Strain Name:
C57BL/6J-MtgxR6647Btlr/Mmmh
Stock Number:
044768-MU
Citation ID:
RRID:MMRRC_044768-MU
Other Names:
R6647 (G1)
Major Collection:

Strain Information

Hells
Name: helicase, lymphoid specific
Synonyms: PASG, YFK8, E130115I21Rik, Lysh, proliferation-associated SNF2-like, LSH
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15201
HGNC: HGNC:4861
Homologene: 50037
Xpa
Name: xeroderma pigmentosum, complementation group A
Synonyms: Xpac
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22590
Homologene: 37298
Rc3h2
Name: ring finger and CCCH-type zinc finger domains 2
Synonyms: Mnab, 2900024N03Rik, Rnf164, D930043C02Rik, 9430019J22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319817
Homologene: 28276
Eprs1
Name: glutamyl-prolyl-tRNA synthetase 1
Synonyms: 2410081F06Rik, 3010002K18Rik, Qprs, Eprs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: U5-200KD, Ascc3l1, A330064G03Rik, HELIC2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320632
Homologene: 5859
Kdm5a
Name: lysine demethylase 5A
Synonyms: RBP2, Jarid1a, Rbbp2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214899
HGNC: HGNC:9886
Homologene: 3419
Ptprg
Name: protein tyrosine phosphatase receptor type G
Synonyms: RPTPgamma, 5430405N12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19270
HGNC: HGNC:9671
Homologene: 2129
Senp7
Name: SUMO1/sentrin specific peptidase 7
Synonyms: 2810413I22Rik, 6030449K19Rik, 2410152H17Rik, 2900036C23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66315
Homologene: 10778
Rsf1
Name: remodeling and spacing factor 1
Synonyms: XAP8, Hbxap, p325, 4832420A03Rik, C030033M12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Kcnk1
Name: potassium channel, subfamily K, member 1
Synonyms: TWIK-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16525
HGNC: HGNC:6272
Homologene: 1691
Ints12
Name: integrator complex subunit 12
Synonyms: A230056J18Rik, 4930529N21Rik, 2810027J24Rik, 1110020M19Rik, Phf22
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71793
Homologene: 32474
Crebbp
Name: CREB binding protein
Synonyms: KAT3A, CBP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12914
HGNC: HGNC:2348
Homologene: 68393
Frat1
Name: frequently rearranged in advanced T cell lymphomas
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14296
HGNC: HGNC:3944
Homologene: 3999
Shisal2a
Name: shisa like 2A
Synonyms: Fam159a, OTTMUSG00000008243
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 545667
Homologene: 82675
Ift81
Name: intraflagellar transport 81
Synonyms: Cdv1, CDV-1R
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12589
Homologene: 7664
Nid2
Name: nidogen 2
Synonyms: entactin-2, entactin 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18074
VEGA: 14
Homologene: 40575
Katnal2
Name: katanin p60 subunit A-like 2
Synonyms: 4933439B08Rik, 3110023G01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71206
Homologene: 41725
Tor1aip1
Name: torsin A interacting protein 1
Synonyms: LAP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208263
Homologene: 9208
Pcdhb16
Name: protocadherin beta 16
Synonyms: Pcdhb8, PcdhbP
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93887
Homologene: 99843
Rap1gap2
Name: RAP1 GTPase activating protein 2
Synonyms: Garnl4, LOC380710
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380711
Homologene: 56695
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1537Clo, b2b1565Clo, Mdnah5, Dnahc5, b2b1134Clo, b2b1154Clo, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Ces1h
Name: carboxylesterase 1H
Synonyms: 2310039D24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75704
HGNC: HGNC:1863
Homologene: 119757
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Vmn2r100
Name: vomeronasal 2, receptor 100
Synonyms: EG627537
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627537
Homologene: 129750
