Strain Name:
C57BL/6J-MtgxR6589Btlr/Mmmh
Stock Number:
044713-MU
Citation ID:
RRID:MMRRC_044713-MU
Other Names:
R6589 (G1)
Major Collection:

Strain Information

B3gnt2
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Synonyms: B3Galt6, B3gnt1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53625
Homologene: 4797
Cramp1
Name: cramped chromatin regulator 1
Synonyms: Cramp1l, Tce4, 5830477H08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57354
VEGA: 17
Homologene: 35373
Taf1b
Name: TATA-box binding protein associated factor, RNA polymerase I, B
Synonyms: p63, mTAFI68, 4930408G01Rik, A230108M10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 21340
VEGA: 12
Homologene: 31331
Mgat4a
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme A
Synonyms: GnT-IVa, 9530018I07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269181
HGNC: HGNC:7047
Homologene: 8153
Lpl
Name: lipoprotein lipase
Synonyms: O 1-4-5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16956
HGNC: HGNC:6677
Homologene: 200
Siva1
Name: SIVA1, apoptosis-inducing factor
Synonyms: CD27bp
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 30954
VEGA: 12
Homologene: 4692
Fam72a
Name: family with sequence similarity 72, member A
Synonyms: 2700049P18Rik, P17
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108900
Homologene: 82352
Myoc
Name: myocilin
Synonyms: GLC1A, TIGR
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17926
HGNC: HGNC:7610
Homologene: 220
Fshr
Name: follicle stimulating hormone receptor
Synonyms: FSH-R, Follitropin receptor, follicle-stimulating hormone receptor
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14309
VEGA: 17
HGNC: HGNC:3969
Homologene: 117
Cdh4
Name: cadherin 4
Synonyms: R-Cadh, Rcad, R-cadherin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12561
HGNC: HGNC:1763
Homologene: 48044
Vmn2r114
Name: vomeronasal 2, receptor 114
Synonyms: EG666002
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 666002
Homologene: 86604
Semp2l1
Name: SUMO/sentrin specific peptidase 2-like 1
Synonyms: Gm5415
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 408191
Homologene: 130042
Tcaf3
Name: TRPM8 channel-associated factor 3
Synonyms: Eapa2, Fam115e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 403088
Homologene: 74374
Fggy
Name: FGGY carbohydrate kinase domain containing
Synonyms: 2310009E04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75578
Homologene: 49535
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: 2610209L14Rik, Snf2l2, brm
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67155
Homologene: 2308
Fbxo43
Name: F-box protein 43
Synonyms: 4930533G20Rik, endogenous meiotic inhibitor 2, Emi2, XErp1 homolog, early mitotic inhibitor 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78803
VEGA: 15
Homologene: 66393
Hspa4l
Name: heat shock protein 4 like
Synonyms: APG-1, Osp94, 94kDa
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18415
Homologene: 22610
Hdac9
Name: histone deacetylase 9
Synonyms: HDRP, Hdac7b, D030072B18Rik, Mitr
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 79221
Homologene: 128578
Tafa2
Name: TAFA chemokine like family member 2
Synonyms: Tafa-2, Tafa2, Sam2, Fam19a2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268354
VEGA: 10
Homologene: 18678
Ankrd55
Name: ankyrin repeat domain 55
Synonyms: C030011J08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 77318
VEGA: 13
Homologene: 12674
Or14j5
Name: olfactory receptor family 14 subfamily J member 5
Synonyms: MOR218-1, Olfr126, GA_x6K02T2PSCP-2307164-2308123
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258892
Homologene: 134080
Asic2
Name: acid-sensing ion channel 2
Synonyms: BNC1, Mdeg, Accn1, BNaC1a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11418
HGNC: HGNC:99
Homologene: 137202
Vmn2r-ps158
Name: vomeronasal 2, receptor, pseudogene 158
Synonyms: Gm9268, Vmn2r126
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668612
Homologene: 104832
Fgf11
Name: fibroblast growth factor 11
Synonyms: Fhf3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14166
HGNC: HGNC:3667
Homologene: 3035
Trim3
Name: tripartite motif-containing 3
Synonyms: Rnf22, BERP1, HAC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 55992
Homologene: 21290
Zfp358
Name: zinc finger protein 358
Synonyms: Zfend
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 140482
Homologene: 9996
Klk1b16
Name: kallikrein 1-related peptidase b16
Synonyms: Klk16, mGk-16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16615
Homologene: 68141
Mup11
Name: major urinary protein 11
Synonyms: Gm12549
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100039028
Homologene: 74304
BC030500
Name: cDNA sequence BC030500
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234290
Gm6465
Name: predicted gene 6465
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 623998
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 32,546,711 bp
  • T to C, chromosome 1 at 37,444,895 bp
  • A to T, chromosome 1 at 131,533,816 bp
  • T to A, chromosome 1 at 162,648,619 bp
  • G to A, chromosome 2 at 179,881,996 bp
  • T to G, chromosome 3 at 40,757,055 bp
  • T to A, chromosome 4 at 60,659,541 bp
  • A to G, chromosome 4 at 95,597,638 bp
  • A to G, chromosome 5 at 11,848,161 bp
  • A to T, chromosome 6 at 42,594,061 bp
  • T to A, chromosome 7 at 43,023,598 bp
  • A to G, chromosome 7 at 44,141,470 bp
  • A to G, chromosome 7 at 105,617,960 bp
  • T to A, chromosome 8 at 3,495,907 bp
  • T to C, chromosome 8 at 58,912,922 bp
  • G to T, chromosome 8 at 68,896,807 bp
  • T to A, chromosome 10 at 123,704,392 bp
  • T to A, chromosome 11 at 22,837,117 bp
  • C to A, chromosome 11 at 69,799,435 bp
  • G to T, chromosome 11 at 80,886,604 bp
  • A to G, chromosome 12 at 24,556,528 bp
  • T to C, chromosome 12 at 34,215,029 bp
  • A to G, chromosome 12 at 112,646,838 bp
  • G to A, chromosome 13 at 112,348,863 bp
  • T to C, chromosome 15 at 36,162,540 bp
  • T to C, chromosome 17 at 23,291,668 bp
  • T to C, chromosome 17 at 24,977,492 bp
  • T to A, chromosome 17 at 37,850,836 bp
  • T to C, chromosome 17 at 88,988,607 bp
  • T to A, chromosome 19 at 26,619,884 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6589 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044713-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.