Strain Name:
C57BL/6J-MtgxR6637Btlr/Mmmh
Stock Number:
044758-MU
Citation ID:
RRID:MMRRC_044758-MU
Other Names:
R6637 (G1)
Major Collection:

Strain Information

Hfe
Name: homeostatic iron regulator
Synonyms: MR2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15216
HGNC: HGNC:4886
Homologene: 88330
Cdh3
Name: cadherin 3
Synonyms: Cadp, Pcad, P-cadherin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12560
HGNC: HGNC:1762
Homologene: 20425
Col3a1
Name: collagen, type III, alpha 1
Synonyms: Tsk-2, Tsk2, Col3a-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Tal1
Name: T cell acute lymphocytic leukemia 1
Synonyms: SCL/tal-1, Hpt, Scl, bHLHa17
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21349
Homologene: 2400
Vcl
Name: vinculin
Synonyms: metavinculin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 22330
VEGA: 14
Homologene: 7594
Ubxn4
Name: UBX domain protein 4
Synonyms: 1300013G12Rik, Ubxd2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67812
Homologene: 40962
Kcnk5
Name: potassium channel, subfamily K, member 5
Synonyms: TASK-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16529
VEGA: 14
HGNC: HGNC:6280
Homologene: 2773
Ap4m1
Name: adaptor-related protein complex AP-4, mu 1
Synonyms: 4930443L05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11781
HGNC: HGNC:574
Homologene: 3467
Atp6v1b2
Name: ATPase, H+ transporting, lysosomal V1 subunit B2
Synonyms: HO57, Atp6b2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11966
HGNC: HGNC:854
Homologene: 1279
Tbr1
Name: T-box brain transcription factor 1
Synonyms: T-box brain gene 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21375
Homologene: 4807
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Adgrl4
Name: adhesion G protein-coupled receptor L4
Synonyms: Eltd1, EGF-TM7 receptor, 1110033N21Rik, Etl
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170757
Homologene: 11170
Ston2
Name: stonin 2
Synonyms: 4933401N24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 108800
Homologene: 84338
Fign
Name: fidgetin
Synonyms: Fgn
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 60344
Homologene: 5813
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Vmn2r26
Name: vomeronasal 2, receptor 26
Synonyms: V2r1b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56552
Homologene: 135915
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: 4930503E15Rik, LOC380658, Gm1557
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74978
Homologene: 46007
Tgm7
Name: transglutaminase 7
Synonyms: TGz
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 640543
Homologene: 14192
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 671232
VEGA: 9
Homologene: 19835
Kcnb1
Name: potassium voltage gated channel, Shab-related subfamily, member 1
Synonyms: Shab, Kv2.1, Kcr1-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16500
HGNC: HGNC:6231
Homologene: 37988
Lamp3
Name: lysosomal-associated membrane protein 3
Synonyms: 1200002D17Rik, Cd208, TSC403, DC-LAMP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239739
VEGA: 16
Homologene: 8670
Cxadr
Name: coxsackie virus and adenovirus receptor
Synonyms: MCAR, CAR, 2610206D03Rik, MCVADR
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13052
HGNC: HGNC:2559
Homologene: 1024
Or4a27
Name: olfactory receptor family 4 subfamily A member 27
Synonyms: MOR225-10P, MOR225-14, GA_x6K02T2Q125-50202854-50201910, Olfr1197
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 433449
Homologene: 123770
Or2g7
Name: olfactory receptor family 2 subfamily G member 7
Synonyms: Olfr130, MOR256-19, GA_x6K02T2PSCP-2515350-2516303
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258480
Homologene: 105876
Adh1
Name: alcohol dehydrogenase 1 (class I)
Synonyms: Adh-1, ADH-AA, class I alcohol dehydrogenase, Adh-1t, Adh-1e, Adh1-t, Adh1tl, Adh-1-t, Adh1-e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11522
Homologene: 73888
Or5b113
Name: olfactory receptor family 5 subfamily B member 113
Synonyms: Olfr1467, GA_x6K02T2RE5P-3695694-3696620, MOR202-15
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258686
Homologene: 133888
Spa17
Name: sperm autoantigenic protein 17
Synonyms: Sp17, band 34
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20686
VEGA: 9
Homologene: 7951
Or5t15
Name: olfactory receptor family 5 subfamily T member 15
Synonyms: MOR179-1, Olfr1095, GA_x6K02T2Q125-48336843-48335917
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258725
Homologene: 28042
Dmgdh
Name: dimethylglycine dehydrogenase precursor
Synonyms: 1200014D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74129
Homologene: 8372
Lrrc8b
Name: leucine rich repeat containing 8 family, member B
Synonyms: R75581, 2210408K08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 433926
Homologene: 9103
Fbxo16
Name: F-box protein 16
Synonyms: Fbx16
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50759
VEGA: 14
Homologene: 9273
Lsamp
Name: limbic system-associated membrane protein
Synonyms: D930023J12Rik, Lamp, Lam, B130007O04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268890
HGNC: HGNC:6705
Homologene: 20533
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 45,347,730 bp
  • C to A, chromosome 1 at 128,277,087 bp
  • A to G, chromosome 2 at 61,811,630 bp
  • A to G, chromosome 2 at 64,027,908 bp
  • T to G, chromosome 2 at 86,851,440 bp
  • T to C, chromosome 2 at 88,728,841 bp
  • T to A, chromosome 2 at 121,101,090 bp
  • T to C, chromosome 2 at 167,105,854 bp
  • T to A, chromosome 3 at 138,282,470 bp
  • G to A, chromosome 3 at 151,517,773 bp
  • G to A, chromosome 4 at 48,416,203 bp
  • A to G, chromosome 4 at 115,068,592 bp
  • A to C, chromosome 5 at 105,480,271 bp
  • A to G, chromosome 5 at 138,172,175 bp
  • A to G, chromosome 6 at 85,619,734 bp
  • A to T, chromosome 6 at 124,061,691 bp
  • T to C, chromosome 7 at 141,818,605 bp
  • T to C, chromosome 8 at 69,101,374 bp
  • G to C, chromosome 8 at 106,511,341 bp
  • A to T, chromosome 9 at 37,611,974 bp
  • A to T, chromosome 9 at 122,749,786 bp
  • A to T, chromosome 10 at 103,221,432 bp
  • T to C, chromosome 12 at 84,875,838 bp
  • G to C, chromosome 12 at 91,714,112 bp
  • C to G, chromosome 13 at 23,706,795 bp
  • T to C, chromosome 13 at 23,706,796 bp
  • A to T, chromosome 13 at 93,709,198 bp
  • A to C, chromosome 14 at 20,144,721 bp
  • A to G, chromosome 14 at 21,003,132 bp
  • A to G, chromosome 14 at 65,295,761 bp
  • A to G, chromosome 16 at 19,701,233 bp
  • C to T, chromosome 16 at 32,753,964 bp
  • T to A, chromosome 16 at 41,533,381 bp
  • C to T, chromosome 16 at 78,333,503 bp
  • G to A, chromosome 17 at 38,067,224 bp
  • T to C, chromosome 19 at 13,365,225 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6637 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044758-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.