Strain Name:
C57BL/6J-MtgxR6724Btlr/Mmmh
Stock Number:
044842-MU
Citation ID:
RRID:MMRRC_044842-MU
Other Names:
R6724 (G1)
Major Collection:

Strain Information

Gabrg1
Name: gamma-aminobutyric acid type A receptor subunit gamma 1
Synonyms: GabaA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14405
HGNC: HGNC:4086
Homologene: 22570
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224273
Homologene: 28544
Top1
Name: topoisomerase (DNA) I
Synonyms: Top-1, D130064I21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21969
Homologene: 2467
Dtnb
Name: dystrobrevin, beta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13528
HGNC: HGNC:3058
Homologene: 74875
Ppp2r3c
Name: protein phosphatase 2, regulatory subunit B'', gamma
Synonyms: 5730412A08Rik, G5pr, 4930511A21Rik, G4-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 59032
VEGA: 12
Homologene: 9915
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: Gcn1l1, GCN1L, G431004K08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Ercc6
Name: excision repair cross-complementing rodent repair deficiency, complementation group 6
Synonyms: CS group B correcting gene, CSB, C130058G22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319955
VEGA: 14
HGNC: HGNC:3438
Homologene: 133552
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Blmh
Name: bleomycin hydrolase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104184
HGNC: HGNC:1059
Homologene: 330
Npepps
Name: aminopeptidase puromycin sensitive
Synonyms: MP100, Psa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19155
HGNC: HGNC:7900
Homologene: 36199
Fip1l1
Name: factor interacting with PAPOLA and CPSF1
Synonyms: 1300019H17Rik, Rje
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66899
Homologene: 136254
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: Cd, skam26Jus, skax26, ska26
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Pvr
Name: poliovirus receptor
Synonyms: mE4, D7Ertd458e, 3830421F03Rik, necl-5, CD155, Tage4, Taa1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52118
HGNC: HGNC:9705
Homologene: 79541
Ipo8
Name: importin 8
Synonyms: Ranbp8, Om1, 6230418K12Rik, OM-1, C130009K11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320727
HGNC: HGNC:9853
Homologene: 48430
Cftr
Name: cystic fibrosis transmembrane conductance regulator
Synonyms: Abcc7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12638
HGNC: HGNC:1884
Homologene: 55465
Ptprj
Name: protein tyrosine phosphatase receptor type J
Synonyms: Scc-1, Byp, CD148, DEP-1, Scc1, RPTPJ
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19271
HGNC: HGNC:9673
Homologene: 2130
Pus10
Name: pseudouridylate synthase 10
Synonyms: 2810013G11Rik, 4933435A13Rik, Ccdc139
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74467
Homologene: 12566
Cnr1
Name: cannabinoid receptor 1
Synonyms: CB1R, CB1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12801
HGNC: HGNC:2159
Homologene: 7273
Kifc1
Name: kinesin family member C1
Synonyms: Kifc5a, Knsl2a, HSET, KNSL2, Tctex7, Tctex-7, Gm4137, kinesin family c-terminal 5A, Tctex7a, Tctex-7A
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100502766
HGNC: HGNC:6389
Homologene: 83229
Isl2
Name: insulin related protein 2 (islet 2)
Synonyms: 3110001N10Rik, islet-2, islet 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 104360
Homologene: 10730
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: perlecan, per, Pcn, Plc
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Man2a1
Name: mannosidase 2, alpha 1
Synonyms: Mana-2, Mana2, Map-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17158
HGNC: HGNC:6824
Homologene: 1777
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Yme1l1
Name: YME1-like 1 (S. cerevisiae)
Synonyms: Ftsh, ATP-dependent metalloprotease FtsH1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27377
Homologene: 31996
Wdr6
Name: WD repeat domain 6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83669
Homologene: 117682
Tpcn2
Name: two pore segment channel 2
Synonyms: D830047E22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233979
Homologene: 16375
Vwa3b
Name: von Willebrand factor A domain containing 3B
