Strain Name:
C57BL/6J-MtgxR6533Btlr/Mmmh
Stock Number:
044659-MU
Citation ID:
RRID:MMRRC_044659-MU
Other Names:
R6533 (G1)
Major Collection:

Strain Information

Dst
Name: dystonin
Synonyms: A830042E19Rik, nmf339, bullous pemphigoid antigen 1, Bpag1, 2310001O04Rik, Bpag, Macf2, BPAG1, BPAG1-n, athetoid, bullous pemphigoid antigen 1, ah, nmf203
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Orc1
Name: origin recognition complex, subunit 1
Synonyms: Orc1l, MmORC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18392
HGNC: HGNC:8487
Homologene: 31221
Sdhc
Name: succinate dehydrogenase complex, subunit C, integral membrane protein
Synonyms: 0610010E03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66052
Homologene: 2256
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Tasp1
Name: taspase, threonine aspartase 1
Synonyms: 4930485D02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75812
Homologene: 9795
Rab3gap2
Name: RAB3 GTPase activating protein subunit 2
Synonyms: 1110059F07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98732
Homologene: 40842
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Dcp2
Name: decapping mRNA 2
Synonyms: 2410015D23Rik, 5730537H01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70640
Homologene: 13968
Marf1
Name: meiosis regulator and mRNA stability 1
Synonyms: 4921513D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 223989
VEGA: 16
Homologene: 40967
Ankrd28
Name: ankyrin repeat domain 28
Synonyms: E430019N21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105522
VEGA: 14
Homologene: 35374
Trappc10
Name: trafficking protein particle complex 10
Synonyms: b2b2613Clo, Tmem1, LOC380642, b2b2416Clo, B230307C21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216131
VEGA: 10
Homologene: 37751
Unc45a
Name: unc-45 myosin chaperone A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101869
Homologene: 32423
P4hb
Name: prolyl 4-hydroxylase, beta polypeptide
Synonyms: Pdia1, Thbp, PDI, protein disulfide isomerase, ERp59
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18453
HGNC: HGNC:8548
Homologene: 55495
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Zftraf1
Name: zinc finger TRAF type containing 1
Synonyms: 1110031M01Rik, Cyhr1, Chrp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54151
Homologene: 32791
Zkscan8
Name: zinc finger with KRAB and SCAN domains 8
Synonyms: 2510038J07Rik, Zfp192, LD5-1, D430019P06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 93681
Homologene: 21268
Med23
Name: mediator complex subunit 23
Synonyms: ESTM7, Sur2, Crsp3, X83317, sno, 3000002A17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70208
HGNC: HGNC:2372
Homologene: 3552
Rnf214
Name: ring finger protein 214
Synonyms: D130054N24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235315
Homologene: 109357
Barx2
Name: BarH-like homeobox 2
Synonyms: Barx2b, 2310006E12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12023
HGNC: HGNC:956
Homologene: 2715
Pigo
Name: phosphatidylinositol glycan anchor biosynthesis, class O
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56703
Homologene: 31761
Ppm1m
Name: protein phosphatase 1M
Synonyms: PP2C eta, 2810423O19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67905
Homologene: 44900
Stxbp2
Name: syntaxin binding protein 2
Synonyms: C79054, Munc-18b, Sxtp2, Munc18b, Munc-18-2, muSec1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20911
Homologene: 55530
Ptprd
Name: protein tyrosine phosphatase receptor type D
Synonyms: B230219D21Rik, 1110002J03Rik, 3000002J10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC382129, 9430076A06Rik, LOC234973
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna-1, ihj, erythroid, Spna1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
Vmn1r59
Name: vomeronasal 1 receptor 59
Synonyms: V1rd10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404284
Homologene: 41799
Ppargc1b
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Synonyms: 4631412G21Rik, PGC-1beta/ERRL1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 170826
Homologene: 15776
Myh3
Name: myosin, heavy polypeptide 3, skeletal muscle, embryonic
Synonyms: MyHC-emb, Myhse, Myhs-e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17883
