Strain Name:
C57BL/6J-MtgxR6552Btlr/Mmmh
Stock Number:
044677-MU
Citation ID:
RRID:MMRRC_044677-MU
Other Names:
R6552 (G1)
Major Collection:

Strain Information

Dnmt3a
Name: DNA methyltransferase 3A
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13435
HGNC: HGNC:2978
Homologene: 7294
Lcat
Name: lecithin cholesterol acyltransferase
Synonyms: D8Wsu61e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16816
HGNC: HGNC:6522
Homologene: 68042
Epb41l4a
Name: erythrocyte membrane protein band 4.1 like 4a
Synonyms: Epb4.1l4a, NBL4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13824
VEGA: 18
Homologene: 8398
Efr3a
Name: EFR3 homolog A
Synonyms: C920006C10Rik, A130089M23Rik, D030063F01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76740
Homologene: 44222
Stam2
Name: signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Synonyms: 1200004O12Rik, 5730456G07Rik, Hbp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56324
Homologene: 68490
Golga4
Name: golgin A4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Sec24d
Name: SEC24 homolog D, COPII coat complex component
Synonyms: LOC383951, 2310020L09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69608
Homologene: 40986
Lsm3
Name: LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
Synonyms: SMX4, USS2, 1010001J12Rik, 2610005D18Rik, 6030401D18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67678
Homologene: 6548
Sumo3
Name: small ubiquitin-like modifier 3
Synonyms: D10Ertd345e, Smt3h1, 2810014B19Rik, SMT3A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20610
Homologene: 38251
Atxn2l
Name: ataxin 2-like
Synonyms: A2D, A2LG, A2RP, A2lp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233871
Homologene: 16513
Qrich1
Name: glutamine-rich 1
Synonyms: 2610028H07Rik, b2b2404Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69232
Homologene: 9803
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skam26Jus, ska26, skax26, Cd
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Synonyms: cholesterol 7 alpha hydroxylase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13122
HGNC: HGNC:2651
Homologene: 30987
Snw1
Name: SNW domain containing 1
Synonyms: SKIP, NCoA-62, Skiip, SNW1, 2310008B08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66354
VEGA: 12
Homologene: 56557
Pex1
Name: peroxisomal biogenesis factor 1
Synonyms: 5430414H02Rik, ZWS1, E330005K07Rik, peroxisome biogenesis factor 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71382
HGNC: HGNC:8850
Homologene: 27006
Rho
Name: rhodopsin
Synonyms: LWS opsin, Noerg1, Ops, Opn2, Red Opsin, L opsin, Long Wavelength Sensitive opsin, Rod Opsin, RP4, opsin 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 212541
Homologene: 68068
Kcnn2
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Synonyms: SK2, fri, bc, small conductance calcium-activated potassium channel 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 140492
HGNC: HGNC:6291
Homologene: 135651
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Klf5
Name: Kruppel-like transcription factor 5
Synonyms: IKLF, 4930520J07Rik, Bteb2, CKLF
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12224
VEGA: 14
HGNC: HGNC:6349
Homologene: 37520
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: ENSMUSG00000043296, 9930021A08Rik, E130209G04Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, D12Ertd777e, diminished cone electroretinogram, Cpfl8, Nesp2g, dice, syne-2, 6820443O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Haspin
Name: histone H3 associated protein kinase
Synonyms: Gsg2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14841
Homologene: 49236
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245026
Homologene: 18260
Skint3
Name: selection and upkeep of intraepithelial T cells 3
Synonyms: A430090E18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 195564
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 1300010F03Rik, 4932416F07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230622
Homologene: 135888
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381157
Homologene: 73393
Bpifa6
Name: BPI fold containing family A, member 6
Synonyms: Gm5840
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545477
Homologene: 129594
Pcdhb2
Name: protocadherin beta 2
Synonyms: PcdhbB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93873
HGNC: HGNC:8687
Homologene: 69266
Ttbk1
Name: tau tubulin kinase 1
Synonyms: C330008L01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106763
VEGA: 17
Homologene: 50342
Spice1
Name: spindle and centriole associated protein 1
Synonyms: Ccdc52, D16Ertd480e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212514