Synonyms: A230074B11Rik, 4921511C04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70853
Homologene: 27053
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: HL19, Hdhc3, Dnahc12, HL-19, LOC380889, DHC3, Dnahc7l, 4921531P07Rik, DLP12
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Unc80
Name: unc-80, NALCN activator
Synonyms: C030018G13Rik, C230061B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Vinac1
Name: vinculin/alpha-catenin family member 1
Synonyms: Gm14025
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668894
Homologene: 86340
Rubcnl
Name: RUN and cysteine rich domain containing beclin 1 interacting protein like
Synonyms: 5031414D18Rik, LOC380917
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271221
VEGA: 14
Homologene: 57021
Nalcn
Name: sodium leak channel, non-selective
Synonyms: Vgcnl1, A530023G15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Hoxa7
Name: homeobox A7
Synonyms: Hox-1.1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15404
HGNC: HGNC:5108
Homologene: 56001
Slc22a26
Name: solute carrier family 22 (organic cation transporter), member 26
Synonyms: BC014805
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 236149
Vmn2r78
Name: vomeronasal 2, receptor 78
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637896
Homologene: 115466
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: LOC235639, C030048J01Rik, Lba1, A230061D21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320429
Homologene: 45845
Tril
Name: TLR4 interactor with leucine-rich repeats
Synonyms: 1200009O22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66873
Homologene: 69404
Or4a72
Name: olfactory receptor family 4 subfamily A member 72
Synonyms: GA_x6K02T2Q125-51020951-51020028, MOR231-12, Olfr1245
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258784
Homologene: 121560
Unc79
Name: unc-79 homolog
Synonyms: Mlca3, 9030205A07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Or8u10
Name: olfactory receptor family 8 subfamily U member 10
Synonyms: GA_x6K02T2Q125-47560740-47559775, MOR256-34P, Olfr1037, MOR171-52
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259151
Homologene: 66572
Guf1
Name: GUF1 homolog, GTPase
Synonyms: mtEF4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231279
Homologene: 6505
Serpina1a
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1A
Synonyms: Spi1-1, Aat2, Aat-2, PI1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20700
HGNC: HGNC:8941
Homologene: 20103
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Alox5
Name: arachidonate 5-lipoxygenase
Synonyms: 5LX, 5LO, 5-LOX
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11689
HGNC: HGNC:435
Homologene: 561
Kcnb2
Name: potassium voltage gated channel, Shab-related subfamily, member 2
Synonyms: 9630047L19Rik, Kv2.2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98741
HGNC: HGNC:6232
Homologene: 31263
Pkn3
Name: protein kinase N3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 263803
Homologene: 50980
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58234
Homologene: 75163
Klra5
Name: killer cell lectin-like receptor, subfamily A, member 5
Synonyms: Ly49e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16636
Homologene: 110821
Vmn1r81
Name: vomeronasal 1 receptor 81
Synonyms: V1rg9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171244
Homologene: 74327
Slc22a22
Name: solute carrier family 22 (organic cation transporter), member 22
Synonyms: BC026439, OAT-PG
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210463
Homologene: 18166
Klhdc10
Name: kelch domain containing 10
Synonyms: 2410127E18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76788
Homologene: 15267
Mrgpra9
Name: MAS-related GPR, member A9
Synonyms: EG668725, MrgA9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668725
Homologene: 79615
Adamts5
Name: ADAM metallopeptidase with thrombospondin type 1 motif 5
Synonyms: 9530092O11Rik, ADAM-TS5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 23794
VEGA: 16
HGNC: HGNC:221
Homologene: 5109
Or9m1
Name: olfactory receptor family 9 subfamily M member 1
Synonyms: GA_x6K02T2Q125-49403456-49402524, Olfr1154, MOR173-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258641
