Strain Name:
C57BL/6J-MtgxR6575Btlr/Mmmh
Stock Number:
044699-MU
Citation ID:
RRID:MMRRC_044699-MU
Other Names:
R6575 (G1)
Major Collection:

Strain Information

Pmp22
Name: peripheral myelin protein 22
Synonyms: TRE002, Gas-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18858
HGNC: HGNC:9118
Homologene: 7482
Fam3c
Name: FAM3 metabolism regulating signaling molecule C
Synonyms: D6Wsu176e, Ilei, Fam3c
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27999
Homologene: 8926
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: p53BP1, 53BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27223
Homologene: 4137
Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330953
VEGA: 9
Homologene: 3997
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: CAGH26, D130023A07Rik, 3110054G10Rik, Tnrc6, 2010321I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233833
Homologene: 41399
Myh10
Name: myosin, heavy polypeptide 10, non-muscle
Synonyms: nonmuscle myosin heavy chain IIB, SMemb, NMHC-B, nonmuscle myosin heavy chain II-B, Myhn-2, 5730504C04Rik, myosin IIB, Fltn, Myhn2, Fltn, NMHC II-B, Myosin IIB, 9330167F11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77579
HGNC: HGNC:7568
Homologene: 55941
Cabin1
Name: calcineurin binding protein 1
Synonyms: A330070M20Rik, Cain, Ppp3in
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Iars1
Name: isoleucyl-tRNA synthetase 1
Synonyms: E430001P04Rik, Iars, 2510016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105148
HGNC: HGNC:5330
Homologene: 5325
Eif3l
Name: eukaryotic translation initiation factor 3, subunit L
Synonyms: PAF67, HSP-66Y, 0610011H21Rik, D15N1e, Eif3s6ip, Eif3eip
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223691
VEGA: 15
Homologene: 9380
Pdcd11
Name: programmed cell death 11
Synonyms: 1110021I22Rik, ALG-4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18572
VEGA: 19
Homologene: 74968
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skam26Jus, ska26, skax26, Cd
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Esr1
Name: estrogen receptor 1 (alpha)
Synonyms: Nr3a1, ESR, ER-alpha, ERalpha, Estr, ER[a], Estra, ERa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13982
HGNC: HGNC:3467
Homologene: 47906
Trhr
Name: thyrotropin releasing hormone receptor
Synonyms: TRH-R1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22045
VEGA: 15
Homologene: 20707
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665775
Homologene: 45109
Osbpl9
Name: oxysterol binding protein-like 9
Synonyms: 2600011I06Rik, ORP-9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100273
Homologene: 69380
Rrp9
Name: ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
Synonyms: Rnu3ip2, U3-55k, 55kDa, D9Wsu10e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 27966
Homologene: 3452
Adgrf3
Name: adhesion G protein-coupled receptor F3
Synonyms: PGR23, Gpr113, LOC381628
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381628
Homologene: 17826
Znrf2
Name: zinc and ring finger 2
Synonyms: D6Ertd365e, 1190002C14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387524
Homologene: 15668
Cog1
Name: component of oligomeric golgi complex 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16834
HGNC: HGNC:6545
Homologene: 8411
2900026A02Rik
Name: RIKEN cDNA 2900026A02 gene
Synonyms: LOC231620, Gm449
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243219
Homologene: 129566
Pfdn4
Name: prefoldin 4
Synonyms: C-1, 0610025M10Rik, C1, 1810063B06Rik, PFD4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 109054
HGNC: HGNC:8868
Homologene: 37645
Lbr
Name: lamin B receptor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98386
HGNC: HGNC:6518
Homologene: 2455
Bicra
Name: BRD4 interacting chromatin remodeling complex associated protein
Synonyms: Gltscr1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243842
HGNC: HGNC:4332
Homologene: 9250
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: 2010013B10Rik, A230048G03Rik, D330050P16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320473
VEGA: 17
Homologene: 25536
Ap3s1
Name: adaptor-related protein complex 3, sigma 1 subunit
Synonyms: [s]3A
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11777
VEGA: 18
HGNC: HGNC:2013
Homologene: 4254
Trpv5
Name: transient receptor potential cation channel, subfamily V, member 5
Synonyms: CaT2, ECaC1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194352
HGNC: HGNC:3145
Homologene: 10520
Hibadh
Name: 3-hydroxyisobutyrate dehydrogenase
Synonyms: 6430402H10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58875
HGNC: HGNC:4907
Homologene: 15088
Vav1
Name: vav 1 oncogene
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22324
Homologene: 3961
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Vmn2r100
Name: vomeronasal 2, receptor 100
Synonyms: EG627537
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627537
Homologene: 129750
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Lipe
Name: lipase, hormone sensitive