HGNC: HGNC:7573
Homologene: 20553
Ces2c
Name: carboxylesterase 2C
Synonyms: Ces2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234671
HGNC: HGNC:1864
Homologene: 138298
Vmn2r85
Name: vomeronasal 2, receptor 85
Synonyms: EG623734
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 623734
Homologene: 129606
Btn2a2
Name: butyrophilin, subfamily 2, member A2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238555
Homologene: 56012
Ncan
Name: neurocan
Synonyms: Cspg3-rs, Tgfbit, Cspg3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13004
HGNC: HGNC:2465
Homologene: 3229
Nipal4
Name: NIPA-like domain containing 4
Synonyms: 9530066K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 214112
Homologene: 133769
Vmn2r4
Name: vomeronasal 2, receptor 4
Synonyms: EG637053
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 637053
Homologene: 129754
Obox5
Name: oocyte specific homeobox 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252829
Homologene: 44937
4932414N04Rik
Name: RIKEN cDNA 4932414N04 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75721
Homologene: 138468
Tas2r144
Name: taste receptor, type 2, member 144
Synonyms: Tas2r44, mt2r33
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387515
Homologene: 47977
Abhd16a
Name: abhydrolase domain containing 16A
Synonyms: NG26, D17H6S82E, Bat5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193742
Homologene: 10904
Gsdmc4
Name: gasdermin C4
Synonyms: 9030605I04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74548
HGNC: HGNC:7151
Homologene: 69487
Lonrf2
Name: LON peptidase N-terminal domain and ring finger 2
Synonyms: 2900060P06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381338
Homologene: 18871
Tmem95
Name: transmembrane protein 95
Synonyms: 432576
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100503361
VEGA: 11
Homologene: 77849
Tigd5
Name: tigger transposable element derived 5
Synonyms: FLJ14926
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105734
Homologene: 129878
1700010B08Rik
Name: RIKEN cDNA 1700010B08 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75485
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 30,806,318 bp
  • A to G, chromosome 1 at 34,303,509 bp
  • A to C, chromosome 1 at 38,813,268 bp
  • A to G, chromosome 1 at 171,129,827 bp
  • C to T, chromosome 1 at 174,244,147 bp
  • T to A, chromosome 1 at 185,232,954 bp
  • G to T, chromosome 2 at 68,716,318 bp
  • A to G, chromosome 2 at 139,834,357 bp
  • C to T, chromosome 2 at 173,719,835 bp
  • T to C, chromosome 3 at 64,415,098 bp
  • A to T, chromosome 4 at 43,022,697 bp
  • A to T, chromosome 4 at 76,128,528 bp
  • T to C, chromosome 4 at 108,597,447 bp
  • A to T, chromosome 6 at 42,215,346 bp
  • A to G, chromosome 7 at 5,454,464 bp
  • A to T, chromosome 7 at 15,757,607 bp
  • C to G, chromosome 7 at 25,530,711 bp
  • T to G, chromosome 7 at 80,334,069 bp
  • A to T, chromosome 7 at 130,622,837 bp
  • T to A, chromosome 8 at 3,642,683 bp
  • G to A, chromosome 8 at 70,096,357 bp
  • T to A, chromosome 8 at 104,852,093 bp
  • T to A, chromosome 9 at 15,998,899 bp
  • T to C, chromosome 9 at 31,912,979 bp
  • A to G, chromosome 9 at 45,900,063 bp
  • T to C, chromosome 9 at 106,196,870 bp
  • T to C, chromosome 9 at 108,961,358 bp
  • T to C, chromosome 10 at 24,893,620 bp
  • T to C, chromosome 10 at 78,188,894 bp
  • A to T, chromosome 10 at 130,426,660 bp
  • A to T, chromosome 11 at 46,150,407 bp
  • A to G, chromosome 11 at 67,090,419 bp
  • A to T, chromosome 11 at 69,878,017 bp
  • A to T, chromosome 11 at 120,571,643 bp
  • A to G, chromosome 13 at 21,520,578 bp
  • C to A, chromosome 13 at 23,481,781 bp
  • T to A, chromosome 14 at 31,732,084 bp
  • T to A, chromosome 15 at 63,892,060 bp
  • A to G, chromosome 15 at 75,910,190 bp
  • C to A, chromosome 15 at 76,647,730 bp
  • T to C, chromosome 16 at 14,115,799 bp
  • T to C, chromosome 17 at 30,746,990 bp
  • G to A, chromosome 17 at 35,098,809 bp
  • T to A, chromosome 18 at 44,399,664 bp
  • C to T, chromosome 18 at 61,307,774 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6533 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044659-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.