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Strain Name:
C57BL/6J-MtgxR6601Btlr/Mmmh
Stock Number:
044725-MU
Citation ID:
RRID:MMRRC_044725-MU
Other Names:
R6601 (G1)
Major Collection:

Strain Information

Dtnbp1
Name: dystrobrevin binding protein 1
Synonyms: dysbindin, 5430437B18Rik, sdy, Bloc1s8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94245
VEGA: 13
Homologene: 12037
Elp3
Name: elongator acetyltransferase complex subunit 3
Synonyms: 2610507P14Rik, KAT9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74195
VEGA: 14
Homologene: 7105
Csnk1a1
Name: casein kinase 1, alpha 1
Synonyms: 4632404G05Rik, 2610208K14Rik, 5430427P18Rik, CK1a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93687
HGNC: HGNC:2451
Homologene: 111694
Rpl7a
Name: ribosomal protein L7A
Synonyms: surfeit 3, Surf-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27176
Homologene: 105462
Ubr7
Name: ubiquitin protein ligase E3 component n-recognin 7 (putative)
Synonyms: 5730410I19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66622
VEGA: 12
Homologene: 11998
Golga1
Name: golgin A1
Synonyms: golgin-97, 0710001G09Rik, 2210418B03Rik, Golgi97, awag
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76899
HGNC: HGNC:4424
Homologene: 68223
Polr1d
Name: polymerase (RNA) I polypeptide D
Synonyms: mRPA16, 16kDa, 1110003G10Rik, Rpo1-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20018
Homologene: 22239
Muc16
Name: mucin 16
Synonyms: LOC385009, 1110008I14Rik, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Synonyms: 2410026C18Rik, eIF2alpha, Eif2a, 0910001O23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13665
HGNC: HGNC:3265
Homologene: 3020
Wwtr1
Name: WW domain containing transcription regulator 1
Synonyms: 2610021I22Rik, TAZ, 2310058J06Rik, transcriptional coactivator with PDZ binding motif
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 97064
Homologene: 9159
Ttn
Name: titin
Synonyms: connectin, L56, 1100001C23Rik, mdm, 2310036G12Rik, D830007G01Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC6, SPC6, PC5A, PC5/6A, b2b585Clo, b2b1549Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Hc
Name: hemolytic complement
Synonyms: C5a, C5, He, Hfib2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4A, Naip-rs4, Birc1f
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Ly75
Name: lymphocyte antigen 75
Synonyms: DEC-205, CD205
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17076
Homologene: 31085
Aox1
Name: aldehyde oxidase 1
Synonyms: retinal oxidase, Aox-2, Aox-1, Aox2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
L3mbtl1
Name: L3MBTL1 histone methyl-lysine binding protein
Synonyms: L3MBTL1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241764
Homologene: 41846
Ccnb1ip1
Name: cyclin B1 interacting protein 1
Synonyms: LOC239083, Hei10, mei4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239083
VEGA: 14
Homologene: 18819
Lipg
Name: lipase, endothelial
Synonyms: mEDL, 3110013K01Rik, endothelial lipase, EL
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16891
VEGA: 18
HGNC: HGNC:6623
Homologene: 21218
Mat1a
Name: methionine adenosyltransferase 1A
Synonyms: AdoMet, SAMS, MAT, SAMS1, MATA1, Ams
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11720
VEGA: 14
HGNC: HGNC:6903
Homologene: 68057
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Zfp108
Name: zinc finger protein 108
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54678
Homologene: 117959
Hcls1
Name: hematopoietic cell specific Lyn substrate 1
Synonyms: HS1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15163
HGNC: HGNC:4844
Homologene: 38034
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76645
Homologene: 124481
Rab26
Name: RAB26, member RAS oncogene family
Synonyms: A830020M03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328778
Homologene: 25655
Ddx28
Name: DEAD box helicase 28
Synonyms: Mddx28, 2410004K13Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71986
Homologene: 10164
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: brm, Snf2l2, 2610209L14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67155
Homologene: 2308
Ovgp1
Name: oviductal glycoprotein 1
Synonyms: MOGP, muc9, mucin 9, oviductin, Chit5, OGP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12659
HGNC: HGNC:8524
