Strain Name:
C57BL/6J-MtgxR6650Btlr/Mmmh
Stock Number:
044771-MU
Citation ID:
RRID:MMRRC_044771-MU
Other Names:
R6650 (G1)
Major Collection:

Strain Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: A230020K14Rik, N-CoR, 5730405M06Rik, Rxrip13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Larp1
Name: La ribonucleoprotein 1, translational regulator
Synonyms: 1810024J12Rik, 3110040D16Rik, Larp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73158
Homologene: 9089
Os9
Name: amplified in osteosarcoma
Synonyms: 4632413K17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216440
VEGA: 10
Homologene: 31409
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: Pcp-1, Pcp1, IP3R1, InsP3R type I, P400, Ip3r, opt, wblo, Itpr-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Eef2
Name: eukaryotic translation elongation factor 2
Synonyms: Ef-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13629
VEGA: 10
HGNC: HGNC:3214
Homologene: 134867
Cep135
Name: centrosomal protein 135
Synonyms: LOC381644, Cep4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381644
Homologene: 45709
Lepr
Name: leptin receptor
Synonyms: OB-RGRP, Leprb, leptin receptor gene-related protein, LEPROT, Obr, obl, Modb1, obese-like
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16847
HGNC: HGNC:6554
Homologene: 1731
Zdhhc20
Name: zinc finger, DHHC domain containing 20
Synonyms: 4930542A17Rik, B230110O18Rik, 5033406L14Rik, ENSMUSG00000055956
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75965
VEGA: 14
Homologene: 57105
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319262
Homologene: 14127
Acsl3
Name: acyl-CoA synthetase long-chain family member 3
Synonyms: C85929, Facl3, 2610510B12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74205
HGNC: HGNC:3570
Homologene: 3278
Pja2
Name: praja ring finger ubiquitin ligase 2
Synonyms: Neurodap1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224938
Homologene: 32233
Tpcn1
Name: two pore channel 1
Synonyms: 5730403B01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 252972
Homologene: 9905
Cdh6
Name: cadherin 6
Synonyms: cad6, K-cadherin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12563
VEGA: 15
HGNC: HGNC:1765
Homologene: 21027
Dcn
Name: decorin
Synonyms: SLRR1B, DC
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13179
VEGA: 10
HGNC: HGNC:2705
Homologene: 22430
Sfxn3
Name: sideroflexin 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 94280
VEGA: 19
Homologene: 23394
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: RGC2, A230067G21Rik, AS250
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Cngb3
Name: cyclic nucleotide gated channel beta 3
Synonyms: Cngbeta2, CNG6, CCNC2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 30952
HGNC: HGNC:2153
Homologene: 40908
Tnn
Name: tenascin N
Synonyms: tenascin-W, Tnw
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329278
Homologene: 18634
Sh3pxd2a
Name: SH3 and PX domains 2A
Synonyms: Sh3md1, 2310014D11Rik, Fish, Tks5
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14218
VEGA: 19
Homologene: 7317
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214642
Homologene: 57014
Zfp235
Name: zinc finger protein 235
Synonyms: 0610030O19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56525
Homologene: 122146
Lbp
Name: lipopolysaccharide binding protein
Synonyms: Bpifd2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16803
HGNC: HGNC:6517
Homologene: 3055
Mrpl22
Name: mitochondrial ribosomal protein L22
Synonyms: MRP-L25, E030011D16Rik, Rpml25, HSPC158
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216767
Homologene: 56664
Scnn1b
Name: sodium channel, nonvoltage-gated 1 beta
Synonyms: ENaC beta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20277
Homologene: 133555
Ercc3
Name: excision repair cross-complementing rodent repair deficiency, complementation group 3
Synonyms: XPB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13872
HGNC: HGNC:3435
Homologene: 96
Mcm8
Name: minichromosome maintenance 8 homologous recombination repair factor
Synonyms: 5730432L01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66634
Homologene: 12001
Pira13
Name: paired-Ig-like receptor A13
Synonyms: ENSMUSG00000074419, Gm15448
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100041146
Homologene: 134028
Nlrp4c
Name: NLR family, pyrin domain containing 4C
Synonyms: Nalp4c, Rnh2, Nalp-alpha