Homologene: 16931
Arsk
Name: arylsulfatase K
Synonyms: 2810429K17Rik, 4833414G15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 77041
Homologene: 12670
Vmn1r80
Name: vomeronasal 1 receptor 80
Synonyms: V1rg3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171238
Slc23a1
Name: solute carrier family 23 (nucleobase transporters), member 1
Synonyms: D18Ucla2, SVCT1, YSPL3, Slc23a2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20522
Homologene: 40769
Creb5
Name: cAMP responsive element binding protein 5
Synonyms: 9430076C15Rik, D430026C09Rik, Crebpa
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 231991
Homologene: 18215
Tmem200a
Name: transmembrane protein 200A
Synonyms: C030003D03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77220
VEGA: 10
Homologene: 14175
Or2ag13
Name: olfactory receptor family 2 subfamily AG member 13
Synonyms: Olfr695, GA_x6K02T2PBJ9-9092181-9091234, MOR283-6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258591
Homologene: 133597
Il34
Name: interleukin 34
Synonyms: 2010004A03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76527
Homologene: 12648
Siae
Name: sialic acid acetylesterase
Synonyms: clone 165, Ysg2, LSE
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22619
Homologene: 8001
Gabra1
Name: gamma-aminobutyric acid type A receptor subunit alpha 1
Synonyms: GABAA alpha 1, GABAAR alpha1, Gabra-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14394
HGNC: HGNC:4075
Homologene: 629
Ang5
Name: angiogenin, ribonuclease A family, member 5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 503844
HGNC: HGNC:483
Homologene: 134083
Mn1
Name: meningioma 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 433938
HGNC: HGNC:7180
Homologene: 37620
Or1o1
Name: olfactory receptor family 1 subfamily O member 1
Synonyms: Olfr107, GA_x6K02T2PSCP-1867165-1868094, MOR156-3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258504
Homologene: 115498
Sdhaf4
Name: succinate dehydrogenase complex assembly factor 4
Synonyms: 1110058L19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68002
Homologene: 32661
Smad9
Name: SMAD family member 9
Synonyms: SMAD8B, MADH6, SMAD8A, Madh9
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 55994
HGNC: HGNC:6774
Homologene: 21198
Ccdc103
Name: coiled-coil domain containing 103
Synonyms: 1700039D13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73293
Homologene: 45831
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 24,005,606 bp
  • T to C, chromosome 2 at 52,708,227 bp
  • G to A, chromosome 2 at 153,987,158 bp
  • G to T, chromosome 2 at 180,181,154 bp
  • A to G, chromosome 3 at 54,782,746 bp
  • A to G, chromosome 3 at 123,290,552 bp
  • C to T, chromosome 4 at 6,272,361 bp
  • T to C, chromosome 4 at 112,290,285 bp
  • A to C, chromosome 4 at 113,067,490 bp
  • G to A, chromosome 5 at 3,623,953 bp
  • T to C, chromosome 5 at 111,420,887 bp
  • A to G, chromosome 6 at 53,685,384 bp
  • GATATATA to GATATATATA, chromosome 6 at 91,519,635 bp
  • A to G, chromosome 6 at 115,931,748 bp
  • A to T, chromosome 6 at 134,454,729 bp
  • C to T, chromosome 7 at 12,193,757 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • TGAAGCC to T, chromosome 7 at 106,714,643 bp
  • C to T, chromosome 7 at 126,493,821 bp
  • T to C, chromosome 8 at 105,939,679 bp
  • T to A, chromosome 8 at 110,742,427 bp
  • T to C, chromosome 9 at 37,646,400 bp
  • C to T, chromosome 9 at 105,698,913 bp
  • T to C, chromosome 9 at 108,534,305 bp
  • T to A, chromosome 9 at 118,514,231 bp
  • T to C, chromosome 10 at 25,993,483 bp
  • G to T, chromosome 10 at 77,606,257 bp
  • A to T, chromosome 11 at 42,147,099 bp
  • A to G, chromosome 11 at 73,137,564 bp
  • A to G, chromosome 11 at 102,884,144 bp
  • T to C, chromosome 12 at 3,907,623 bp
  • T to G, chromosome 12 at 75,890,241 bp
  • A to G, chromosome 12 at 87,459,419 bp
  • A to G, chromosome 13 at 76,072,196 bp
  • A to T, chromosome 14 at 43,962,797 bp
  • A to T, chromosome 14 at 79,198,222 bp
  • T to C, chromosome 14 at 99,301,642 bp
  • A to G, chromosome 15 at 65,857,490 bp
  • A to G, chromosome 16 at 44,379,033 bp
  • G to A, chromosome 17 at 37,405,905 bp
  • G to T, chromosome 17 at 46,478,962 bp
  • G to T, chromosome 17 at 46,966,268 bp
  • G to A, chromosome 18 at 10,541,814 bp
  • A to G, chromosome 18 at 33,878,979 bp
  • C to A, chromosome 18 at 35,622,338 bp
  • A to T, chromosome 18 at 37,295,993 bp
  • A to G, chromosome 18 at 45,560,098 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6552 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044677-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.