Strain Name:
C57BL/6J-MtgxR6555Btlr/Mmmh
Stock Number:
044680-MU
Citation ID:
RRID:MMRRC_044680-MU
Other Names:
R6555 (G1)
Major Collection:

Strain Information

Cntnap2
Name: contactin associated protein-like 2
Synonyms: Caspr2, 5430425M22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66797
Homologene: 69159
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Mta3
Name: metastasis associated 3
Synonyms: 1110002J22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 116871
Homologene: 14282
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, Gp330, Megalin, D230004K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Lsm3
Name: LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
Synonyms: 6030401D18Rik, 1010001J12Rik, SMX4, USS2, 2610005D18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67678
Homologene: 6548
Ercc6
Name: excision repair cross-complementing rodent repair deficiency, complementation group 6
Synonyms: CS group B correcting gene, C130058G22Rik, CSB
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319955
VEGA: 14
HGNC: HGNC:3438
Homologene: 133552
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27103
Homologene: 40891
Akap1
Name: A kinase anchor protein 1
Synonyms: S-AKAP84, DAKAP1, AKAP121, AKAP84
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11640
HGNC: HGNC:367
Homologene: 31165
Safb2
Name: scaffold attachment factor B2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224902
Homologene: 35210
Iqsec3
Name: IQ motif and Sec7 domain 3
Synonyms: synarfGEF, BRAG3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243621
Homologene: 46091
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, C330002D13Rik, Coh1, 2310042E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
C1qtnf3
Name: C1q and tumor necrosis factor related protein 3
Synonyms: CTRP3, CORS-26, Corcs, 2310005P21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 81799
Homologene: 12788
Nup88
Name: nucleoporin 88
Synonyms: Prei2, Nup84
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19069
HGNC: HGNC:8067
Homologene: 1901
Carm1
Name: coactivator-associated arginine methyltransferase 1
Synonyms: Prmt4, m9Bei
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 59035
Homologene: 10990
Trmt2a
Name: TRM2 tRNA methyltransferase 2A
Synonyms: Htf9c
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15547
Homologene: 7374
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: sba, 1700096C21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240411
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: flamingo, mfmi1, Adgrc2, EGFL2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Cfap206
Name: cilia and flagella associated protein 206
Synonyms: 1700003M02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69329
Homologene: 18713
Ctss
Name: cathepsin S
Synonyms: Cat S
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13040
HGNC: HGNC:2545
Homologene: 20867
Slc16a10
Name: solute carrier family 16 (monocarboxylic acid transporters), member 10
Synonyms: PRO0813, TAT1, 2610103N14Rik, Mct10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72472
VEGA: 10
Homologene: 75089
Wdr64
Name: WD repeat domain 64
Synonyms: 4930415O10Rik, 4930511H01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75820
Homologene: 51634
Ptprn2
Name: protein tyrosine phosphatase receptor type N polypeptide 2
Synonyms: IA-2beta, 4930425H11Rik, PTP-NP, phogrin, IA-2 beta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19276
HGNC: HGNC:9677
Homologene: 2134
Gp6
Name: glycoprotein 6 platelet
Synonyms: 9830166G18Rik, Gpvi
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243816
Homologene: 9488
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Ppip5k1
Name: diphosphoinositol pentakisphosphate kinase 1
Synonyms: Hisppd2a, B430315C20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 327655
Homologene: 49395
Tsen54
Name: tRNA splicing endonuclease subunit 54
Synonyms: 0610034P02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76265
Homologene: 35476
Or5d16
Name: olfactory receptor family 5 subfamily D member 16