Homologene: 74442
Nphp4
Name: nephronophthisis 4 (juvenile) homolog (human)
Synonyms: 4930564O18Rik, nmf192
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 260305
Homologene: 9024
Rasgef1c
Name: RasGEF domain family, member 1C
Synonyms: 9130006A14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74563
Homologene: 17918
Ces1b
Name: carboxylesterase 1B
Synonyms: Gm5158
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382044
HGNC: HGNC:1863
Homologene: 117484
Or8u8
Name: olfactory receptor family 8 subfamily U member 8
Synonyms: IE6, GA_x6K02T2Q125-47650922-47649963, MOR185-6, Olfr52
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18352
Homologene: 105200
Ndufaf3
Name: NADH:ubiquinone oxidoreductase complex assembly factor 3
Synonyms: 4733401H18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66706
Homologene: 32460
Klhl3
Name: kelch-like 3
Synonyms: 7530408C15Rik, EG627648
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100503085
HGNC: HGNC:6354
Homologene: 79542
Tmem198
Name: transmembrane protein 198
Synonyms: Tmem198-1, Tmem198a, A230078I05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319998
Homologene: 44245
Ccdc172
Name: coiled-coil domain containing 172
Synonyms: 1700011F14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 75645
VEGA: 19
Homologene: 36871
Styxl1
Name: serine/threonine/tyrosine interacting-like 1
Synonyms: 1700011C14Rik, Dusp24
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76571
Homologene: 9378
Taar9
Name: trace amine-associated receptor 9
Synonyms: Tar3, Ta3, Trar3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 503558
Homologene: 65286
Otop3
Name: otopetrin 3
Synonyms: 2310011E08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69602
Homologene: 26091
Coro2a
Name: coronin, actin binding protein 2A
Synonyms: coronin 4, IR10, 9030208C03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107684
HGNC: HGNC:2255
Homologene: 2546
Zfp612
Name: zinc finger protein 612
Synonyms: B230354B21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234725
Homologene: 27083
Zscan4-ps1
Name: zinc finger and SCAN domain containing 4, pseudogene 1
Synonyms: EG545912
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545912
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 58,063,506 bp
  • T to A, chromosome 1 at 75,480,373 bp
  • T to C, chromosome 2 at 26,911,524 bp
  • T to C, chromosome 2 at 31,920,532 bp
  • T to A, chromosome 2 at 35,045,894 bp
  • T to C, chromosome 2 at 39,020,106 bp
  • G to A, chromosome 2 at 60,318,376 bp
  • T to A, chromosome 2 at 76,764,729 bp
  • T to A, chromosome 2 at 86,181,965 bp
  • C to T, chromosome 2 at 162,948,175 bp
  • T to C, chromosome 3 at 57,575,738 bp
  • T to C, chromosome 3 at 105,986,431 bp
  • A to T, chromosome 4 at 46,543,421 bp
  • A to T, chromosome 4 at 152,503,007 bp
  • C to G, chromosome 5 at 135,755,496 bp
  • T to A, chromosome 5 at 147,078,549 bp
  • T to A, chromosome 6 at 3,377,229 bp
  • T to C, chromosome 7 at 11,068,834 bp
  • T to C, chromosome 7 at 24,261,394 bp
  • T to C, chromosome 7 at 83,722,469 bp
  • T to C, chromosome 8 at 93,079,481 bp
  • A to T, chromosome 8 at 106,010,616 bp
  • C to A, chromosome 8 at 110,089,549 bp
  • T to C, chromosome 8 at 117,040,666 bp
  • A to T, chromosome 9 at 18,637,570 bp
  • T to C, chromosome 9 at 108,566,217 bp
  • T to C, chromosome 10 at 24,109,047 bp
  • T to A, chromosome 11 at 49,971,419 bp
  • T to C, chromosome 11 at 115,339,847 bp
  • T to C, chromosome 12 at 78,883,352 bp
  • T to A, chromosome 12 at 102,761,464 bp
  • A to G, chromosome 13 at 44,931,245 bp
  • C to A, chromosome 13 at 58,095,116 bp
  • G to A, chromosome 13 at 100,283,758 bp
  • T to A, chromosome 14 at 41,105,604 bp
  • G to T, chromosome 14 at 50,793,664 bp
  • T to C, chromosome 14 at 65,547,039 bp
  • G to A, chromosome 16 at 36,962,386 bp
  • T to A, chromosome 17 at 24,529,621 bp
  • T to C, chromosome 18 at 61,578,758 bp
  • T to C, chromosome 18 at 74,948,204 bp
  • T to G, chromosome 19 at 17,511,380 bp
  • C to A, chromosome 19 at 26,654,377 bp
  • T to A, chromosome 19 at 58,537,291 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6601 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044725-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.