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 1110061O17Rik, 9630046L06Rik, 9430004C13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Ogfod2
Name: 2-oxoglutarate and iron-dependent oxygenase domain containing 2
Synonyms: 1300006G11Rik, 5730405M13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66627
Homologene: 32588
Cyp2b13
Name: cytochrome P450, family 2, subfamily b, polypeptide 13
Synonyms: phenobarbital inducible, type c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13089
HGNC: HGNC:2615
Homologene: 74933
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: Wilson protein, WND, Atp7a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Spata31e2
Name: spermatogenesis associated 31 subfamily E member 2
Synonyms: 4931408C20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210940
Homologene: 86827
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Ermp1
Name: endoplasmic reticulum metallopeptidase 1
Synonyms: D19Ertd410e, D19Wsu12e, b2b2633Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226090
Homologene: 121891
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: GluRepsilon2, NR2B, Nmdar2b, GluN2B, NMDAR2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
Shkbp1
Name: Sh3kbp1 binding protein 1
Synonyms: B930062H15Rik, SB1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 192192
Homologene: 26700
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17836
HGNC: HGNC:9750
Homologene: 136663
Kdr
Name: kinase insert domain protein receptor
Synonyms: VEGFR2, Flk-1, orv, Flk1, VEGF receptor-2, vascular endothelial growth factor receptor- 2, VEGFR-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16542
HGNC: HGNC:6307
Homologene: 55639
Spata22
Name: spermatogenesis associated 22
Synonyms: LOC380709
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380709
Homologene: 13076
Or8g21
Name: olfactory receptor family 8 subfamily G member 21
Synonyms: GA_x6K02T2PVTD-32691280-32690354, MOR171-11, Olfr935
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258741
VEGA: 9
Homologene: 133683
Lats1
Name: large tumor suppressor
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16798
VEGA: 10
HGNC: HGNC:6514
Homologene: 55843
Gcc2
Name: GRIP and coiled-coil domain containing 2
Synonyms: 0610043A03Rik, 2600014C01Rik, 2210420P05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70297
Homologene: 45639
Rasgrf1
Name: RAS protein-specific guanine nucleotide-releasing factor 1
Synonyms: CDC25Mm, Grf1, Grfbeta, CDC25
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19417
HGNC: HGNC:9875
Homologene: 74972
Ddx31
Name: DEAD/H box helicase 31
Synonyms: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31, 5830444G11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227674
Homologene: 6389
Oprk1
Name: opioid receptor, kappa 1
Synonyms: KOR-1, R21, Oprk2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18387
HGNC: HGNC:8154
Homologene: 20253
Setd7
Name: SET domain containing (lysine methyltransferase) 7
Synonyms: 1600028F23Rik, Set7, Set7/9, KMT7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73251
Homologene: 12741
Nlrp4e
Name: NLR family, pyrin domain containing 4E
Synonyms: 4930406H16Rik, Nalp4e, Nalp-epsilon
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 446099
Homologene: 75315
Vmn1r43
Name: vomeronasal 1 receptor 43
Synonyms: V1ra5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113847
Homologene: 130651
Or7g27
Name: olfactory receptor family 7 subfamily G member 27
Synonyms: MOR150-1P, MOR150-2, MOR150-1P, MOR150-1, Olfr1522-ps1, Olfr845, GA_x6K02T2PVTD-13076685-13077623
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258249
Homologene: 133689
Vav3
Name: vav 3 oncogene
Synonyms: Idd18.1, A530094I06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 57257
Homologene: 38143
Tas2r138
Name: taste receptor, type 2, member 138
