Strain Name:
C57BL/6J-MtgxR6709Btlr/Mmmh
Stock Number:
044827-MU
Citation ID:
RRID:MMRRC_044827-MU
Other Names:
R6709 (G1)
Major Collection:

Strain Information

Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Adgre1
Name: adhesion G protein-coupled receptor E1
Synonyms: DD7A5-7, F4/80, EGF-TM7, Emr1, TM7LN3, Ly71
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13733
VEGA: 17
HGNC: HGNC:3336
Homologene: 1493
Etv1
Name: ets variant 1
Synonyms: Etsrp81, ER81
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14009
HGNC: HGNC:3490
Homologene: 3636
Fgd4
Name: FYVE, RhoGEF and PH domain containing 4
Synonyms: 9330209B17Rik, Frabin-gamma, Frabin, Frabin-beta, ZFYVE6, Frabin-alpha
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224014
Homologene: 26727
Slc25a13
Name: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
Synonyms: Ctrn, citrin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50799
Homologene: 22800
Usp25
Name: ubiquitin specific peptidase 25
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 30940
VEGA: 16
Homologene: 8374
Fam133b
Name: family with sequence similarity 133, member B
Synonyms: 5830415L20Rik, 2900022K02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68152
Homologene: 85443
Ints8
Name: integrator complex subunit 8
Synonyms: 2810013E07Rik, D130008D20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72656
Homologene: 9888
Actn1
Name: actinin, alpha 1
Synonyms: 3110023F10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109711
VEGA: 12
HGNC: HGNC:163
Homologene: 55553
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: Ssfa2, CS1, CS-1, SPAG13, KRAP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70599
Homologene: 4912
Slc33a1
Name: solute carrier family 33 (acetyl-CoA transporter), member 1
Synonyms: Acatn, D630022N01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11416
HGNC: HGNC:95
Homologene: 3476
L3mbtl3
Name: L3MBTL3 histone methyl-lysine binding protein
Synonyms: MBT-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237339
Homologene: 18226
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: Zfp650, 1110059H15Rik, A130030D10Rik, 4833421P10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Pwwp2a
Name: PWWP domain containing 2A
Synonyms: 4631424J17Rik, D930040F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70802
Homologene: 19687
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Plxna2
Name: plexin A2
Synonyms: Plxn2, 2810428A13Rik, OCT, PlexA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Sv2b
Name: synaptic vesicle glycoprotein 2b
Synonyms: A830038F04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64176
Homologene: 32236
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: Dpde3, 9630011N22Rik, dunce
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Myo7a
Name: myosin VIIA
Synonyms: Myo7, polka, USH1B, nmf371, Hdb
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: IDPm, Idh-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Sox6
Name: SRY (sex determining region Y)-box 6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20679
Homologene: 22631
Slc45a2
Name: solute carrier family 45, member 2
Synonyms: Matp, bls, Aim1, Dbr, blanc-sale, Oca4, Aim-1, dominant brown
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22293
Homologene: 9412
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTP-BL, PTPL1, Ptpri
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Hdhc3, HL19, LOC380889, Dnahc7l, DLP12, Dnahc12, 4921531P07Rik, DHC3, HL-19
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: SM2, smMHC, SM1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Trp53i11
Name: transformation related protein 53 inducible protein 11
Synonyms: Tp53i11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277414
Homologene: 4404
Olfm2
Name: olfactomedin 2
Synonyms: A030009A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244723
VEGA: 9
Homologene: 14380
Galnt11
Name: polypeptide N-acetylgalactosaminyltransferase 11
Synonyms: E430002F06Rik, A430075I06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231050
Homologene: 11126
Slc4a11
Name: solute carrier family 4, sodium bicarbonate transporter-like, member 11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269356
Homologene: 12931
Col19a1
Name: collagen, type XIX, alpha 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12823
HGNC: HGNC:2196
Homologene: 55608
Htra1
Name: HtrA serine peptidase 1
Synonyms: RSPP11, Prss11, L56, HtrA1, insulin-like growth factor binding protein 5 protease
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56213
HGNC: HGNC:9476
Homologene: 31114
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: b2b1735Clo, prh, b2b2025.1Clo, D3Ertd789e, 4921507O14Rik, b2b1304Clo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 51938
Homologene: 12149
Zfp14
Name: zinc finger protein 14
Synonyms: Zfp-14, Krox-9, 4732429I09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243906
Homologene: 45619
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243961
Homologene: 22949
Trim10
Name: tripartite motif-containing 10
Synonyms: Rnf9, Herf1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19824
Homologene: 4932
Gm136
Name: predicted gene 136
Synonyms: LOC214568
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214568
Homologene: 79759
Actl6b
Name: actin-like 6B
Synonyms: ArpNa, Actl6, Baf53b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83766
HGNC: HGNC:160
Homologene: 81844
Mlxip
Name: MLX interacting protein
Synonyms: Mondoa, Mir, bHLHe36
