Strain Name:
C57BL/6J-MtgxR6550Btlr/Mmmh
Stock Number:
044675-MU
Citation ID:
RRID:MMRRC_044675-MU
Other Names:
R6550 (G1)
Major Collection:

Strain Information

Col2a1
Name: collagen, type II, alpha 1
Synonyms: M100856, Col2a, Col2, Rgsc413, Rgsc856, Col2a-1, Del1, Lpk, M100413
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12824
HGNC: HGNC:2200
Homologene: 55607
Bahcc1
Name: BAH domain and coiled-coil containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268515
Homologene: 129585
Mtarc2
Name: mitochondrial amidoxime reducing component 2
Synonyms: Marc2, Mosc2, 2810484M10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67247
Homologene: 9904
Atl3
Name: atlastin GTPase 3
Synonyms: 5730596K20Rik, 4633402C03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109168
VEGA: 19
Homologene: 9149
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: Alfy, Bchs, Ggtb3, Bwf1, D5Ertd66e, 2610509D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72145
Homologene: 22855
Tmem87b
Name: transmembrane protein 87B
Synonyms: 2810431I02Rik, 2610301K12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72477
Homologene: 69513
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108989
Homologene: 37753
Tmem161b
Name: transmembrane protein 161B
Synonyms: 2810446P07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72745
Homologene: 14519
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Mcm2
Name: minichromosome maintenance complex component 2
Synonyms: Mcmd2, CDCL1, BM28
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17216
HGNC: HGNC:6944
Homologene: 3325
Rars1
Name: arginyl-tRNA synthetase 1
Synonyms: 2610037E21Rik, 2610011N19Rik, Rars
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104458
HGNC: HGNC:9870
Homologene: 68281
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: Fam208b, BC016423
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Camta1
Name: calmodulin binding transcription activator 1
Synonyms: 2310058O09Rik, 1810059M14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100072
Homologene: 18942
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Zdhhc5
Name: zinc finger, DHHC domain containing 5
Synonyms: 1110032A17Rik, Zisp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228136
Homologene: 9147
Cd22
Name: CD22 antigen
Synonyms: Lyb8, Lyb-8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12483
HGNC: HGNC:1643
Homologene: 31052
Hsh2d
Name: hematopoietic SH2 domain containing
Synonyms: Hsh2, ALX
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 209488
Homologene: 13142
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: 1700016D22Rik, F77
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56523
Homologene: 23182
Cfap69
Name: cilia and flagella associated protein 69
Synonyms: A330021E22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207686
Homologene: 11718
Slc8b1
Name: solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
Synonyms: Slc24a6, NCKX6, NCLX
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 170756
Homologene: 41602
Lrrc49
Name: leucine rich repeat containing 49
Synonyms: D430025H09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102747
Homologene: 9782
Gm10912
Name: predicted gene 10912
Type: Gene
Species: Mouse
Chromosome: 2
Map3k21
Name: mitogen-activated protein kinase kinase kinase 21
Synonyms: BC021891
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234878
Homologene: 32778
Or2n1d
Name: olfactory receptor family 2 subfamily N member 1D
Synonyms: GA_x6K02T2PSCP-2779375-2780313, MOR256-7, Olfr136
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258803
Homologene: 119758
Atp8b4
Name: ATPase, class I, type 8B, member 4
Synonyms: Im
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241633
Homologene: 133162
Polrmt
Name: polymerase (RNA) mitochondrial (DNA directed)
Synonyms: 1110018N15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216151
HGNC: HGNC:9200
Homologene: 37996
Asz1
Name: ankyrin repeat, SAM and basic leucine zipper domain containing 1
Synonyms: Gasz, ORF3, 4933400N19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74068
HGNC: HGNC:1350
Homologene: 11374
