Strain Name:
C57BL/6J-MtgxR6710Btlr/Mmmh
Stock Number:
044828-MU
Citation ID:
RRID:MMRRC_044828-MU
Other Names:
R6710 (G1)
Major Collection:

Strain Information

Ash2l
Name: ASH2 like histone lysine methyltransferase complex subunit
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23808
HGNC: HGNC:744
Homologene: 3436
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70699
Homologene: 45971
Plcg2
Name: phospholipase C, gamma 2
Synonyms: PLCgamma2, Plcg-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234779
HGNC: HGNC:9066
Homologene: 55671
Sem1
Name: SEM1, 26S proteasome complex subunit
Synonyms: Shfm1, Shfdg1, Shfg, DSS1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20422
Homologene: 38165
Ifnar2
Name: interferon (alpha and beta) receptor 2
Synonyms: Ifnar-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15976
HGNC: HGNC:5433
Homologene: 49242
Tap1
Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms: Ham1, Ham-1, Tap-1, RING4, Abcb2, PSF-1, MTP1, TAP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21354
HGNC: HGNC:43
Homologene: 495
Aph1c
Name: aph1 homolog C, gamma secretase subunit
Synonyms: 0610008A10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68318
Homologene: 134745
Erfe
Name: erythroferrone
Synonyms: myonectin, Fam132b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227358
Homologene: 87245
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Marchf11
Name: membrane associated ring-CH-type finger 11
Synonyms: March11
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 211147
Homologene: 45584
Tmem26
Name: transmembrane protein 26
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327766
VEGA: 10
Homologene: 14428
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627636
Homologene: 115024
Or7e175
Name: olfactory receptor family 7 subfamily E member 175
Synonyms: Olfr869, MOR145-6, GA_x6K02T2PVTD-13878275-13879204
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258550
HGNC: HGNC:8396
Homologene: 138312
Drc1
Name: dynein regulatory complex subunit 1
Synonyms: b2b1654Clo, Ccdc164, Gm1060, LOC381738
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381738
Homologene: 35977
1700113H08Rik
Name: RIKEN cDNA 1700113H08 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76640
Homologene: 45695
Cela2a
Name: chymotrypsin-like elastase family, member 2A
Synonyms: Ela-2, Ela2, Ela2a
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13706
Homologene: 40598
Pcdhb17
Name: protocadherin beta 17
Synonyms: PcdhbQ, Pcdhb16
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93888
Homologene: 81881
Dcpp3
Name: demilune cell and parotid protein 3
Synonyms: EG620253
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 620253
VEGA: 17
Homologene: 103921
Or2h1
Name: olfactory receptor family 2 subfamily H member 1
Synonyms: Olfr91, GA_x6K02T2PSCP-1533927-1532989, MOR256-20
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258470
HGNC: HGNC:8252
Homologene: 72346
Zfp174
Name: zinc finger protein 174
Synonyms: LOC385674
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385674
Homologene: 55755
Zbtb39
Name: zinc finger and BTB domain containing 39
Synonyms: 7030401O21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320080
VEGA: 10
Homologene: 8890
Epn1
Name: epsin 1
Synonyms: Ibp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13854
Homologene: 32172
Nit2
Name: nitrilase family, member 2
Synonyms: 1190017B19Rik, D16Ertd502e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 52633
VEGA: 16
Homologene: 6520
Utp3
Name: UTP3 small subunit processome component
Synonyms: Crlz1, 2400011K09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 65961
Homologene: 10681
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 91,372,406 bp
  • C to A, chromosome 4 at 141,822,243 bp
  • A to G, chromosome 5 at 30,363,085 bp
  • T to C, chromosome 5 at 88,555,964 bp
  • C to A, chromosome 6 at 6,578,497 bp
  • T to G, chromosome 6 at 35,247,373 bp
  • A to G, chromosome 7 at 5,097,304 bp
  • T to C, chromosome 8 at 25,819,712 bp
  • A to G, chromosome 8 at 117,557,347 bp
  • A to T, chromosome 9 at 18,642,070 bp
  • C to T, chromosome 9 at 20,138,082 bp
  • T to C, chromosome 9 at 66,834,520 bp
  • T to C, chromosome 10 at 68,724,054 bp
  • G to T, chromosome 10 at 87,226,061 bp
  • T to A, chromosome 10 at 127,743,636 bp
  • A to G, chromosome 15 at 26,387,863 bp
  • A to G, chromosome 16 at 3,848,057 bp
  • A to G, chromosome 16 at 57,160,130 bp
  • T to C, chromosome 16 at 91,393,883 bp
  • T to A, chromosome 17 at 19,811,977 bp
  • AGGCCATGCTGGCC to AGGCC, chromosome 17 at 23,917,598 bp
  • C to T, chromosome 17 at 34,188,109 bp
  • T to G, chromosome 17 at 37,093,746 bp
  • T to C, chromosome 18 at 37,485,399 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6710 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044828-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.