Strain Name:
C57BL/6J-MtgxR6607Btlr/Mmmh
Stock Number:
044730-MU
Citation ID:
RRID:MMRRC_044730-MU
Other Names:
R6607 (G1)
Major Collection:

Strain Information

Foxq1
Name: forkhead box Q1
Synonyms: Hfh1, Hfh1l, sa, HFH-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15220
Homologene: 7359
Ep400
Name: E1A binding protein p400
Synonyms: mDomino, p400, 1700020J09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75560
Homologene: 38779
Slc29a1
Name: solute carrier family 29 (nucleoside transporters), member 1
Synonyms: 1200014D21Rik, NBMPR-sensitive equilibrative nucleoside transporter, ENT1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 63959
Homologene: 37985
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: Gcn1l1, GCN1L, G431004K08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Esyt2
Name: extended synaptotagmin-like protein 2
Synonyms: Fam62b, D12Ertd551e, 2310058N22Rik, 2410017M09Rik, 4921504I16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 52635
VEGA: 12
Homologene: 32699
Fbxo15
Name: F-box protein 15
Synonyms: ecat3, Fbx15
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 50764
VEGA: 18
Homologene: 17644
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, XAP8, Hbxap, C030033M12Rik, p325
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, tbl, 2810449H11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: Ten-m2, 9330187F13Rik, 2610040L17Rik, D3Bwg1534e, Odz2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23964
Homologene: 22672
Rnd2
Name: Rho family GTPase 2
Synonyms: Arhn, Rohn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11858
Homologene: 21123
Gclm
Name: glutamate-cysteine ligase, modifier subunit
Synonyms: Glclr, Gcmc
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14630
HGNC: HGNC:4312
Homologene: 1557
Cacna1a
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Synonyms: Cacnl1a4, SCA6, Ccha1a, nmf352, smrl, alpha1A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12286
HGNC: HGNC:1388
Homologene: 56383
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b3491Clo, Mdnah5, b2b1537Clo, b2b1134Clo, Dnahc5, b2b1154Clo, b2b1565Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, b2b1554Clo, A2mr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Tmem26
Name: transmembrane protein 26
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327766
VEGA: 10
Homologene: 14428
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Crsh, Scy, crash, Adgrc1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
A4galt
Name: alpha 1,4-galactosyltransferase
Synonyms: Gb3 synthase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239559
VEGA: 15
Homologene: 9690
Adtrp
Name: androgen dependent TFPI regulating protein
Synonyms: 9530008L14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109254
Homologene: 13107
Vmn2r84
Name: vomeronasal 2, receptor 84
Synonyms: EG625068
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625068
Homologene: 129606
Cdh4
Name: cadherin 4
Synonyms: R-cadherin, R-Cadh, Rcad
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12561
HGNC: HGNC:1763
Homologene: 48044
Ctbs
Name: chitobiase
Synonyms: 2210401K11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74245
HGNC: HGNC:2496
Homologene: 3231
Agbl2
Name: ATP/GTP binding protein-like 2
Synonyms: Ccp2, A430081C19Rik, Ccp2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271813
Homologene: 11715
Dut
Name: deoxyuridine triphosphatase
Synonyms: D2Bwg0749e, Dutp, 5133400F09Rik, 5031412I06Rik, dUTPase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110074
HGNC: HGNC:3078
Homologene: 31475
Rbks
Name: ribokinase
Synonyms: 5230400M11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71336
Homologene: 5482
Vmn2r101
Name: vomeronasal 2, receptor 101
Synonyms: EG627576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627576
Homologene: 115024
Ace
Name: angiotensin I converting enzyme
Synonyms: CD143
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11421
HGNC: HGNC:2707
Homologene: 37351
Vmn1r203
Name: vomeronasal 1 receptor 203
Synonyms: V1rh11
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171270
Homologene: 110880
Hamp2
Name: hepcidin antimicrobial peptide 2
Synonyms: HEPC2, 1810073K19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66438
Homologene: 10911
Vmn1r223
Name: vomeronasal 1 receptor 223
Synonyms: Gm11330
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100036518
Homologene: 110880
Slc17a4
Name: solute carrier family 17 (sodium phosphate), member 4
Synonyms: 9130214H05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319848
Homologene: 21127
Fam174b
Name: family with sequence similarity 174, member B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100038347
Homologene: 121932
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 2 at 90,801,326 bp
  • A to G, chromosome 2 at 125,256,867 bp
  • G to A, chromosome 2 at 179,874,096 bp
  • G to A, chromosome 3 at 122,255,615 bp
  • A to G, chromosome 3 at 146,457,373 bp
  • C to T, chromosome 5 at 31,647,792 bp
  • T to C, chromosome 5 at 110,683,314 bp
  • T to A, chromosome 5 at 115,609,478 bp
  • T to A, chromosome 7 at 30,922,588 bp
  • T to C, chromosome 7 at 73,766,564 bp
  • CG to CGACGGCGGTG, chromosome 7 at 97,579,908 bp
  • A to T, chromosome 8 at 84,579,492 bp
  • C to T, chromosome 9 at 66,418,567 bp
  • T to A, chromosome 10 at 68,778,713 bp
  • G to A, chromosome 10 at 127,560,136 bp
  • T to C, chromosome 10 at 130,390,862 bp
  • A to G, chromosome 11 at 36,063,775 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • A to T, chromosome 11 at 105,972,377 bp
  • G to A, chromosome 12 at 116,368,740 bp
  • A to G, chromosome 13 at 22,524,721 bp
  • T to C, chromosome 13 at 23,249,749 bp
  • T to C, chromosome 13 at 23,905,414 bp
  • A to G, chromosome 13 at 31,559,146 bp
  • A to G, chromosome 13 at 41,777,611 bp
  • A to G, chromosome 15 at 28,445,200 bp
  • T to C, chromosome 15 at 83,228,306 bp
  • A to G, chromosome 15 at 85,963,285 bp
  • T to C, chromosome 17 at 19,612,034 bp
  • A to C, chromosome 17 at 45,588,927 bp
  • A to T, chromosome 18 at 84,959,145 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6607 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044730-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.