Synonyms: MOR174-10, GA_x6K02T2Q125-49426894-49425950, Olfr1155
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258636
Homologene: 133739
Pramel27
Name: PRAME like 27
Synonyms: Gm13103
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 194225
Homologene: 129883
Slc22a22
Name: solute carrier family 22 (organic cation transporter), member 22
Synonyms: OAT-PG, BC026439
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210463
Homologene: 18166
Abcb1a
Name: ATP-binding cassette, sub-family B member 1A
Synonyms: Pgy-3, P-gp, multiple drug resistant 1a, MDR3, Pgp, P-glycoprotein, mdr-3, Pgy3, Mdr1a, Evi32
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Or8b51
Name: olfactory receptor family 8 subfamily B member 51
Synonyms: GA_x6K02T2PVTD-32360710-32359778, Olfr916, MOR168-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258780
VEGA: 9
Homologene: 74147
Gtsf1
Name: gametocyte specific factor 1
Synonyms: Cue110, 1700006H03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74174
Homologene: 16942
Or4q3
Name: olfactory receptor family 4 subfamily Q member 3
Synonyms: MOR243-1, Olfr735, GA_x6K02T2PMLR-6042130-6041183
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 257909
Homologene: 71977
Or1o1
Name: olfactory receptor family 1 subfamily O member 1
Synonyms: MOR156-3, GA_x6K02T2PSCP-1867165-1868094, Olfr107
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258504
Homologene: 115498
Il36a
Name: interleukin 36A
Synonyms: IL-1H1, Fil1, If36a, Fil1epsilon, Il1f6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54448
Homologene: 8688
Selp
Name: selectin, platelet
Synonyms: P-selectin, CD62P, Grmp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20344
Homologene: 2260
Krtap10-31
Name: keratin associated protein 10-31
Synonyms: EG622629, Gm10318
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 622629
Homologene: 115744
Igkv1-99
Name: immunoglobulin kappa variable 1-99
Synonyms: Gm16800
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434028
Pcdhga10
Name: protocadherin gamma subfamily A, 10
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93722
HGNC: HGNC:8697
Homologene: 49567
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 164,141,602 bp
  • G to A, chromosome 1 at 175,720,290 bp
  • G to A, chromosome 2 at 24,224,599 bp
  • T to C, chromosome 2 at 69,509,303 bp
  • T to A, chromosome 2 at 87,943,288 bp
  • A to T, chromosome 2 at 118,427,869 bp
  • T to C, chromosome 2 at 121,337,612 bp
  • T to A, chromosome 3 at 95,543,029 bp
  • T to C, chromosome 3 at 108,394,919 bp
  • A to G, chromosome 4 at 34,719,049 bp
  • A to G, chromosome 4 at 143,851,570 bp
  • A to G, chromosome 5 at 8,702,468 bp
  • T to A, chromosome 6 at 46,759,760 bp
  • A to G, chromosome 6 at 68,542,316 bp
  • GATATATA to GATATATATA, chromosome 6 at 91,519,635 bp
  • T to C, chromosome 6 at 121,384,219 bp
  • C to T, chromosome 7 at 4,384,930 bp
  • T to A, chromosome 9 at 21,586,962 bp
  • C to A, chromosome 9 at 38,658,289 bp
  • A to G, chromosome 9 at 109,108,405 bp
  • T to C, chromosome 10 at 40,080,778 bp
  • G to A, chromosome 10 at 77,853,021 bp
  • T to C, chromosome 11 at 70,944,180 bp
  • A to T, chromosome 11 at 88,844,882 bp
  • C to T, chromosome 11 at 115,820,693 bp
  • T to C, chromosome 12 at 117,227,200 bp
  • A to G, chromosome 13 at 13,648,925 bp
  • G to A, chromosome 14 at 32,517,107 bp
  • G to A, chromosome 14 at 50,345,846 bp
  • A to G, chromosome 15 at 10,975,656 bp
  • A to G, chromosome 15 at 35,846,847 bp
  • G to A, chromosome 15 at 57,259,131 bp
  • T to C, chromosome 15 at 103,425,475 bp
  • A to T, chromosome 16 at 18,253,203 bp
  • G to A, chromosome 17 at 37,405,905 bp
  • A to G, chromosome 17 at 56,567,600 bp
  • A to G, chromosome 17 at 56,582,982 bp
  • C to T, chromosome 17 at 83,708,446 bp
  • A to G, chromosome 18 at 37,749,435 bp
  • T to C, chromosome 18 at 77,293,269 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6555 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044680-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.