Synonyms: 4933403G17Rik, HSL
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16890
HGNC: HGNC:6621
Homologene: 3912
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381157
Homologene: 73393
Trgv4
Name: T cell receptor gamma, variable 4
Synonyms: Tcrg-V4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21638
Fcrla
Name: Fc receptor-like A
Synonyms: mFcrX, Fcrx, FREB, mFREB, FCRL1, Freb1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98752
Homologene: 13106
Zfp687
Name: zinc finger protein 687
Synonyms: 4931408L03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78266
Homologene: 10827
Atp8b4
Name: ATPase, class I, type 8B, member 4
Synonyms: Im
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241633
Homologene: 133162
Zfp938
Name: zinc finger protein 938
Synonyms: B230315N10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237411
Homologene: 135924
Or2c1
Name: olfactory receptor family 2 subfamily C member 1
Synonyms: Olfr15, MOR256-17, OR3, GA_x54KRFPKG5P-348087-349025
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 18312
HGNC: HGNC:8242
Homologene: 7459
Acnat1
Name: acyl-coenzyme A amino acid N-acyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230161
Homologene: 28287
Dnajb8
Name: DnaJ heat shock protein family (Hsp40) member B8
Synonyms: 1700016F14Rik, mDj6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56691
Homologene: 23184
Icam2
Name: intercellular adhesion molecule 2
Synonyms: Icam-2, CD102
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15896
HGNC: HGNC:5345
Homologene: 675
Hemgn
Name: hemogen
Synonyms: EDAG, 4921524M03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 93966
Homologene: 14223
Afg1l
Name: AFG1 like ATPase
Synonyms: Lace1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215951
Homologene: 5782
Cyb5rl
Name: cytochrome b5 reductase-like
Synonyms: 2810410C14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230582
Homologene: 45506
Glra1
Name: glycine receptor, alpha 1 subunit
Synonyms: B230397M16Rik, oscillator, nmf11, ot
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14654
HGNC: HGNC:4326
Homologene: 20083
Malrd1
Name: MAM and LDL receptor class A domain containing 1
Synonyms: Gm13364, Gm13318, Diet1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 102635496
Homologene: 136214
Eif1ad11
Name: eukaryotic translation initiation factor 1A domain containing 11
Synonyms: Gm2056
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100039129
VEGA: 12
Speer1m
Name: spermatogenesis associated glutamate (E)-rich protein 1M
Synonyms: 4933402N22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 545732
Homologene: 69402
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • GCCC to GC, chromosome 1 at 88,232,257 bp
  • A to G, chromosome 1 at 170,922,228 bp
  • A to G, chromosome 1 at 181,836,198 bp
  • A to G, chromosome 2 at 15,842,628 bp
  • T to C, chromosome 2 at 76,888,915 bp
  • G to A, chromosome 2 at 121,228,603 bp
  • A to G, chromosome 2 at 126,414,364 bp
  • C to A, chromosome 2 at 170,516,636 bp
  • T to C, chromosome 3 at 95,008,389 bp
  • C to A, chromosome 4 at 46,395,990 bp
  • A to G, chromosome 4 at 49,450,785 bp
  • T to C, chromosome 4 at 107,085,353 bp
  • T to C, chromosome 4 at 109,072,932 bp
  • A to T, chromosome 5 at 11,920,645 bp
  • T to A, chromosome 5 at 30,196,524 bp
  • T to C, chromosome 5 at 41,838,068 bp
  • T to C, chromosome 5 at 113,182,817 bp
  • G to T, chromosome 6 at 22,329,608 bp
  • A to T, chromosome 6 at 41,675,969 bp
  • G to A, chromosome 6 at 52,547,028 bp
  • A to G, chromosome 6 at 54,878,445 bp
  • A to G, chromosome 6 at 88,223,075 bp
  • T to C, chromosome 6 at 134,541,971 bp
  • G to A, chromosome 7 at 15,979,131 bp
  • G to A, chromosome 7 at 25,383,324 bp
  • A to G, chromosome 7 at 123,169,910 bp
  • T to C, chromosome 9 at 58,824,152 bp
  • C to T, chromosome 9 at 106,483,579 bp
  • T to C, chromosome 10 at 4,966,301 bp
  • T to C, chromosome 10 at 42,318,716 bp
  • T to C, chromosome 10 at 75,725,701 bp
  • C to A, chromosome 10 at 82,225,326 bp
  • A to G, chromosome 11 at 55,520,996 bp
  • C to T, chromosome 11 at 63,158,273 bp
  • A to G, chromosome 11 at 68,808,850 bp
  • G to A, chromosome 11 at 106,378,759 bp
  • C to A, chromosome 11 at 113,656,061 bp
  • T to C, chromosome 12 at 88,027,347 bp
  • T to A, chromosome 13 at 19,185,080 bp
  • T to C, chromosome 13 at 49,725,269 bp
  • A to G, chromosome 15 at 44,229,206 bp
  • C to A, chromosome 15 at 79,086,578 bp
  • A to G, chromosome 16 at 3,839,030 bp
  • A to T, chromosome 17 at 19,521,409 bp
  • A to C, chromosome 17 at 57,305,280 bp
  • A to T, chromosome 17 at 78,762,989 bp
  • A to G, chromosome 18 at 10,547,347 bp
  • C to T, chromosome 18 at 46,754,381 bp
  • T to A, chromosome 18 at 90,591,720 bp
  • A to G, chromosome 19 at 47,109,678 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6575 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044699-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.