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Strain Name:
C57BL/6J-MtgxR6720Btlr/Mmmh
Stock Number:
044838-MU
Citation ID:
RRID:MMRRC_044838-MU
Other Names:
R6720 (G1)
Major Collection:

Strain Information

Gria2
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: GluR-B, GluR2, Glur-2, Glur2, GluA2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14800
HGNC: HGNC:4572
Homologene: 20225
Chrm1
Name: cholinergic receptor, muscarinic 1, CNS
Synonyms: M1, muscarinic acetylcholine receptor 1, Chrm-1, M1R, AW495047
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12669
HGNC: HGNC:1950
Homologene: 20189
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: eIF4GII, 1500002J22Rik, 4930523M17Rik, G1-419-52, repro8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Parvb
Name: parvin, beta
Synonyms: D15Gsk1, affixin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170736
Homologene: 8342
Eftud2
Name: elongation factor Tu GTP binding domain containing 2
Synonyms: U5-116kD, 116kDa, Snrp116
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20624
Homologene: 3133
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 5730455C01Rik, 9130215G10Rik, 5730555F13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66660
VEGA: 9
Homologene: 11696
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 62,159,470 bp
  • A to C, chromosome 1 at 63,058,610 bp
  • A to G, chromosome 1 at 78,472,497 bp
  • T to C, chromosome 1 at 94,041,389 bp
  • A to G, chromosome 1 at 106,994,062 bp
  • T to C, chromosome 1 at 195,155,200 bp
  • T to A, chromosome 2 at 32,905,826 bp
  • G to T, chromosome 2 at 59,924,890 bp
  • A to G, chromosome 2 at 86,315,065 bp
  • T to A, chromosome 2 at 152,932,720 bp
  • T to C, chromosome 3 at 80,802,304 bp
  • T to G, chromosome 3 at 98,877,135 bp
  • T to A, chromosome 4 at 47,247,552 bp
  • A to C, chromosome 4 at 53,083,733 bp
  • T to G, chromosome 4 at 83,013,832 bp
  • T to C, chromosome 4 at 136,657,502 bp
  • G to A, chromosome 4 at 137,454,686 bp
  • T to A, chromosome 4 at 138,175,832 bp
  • T to A, chromosome 4 at 145,536,927 bp
  • C to T, chromosome 5 at 121,307,381 bp
  • C to A, chromosome 5 at 145,101,222 bp
  • A to G, chromosome 7 at 30,554,347 bp
  • A to T, chromosome 7 at 45,540,886 bp
  • G to A, chromosome 8 at 35,807,576 bp
  • A to G, chromosome 8 at 62,000,689 bp
  • A to G, chromosome 8 at 95,365,314 bp
  • A to T, chromosome 8 at 104,836,869 bp
  • T to A, chromosome 9 at 38,143,153 bp
  • A to G, chromosome 9 at 57,614,072 bp
  • T to G, chromosome 9 at 70,573,710 bp
  • T to C, chromosome 10 at 18,140,264 bp
  • A to G, chromosome 10 at 92,821,119 bp
  • A to G, chromosome 11 at 52,144,693 bp
  • A to G, chromosome 11 at 73,965,465 bp
  • C to A, chromosome 11 at 96,366,987 bp
  • G to A, chromosome 11 at 102,838,623 bp
  • T to A, chromosome 12 at 113,578,506 bp
  • A to G, chromosome 12 at 118,045,646 bp
  • T to A, chromosome 13 at 42,164,284 bp
  • T to C, chromosome 13 at 67,071,432 bp
  • T to C, chromosome 13 at 73,618,516 bp
  • T to C, chromosome 13 at 100,423,077 bp
  • T to A, chromosome 14 at 44,102,959 bp
  • C to T, chromosome 15 at 84,297,979 bp
  • G to T, chromosome 16 at 17,326,052 bp
  • T to A, chromosome 17 at 34,030,108 bp
  • A to G, chromosome 17 at 35,442,678 bp
  • T to C, chromosome 18 at 36,998,069 bp
  • A to G, chromosome 19 at 8,678,548 bp
  • T to A, chromosome 19 at 10,794,609 bp
  • A to G, chromosome 19 at 43,736,789 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6720 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044838-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.