Strain Name:
C57BL/6J-MtgxR6604Btlr/Mmmh
Stock Number:
044727-MU
Citation ID:
RRID:MMRRC_044727-MU
Other Names:
R6604 (G1)
Major Collection:

Strain Information

Slc12a1
Name: solute carrier family 12, member 1
Synonyms: urehr3, Nkcc2, mBSC1, D630042G03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20495
Homologene: 286
Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Adcy9
Name: adenylate cyclase 9
Synonyms: D16Wsu65e, ACtp10
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11515
HGNC: HGNC:240
Homologene: 868
Shc1
Name: src homology 2 domain-containing transforming protein C1
Synonyms: p66, p66shc, ShcA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20416
Homologene: 7934
Lmna
Name: lamin A
Synonyms: Dhe, lamin A/C
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16905
HGNC: HGNC:6636
Homologene: 41321
Gpbp1l1
Name: GC-rich promoter binding protein 1-like 1
Synonyms: 5330440M15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77110
Homologene: 84840
Pgr
Name: progesterone receptor
Synonyms: PR-A, 9930019P03Rik, ENSMUSG00000074510, NR3C3, PR, PR-B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18667
HGNC: HGNC:8910
Homologene: 713
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230895
Homologene: 15583
Lrrtm1
Name: leucine rich repeat transmembrane neuronal 1
Synonyms: 4632401D06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74342
Homologene: 41763
Golm1
Name: golgi membrane protein 1
Synonyms: Golph2, GP73, PSEC0257, D030064E01Rik, 2310001L02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105348
VEGA: 13
Homologene: 12346
Zfp958
Name: zinc finger protein 958
Synonyms: BC003267
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 233987
Homologene: 129582
Dna2
Name: DNA replication helicase/nuclease 2
Synonyms: E130315B21Rik, Dna2l
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327762
HGNC: HGNC:2939
Homologene: 6124
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230676
Homologene: 49413
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Rasgrp3
Name: RAS, guanyl releasing protein 3
Synonyms: LOC240168
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240168
VEGA: 17
Homologene: 15019
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: mXin beta, myomaxin, 2310003D02Rik, Cmya3, 2310008C07Rik, A530024P18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: Rp1h, mG145, oxygen-regulated protein 1, Dcdc3, Orp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19888
Homologene: 4564
Kcnj6
Name: potassium inwardly-rectifying channel, subfamily J, member 6
Synonyms: Kir3.2, KCNJ7, GIRK2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16522
VEGA: 16
HGNC: HGNC:6267
Homologene: 1688
Hpd
Name: 4-hydroxyphenylpyruvic acid dioxygenase
Synonyms: Laf, Fla, Flp, Hppd
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15445
HGNC: HGNC:5147
Homologene: 1620
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Bbs10
Name: Bardet-Biedl syndrome 10
Synonyms: 1300007O09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71769
VEGA: 10
Homologene: 49781
Grk4
Name: G protein-coupled receptor kinase 4
Synonyms: Gprk2l, A830025H08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14772
HGNC: HGNC:4543
Homologene: 23158
Haus1
Name: HAUS augmin-like complex, subunit 1
Synonyms: spindle associated, Ccdc5, HEI-C
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225745
VEGA: 18
Homologene: 15516
Tmem236
Name: transmembrane protein 236
Synonyms: 2010003H20Rik, Fam23a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 625286
Homologene: 46598
Aurkb
Name: aurora kinase B
Synonyms: aurora B, Stk5, Aik2, STK-1, IPL1, Stk12, AIRK2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20877
Homologene: 55807
Tmem163
Name: transmembrane protein 163
Synonyms: 2610024A01Rik, SV31
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72160
Homologene: 12798
Sncaip
Name: synuclein, alpha interacting protein (synphilin)
Synonyms: SYPH1, synphilin-1, 4933427B05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67847
Homologene: 3987
Ppig
Name: peptidyl-prolyl isomerase G (cyclophilin G)
Synonyms: SRCyp, B230312B02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228005
Homologene: 3520
4930447A16Rik
Name: RIKEN cDNA 4930447A16 gene
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74892
Socs5
Name: suppressor of cytokine signaling 5
Synonyms: 1810018L08Rik, Cish5, SOCS-5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56468
VEGA: 17
Homologene: 10495
Vmn2r29
Name: vomeronasal 2, receptor 29
Synonyms: 6430701C03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76229
Homologene: 113703
Gm5129
Name: predicted gene 5129
Synonyms: ENSMUSG00000053121
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 332993
VEGA: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 4,019,128 bp
  • A to G, chromosome 1 at 127,491,610 bp
  • A to G, chromosome 2 at 14,174,701 bp
  • T to C, chromosome 2 at 67,509,845 bp
  • T to C, chromosome 2 at 69,741,581 bp
  • G to T, chromosome 2 at 125,184,815 bp
  • A to G, chromosome 3 at 88,488,282 bp
  • A to G, chromosome 3 at 89,421,879 bp
  • C to T, chromosome 4 at 116,573,505 bp
  • T to C, chromosome 4 at 118,385,474 bp
  • T to C, chromosome 4 at 143,965,997 bp
  • A to G, chromosome 4 at 145,181,124 bp
  • A to G, chromosome 5 at 29,735,767 bp
  • A to T, chromosome 5 at 34,719,864 bp
  • T to C, chromosome 5 at 123,180,901 bp
  • T to C, chromosome 6 at 77,244,238 bp
  • A to T, chromosome 7 at 7,231,859 bp
  • T to C, chromosome 8 at 4,628,245 bp
  • A to C, chromosome 9 at 8,946,866 bp
  • G to T, chromosome 10 at 62,967,743 bp
  • T to C, chromosome 10 at 107,822,034 bp
  • T to G, chromosome 10 at 111,301,104 bp
  • T to G, chromosome 11 at 9,378,384 bp
  • T to A, chromosome 11 at 69,048,562 bp
  • T to A, chromosome 11 at 104,698,946 bp
  • A to G, chromosome 13 at 59,638,383 bp
  • A to G, chromosome 15 at 37,439,579 bp
  • A to G, chromosome 15 at 53,083,159 bp
  • A to G, chromosome 16 at 4,304,407 bp
  • C to A, chromosome 16 at 94,762,645 bp
  • A to C, chromosome 17 at 75,503,115 bp
  • T to C, chromosome 17 at 87,135,125 bp
  • A to G, chromosome 18 at 52,905,846 bp
  • T to C, chromosome 18 at 77,764,097 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6604 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044727-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.