Strain Name:
C57BL/6J-MtgxR6759Btlr/Mmmh
Stock Number:
044875-MU
Citation ID:
RRID:MMRRC_044875-MU
Other Names:
R6759 (G1)
Major Collection:

Strain Information

Wwp2
Name: WW domain containing E3 ubiquitin protein ligase 2
Synonyms: 1300010O06Rik, AIP2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66894
Homologene: 48490
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Tex21
Name: testis expressed gene 21
Synonyms: 4931406F04Rik, tsec-2, 4931412D23Rik, 4931421K24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 80384
VEGA: 12
Homologene: 10510
Strn4
Name: striatin, calmodulin binding protein 4
Synonyms: ZIN, zinedin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 97387
Homologene: 8378
Dock5
Name: dedicator of cytokinesis 5
Synonyms: lr2, 1110060D06Rik, rlc
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68813
VEGA: 14
Homologene: 57016
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: 4932438A13Rik, FSA, Tweek
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Jam3
Name: junction adhesion molecule 3
Synonyms: JAM-3, 1110002N23Rik, JAM-C, Jcam3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83964
Homologene: 11338
Parp4
Name: poly (ADP-ribose) polymerase family, member 4
Synonyms: VPARP, PH5P, C030027K23Rik, p193, E230037B21Rik, Adprtl1, VAULT3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328417
HGNC: HGNC:271
Homologene: 124423
Dact1
Name: dishevelled-binding antagonist of beta-catenin 1
Synonyms: Frd1, Frodo, THYEX3, Frodo1, Dapper1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 59036
Homologene: 9613
Rrp1b
Name: ribosomal RNA processing 1B
Synonyms: 2600005C20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72462
Homologene: 57086
Mcm3ap
Name: minichromosome maintenance complex component 3 associated protein
Synonyms: GANP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54387
VEGA: 10
HGNC: HGNC:6946
Homologene: 2902
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Cacng3
Name: calcium channel, voltage-dependent, gamma subunit 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54376
HGNC: HGNC:1407
Homologene: 4767
Anxa2
Name: annexin A2
Synonyms: Cal1h, annexin II, lipocortin II, 36-kDa calelectrin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12306
Homologene: 20857
Uty
Name: ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Synonyms: Hydb
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 22290
Man2a1
Name: mannosidase 2, alpha 1
Synonyms: Mana-2, Mana2, Map-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17158
HGNC: HGNC:6824
Homologene: 1777
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Aak1
Name: AP2 associated kinase 1
Synonyms: 5530400K14Rik, D6Ertd245e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269774
Homologene: 128746
2900026A02Rik
Name: RIKEN cDNA 2900026A02 gene
Synonyms: Gm449, LOC231620
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243219
Homologene: 129566
Apip
Name: APAF1 interacting protein
Synonyms: CGI-29, Mmrp19, APIP2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56369
Homologene: 6277
Cnot3
Name: CCR4-NOT transcription complex, subunit 3
Synonyms: A930039N10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232791
HGNC: HGNC:7879
Homologene: 133900
Usp37
Name: ubiquitin specific peptidase 37
Synonyms: 4932415L06Rik, C330008N13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319651
Homologene: 10858
St3gal1
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Synonyms: CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase, ST3GalI, Siat4, Siat4a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20442
VEGA: 15
Homologene: 7540
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: FIC1, Ic
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 1200017A24Rik, 5830472H07Rik, A130095G14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Enam
Name: enamelin
Synonyms: abte
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13801
HGNC: HGNC:3344
Homologene: 9698
Nobox
Name: NOBOX oogenesis homeobox
Synonyms: Og2x
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18291
Homologene: 51066
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: Ptpri, PTPL1, PTP-BL
