Strain Name:
C57BL/6J-MtgxR6524Btlr/Mmmh
Stock Number:
044650-MU
Citation ID:
RRID:MMRRC_044650-MU
Other Names:
R6524 (G1)
Major Collection:

Strain Information

Ssu72
Name: Ssu72 RNA polymerase II CTD phosphatase homolog (yeast)
Synonyms: 1500011L16Rik, 2610101M12Rik, 1190002E22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68991
Homologene: 6754
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, D230004K18Rik, Megalin, Gp330
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Phax
Name: phosphorylated adaptor for RNA export
Synonyms: phosphorylation regulated, 4933427L19Rik, Phax, Rnuxa, p55, D18Ertd65e, 2810055C14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 56698
Homologene: 10558
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Sh3p17, EHSH1, Intersectin-L, Ese1, Eh domain, SH3 domain regulator of endocytosis 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Mybl2
Name: myeloblastosis oncogene-like 2
Synonyms: Bmyb, B-Myb
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17865
HGNC: HGNC:7548
Homologene: 1847
Tyw5
Name: tRNA-yW synthesizing protein 5
Synonyms: 1110034B05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68736
Homologene: 72085
Mtcl1
Name: microtubule crosslinking factor 1
Synonyms: t8219b25, Soga2, 1110012J17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68617
Homologene: 41017
Eefsec
Name: eukaryotic elongation factor, selenocysteine-tRNA-specific
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 65967
Homologene: 11073
Wdr1
Name: WD repeat domain 1
Synonyms: D5Wsu185e, Aip1, rede
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22388
Homologene: 6628
Ankfy1
Name: ankyrin repeat and FYVE domain containing 1
Synonyms: Ankhzn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11736
Homologene: 9491
Dyrk1a
Name: dual-specificity tyrosine phosphorylation regulated kinase 1a
Synonyms: Mnbh, 2310043O08Rik, D16Ertd493e, Dyrk, D16Ertd272e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13548
HGNC: HGNC:3091
Homologene: 55576
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: Pcp-1, Pcp1, IP3R1, InsP3R type I, P400, Ip3r, opt, wblo, Itpr-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Acin1
Name: apoptotic chromatin condensation inducer 1
Synonyms: 2610036I19Rik, Acinus, 2610510L13Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56215
Homologene: 22853
Nif3l1
Name: Ngg1 interacting factor 3-like 1 (S. pombe)
Synonyms: 1110030G24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 65102
Homologene: 5881
Lbhd2
Name: LBH domain containing 2
Synonyms: LOC380787, A230065H16Rik, Lbh2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380787
Homologene: 78587
Med13
Name: mediator complex subunit 13
Synonyms: 1110067M05Rik, Trap240, Thrap1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327987
Homologene: 21067
C3
Name: complement component 3
Synonyms: Plp, complement factor 3, acylation stimulating protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12266
HGNC: HGNC:1318
Homologene: 68031
Dsg2
Name: desmoglein 2
Synonyms: D18Ertd293e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13511
HGNC: HGNC:3049
Homologene: 1464
Pnpla6
Name: patatin-like phospholipase domain containing 6
Synonyms: Nte, Swiss-cheese, MSws
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50767
Homologene: 21333
Esco1
Name: establishment of sister chromatid cohesion N-acetyltransferase 1
Synonyms: A930014I12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 77805
Homologene: 62166
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: 2010013B10Rik, A230048G03Rik, D330050P16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320473
VEGA: 17
Homologene: 25536
Slc4a4
Name: solute carrier family 4 (anion exchanger), member 4
Synonyms: NBC, NBC1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54403
Homologene: 55776
Six3
Name: sine oculis-related homeobox 3
Synonyms: E130112M24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20473
Homologene: 3947
Ubxn10
Name: UBX domain protein 10
Synonyms: Ubxd3, 5730509E04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212190
Homologene: 17568
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Hgsnat
Name: heparan-alpha-glucosaminide N-acetyltransferase
Synonyms: Tmem76, 9430010M12Rik, D8Ertd354e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52120
Homologene: 15586
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC234973, LOC382129, 9430076A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Nav3
