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Strain Name:
C57BL/6J-MtgxR6523Btlr/Mmmh
Stock Number:
044649-MU
Citation ID:
RRID:MMRRC_044649-MU
Other Names:
R6523 (G1)
Major Collection:

Strain Information

Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Oatp3, Slc21a7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108096
Homologene: 56603
Cox4i1
Name: cytochrome c oxidase subunit 4I1
Synonyms: Cox4, Cox4a, COXIV
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12857
HGNC: HGNC:2265
Homologene: 37537
Csnk1a1
Name: casein kinase 1, alpha 1
Synonyms: 4632404G05Rik, 2610208K14Rik, 5430427P18Rik, CK1a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93687
HGNC: HGNC:2451
Homologene: 111694
Ncaph
Name: non-SMC condensin I complex, subunit H
Synonyms: HCAP-H, A730011O11Rik, Brrn1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215387
HGNC: HGNC:1112
Homologene: 133986
Utp4
Name: UTP4 small subunit processome component
Synonyms: TEG-292, Tex292, Cirh1a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21771
HGNC: HGNC:1983
Homologene: 40775
Ankfy1
Name: ankyrin repeat and FYVE domain containing 1
Synonyms: Ankhzn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11736
Homologene: 9491
Zfp292
Name: zinc finger protein 292
Synonyms: Zn-16, Zn-15, Krox-10, Zfp-15, 9430062L07Rik, 5730450D02Rik, Zfp15
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 30046
Homologene: 8493
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 140,101,707 bp
  • A to G, chromosome 1 at 173,332,553 bp
  • A to G, chromosome 1 at 181,643,621 bp
  • A to T, chromosome 2 at 62,286,961 bp
  • T to C, chromosome 2 at 76,796,046 bp
  • T to A, chromosome 2 at 104,439,408 bp
  • T to C, chromosome 2 at 120,065,614 bp
  • A to T, chromosome 2 at 127,105,889 bp
  • G to A, chromosome 2 at 157,060,343 bp
  • G to A, chromosome 3 at 76,536,334 bp
  • C to G, chromosome 3 at 89,373,501 bp
  • G to C, chromosome 4 at 34,816,301 bp
  • T to A, chromosome 4 at 40,205,947 bp
  • A to T, chromosome 4 at 47,472,071 bp
  • A to T, chromosome 4 at 52,935,500 bp
  • AAGATTTCCAG to A, chromosome 4 at 115,032,714 bp
  • G to A, chromosome 4 at 126,868,760 bp
  • A to C, chromosome 4 at 129,620,987 bp
  • T to C, chromosome 4 at 144,331,648 bp
  • A to T, chromosome 5 at 72,667,608 bp
  • A to T, chromosome 6 at 42,643,019 bp
  • C to T, chromosome 6 at 142,266,395 bp
  • C to T, chromosome 7 at 16,095,520 bp
  • T to A, chromosome 7 at 21,011,852 bp
  • C to A, chromosome 7 at 27,465,717 bp
  • A to C, chromosome 7 at 108,081,555 bp
  • T to A, chromosome 7 at 113,886,785 bp
  • T to A, chromosome 8 at 46,055,855 bp
  • G to T, chromosome 8 at 63,927,504 bp
  • A to T, chromosome 8 at 70,846,525 bp
  • G to A, chromosome 8 at 106,898,463 bp
  • A to T, chromosome 8 at 114,425,605 bp
  • T to A, chromosome 8 at 120,672,741 bp
  • G to A, chromosome 9 at 21,737,253 bp
  • G to A, chromosome 9 at 109,604,980 bp
  • C to T, chromosome 10 at 28,781,898 bp
  • A to T, chromosome 10 at 81,544,854 bp
  • T to A, chromosome 11 at 20,332,114 bp
  • T to A, chromosome 11 at 54,398,501 bp
  • A to T, chromosome 11 at 68,990,457 bp
  • G to A, chromosome 11 at 72,730,482 bp
  • A to T, chromosome 11 at 74,083,142 bp
  • T to C, chromosome 11 at 100,205,097 bp
  • T to A, chromosome 11 at 101,086,118 bp
  • T to A, chromosome 12 at 16,656,696 bp
  • C to T, chromosome 12 at 16,684,373 bp
  • A to T, chromosome 12 at 51,643,098 bp
  • A to G, chromosome 12 at 71,067,341 bp
  • T to C, chromosome 12 at 72,144,791 bp
  • A to T, chromosome 12 at 100,134,405 bp
  • G to A, chromosome 12 at 111,627,235 bp
  • T to C, chromosome 13 at 15,713,650 bp
  • T to A, chromosome 13 at 58,163,643 bp
  • A to G, chromosome 13 at 91,693,051 bp
  • T to C, chromosome 14 at 31,135,705 bp
  • T to A, chromosome 14 at 51,039,227 bp
  • C to A, chromosome 14 at 61,202,961 bp
  • T to A, chromosome 14 at 123,317,843 bp
  • C to A, chromosome 15 at 84,115,711 bp
  • A to G, chromosome 15 at 91,231,581 bp
  • T to C, chromosome 16 at 32,793,450 bp
  • A to G, chromosome 16 at 36,752,321 bp
  • A to G, chromosome 16 at 45,400,270 bp
  • A to G, chromosome 17 at 25,839,420 bp
  • G to A, chromosome 17 at 28,162,388 bp
  • A to G, chromosome 17 at 34,957,191 bp
  • A to G, chromosome 17 at 48,319,165 bp
  • A to T, chromosome 17 at 56,017,617 bp
  • G to A, chromosome 18 at 61,555,758 bp
  • C to T, chromosome 18 at 80,973,188 bp
  • A to C, chromosome 19 at 13,282,364 bp
  • A to G, chromosome 19 at 34,588,155 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6523 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044649-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.