Strain Name:
C57BL/6J-MtgxR6688Btlr/Mmmh
Stock Number:
044806-MU
Citation ID:
RRID:MMRRC_044806-MU
Other Names:
R6688 (G1)
Major Collection:

Strain Information

Plg
Name: plasminogen
Synonyms: Pg
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18815
VEGA: 17
HGNC: HGNC:9071
Homologene: 55452
Cwf19l2
Name: CWF19 like cell cycle control factor 2
Synonyms: 3230401L03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244672
Homologene: 12366
Rapgef2
Name: Rap guanine nucleotide exchange factor (GEF) 2
Synonyms: 5830453M24Rik, Pdzgef1, CNRasGEF, nRapGEP, RA-GEF-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76089
Homologene: 35477
Wasf1
Name: WASP family, member 1
Synonyms: Scar, WAVE-1, WAVE
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83767
Homologene: 2920
Golga4
Name: golgin A4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Dnttip1
Name: deoxynucleotidyltransferase, terminal, interacting protein 1
Synonyms: 6430706C13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76233
Homologene: 14189
Mdn1
Name: midasin AAA ATPase 1
Synonyms: 4833432B22Rik, LOC213784, D4Abb1e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Cep120
Name: centrosomal protein 120
Synonyms: Ccdc100
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225523
VEGA: 18
Homologene: 27415
Gm2381
Name: predicted gene 2381
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100039706
Tcf20
Name: transcription factor 20
Synonyms: 2810438H08Rik, SPBP, stromelysin 1 PDGF responsive element binding protein
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21411
VEGA: 15
Homologene: 4131
Tpst2
Name: protein-tyrosine sulfotransferase 2
Synonyms: grt, grm, Tango13b, D5Ucla3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22022
Homologene: 2666
Paxip1
Name: PAX interacting (with transcription-activation domain) protein 1
Synonyms: D5Ertd149e, PTIP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 55982
HGNC: HGNC:8624
Nop53
Name: NOP53 ribosome biogenesis factor
Synonyms: 9430097C02Rik, Gltscr2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68077
HGNC: HGNC:4333
Homologene: 44130
Zfp958
Name: zinc finger protein 958
Synonyms: BC003267
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 233987
Homologene: 129582
Cd22
Name: CD22 antigen
Synonyms: Lyb8, Lyb-8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12483
HGNC: HGNC:1643
Homologene: 31052
Cntnap5c
Name: contactin associated protein-like 5C
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 620292
VEGA: 17
Homologene: 128806
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: SM2, SM1, smMHC
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Zfp429
Name: zinc finger protein 429
Synonyms: 2810487A22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72807
Homologene: 110878
Kif5c
Name: kinesin family member 5C
Synonyms: Khc
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16574
HGNC: HGNC:6325
Homologene: 56234
Atxn1
Name: ataxin 1
Synonyms: 2900016G23Rik, Sca1, Atx1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20238
VEGA: 13
Homologene: 281
Ces2h
Name: carboxylesterase 2H
Synonyms: Gm5744
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 436059
HGNC: HGNC:1864
Homologene: 128645
Serpini2
Name: serine (or cysteine) peptidase inhibitor, clade I, member 2
Synonyms: 1810006A24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67931
HGNC: HGNC:8945
Homologene: 21248
Ip6k2
Name: inositol hexaphosphate kinase 2
Synonyms: Ihpk2, 1500005N04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76500
Homologene: 56929
Usp31
Name: ubiquitin specific peptidase 31
Synonyms: 6330567E21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76179
Homologene: 44504
Ces1g
Name: carboxylesterase 1G
Synonyms: Ses-1, Ces-1, Ces1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12623
HGNC: HGNC:1863
Homologene: 137354
Nherf4
Name: NHERF family PDZ scaffold protein 4
Synonyms: Pdzk2, sodium-phosphate cotransporter IIa C-terminal-associated protein 2, NaPi-Cap2, Pdzd3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 170761
VEGA: 9
Homologene: 11719
Stx1b
Name: syntaxin 1B
Synonyms: Stx1b2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56216
Homologene: 69375
Or1o1
Name: olfactory receptor family 1 subfamily O member 1
Synonyms: Olfr107, GA_x6K02T2PSCP-1867165-1868094, MOR156-3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258504
Homologene: 115498
Cyb5rl
Name: cytochrome b5 reductase-like
Synonyms: 2810410C14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230582
Homologene: 45506
Tmem252
Name: transmembrane protein 252
Synonyms: E030010A14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226040
VEGA: 19
Homologene: 17717
Psmb5
Name: proteasome (prosome, macropain) subunit, beta type 5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19173
VEGA: 14
HGNC: HGNC:9542
Homologene: 55690
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 2 at 49,688,737 bp
  • T to C, chromosome 2 at 164,765,161 bp
  • T to C, chromosome 3 at 75,259,563 bp
  • T to A, chromosome 3 at 79,069,128 bp
  • T to A, chromosome 4 at 32,774,041 bp
  • C to T, chromosome 4 at 107,073,905 bp
  • T to C, chromosome 5 at 27,744,137 bp
  • A to G, chromosome 5 at 112,307,757 bp
  • A to G, chromosome 7 at 15,945,854 bp
  • A to C, chromosome 7 at 30,872,964 bp
  • G to A, chromosome 7 at 42,820,586 bp
  • T to C, chromosome 7 at 121,678,330 bp
  • C to T, chromosome 7 at 127,807,896 bp
  • A to G, chromosome 8 at 4,628,940 bp
  • G to A, chromosome 8 at 93,306,972 bp
  • A to G, chromosome 8 at 105,017,840 bp
  • T to C, chromosome 9 at 3,450,015 bp
  • C to T, chromosome 9 at 44,248,230 bp
  • C to A, chromosome 9 at 108,806,011 bp
  • A to G, chromosome 9 at 118,514,210 bp
  • T to C, chromosome 10 at 40,926,620 bp
  • A to T, chromosome 13 at 45,567,671 bp
  • A to T, chromosome 13 at 67,396,130 bp
  • C to A, chromosome 14 at 54,616,673 bp
  • A to G, chromosome 15 at 82,854,535 bp
  • A to G, chromosome 16 at 14,205,553 bp
  • A to T, chromosome 17 at 12,391,845 bp
  • G to A, chromosome 17 at 37,405,905 bp
  • T to A, chromosome 17 at 58,293,904 bp
  • G to A, chromosome 18 at 53,724,536 bp
  • G to A, chromosome 19 at 24,674,099 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6688 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044806-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.