Apbb1ip
Name: amyloid beta precursor protein binding family B member 1 interacting protein
Synonyms: proline-rich protein 48, Prp48, 9930118P07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54519
Homologene: 32434
Selplg
Name: selectin, platelet (p-selectin) ligand
Synonyms: Psgl1, CD162, Psgl-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20345
Homologene: 2261
Spata31e3
Name: spermatogenesis associated 31 subfamily E member 3
Synonyms: LOC380882, Gm906
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380882
VEGA: 13
Homologene: 134512
Pp2d1
Name: protein phosphatase 2C-like domain containing 1
Synonyms: 4921523A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110332
VEGA: 17
Homologene: 16981
E330034G19Rik
Name: RIKEN cDNA E330034G19 gene
Synonyms: ZPAC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105418
Cyp2c67
Name: cytochrome P450, family 2, subfamily c, polypeptide 67
Synonyms: C730004C24Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 545288
Homologene: 74936
Efhb
Name: EF hand domain family, member B
Synonyms: 4921525D22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 211482
VEGA: 17
Homologene: 16982
Cbx2
Name: chromobox 2
Synonyms: M33
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12416
HGNC: HGNC:1552
Homologene: 7256
Or1o1
Name: olfactory receptor family 1 subfamily O member 1
Synonyms: GA_x6K02T2PSCP-1867165-1868094, Olfr107, MOR156-3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258504
Homologene: 115498
Erlin1
Name: ER lipid raft associated 1
Synonyms: Spfh1, Keo4, 2810439N09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226144
Homologene: 4716
Defa27
Name: defensin, alpha, 27
Synonyms: Gm15299, ENSMUSG00000074438
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100041811
Homologene: 113382
Bin2
Name: bridging integrator 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 668218
HGNC: HGNC:1053
Homologene: 22965
Trir
Name: telomerase RNA component interacting RNase
Synonyms: 2310036O22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68544
Homologene: 11428
D630044L22Rik
Name: RIKEN cDNA gene D630044L22 gene
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240054
VEGA: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 150,423,977 bp
  • C to A, chromosome 1 at 184,819,342 bp
  • A to G, chromosome 2 at 22,858,233 bp
  • T to C, chromosome 2 at 84,696,341 bp
  • C to T, chromosome 2 at 104,066,651 bp
  • T to A, chromosome 2 at 126,424,193 bp
  • T to A, chromosome 2 at 128,824,465 bp
  • A to C, chromosome 4 at 151,138,375 bp
  • A to T, chromosome 5 at 5,581,220 bp
  • A to G, chromosome 5 at 101,953,166 bp
  • G to A, chromosome 5 at 113,820,149 bp
  • A to G, chromosome 5 at 120,524,017 bp
  • T to C, chromosome 6 at 18,051,381 bp
  • A to G, chromosome 6 at 88,886,959 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • T to C, chromosome 7 at 30,877,552 bp
  • A to C, chromosome 8 at 21,316,324 bp
  • C to A, chromosome 8 at 72,198,453 bp
  • G to T, chromosome 8 at 85,029,920 bp
  • T to C, chromosome 8 at 109,520,207 bp
  • A to G, chromosome 8 at 125,937,292 bp
  • T to C, chromosome 9 at 59,868,199 bp
  • G to T, chromosome 9 at 60,677,147 bp
  • C to A, chromosome 10 at 79,739,680 bp
  • T to C, chromosome 11 at 35,833,183 bp
  • T to C, chromosome 11 at 119,029,025 bp
  • C to T, chromosome 11 at 120,276,651 bp
  • A to G, chromosome 13 at 3,590,519 bp
  • G to A, chromosome 13 at 50,245,446 bp
  • C to A, chromosome 13 at 84,222,418 bp
  • A to G, chromosome 14 at 24,296,818 bp
  • A to G, chromosome 15 at 97,976,793 bp
  • A to G, chromosome 15 at 100,645,477 bp
  • A to T, chromosome 17 at 25,961,654 bp
  • G to A, chromosome 17 at 37,405,905 bp
  • C to T, chromosome 17 at 38,336,005 bp
  • G to T, chromosome 17 at 53,421,940 bp
  • T to C, chromosome 17 at 53,515,576 bp
  • A to G, chromosome 19 at 7,522,138 bp
  • G to T, chromosome 19 at 39,617,410 bp
  • A to T, chromosome 19 at 44,037,163 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6550 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044675-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.