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms: Gm10937, LOC380650, C030032C09Rik, E530015N03Rik, AIDA-1b
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77531
Homologene: 51570
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240427
Homologene: 9192
Serpina1b
Name: serine (or cysteine) preptidase inhibitor, clade A, member 1B
Synonyms: PI2, Spi1-2, D12Ucla2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20701
HGNC: HGNC:8941
Homologene: 20103
Or52a33
Name: olfactory receptor family 52 subfamily A member 33
Synonyms: GA_x6K02T2PBJ9-6362863-6361910, MOR26-1, Olfr622
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259087
Homologene: 100540
Tti2
Name: TELO2 interacting protein 2
Synonyms: BC019943
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234138
Homologene: 11836
Gtf2e1
Name: general transcription factor II E, polypeptide 1 (alpha subunit)
Synonyms: 2610024P03Rik, 56kDa, TFIIE-A, FE
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74197
HGNC: HGNC:4650
Homologene: 38062
Pcdha7
Name: protocadherin alpha 7
Synonyms: Cnr4, Crnr4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12939
HGNC: HGNC:8673
Homologene: 117962
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 82,487,583 bp
  • T to C, chromosome 1 at 152,827,463 bp
  • G to A, chromosome 1 at 179,546,046 bp
  • G to A, chromosome 1 at 193,335,453 bp
  • T to C, chromosome 2 at 88,756,108 bp
  • C to T, chromosome 2 at 127,221,827 bp
  • A to T, chromosome 3 at 36,465,302 bp
  • T to C, chromosome 3 at 51,471,514 bp
  • T to C, chromosome 3 at 89,403,183 bp
  • T to C, chromosome 4 at 133,250,024 bp
  • T to C, chromosome 4 at 137,555,275 bp
  • T to C, chromosome 5 at 21,561,556 bp
  • G to T, chromosome 5 at 127,783,768 bp
  • A to G, chromosome 6 at 108,388,276 bp
  • A to T, chromosome 6 at 125,662,963 bp
  • G to T, chromosome 6 at 128,893,729 bp
  • G to A, chromosome 6 at 132,572,033 bp
  • G to A, chromosome 6 at 141,655,419 bp
  • A to G, chromosome 6 at 149,484,005 bp
  • A to G, chromosome 7 at 49,597,533 bp
  • A to C, chromosome 7 at 96,843,044 bp
  • T to C, chromosome 7 at 103,639,297 bp
  • A to T, chromosome 7 at 104,348,324 bp
  • G to A, chromosome 7 at 108,544,995 bp
  • A to C, chromosome 8 at 3,718,803 bp
  • A to G, chromosome 8 at 31,153,603 bp
  • G to T, chromosome 8 at 94,942,068 bp
  • G to A, chromosome 9 at 107,913,239 bp
  • C to A, chromosome 10 at 10,377,892 bp
  • C to T, chromosome 10 at 90,897,327 bp
  • T to C, chromosome 10 at 111,494,223 bp
  • A to G, chromosome 11 at 68,588,220 bp
  • A to G, chromosome 11 at 114,785,779 bp
  • A to T, chromosome 11 at 115,243,753 bp
  • A to G, chromosome 11 at 120,971,623 bp
  • A to G, chromosome 12 at 51,431,541 bp
  • A to C, chromosome 12 at 103,735,037 bp
  • A to G, chromosome 12 at 108,187,187 bp
  • G to A, chromosome 12 at 110,616,737 bp
  • G to A, chromosome 13 at 9,575,228 bp
  • A to G, chromosome 13 at 102,761,293 bp
  • A to G, chromosome 14 at 33,146,944 bp
  • A to G, chromosome 14 at 64,097,406 bp
  • T to C, chromosome 15 at 89,164,426 bp
  • A to C, chromosome 15 at 100,693,355 bp
  • T to A, chromosome 16 at 21,442,379 bp
  • T to A, chromosome 16 at 29,625,514 bp
  • T to C, chromosome 16 at 37,511,454 bp
  • A to T, chromosome 17 at 14,956,007 bp
  • A to G, chromosome 17 at 26,789,745 bp
  • T to C, chromosome 17 at 47,789,702 bp
  • T to C, chromosome 18 at 36,973,942 bp
  • T to C, chromosome 18 at 37,474,261 bp
  • T to C, chromosome 18 at 78,857,390 bp
  • C to T, chromosome 19 at 4,156,184 bp
  • C to A, chromosome 19 at 4,324,826 bp
  • T to A, chromosome 19 at 5,905,532 bp
  • T to A, chromosome 19 at 38,748,521 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6522 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044648-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.