Synonyms: T2R138, Tas2r38, mt2r31
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387513
HGNC: HGNC:9584
Homologene: 47976
Cfap157
Name: cilia and flagella associated protein 157
Synonyms: 1700019L03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227736
Homologene: 53056
Nkx2-4
Name: NK2 homeobox 4
Synonyms: Nkx-2.4, 1700001P03Rik, tinman
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228731
HGNC: HGNC:7837
Homologene: 41526
Or5d36
Name: olfactory receptor family 5 subfamily D member 36
Synonyms: Olfr1163, GA_x6K02T2Q125-49563265-49562315, MOR174-8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258638
Homologene: 17328
Pycard
Name: PYD and CARD domain containing
Synonyms: Asc, 9130417A21Rik, TMS-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66824
Homologene: 8307
Gm9857
Name: predicted gene 9857
Type: Gene
Species: Mouse
Chromosome: 3
Or6c35
Name: olfactory receptor family 6 subfamily C member 35
Synonyms: GA_x6K02T2PULF-11013616-11014551, Olfr781, MOR114-6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258723
Homologene: 37000
Krtap10-24
Name: keratin associated protein 10-24
Synonyms: Gm3285
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100041351
VEGA: 10
Homologene: 115744
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 5,602,284 bp
  • T to A, chromosome 1 at 26,682,578 bp
  • T to C, chromosome 1 at 156,018,253 bp
  • T to A, chromosome 1 at 174,593,104 bp
  • C to T, chromosome 1 at 185,414,424 bp
  • A to T, chromosome 2 at 28,875,738 bp
  • G to T, chromosome 2 at 32,779,074 bp
  • G to A, chromosome 2 at 37,382,944 bp
  • A to T, chromosome 2 at 88,070,709 bp
  • A to G, chromosome 2 at 127,226,452 bp
  • A to T, chromosome 2 at 147,084,267 bp
  • A to G, chromosome 3 at 51,542,762 bp
  • T to C, chromosome 3 at 108,940,063 bp
  • A to T, chromosome 3 at 109,527,416 bp
  • T to C, chromosome 3 at 116,750,411 bp
  • G to A, chromosome 3 at 133,096,878 bp
  • T to A, chromosome 4 at 46,183,089 bp
  • A to G, chromosome 4 at 108,368,027 bp
  • G to A, chromosome 5 at 75,952,889 bp
  • A to G, chromosome 5 at 96,735,202 bp
  • T to A, chromosome 5 at 122,610,166 bp
  • G to C, chromosome 5 at 124,114,803 bp
  • G to T, chromosome 6 at 40,612,799 bp
  • A to T, chromosome 6 at 73,138,760 bp
  • A to G, chromosome 6 at 89,869,859 bp
  • A to G, chromosome 6 at 120,412,461 bp
  • A to G, chromosome 6 at 121,840,241 bp
  • C to A, chromosome 6 at 135,733,110 bp
  • A to G, chromosome 7 at 23,321,315 bp
  • A to G, chromosome 7 at 26,085,899 bp
  • A to G, chromosome 7 at 27,342,375 bp
  • G to A, chromosome 7 at 97,579,910 bp
  • T to C, chromosome 7 at 127,993,569 bp
  • A to T, chromosome 8 at 21,085,185 bp
  • A to G, chromosome 8 at 22,028,478 bp
  • A to C, chromosome 8 at 93,352,026 bp
  • A to G, chromosome 8 at 125,995,460 bp
  • T to A, chromosome 9 at 19,338,629 bp
  • T to C, chromosome 9 at 38,994,914 bp
  • C to G, chromosome 9 at 90,010,463 bp
  • G to C, chromosome 10 at 7,697,507 bp
  • T to A, chromosome 10 at 58,287,281 bp
  • T to C, chromosome 10 at 77,862,613 bp
  • T to A, chromosome 10 at 129,333,164 bp
  • T to A, chromosome 11 at 73,354,700 bp
  • G to A, chromosome 11 at 74,407,928 bp
  • C to A, chromosome 14 at 11,962,714 bp
  • A to G, chromosome 14 at 19,802,416 bp
  • G to A, chromosome 15 at 28,403,487 bp
  • C to T, chromosome 16 at 4,119,806 bp
  • T to C, chromosome 16 at 56,173,255 bp
  • T to A, chromosome 17 at 19,522,523 bp
  • A to G, chromosome 18 at 37,479,172 bp
  • C to T, chromosome 18 at 76,980,037 bp
  • T to C, chromosome 19 at 29,626,935 bp
  • T to A, chromosome 19 at 38,931,504 bp
  • C to T, chromosome 19 at 41,830,825 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6647 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044768-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.