Strain Name:
C57BL/6J-MtgxR6641Btlr/Mmmh
Stock Number:
044762-MU
Citation ID:
RRID:MMRRC_044762-MU
Other Names:
R6641 (G1)
Major Collection:

Strain Information

Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: MYH-beta/slow, beta-MHC, MyHC-I, B-MHC, Myhcb, Myhc-b, betaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Mtg2
Name: mitochondrial ribosome associated GTPase 2
Synonyms: Gtpbp5, D2Bwg0647e, 2900056P18Rik, 1810011P19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 52856
Homologene: 9233
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LRP7, LR3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16973
Homologene: 1746
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Specc1l
Name: sperm antigen with calponin homology and coiled-coil domains 1-like
Synonyms: 9530057A13Rik, 4932439K10Rik, Specc1l, Cytsa, 4930470P14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74392
VEGA: 10
Homologene: 15610
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: Mll, trithorax Drosophila, Mll1, All1, HTRX1, ALL-1, Cxxc7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Prpf40a
Name: pre-mRNA processing factor 40A
Synonyms: 2810012K09Rik, FBP11, Fnbp3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56194
Homologene: 6377
Septin11
Name: septin 11
Synonyms: D5Ertd606e, Sept11, 6230410I01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52398
Homologene: 56800
Slc33a1
Name: solute carrier family 33 (acetyl-CoA transporter), member 1
Synonyms: Acatn, D630022N01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11416
HGNC: HGNC:95
Homologene: 3476
Tmem161b
Name: transmembrane protein 161B
Synonyms: 2810446P07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72745
Homologene: 14519
Zfyve1
Name: zinc finger, FYVE domain containing 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217695
VEGA: 12
Homologene: 10945
Casp12
Name: caspase 12
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12364
Homologene: 7654
Lepr
Name: leptin receptor
Synonyms: OB-RGRP, Leprb, Obr, LEPROT, obese-like, obl, Modb1, leptin receptor gene-related protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16847
HGNC: HGNC:6554
Homologene: 1731
Zbtb18
Name: zinc finger and BTB domain containing 18
Synonyms: RP58, Zfp238
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 30928
Homologene: 21276
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: Pdgfr-2, CD140a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Cubn
Name: cubilin
Synonyms: intrinsic factor-cobalamin receptor, D2Wsu88e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Reln
Name: reelin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Hipk1
Name: homeodomain interacting protein kinase 1
Synonyms: 1110062K04Rik, Myak
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15257
Homologene: 56483
Spata31g1
Name: SPATA31 subfamily G member 1
Synonyms: 1700022I11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67317
Homologene: 52406
Vipr1
Name: vasoactive intestinal peptide receptor 1
Synonyms: VIP receptor subtype 1, VIP-R1, VPAC1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22354
Homologene: 3399
Dym
Name: dymeclin
Synonyms: 1810041M12Rik, 4933427L07Rik, C030019K18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69190
VEGA: 18
Homologene: 69237
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320277
Homologene: 23371
Or2b11
Name: olfactory receptor family 2 subfamily B member 11
Synonyms: MOR256-45P, GA_x6K02SYYHDF-1415-2371, Olfr222
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257962
Homologene: 71979
Slc7a13
Name: solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
Synonyms: XAT2, 0610009O04Rik, AGT-1, AGT1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74087
Homologene: 23656
Slc22a15
Name: solute carrier family 22 (organic anion/cation transporter), member 15
Synonyms: A530052I06Rik, 2610034P21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242126
Homologene: 41263
Aadac
Name: arylacetamide deacetylase
Synonyms: Aada, 5033417E09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67758
HGNC: HGNC:17
Homologene: 37436
Nrsn2
Name: neurensin 2
Synonyms: LOC228777, Neurensin-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228777
Homologene: 11802
Chil6
Name: chitinase-like 6
Synonyms: BYm, BC051070
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229688
Homologene: 77638
Klk10
Name: kallikrein related-peptidase 10
Synonyms: 2300002A13Rik, NES1, PRSSL1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69540
HGNC: HGNC:6358
Homologene: 26428
Slc5a11
Name: solute carrier family 5 (sodium/glucose cotransporter), member 11
Synonyms: 2010013B02Rik, Kst1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233836
Homologene: 14184
Desi2
Name: desumoylating isopeptidase 2
Synonyms: Pppde1, Fam152a, 5830417C01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78825
Homologene: 56741
Gm3404
Name: predicted gene 3404
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041554
Homologene: 86127
Krtap13-20
Name: keratin associated protein 13-20
Synonyms: 2310034C09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 117172
Homologene: 114409
Pcdha8
Name: protocadherin alpha 8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353235
HGNC: HGNC:8675
Homologene: 129614
Gm28042
Name: predicted gene, 28042
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 102238433
Gm14418
Name: predicted gene 14418
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668066
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 177,448,043 bp
  • A to T, chromosome 1 at 178,244,377 bp
  • A to C, chromosome 2 at 13,476,064 bp
  • T to G, chromosome 2 at 53,141,626 bp
  • T to A, chromosome 2 at 120,039,683 bp
  • A to G, chromosome 2 at 152,369,910 bp
  • G to T, chromosome 2 at 177,387,830 bp
  • A to G, chromosome 2 at 180,085,508 bp
  • T to C, chromosome 3 at 60,039,732 bp
  • T to A, chromosome 3 at 63,953,906 bp
  • G to A, chromosome 3 at 101,875,706 bp
  • A to T, chromosome 3 at 103,753,405 bp
  • T to A, chromosome 3 at 106,388,924 bp
  • G to A, chromosome 4 at 19,839,534 bp
  • A to G, chromosome 4 at 42,971,245 bp
  • T to A, chromosome 4 at 101,765,305 bp
  • A to C, chromosome 5 at 21,929,134 bp
  • T to C, chromosome 5 at 75,162,101 bp
  • T to A, chromosome 5 at 93,139,552 bp
  • C to A, chromosome 5 at 146,527,708 bp
  • G to T, chromosome 7 at 43,784,900 bp
  • T to C, chromosome 7 at 116,340,225 bp
  • A to G, chromosome 7 at 123,238,155 bp
  • G to A, chromosome 9 at 5,354,612 bp
  • T to C, chromosome 9 at 44,819,835 bp
  • A to G, chromosome 9 at 121,669,565 bp
  • A to G, chromosome 10 at 75,246,549 bp
  • T to C, chromosome 11 at 59,570,840 bp
  • A to G, chromosome 12 at 83,594,496 bp
  • C to A, chromosome 13 at 84,222,418 bp
  • A to G, chromosome 14 at 54,982,280 bp
  • A to T, chromosome 15 at 9,625,973 bp
  • C to T, chromosome 16 at 88,759,086 bp
  • A to G, chromosome 18 at 36,993,797 bp
  • T to A, chromosome 18 at 75,056,641 bp
  • G to A, chromosome 19 at 3,652,287 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6641 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044762-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.