Strain Name:
C57BL/6J-MtgxR6599Btlr/Mmmh
Stock Number:
044723-MU
Citation ID:
RRID:MMRRC_044723-MU
Other Names:
R6599 (G1)
Major Collection:

Strain Information

Ptch1
Name: patched 1
Synonyms: Ptc, Patched 1, Ptc1, A230106A15Rik, wig
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Dnmbp
Name: dynamin binding protein
Synonyms: 2410003M15Rik, Tuba, 2410003L07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71972
Homologene: 9061
Unk
Name: unkempt family zinc finger
Synonyms: Zc3h5, B230379M23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217331
Homologene: 18194
Rps6ka5
Name: ribosomal protein S6 kinase, polypeptide 5
Synonyms: 6330404E13Rik, MSK1, 3110005L17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73086
VEGA: 12
Homologene: 48302
Ep300
Name: E1A binding protein p300
Synonyms: p300, KAT3B
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328572
HGNC: HGNC:3373
Homologene: 1094
Dhx40
Name: DEAH-box helicase 40
Synonyms: ARG147, DDX40, 2410016C14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67487
Homologene: 57000
Prokr2
Name: prokineticin receptor 2
Synonyms: PKR2, B830005M06Rik, EG-VEGRF2, Gpr73l1, Gpcr73l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 246313
Homologene: 16368
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: Mpr300, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, CD222, mannose-6-phosphate receptor, cation independent
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
H1f3
Name: H1.3 linker histone, cluster member
Synonyms: H1.3, H1D, H1s-4, H1f3, Hist1h1d
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14957
HGNC: HGNC:4717
Homologene: 68456
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Acbd5
Name: acyl-Coenzyme A binding domain containing 5
Synonyms: 1300014E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74159
Homologene: 12541
Ubxn7
Name: UBX domain protein 7
Synonyms: Ubxd7
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224111
VEGA: 16
Homologene: 45585
Zfp979
Name: zinc finger protein 979
Synonyms: Ssm1, 2610305D13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 112422
Homologene: 133076
Parm1
Name: prostate androgen-regulated mucin-like protein 1
Synonyms: 2210012L08Rik, 9130213B05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231440
Homologene: 41036
Trpc7
Name: transient receptor potential cation channel, subfamily C, member 7
Synonyms: TRP7, Trrp8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26946
Homologene: 22689
Tcaim
Name: T cell activation inhibitor, mitochondrial
Synonyms: LOC382117, D9Ertd402e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382117
Homologene: 45481
Cubn
Name: cubilin
Synonyms: D2Wsu88e, intrinsic factor-cobalamin receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Trappc14
Name: trafficking protein particle complex 14
Synonyms: Map11, BC037034
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231807
Homologene: 10106
4930579F01Rik
Name: RIKEN cDNA 4930579F01 gene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67741
Homologene: 12962
Fcsk
Name: fucose kinase
Synonyms: L-fucose kinase, 1110046B12Rik, Fuk
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234730
Homologene: 15452
Nqo2
Name: N-ribosyldihydronicotinamide quinone reductase 2
Synonyms: NRH: quinone oxidoreductase, Ox-2, Ox2, Nmor2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18105
VEGA: 13
HGNC: HGNC:7856
Homologene: 696
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: V2Rp4, EG638102
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 638102
Homologene: 86604
Vmn2r10
Name: vomeronasal 2, receptor 10
Synonyms: VR16, V2r16
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22307
Homologene: 129606
Exoc3
Name: exocyst complex component 3
Synonyms: E430013E20Rik, Sec6l1, 2810050O03Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 211446
VEGA: 13
Homologene: 38296
Or7e175
Name: olfactory receptor family 7 subfamily E member 175