Name: neuron navigator 3
Synonyms: Pomfil1p, 4732483H20Rik, 9630020C08Rik, steerin 3, unc53H3, POMFIL1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 260315
Homologene: 56688
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Rint1
Name: RAD50 interactor 1
Synonyms: 2810450M21Rik, 1500019C06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72772
Homologene: 11070
4933405L10Rik
Name: RIKEN cDNA 4933405L10 gene
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71046
Homologene: 19274
Krt84
Name: keratin 84
Synonyms: HRb-1, Krt2-16, Krt2-3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16680
VEGA: 15
HGNC: HGNC:6461
Homologene: 22473
Fam83a
Name: family with sequence similarity 83, member A
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239463
Homologene: 13158
Meiob
Name: meiosis specific with OB domains
Synonyms: 4930528F23Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75178
VEGA: 17
Homologene: 102013
Or5h23
Name: olfactory receptor family 5 subfamily H member 23
Synonyms: GA_x54KRFPKG5P-55314632-55313703, MOR183-5P, Olfr191
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258035
Homologene: 128162
Dnaaf2
Name: dynein, axonemal assembly factor 2
Synonyms: Ktu, 2810020C19Rik, 1110034A24Rik, kintoun
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109065
Homologene: 10026
Lcmt2
Name: leucine carboxyl methyltransferase 2
Synonyms: Tyw4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329504
Homologene: 19642
Timm44
Name: translocase of inner mitochondrial membrane 44
Synonyms: 0710005E20Rik, Tim44, Mimt44, D8Ertd118e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21856
Homologene: 4631
H1f11-ps
Name: H1.11 linker histone, pseudogene
Synonyms: Gm6970
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 629389
VEGA: 19
Vmn2r23
Name: vomeronasal 2, receptor 23
Synonyms: EG435916
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 435916
Homologene: 135826
Tspan8
Name: tetraspanin 8
Synonyms: Tm4sf3, E330007O21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216350
VEGA: 10
Homologene: 20968
Yif1a
Name: Yip1 interacting factor homolog A (S. cerevisiae)
Synonyms: Yif1p, 5330422J23Rik, 54TM
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68090
VEGA: 19
Homologene: 56295
Scand1
Name: SCAN domain-containing 1
Synonyms: PGC-2, 2310003H23Rik, Ppargc2, Leap1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19018
VEGA: 2
Homologene: 10642
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 57,388,731 bp
  • T to C, chromosome 1 at 58,457,840 bp
  • T to C, chromosome 2 at 40,851,804 bp
  • T to C, chromosome 2 at 69,436,639 bp
  • T to C, chromosome 2 at 121,138,931 bp
  • C to T, chromosome 2 at 156,312,249 bp
  • C to A, chromosome 2 at 163,074,530 bp
  • T to A, chromosome 4 at 138,720,883 bp
  • T to G, chromosome 4 at 155,715,540 bp
  • G to A, chromosome 5 at 14,718,869 bp
  • A to T, chromosome 5 at 23,815,739 bp
  • A to T, chromosome 5 at 38,530,063 bp
  • T to C, chromosome 5 at 89,232,764 bp
  • T to C, chromosome 6 at 88,297,920 bp
  • C to T, chromosome 6 at 108,363,683 bp
  • T to A, chromosome 6 at 123,713,425 bp
  • T to C, chromosome 6 at 146,345,211 bp
  • T to A, chromosome 8 at 3,534,519 bp
  • T to C, chromosome 8 at 4,267,988 bp
  • A to G, chromosome 8 at 25,945,232 bp
  • A to G, chromosome 8 at 105,709,009 bp
  • A to T, chromosome 9 at 15,992,256 bp
  • T to C, chromosome 10 at 109,720,030 bp
  • T to C, chromosome 10 at 115,844,079 bp
  • G to A, chromosome 11 at 72,730,482 bp
  • A to G, chromosome 11 at 86,301,467 bp
  • A to T, chromosome 12 at 69,190,385 bp
  • G to A, chromosome 12 at 111,410,290 bp
  • G to T, chromosome 14 at 54,645,283 bp
  • T to C, chromosome 15 at 57,995,340 bp
  • A to G, chromosome 15 at 101,532,752 bp
  • C to T, chromosome 16 at 59,086,277 bp
  • T to C, chromosome 16 at 91,911,995 bp
  • C to T, chromosome 16 at 94,685,120 bp
  • G to A, chromosome 17 at 24,832,517 bp
  • A to T, chromosome 17 at 57,217,264 bp
  • A to T, chromosome 17 at 66,348,285 bp
  • A to G, chromosome 17 at 78,814,106 bp
  • C to T, chromosome 17 at 85,621,970 bp
  • T to G, chromosome 18 at 10,582,188 bp
  • T to G, chromosome 18 at 20,583,036 bp
  • T to A, chromosome 18 at 56,587,002 bp
  • A to G, chromosome 19 at 5,092,176 bp
  • G to A, chromosome 19 at 47,170,560 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6524 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044650-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.