Strain Name:
C57BL/6J-MtgxR6628Btlr/Mmmh
Stock Number:
044750-MU
Citation ID:
RRID:MMRRC_044750-MU
Other Names:
R6628 (G1)
Major Collection:

Strain Information

Gulo
Name: gulonolactone (L-) oxidase
Synonyms: sfx, L-gulono-gamma-lactone oxidase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268756
VEGA: 14
HGNC: HGNC:4695
Homologene: 6566
Cd4
Name: CD4 antigen
Synonyms: Ly-4, L3T4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12504
HGNC: HGNC:1678
Homologene: 513
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: HALR, E330008K23Rik, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Senp6
Name: SUMO/sentrin specific peptidase 6
Synonyms: 2810017C20Rik, E130319N12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215351
Homologene: 9196
Wwp1
Name: WW domain containing E3 ubiquitin protein ligase 1
Synonyms: Tiul1, 8030445B08Rik, AIP5, SDRP1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107568
Homologene: 21385
Gtf3c1
Name: general transcription factor III C 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233863
HGNC: HGNC:4664
Homologene: 31040
Clasp2
Name: CLIP associating protein 2
Synonyms: 8030404L10Rik, CLASP2gamma, CLASP2beta, CLASP2, 1500004F14Rik, CLASP2alpha
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76499
VEGA: 9
Homologene: 24944
Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
Synonyms: 2700084A17Rik, Syp, SHP-2, SH-PTP2, PTP1D, PTP2C, Shp2, SH2 domain-containing protein tyrosine phosphatase-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19247
HGNC: HGNC:9644
Homologene: 2122
Lmtk2
Name: lemur tyrosine kinase 2
Synonyms: KPI-2, KPI2, A330101P12Rik, 2900041G10Rik, BREK, AATYK2, cprk
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231876
Homologene: 8948
Tbc1d5
Name: TBC1 domain family, member 5
Synonyms: 1600014N05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72238
VEGA: 17
Homologene: 8834
Wrap53
Name: WD repeat containing, antisense to Trp53
Synonyms: Wdr79
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216853
Homologene: 9995
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, rul, 2300002E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Pdcd10
Name: programmed cell death 10
Synonyms: TF-1 cell apoptosis related protein-15, Tfa15, 2410003B13Rik, CCM3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56426
HGNC: HGNC:8761
Homologene: 10505
Clmn
Name: calmin
Synonyms: 9330188N17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 94040
VEGA: 12
Homologene: 11683
Mphosph9
Name: M-phase phosphoprotein 9
Synonyms: 9630025B04Rik, MPP9, 4930548D04Rik, B930097C17Rik, MPP-9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269702
HGNC: HGNC:7215
Homologene: 11256
Fam168b
Name: family with sequence similarity 168, member B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214469
Homologene: 18390
Myo16
Name: myosin XVI
Synonyms: BM140241, Nyap3, C230040D10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244281
Homologene: 34710
Kif27
Name: kinesin family member 27
Synonyms: 4930517I18Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75050
VEGA: 13
Homologene: 69235
Kdm5d
Name: lysine demethylase 5D
Synonyms: Jarid1d, Smcy, HY
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 20592
Homologene: 55838
Pxdn
Name: peroxidasin
Synonyms: VPO1, 2310075M15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69675
Homologene: 33907
Chrm2
Name: cholinergic receptor, muscarinic 2, cardiac
Synonyms: Chrm-2, M2, AChR M2, muscarinic acetylcholine receptor 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243764
HGNC: HGNC:1951
Homologene: 20190
Adamts1
Name: ADAM metallopeptidase with thrombospondin type 1 motif 1
Synonyms: METH-1, ADAM-TS1, METH1, ADAMTS-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11504
HGNC: HGNC:217
Homologene: 21381
Tbx18
Name: T-box18
Synonyms: 2810012F10Rik, 2810404D13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76365
Homologene: 11384
Cyp2s1
Name: cytochrome P450, family 2, subfamily s, polypeptide 1
Synonyms: 1200011C15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74134
Homologene: 75274
Or8j3c
Name: olfactory receptor family 8 subfamily J member 3C
Synonyms: Olfr1062, GA_x6K02T2Q125-47892992-47892045, MOR185-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259082
Homologene: 83135
Or5h26
Name: olfactory receptor family 5 subfamily H member 26
Synonyms: MOR183-1, GA_x54KRFPKG5P-55389051-55388122, Olfr196
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258775
Homologene: 74113
Gm7030
Name: predicted gene 7030
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 630294
Homologene: 133121
Dagla
Name: diacylglycerol lipase, alpha
Synonyms: Nsddr
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 269060
HGNC: HGNC:1165
Homologene: 4468
Clec4a4
Name: C-type lectin domain family 4, member a4
Synonyms: Dcir2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 474145
Homologene: 133910
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 34,836,741 bp
  • T to G, chromosome 2 at 86,423,017 bp
  • A to G, chromosome 3 at 75,521,071 bp
  • T to C, chromosome 4 at 19,661,963 bp
  • T to C, chromosome 5 at 25,298,928 bp
  • G to T, chromosome 5 at 121,134,829 bp
  • G to T, chromosome 5 at 124,298,762 bp
  • A to G, chromosome 5 at 144,174,685 bp
  • G to T, chromosome 6 at 36,523,357 bp
  • A to G, chromosome 6 at 123,012,804 bp
  • A to G, chromosome 6 at 124,879,468 bp
  • T to C, chromosome 7 at 25,815,041 bp
  • A to T, chromosome 7 at 125,668,074 bp
  • T to C, chromosome 8 at 10,570,638 bp
  • A to G, chromosome 9 at 80,132,954 bp
  • A to T, chromosome 9 at 87,715,535 bp
  • A to G, chromosome 9 at 113,896,720 bp
  • T to C, chromosome 11 at 69,562,144 bp
  • T to C, chromosome 12 at 29,999,918 bp
  • T to C, chromosome 12 at 104,773,786 bp
  • A to T, chromosome 13 at 38,167,622 bp
  • A to T, chromosome 13 at 58,354,797 bp
  • T to C, chromosome 14 at 66,004,170 bp
  • T to C, chromosome 16 at 59,167,981 bp
  • A to C, chromosome 16 at 85,795,825 bp
  • T to C, chromosome 17 at 36,129,054 bp
  • T to C, chromosome 17 at 50,736,208 bp
  • T to C, chromosome 19 at 10,263,227 bp
  • A to G, chromosome Y at 900,525 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6628 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044750-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.