Strain Name:
C57BL/6J-MtgxR6631Btlr/Mmmh
Stock Number:
044753-MU
Citation ID:
RRID:MMRRC_044753-MU
Other Names:
R6631 (G1)
Major Collection:

Strain Information

Itgb8
Name: integrin beta 8
Synonyms: 4832412O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320910
HGNC: HGNC:6163
Homologene: 18567
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Arip4, G630026H09Rik, Srisnf2l
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81000
Homologene: 56698
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: 220kDa, Rpo2-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Prdm2
Name: PR domain containing 2, with ZNF domain
Synonyms: Riz, Riz1, LOC381568, E330024L24Rik, 4833427P12Rik, KMT8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110593
HGNC: HGNC:9347
Homologene: 40822
Erbin
Name: Erbb2 interacting protein
Synonyms: 1700028E05Rik, Erbin, Erbb2ip
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 59079
Homologene: 41282
Slain2
Name: SLAIN motif family, member 2
Synonyms: 8030444K12Rik, 5033405K12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75991
Homologene: 18952
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227648
Homologene: 10533
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100683
Homologene: 39246
Cramp1
Name: cramped chromatin regulator 1
Synonyms: 5830477H08Rik, Tce4, Cramp1l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57354
VEGA: 17
Homologene: 35373
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277939
Homologene: 19524
Peg3
Name: paternally expressed 3
Synonyms: Pw1, Zfp102, End4, Gcap4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18616
HGNC: HGNC:8826
Homologene: 31363
Noct
Name: nocturnin
Synonyms: Ccr4, Ccrn4l
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12457
Homologene: 7661
Irx4
Name: Iroquois homeobox 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 50916
HGNC: HGNC:6129
Homologene: 9485
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Pomt2
Name: protein-O-mannosyltransferase 2
Synonyms: A830009D15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217734
VEGA: 12
Homologene: 5297
Avil
Name: advillin
Synonyms: DOC6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11567
Homologene: 38200
Mpc2
Name: mitochondrial pyruvate carrier 2
Synonyms: ESTM43, 0610006C01Rik, 2610205H19Rik, 2010002I07Rik, Brp44
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70456
Homologene: 31675
4931406C07Rik
Name: RIKEN cDNA 4931406C07 gene
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70984
VEGA: 9
Homologene: 8531
Mocos
Name: molybdenum cofactor sulfurase
Synonyms: 1110018O12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68591
VEGA: 18
Homologene: 9931
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Kctd19
Name: potassium channel tetramerisation domain containing 19
Synonyms: 4922504H04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 279499
Homologene: 18630
Ptgdr2
Name: prostaglandin D2 receptor 2
Synonyms: Crth2, PGD2 receptor, Gpr44
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14764
HGNC: HGNC:4502
Homologene: 3508
Mrc1
Name: mannose receptor, C type 1
Synonyms: CD206, MR
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Man2b1
Name: mannosidase 2, alpha B1
Synonyms: lysosomal alpha-mannosidase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17159
HGNC: HGNC:6826
Homologene: 37322
Nalcn
Name: sodium leak channel, non-selective
Synonyms: A530023G15Rik, Vgcnl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Ppp6r2
Name: protein phosphatase 6, regulatory subunit 2
Synonyms: 1110033O10Rik, 8430411H09Rik, B230107H12Rik, Pp6r2, Saps2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71474
VEGA: 15
Homologene: 36455
Gas7
Name: growth arrest specific 7
Synonyms: Gas7-cb, B230343A10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14457
HGNC: HGNC:4169
Homologene: 69015
Clca3a2
Name: chloride channel accessory 3A2
Synonyms: Clca2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80797
HGNC: HGNC:2017
Homologene: 77224
Exoc3l
Name: exocyst complex component 3-like
Synonyms: C730015A04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 277978
Homologene: 18629
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Atosa
Name: atos homolog A
Synonyms: 6330415I01Rik, C130047D21Rik, BC031353, Fam214a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235493
VEGA: 9
Homologene: 35065
Arhgef10l
Name: Rho guanine nucleotide exchange factor 10-like
Synonyms: 2810441C07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72754
Homologene: 10017
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: Cryabp1, alphaA-CRYBP1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Tdrd12
Name: tudor domain containing 12
Synonyms: 2410070K17Rik, G1-476-14, ecat8, 2410004F06Rik, EG434165, repro23
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71981
Homologene: 87053
Serpina3i
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3I
Synonyms: 2B2, antitrypsin, alpha-1 antiproteinase, Gm6930