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208104
Homologene: 22851
Agbl4
Name: ATP/GTP binding protein-like 4
Synonyms: 4930578N11Rik, 4931433A01Rik, Ccp6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 78933
Homologene: 84880
Mpz
Name: myelin protein zero
Synonyms: P0, Mpp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17528
HGNC: HGNC:7225
Homologene: 445
Dcpp3
Name: demilune cell and parotid protein 3
Synonyms: EG620253
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 620253
VEGA: 17
Homologene: 103921
Cyp3a44
Name: cytochrome P450, family 3, subfamily a, polypeptide 44
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 337924
HGNC: HGNC:2638
Homologene: 133568
Trdn
Name: triadin
Synonyms: triadin-2, triadin 2, triadin-3, triadin 3, triadin 1, 2310045H21Rik, triadin-1, EG432451
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76757
VEGA: 10
Homologene: 38137
Or2t47
Name: olfactory receptor family 2 subfamily T member 47
Synonyms: Olfr328, GA_x6K02T2NKPP-873285-874217, MOR275-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258495
Homologene: 133015
Or6s1
Name: olfactory receptor family 6 subfamily S member 1
Synonyms: MOR103-18, Olfr750, GA_x6K02T2PMLR-6808276-6807281
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 404319
Homologene: 19719
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330581
Homologene: 115466
Csnka2ip
Name: casein kinase 2, alpha prime interacting protein
Synonyms: Ckt2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224291
Homologene: 77570
Reep2
Name: receptor accessory protein 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225362
VEGA: 18
Homologene: 41146
Atg4d
Name: autophagy related 4D, cysteine peptidase
Synonyms: APG4-D, 9830134P12Rik, Apg4d, Autl4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235040
VEGA: 9
Homologene: 13156
Eepd1
Name: endonuclease/exonuclease/phosphatase family domain containing 1
Synonyms: 2310005P05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67484
Homologene: 12144
Gm5591
Name: predicted gene 5591
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434171
Homologene: 80005
Syngr4
Name: synaptogyrin 4
Synonyms: 1700016O14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 58867
Homologene: 8258
Vmn2r42
Name: vomeronasal 2, receptor 42
Synonyms: V2r4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22310
Homologene: 113703
H1f9
Name: H1.9 linker histone
Synonyms: Hils1, TISP64
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54388
Homologene: 56818
Ltb4r2
Name: leukotriene B4 receptor 2
Synonyms: 5830462O07Rik, BLT2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57260
VEGA: 14
Homologene: 10519
Gm17409
Name: predicted gene, 17409
Type: Gene
Species: Mouse
Chromosome: 2
Tmem185b
Name: transmembrane protein 185B
Synonyms: 2500001K11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226351
Homologene: 15760
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 24,282,496 bp
  • G to A, chromosome 1 at 119,526,874 bp
  • A to T, chromosome 1 at 171,150,732 bp
  • T to A, chromosome 1 at 194,789,766 bp
  • A to T, chromosome 2 at 58,471,076 bp
  • C to A, chromosome 2 at 70,013,092 bp
  • A to G, chromosome 2 at 79,644,932 bp
  • A to T, chromosome 2 at 93,199,818 bp
  • A to T, chromosome 2 at 130,684,696 bp
  • T to C, chromosome 3 at 33,830,093 bp
  • C to A, chromosome 3 at 63,944,701 bp
  • A to T, chromosome 4 at 11,221,117 bp
  • T to A, chromosome 4 at 34,755,884 bp
  • T to A, chromosome 4 at 111,566,782 bp
  • T to C, chromosome 5 at 3,569,059 bp
  • C to T, chromosome 5 at 25,248,853 bp
  • A to C, chromosome 5 at 103,586,756 bp
  • A to T, chromosome 5 at 123,447,276 bp
  • A to G, chromosome 5 at 137,554,517 bp
  • A to T, chromosome 5 at 145,778,092 bp
  • A to G, chromosome 6 at 6,073,440 bp
  • T to A, chromosome 7 at 8,192,619 bp
  • A to G, chromosome 7 at 19,206,211 bp
  • T to C, chromosome 7 at 25,529,837 bp
  • T to C, chromosome 7 at 30,038,132 bp
  • A to G, chromosome 7 at 38,522,075 bp
  • A to T, chromosome 7 at 44,354,176 bp
  • A to G, chromosome 7 at 45,888,698 bp
  • A to T, chromosome 7 at 75,124,139 bp
  • TCCCAGG to T, chromosome 7 at 80,098,331 bp
  • T to C, chromosome 7 at 85,411,861 bp
  • A to G, chromosome 7 at 98,054,699 bp
  • T to C, chromosome 7 at 115,701,789 bp
  • C to T, chromosome 7 at 130,936,218 bp
  • A to G, chromosome 9 at 20,672,713 bp
  • T to C, chromosome 9 at 21,268,648 bp
  • A to T, chromosome 9 at 25,482,868 bp
  • G to A, chromosome 10 at 26,282,797 bp
  • A to G, chromosome 10 at 33,464,591 bp
  • C to G, chromosome 11 at 43,704,727 bp
  • T to C, chromosome 11 at 58,552,036 bp
  • T to A, chromosome 11 at 94,967,946 bp
  • C to T, chromosome 12 at 38,783,797 bp
  • T to A, chromosome 12 at 80,193,644 bp
  • T to G, chromosome 13 at 109,948,279 bp
  • A to G, chromosome 14 at 26,872,749 bp
  • A to T, chromosome 14 at 51,070,829 bp
  • A to C, chromosome 14 at 55,762,533 bp
  • A to G, chromosome 15 at 11,001,130 bp
  • A to G, chromosome 16 at 14,223,494 bp
  • T to C, chromosome 16 at 16,484,481 bp
  • A to T, chromosome 16 at 64,478,569 bp
  • A to C, chromosome 16 at 77,083,932 bp
  • AGGCCATGCTGGCC to AGGCC, chromosome 17 at 23,917,598 bp
  • T to A, chromosome 17 at 36,872,370 bp
  • A to T, chromosome 17 at 57,406,917 bp
  • T to C, chromosome 18 at 34,846,210 bp
  • G to A, chromosome 19 at 5,747,857 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6709 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044827-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.