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Strain Name:
C57BL/6J-MtgxR6603Btlr/Mmmh
Stock Number:
044726-MU
Citation ID:
RRID:MMRRC_044726-MU
Other Names:
R6603 (G1)
Major Collection:

Strain Information

Xrcc1
Name: X-ray repair complementing defective repair in Chinese hamster cells 1
Synonyms: Xrcc-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22594
Homologene: 31368
Col18a1
Name: collagen, type XVIII, alpha 1
Synonyms: endostatin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12822
HGNC: HGNC:2195
Homologene: 7673
Tmem59l
Name: transmembrane protein 59-like
Synonyms: 5330410G16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67937
Homologene: 8104
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208440
Homologene: 40996
Scrib
Name: scribbled planar cell polarity
Synonyms: Scrb1, Crc
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105782
Homologene: 44228
Prpf40a
Name: pre-mRNA processing factor 40A
Synonyms: FBP11, 2810012K09Rik, Fnbp3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56194
Homologene: 6377
Caprin1
Name: cell cycle associated protein 1
Synonyms: MMGPIP137, Gpiap1, caprin-1, RNG105
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53872
HGNC: HGNC:6743
Homologene: 4310
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 34,836,741 bp
  • A to G, chromosome 1 at 40,623,504 bp
  • T to A, chromosome 1 at 60,082,624 bp
  • T to G, chromosome 2 at 53,152,963 bp
  • A to G, chromosome 2 at 67,516,544 bp
  • A to T, chromosome 2 at 103,775,511 bp
  • A to G, chromosome 2 at 106,866,977 bp
  • G to A, chromosome 2 at 150,003,288 bp
  • A to T, chromosome 2 at 154,554,922 bp
  • C to T, chromosome 3 at 32,585,146 bp
  • T to C, chromosome 3 at 69,022,461 bp
  • A to T, chromosome 3 at 95,895,496 bp
  • C to T, chromosome 3 at 103,993,873 bp
  • T to A, chromosome 4 at 126,792,253 bp
  • A to G, chromosome 4 at 139,455,586 bp
  • T to C, chromosome 4 at 141,683,870 bp
  • A to T, chromosome 4 at 145,292,598 bp
  • T to G, chromosome 4 at 147,865,923 bp
  • T to A, chromosome 4 at 154,839,305 bp
  • C to A, chromosome 5 at 114,730,991 bp
  • T to C, chromosome 6 at 58,987,189 bp
  • A to T, chromosome 6 at 127,729,413 bp
  • A to T, chromosome 6 at 132,893,458 bp
  • A to G, chromosome 6 at 146,347,171 bp
  • G to A, chromosome 7 at 4,758,432 bp
  • T to C, chromosome 7 at 6,325,476 bp
  • T to A, chromosome 7 at 8,138,360 bp
  • C to T, chromosome 7 at 24,571,034 bp
  • A to T, chromosome 7 at 102,900,414 bp
  • A to T, chromosome 7 at 131,046,510 bp
  • A to T, chromosome 8 at 24,665,502 bp
  • T to A, chromosome 8 at 36,222,941 bp
  • G to A, chromosome 8 at 70,486,356 bp
  • A to T, chromosome 8 at 105,268,210 bp
  • A to C, chromosome 9 at 60,593,769 bp
  • A to G, chromosome 9 at 89,910,257 bp
  • G to A, chromosome 9 at 94,939,546 bp
  • A to G, chromosome 10 at 77,063,977 bp
  • A to G, chromosome 10 at 80,714,047 bp
  • C to T, chromosome 11 at 70,609,593 bp
  • A to G, chromosome 11 at 101,556,105 bp
  • A to G, chromosome 12 at 114,764,521 bp
  • T to A, chromosome 13 at 9,654,588 bp
  • T to C, chromosome 13 at 64,922,665 bp
  • T to G, chromosome 13 at 96,082,262 bp
  • G to A, chromosome 13 at 100,423,070 bp
  • C to T, chromosome 13 at 100,423,158 bp
  • A to G, chromosome 14 at 27,446,386 bp
  • A to G, chromosome 14 at 45,151,767 bp
  • T to A, chromosome 14 at 63,948,188 bp
  • T to C, chromosome 14 at 106,107,049 bp
  • T to A, chromosome 15 at 56,668,572 bp
  • T to A, chromosome 15 at 76,062,723 bp
  • A to G, chromosome 16 at 36,029,520 bp
  • A to G, chromosome 17 at 50,607,117 bp
  • T to C, chromosome 18 at 40,258,491 bp
  • T to A, chromosome 18 at 69,985,304 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6603 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044726-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.