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 628900
HGNC: HGNC:16
Homologene: 115927
Kif14
Name: kinesin family member 14
Synonyms: N-3 kinesin, D1Ertd367e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381293
Homologene: 8916
Cyp2c37
Name: cytochrome P450, family 2. subfamily c, polypeptide 37
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13096
Homologene: 137231
Prr5
Name: proline rich 5 (renal)
Synonyms: C030017C09Rik, Protor-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109270
Homologene: 17132
Fap
Name: fibroblast activation protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14089
HGNC: HGNC:3590
Homologene: 48282
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: Snep, 6720455I24Rik, D430044C15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208777
Homologene: 14708
Zfp558
Name: zinc finger protein 558
Synonyms: 1700007A21Rik, 4932704I17Rik, Zfp558-ps
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72230
Homologene: 44903
Steap4
Name: STEAP family member 4
Synonyms: Tiarp, Tnfaip9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 117167
Homologene: 36422
Ndufs3
Name: NADH:ubiquinone oxidoreductase core subunit S3
Synonyms: 0610010M09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68349
HGNC: HGNC:7710
Homologene: 3346
Or5b117
Name: olfactory receptor family 5 subfamily B member 117
Synonyms: GA_x6K02T2RE5P-3787124-3786180, MOR202-16, Olfr1472
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258685
Homologene: 77370
Taar8c
Name: trace amine-associated receptor 8C
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 494546
Homologene: 77586
H2bc12
Name: H2B clustered histone 12
Synonyms: Hist1h2bk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319184
Homologene: 135980
Defb8
Name: defensin beta 8
Synonyms: mBD8, Defr1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244334
Klk1b3
Name: kallikrein 1-related peptidase b3
Synonyms: mGk-3, Ngfg, Ngfg
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18050
Homologene: 68141
Pcdha11
Name: protocadherin alpha 11
Synonyms: Cnr7, Crnr7, A830022B16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12942
HGNC: HGNC:8665
Homologene: 75095
Pcdhga8
Name: protocadherin gamma subfamily A, 8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93716
HGNC: HGNC:8706
Homologene: 57162
Phlda2
Name: pleckstrin homology like domain, family A, member 2
Synonyms: Ipl, Tssc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22113
Homologene: 2482
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 93,281,652 bp
  • G to A, chromosome 1 at 136,515,959 bp
  • G to T, chromosome 1 at 165,479,512 bp
  • G to A, chromosome 2 at 14,238,485 bp
  • T to A, chromosome 2 at 26,439,957 bp
  • T to C, chromosome 2 at 62,503,381 bp
  • G to A, chromosome 2 at 90,902,400 bp
  • T to C, chromosome 3 at 51,250,200 bp
  • C to A, chromosome 3 at 90,277,732 bp
  • G to A, chromosome 3 at 144,813,644 bp
  • T to C, chromosome 4 at 140,517,747 bp
  • T to G, chromosome 4 at 143,134,884 bp
  • G to A, chromosome 5 at 7,976,995 bp
  • T to A, chromosome 5 at 72,957,405 bp
  • A to G, chromosome 5 at 144,771,650 bp
  • T to C, chromosome 7 at 6,709,070 bp
  • T to A, chromosome 7 at 35,485,229 bp
  • C to T, chromosome 7 at 44,201,464 bp
  • G to A, chromosome 7 at 100,418,540 bp
  • G to A, chromosome 7 at 141,356,202 bp
  • T to A, chromosome 7 at 143,502,181 bp
  • T to A, chromosome 8 at 19,445,934 bp
  • A to G, chromosome 8 at 85,086,811 bp
  • A to G, chromosome 8 at 105,295,361 bp
  • A to G, chromosome 8 at 105,385,328 bp
  • A to T, chromosome 9 at 15,292,030 bp
  • C to A, chromosome 9 at 18,456,923 bp
  • A to G, chromosome 9 at 74,953,825 bp
  • A to T, chromosome 9 at 106,713,540 bp
  • A to G, chromosome 10 at 24,101,803 bp
  • A to G, chromosome 10 at 127,007,749 bp
  • A to T, chromosome 10 at 127,574,332 bp
  • A to G, chromosome 11 at 67,674,281 bp
  • A to G, chromosome 11 at 69,735,513 bp
  • C to T, chromosome 12 at 87,139,643 bp
  • A to G, chromosome 12 at 104,266,466 bp
  • A to T, chromosome 12 at 119,180,977 bp
  • T to A, chromosome 13 at 22,036,221 bp
  • C to A, chromosome 13 at 42,156,480 bp
  • G to T, chromosome 13 at 73,268,426 bp
  • A to G, chromosome 13 at 103,824,892 bp
  • T to C, chromosome 14 at 123,460,251 bp
  • C to A, chromosome 15 at 84,702,777 bp
  • G to A, chromosome 15 at 89,253,255 bp
  • T to A, chromosome 17 at 24,983,957 bp
  • A to G, chromosome 17 at 34,718,248 bp
  • A to G, chromosome 17 at 67,774,482 bp
  • A to G, chromosome 18 at 24,699,931 bp
  • G to T, chromosome 18 at 37,005,791 bp
  • T to A, chromosome 18 at 37,727,056 bp
  • T to C, chromosome 19 at 10,940,869 bp
  • T to A, chromosome 19 at 13,453,821 bp
  • C to T, chromosome 19 at 40,009,843 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6631 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044753-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.