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Strain Name:
C57BL/6J-MtgxR6630Btlr/Mmmh
Stock Number:
044752-MU
Citation ID:
RRID:MMRRC_044752-MU
Other Names:
R6630 (G1)
Major Collection:

Strain Information

Calb1
Name: calbindin 1
Synonyms: Brain-2, CB, Calb-1, Calb, calbindin-D (28k), calbindin, CalbindinD28K
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12307
HGNC: HGNC:1434
Homologene: 21026
Mapk1
Name: mitogen-activated protein kinase 1
Synonyms: p42mapk, MAPK2, Prkm1, Erk2, 9030612K14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26413
HGNC: HGNC:6871
Homologene: 37670
Mga
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: 220kDa, Rpo2-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Cep131
Name: centrosomal protein 131
Synonyms: AZ1, Azi1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12009
Homologene: 7638
Usp24
Name: ubiquitin specific peptidase 24
Synonyms: 2810030C21Rik, 2700066K03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329908
Homologene: 35420
Mepce
Name: methylphosphate capping enzyme
Synonyms: D5Wsu46e, Bcdin3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231803
Homologene: 32447
Cnr1
Name: cannabinoid receptor 1
Synonyms: CB1, CB1R
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12801
HGNC: HGNC:2159
Homologene: 7273
Cecr2
Name: CECR2, histone acetyl-lysine reader
Synonyms: 2810409N01Rik, 2610101O16Rik, Gtl4, cat eye syndrome chromosome region, candidate 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330409
HGNC: HGNC:1840
Homologene: 64662
Ppp4r3a
Name: protein phosphatase 4 regulatory subunit 3A
Synonyms: 1110034C04Rik, Smek1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68734
VEGA: 12
Homologene: 69510
Irx4
Name: Iroquois homeobox 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 50916
HGNC: HGNC:6129
Homologene: 9485
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: 9930021A08Rik, E130209G04Rik, ENSMUSG00000043296
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
Map1s
Name: microtubule-associated protein 1S
Synonyms: VCY2IP1, 6430517J16Rik, Bpy2ip1, Map8, Mtap1s
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270058
Homologene: 10047
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: alpha myosin, Myhc-a, alpha cardiac MHC, cardiomyopathy, hypertrophic 1, Myhca, A830009F23Rik, alpha-MHC, alphaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: B930001P07Rik, 6330504P12Rik, MLSN2, melastatin 2, LTRPC3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Heca
Name: hdc homolog, cell cycle regulator
Synonyms: LOC380629
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380629
VEGA: 10
Homologene: 32300
Dhh
Name: desert hedgehog
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13363
VEGA: 15
HGNC: HGNC:2865
Homologene: 22431
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Cenpo
Name: centromere protein O
Synonyms: D12Ertd482e, 8430427C03Rik, 2810429O05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 52504
Homologene: 49760
Vmn2r24
Name: vomeronasal 2, receptor 24
Synonyms: EG243628
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243628
Homologene: 135915
Vmn1r81
Name: vomeronasal 1 receptor 81
Synonyms: V1rg9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171244
Homologene: 74327
Or1e33
Name: olfactory receptor family 1 subfamily E member 33
Synonyms: GA_x6K02T2P1NL-4004140-4003208, MOR135-7, Olfr393
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259010
Homologene: 79335
Samsn1
Name: SAM domain, SH3 domain and nuclear localization signals, 1
Synonyms: 4930571B16Rik, Hacs1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67742
Homologene: 11148
Phc2
Name: polyhomeotic 2
Synonyms: Mph2, D4Ertd810e, Edr2, D130050K19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54383
HGNC: HGNC:3183
Homologene: 75090
Dcst1
Name: DC-STAMP domain containing 1
Synonyms: A330106H01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77772
Homologene: 14981
Mapre3
Name: microtubule-associated protein, RP/EB family, member 3
Synonyms: EB3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100732
HGNC: HGNC:6892
Homologene: 56565
A4gnt
Name: alpha-1,4-N-acetylglucosaminyltransferase
Synonyms: LOC333424, alpha4GnT
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 333424
Homologene: 87446
Dhrs9
Name: dehydrogenase/reductase 9
Synonyms: C730025I08Rik, Rdh15, dehydrogenase/reductase (SDR family) member 9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241452
Homologene: 26079
Defa40
Name: defensin, alpha, 40
Synonyms: ENSMUSG00000074441, Gm15292
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100041787
Homologene: 113382
Trbv3
Name: T cell receptor beta, variable 3
Synonyms: Gm2426, Tcrb-V16
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100039790
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 2 at 69,397,723 bp
  • T to A, chromosome 2 at 119,923,659 bp
  • A to T, chromosome 3 at 89,364,326 bp
  • T to A, chromosome 4 at 15,885,637 bp
  • T to A, chromosome 4 at 33,944,659 bp
  • T to C, chromosome 4 at 106,387,835 bp
  • C to A, chromosome 4 at 128,723,630 bp
  • G to T, chromosome 5 at 30,862,542 bp
  • G to A, chromosome 5 at 137,784,921 bp
  • T to A, chromosome 6 at 41,048,572 bp
  • A to T, chromosome 6 at 120,762,178 bp
  • T to A, chromosome 6 at 123,787,022 bp
  • A to T, chromosome 7 at 12,260,657 bp
  • A to T, chromosome 7 at 122,124,529 bp
  • T to A, chromosome 8 at 21,249,888 bp
  • T to C, chromosome 8 at 70,913,798 bp
  • A to G, chromosome 9 at 99,613,918 bp
  • G to A, chromosome 10 at 17,908,108 bp
  • A to T, chromosome 10 at 82,287,072 bp
  • A to G, chromosome 11 at 69,735,513 bp
  • T to A, chromosome 11 at 73,847,876 bp
  • A to G, chromosome 11 at 120,073,815 bp
  • G to A, chromosome 12 at 4,217,236 bp
  • A to G, chromosome 12 at 101,049,776 bp
  • G to T, chromosome 13 at 73,268,426 bp
  • T to C, chromosome 14 at 54,942,001 bp
  • C to T, chromosome 15 at 98,894,366 bp
  • A to G, chromosome 16 at 17,026,385 bp
  • G to A, chromosome 16 at 75,879,204 bp
  • T to C, chromosome 17 at 46,951,984 bp
  • A to G, chromosome 19 at 21,852,229 bp
  • A to T, chromosome 19 at 22,987,983 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6630 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044752-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.