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 83564
Homologene: 75315
Msln
Name: mesothelin
Synonyms: megakaryocyte potentiating factor, MPF
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56047
VEGA: 17
HGNC: HGNC:7371
Homologene: 4249
Ccdc102a
Name: coiled-coil domain containing 102A
Synonyms: LOC234582
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234582
Homologene: 13240
Fmod
Name: fibromodulin
Synonyms: SLRR2E
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14264
HGNC: HGNC:3774
Homologene: 1530
Ifih1
Name: interferon induced with helicase C domain 1
Synonyms: MDA-5, Helicard, 9130009C22Rik, MDA5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71586
Homologene: 32535
Zfp354c
Name: zinc finger protein 354C
Synonyms: 5330421P20Rik, Kid3, AJ18
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 30944
Homologene: 56606
Xkr8
Name: X-linked Kx blood group related 8
Synonyms: LOC381560, 4931440N07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381560
Homologene: 23068
Prl2b1
Name: prolactin family 2, subfamily b, member 1
Synonyms: PLP-K, 2310047B08Rik, Prlpk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66392
Homologene: 11963
Mcpt4
Name: mast cell protease 4
Synonyms: Mcp-4, MMCP-4B, MMCP-4A, MMCP-4, myonase, Mcp4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17227
VEGA: 14
Homologene: 130645
Pira12
Name: paired-Ig-like receptor A12
Synonyms: Gm14548
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100038909
Homologene: 134028
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Pofut1
Name: protein O-fucosyltransferase 1
Synonyms: O-FucT-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140484
Homologene: 9104
Aph1a
Name: aph1 homolog A, gamma secretase subunit
Synonyms: 6530402N02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 226548
Homologene: 9345
Six4
Name: sine oculis-related homeobox 4
Synonyms: TrexBF, AREC3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20474
Homologene: 69089
Bin2
Name: bridging integrator 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 668218
HGNC: HGNC:1053
Homologene: 22965
Ugt2a2
Name: UDP glucuronosyltransferase 2 family, polypeptide A2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 552899
Homologene: 115736
Gm45861
Name: predicted gene 45861
Type: Gene
Species: Mouse
Chromosome: 8
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 46,649,340 bp
  • A to G, chromosome 1 at 46,649,351 bp
  • A to G, chromosome 1 at 78,681,922 bp
  • A to G, chromosome 1 at 134,041,007 bp
  • G to A, chromosome 1 at 160,114,583 bp
  • T to C, chromosome 2 at 62,606,447 bp
  • C to A, chromosome 2 at 132,821,407 bp
  • T to C, chromosome 2 at 146,388,502 bp
  • T to A, chromosome 2 at 153,259,350 bp
  • T to A, chromosome 2 at 158,309,667 bp
  • T to C, chromosome 3 at 95,896,286 bp
  • T to C, chromosome 4 at 19,364,168 bp
  • C to A, chromosome 4 at 101,815,201 bp
  • T to C, chromosome 4 at 132,727,938 bp
  • T to A, chromosome 5 at 76,633,701 bp
  • A to G, chromosome 5 at 87,474,600 bp
  • T to A, chromosome 5 at 120,537,562 bp
  • A to G, chromosome 6 at 22,233,976 bp
  • A to G, chromosome 6 at 108,394,073 bp
  • T to A, chromosome 7 at 3,816,899 bp
  • T to A, chromosome 7 at 3,895,633 bp
  • T to A, chromosome 7 at 6,065,949 bp
  • T to A, chromosome 7 at 24,137,038 bp
  • G to A, chromosome 7 at 121,902,820 bp
  • T to C, chromosome 8 at 27,505,015 bp
  • T to C, chromosome 8 at 94,913,264 bp
  • CCC to CCCC, chromosome 10 at 81,178,768 bp
  • C to A, chromosome 10 at 97,507,743 bp
  • C to T, chromosome 10 at 127,100,084 bp
  • A to G, chromosome 11 at 50,814,691 bp
  • CA to CAA, chromosome 11 at 58,058,596 bp
  • A to G, chromosome 11 at 58,175,308 bp
  • G to A, chromosome 11 at 62,334,541 bp
  • C to A, chromosome 12 at 73,103,525 bp
  • G to T, chromosome 13 at 27,385,266 bp
  • T to G, chromosome 14 at 56,060,633 bp
  • T to A, chromosome 14 at 57,858,575 bp
  • A to G, chromosome 15 at 13,051,401 bp
  • T to A, chromosome 15 at 100,669,420 bp
  • T to C, chromosome 17 at 25,750,170 bp
  • T to C, chromosome 17 at 64,292,941 bp
  • C to T, chromosome 18 at 32,261,336 bp
  • A to T, chromosome 18 at 37,966,502 bp
  • G to A, chromosome 19 at 45,049,915 bp
  • C to T, chromosome 19 at 47,268,224 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6650 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044771-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.