Synonyms: GA_x6K02T2PVTD-13878275-13879204, MOR145-6, Olfr869
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258550
HGNC: HGNC:8396
Homologene: 138312
Or1e29
Name: olfactory receptor family 1 subfamily E member 29
Synonyms: GA_x6K02T2P1NL-3932085-3931147, MOR135-6, Olfr389
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259011
Homologene: 85925
Yipf2
Name: Yip1 domain family, member 2
Synonyms: 1300010K09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74766
VEGA: 9
Homologene: 23430
Mthfs
Name: 5, 10-methenyltetrahydrofolate synthetase
Synonyms: 1110034I12Rik, 2310020H23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107885
Homologene: 4702
Ccdc7b
Name: coiled-coil domain containing 7B
Synonyms: 1700008F21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75453
Homologene: 49919
Megf6
Name: multiple EGF-like-domains 6
Synonyms: 2600001P17Rik, Egfl3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Vmn1r87
Name: vomeronasal 1 receptor 87
Synonyms: V1rk1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171261
Homologene: 134023
Adcyap1r1
Name: adenylate cyclase activating polypeptide 1 receptor 1
Synonyms: PACAP1-R, PAC1, PAC1R, 2900024I10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11517
HGNC: HGNC:242
Homologene: 870
Nnmt
Name: nicotinamide N-methyltransferase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18113
HGNC: HGNC:7861
Homologene: 4496
Vmn1r226
Name: vomeronasal 1 receptor 226
Synonyms: V1re2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171225
Homologene: 74362
Hif3a
Name: hypoxia inducible factor 3, alpha subunit
Synonyms: MOP7, bHLHe17, Nepas
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53417
Homologene: 9646
Akr1c6
Name: aldo-keto reductase family 1, member C6
Synonyms: estradiol 17-beta-dehydrogenase (A-specific), 3alpha-HSD, Akr1c1, Hsd17b5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 83702
Homologene: 84695
Gm6401
Name: predicted gene 6401
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 115486427
Gm8267
Name: predicted gene 8267
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 666744
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 13,310,673 bp
  • C to T, chromosome 2 at 23,069,080 bp
  • T to C, chromosome 2 at 69,469,405 bp
  • C to T, chromosome 2 at 132,373,549 bp
  • T to C, chromosome 3 at 138,176,489 bp
  • A to T, chromosome 4 at 147,613,626 bp
  • A to G, chromosome 4 at 154,258,087 bp
  • T to C, chromosome 5 at 91,593,859 bp
  • T to A, chromosome 5 at 108,996,078 bp
  • G to T, chromosome 5 at 138,263,458 bp
  • G to A, chromosome 6 at 55,479,994 bp
  • T to A, chromosome 7 at 13,131,959 bp
  • T to A, chromosome 7 at 17,042,605 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • A to T, chromosome 8 at 110,893,283 bp
  • T to A, chromosome 8 at 129,166,981 bp
  • T to C, chromosome 9 at 20,137,943 bp
  • T to C, chromosome 9 at 21,589,848 bp
  • T to C, chromosome 9 at 48,603,369 bp
  • G to A, chromosome 9 at 89,239,908 bp
  • C to T, chromosome 9 at 122,834,779 bp
  • T to A, chromosome 11 at 73,776,680 bp
  • T to A, chromosome 11 at 86,804,349 bp
  • G to A, chromosome 11 at 116,047,802 bp
  • C to A, chromosome 12 at 100,597,909 bp
  • T to G, chromosome 13 at 4,449,319 bp
  • T to C, chromosome 13 at 23,555,277 bp
  • T to C, chromosome 13 at 33,979,556 bp
  • T to C, chromosome 13 at 56,810,380 bp
  • T to A, chromosome 13 at 63,523,104 bp
  • T to C, chromosome 13 at 74,189,158 bp
  • C to A, chromosome 14 at 41,966,864 bp
  • G to T, chromosome 14 at 44,717,910 bp
  • G to C, chromosome 15 at 81,586,713 bp
  • A to G, chromosome 16 at 32,384,925 bp
  • T to C, chromosome 17 at 12,698,618 bp
  • A to T, chromosome 17 at 20,688,289 bp
  • A to G, chromosome 17 at 23,346,032 bp
  • A to T, chromosome 19 at 43,856,586 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6599 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044723-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.