Homologene: 74192
Dnajb12
Name: DnaJ heat shock protein family (Hsp40) member B12
Synonyms: mDj10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56709
Homologene: 9749
Semp2l2a
Name: SUMO/sentrin specific peptidase 2-like 2A
Synonyms: AF366264
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 231201
Homologene: 130042
Maml3
Name: mastermind like transcriptional coactivator 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433586
Homologene: 41284
Adgra2
Name: adhesion G protein-coupled receptor A2
Synonyms: 8430414O08Rik, Gpr124, 9530074E10Rik, Tem5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78560
Homologene: 13112
Plekha3
Name: pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3
Synonyms: FAPP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 83435
Homologene: 10417
Spz1
Name: spermatogenic leucine zipper 1
Synonyms: 1700027M20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 79401
VEGA: 13
Homologene: 49934
Gm11011
Name: predicted gene 11011
Type: Gene
Species: Mouse
Chromosome: 2
Gm13762
Name: predicted gene 13762
Type: Gene
Species: Mouse
Chromosome: 2
Eif1ad6
Name: eukaryotic translation initiation factor 1A domain containing 6
Synonyms: Gm4027
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100042776
Homologene: 103865
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 15,710,440 bp
  • G to A, chromosome 1 at 37,045,031 bp
  • C to T, chromosome 1 at 66,683,191 bp
  • T to C, chromosome 1 at 90,779,152 bp
  • C to T, chromosome 2 at 23,194,762 bp
  • C to A, chromosome 2 at 30,090,550 bp
  • T to A, chromosome 2 at 76,687,401 bp
  • A to T, chromosome 2 at 86,085,357 bp
  • T to G, chromosome 2 at 87,903,602 bp
  • T to G, chromosome 2 at 88,973,268 bp
  • A to T, chromosome 2 at 89,574,965 bp
  • T to C, chromosome 2 at 90,450,851 bp
  • A to C, chromosome 2 at 129,038,056 bp
  • G to A, chromosome 2 at 160,712,696 bp
  • T to A, chromosome 2 at 169,587,482 bp
  • T to C, chromosome 3 at 51,855,875 bp
  • T to A, chromosome 4 at 33,944,728 bp
  • A to G, chromosome 4 at 128,563,371 bp
  • G to A, chromosome 4 at 137,515,307 bp
  • C to A, chromosome 5 at 69,566,393 bp
  • T to A, chromosome 5 at 70,754,209 bp
  • T to G, chromosome 5 at 74,591,774 bp
  • T to G, chromosome 5 at 115,609,158 bp
  • T to A, chromosome 6 at 18,255,974 bp
  • A to G, chromosome 6 at 30,446,641 bp
  • T to C, chromosome 6 at 52,215,739 bp
  • T to A, chromosome 6 at 53,819,574 bp
  • A to T, chromosome 6 at 116,414,548 bp
  • T to A, chromosome 6 at 129,906,680 bp
  • T to C, chromosome 6 at 134,486,541 bp
  • A to T, chromosome 6 at 148,809,975 bp
  • A to T, chromosome 7 at 12,260,672 bp
  • T to C, chromosome 7 at 19,918,679 bp
  • A to G, chromosome 7 at 47,235,038 bp
  • A to T, chromosome 7 at 86,954,258 bp
  • A to G, chromosome 7 at 130,728,762 bp
  • G to A, chromosome 7 at 145,256,520 bp
  • A to T, chromosome 8 at 13,837,083 bp
  • G to A, chromosome 8 at 27,114,182 bp
  • A to G, chromosome 9 at 55,541,288 bp
  • G to A, chromosome 9 at 108,574,894 bp
  • C to G, chromosome 9 at 111,365,916 bp
  • A to G, chromosome 10 at 59,892,780 bp
  • T to C, chromosome 11 at 23,729,037 bp
  • A to G, chromosome 11 at 76,971,907 bp
  • A to T, chromosome 11 at 97,206,002 bp
  • T to A, chromosome 12 at 3,686,817 bp
  • A to T, chromosome 12 at 55,288,496 bp
  • A to T, chromosome 12 at 87,621,984 bp
  • C to T, chromosome 12 at 103,104,861 bp
  • G to T, chromosome 12 at 103,860,420 bp
  • A to T, chromosome 13 at 92,575,484 bp
  • A to T, chromosome 14 at 26,796,223 bp
  • A to T, chromosome 14 at 32,566,331 bp
  • A to G, chromosome 14 at 75,052,010 bp
  • A to G, chromosome 14 at 123,298,067 bp
  • C to T, chromosome 15 at 57,247,532 bp
  • G to A, chromosome 15 at 89,532,453 bp
  • A to T, chromosome 16 at 59,544,138 bp
  • T to A, chromosome 16 at 85,868,557 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • T to A, chromosome 17 at 33,886,733 bp
  • A to G, chromosome 17 at 64,731,269 bp
  • A to G, chromosome 19 at 7,802,361 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6724 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044842-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.