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Clk4
Name: CDC like kinase 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12750
Homologene: 56895
Efr3b
Name: EFR3 homolog B
Synonyms: C030014M07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668212
VEGA: 12
Homologene: 66195
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Fgl2
Name: fibrinogen-like protein 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14190
HGNC: HGNC:3696
Homologene: 4864
Acnat2
Name: acyl-coenzyme A amino acid N-acyltransferase 2
Synonyms: C730036D15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 209186
Homologene: 28287
4933427I04Rik
Name: Riken cDNA 4933427I04 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 115489902
VEGA: 4
Aldh3a2
Name: aldehyde dehydrogenase family 3, subfamily A2
Synonyms: Aldh4-r, Ahd3-r, Ahd3, Ahd-3, FALDH, Ahd-3r, Aldh4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11671
HGNC: HGNC:403
Homologene: 55458
Gfra3
Name: glial cell line derived neurotrophic factor family receptor alpha 3
Synonyms: GFRalpha3, GFR alpha-3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14587
VEGA: 18
HGNC: HGNC:4245
Homologene: 1146
Aldh1a7
Name: aldehyde dehydrogenase family 1, subfamily A7
Synonyms: Aldh-pb, Ahd2-like
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26358
HGNC: HGNC:402
Homologene: 137245
Rad51ap2
Name: RAD51 associated protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209550
VEGA: 12
Homologene: 85245
Or2ag12
Name: olfactory receptor family 2 subfamily AG member 12
Synonyms: Olfr693, MOR283-8, GA_x6K02T2PBJ9-9055944-9054994
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258445
Rgl1
Name: ral guanine nucleotide dissociation stimulator,-like 1
Synonyms: Rgl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19731
Homologene: 9039
Clca3a1
Name: chloride channel accessory 3A1
Synonyms: Clca1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12722
HGNC: HGNC:2017
Homologene: 77224
Or51a10
Name: olfactory receptor family 51 subfamily A member 10
Synonyms: GA_x6K02T2PBJ9-6784380-6783436, MOR13-6, Olfr642
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258326
Homologene: 17196
Rassf5
Name: Ras association (RalGDS/AF-6) domain family member 5
Synonyms: Nore1B, Rapl, 1300019G20Rik, Nore1A
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54354
Homologene: 10296
Bicdl2
Name: BICD family like cargo adaptor 2
Synonyms: Ccdc64b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 212733
VEGA: 17
Homologene: 17815
Zfp40
Name: zinc finger protein 40
Synonyms: NTfin12, Zfp-40
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22700
Homologene: 136312
Cyp4a30b
Name: cytochrome P450, family 4, subfamily a, polypeptide 30b
Synonyms: Cyp4a30b-ps, OTTMUSG00000008626
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435802
Pim3
Name: proviral integration site 3
Synonyms: KID-1/kinase induced by depolarization, Kid1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223775
VEGA: 15
Homologene: 56955
Smok3c
Name: sperm motility kinase 3C
Synonyms: EG622486
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622486
Homologene: 128738
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 74,495,749 bp
  • C to T, chromosome 1 at 131,182,251 bp
  • T to G, chromosome 1 at 152,533,530 bp
  • T to C, chromosome 2 at 103,091,846 bp
  • C to T, chromosome 3 at 36,988,085 bp
  • G to T, chromosome 3 at 144,749,689 bp
  • C to A, chromosome 4 at 49,380,254 bp
  • C to T, chromosome 4 at 115,461,374 bp
  • G to T, chromosome 4 at 123,860,086 bp
  • A to G, chromosome 5 at 21,373,258 bp
  • G to A, chromosome 5 at 88,501,691 bp
  • A to T, chromosome 5 at 103,565,255 bp
  • T to C, chromosome 5 at 113,183,826 bp
  • T to A, chromosome 5 at 138,065,437 bp
  • A to T, chromosome 6 at 43,307,604 bp
  • A to G, chromosome 6 at 86,944,417 bp
  • G to T, chromosome 7 at 3,651,919 bp
  • A to T, chromosome 7 at 16,823,053 bp
  • A to G, chromosome 7 at 104,050,127 bp
  • T to A, chromosome 7 at 106,677,893 bp
  • G to A, chromosome 7 at 122,762,324 bp
  • A to G, chromosome 8 at 107,540,682 bp
  • G to C, chromosome 9 at 27,101,980 bp
  • C to T, chromosome 9 at 53,518,559 bp
  • T to C, chromosome 9 at 69,483,821 bp
  • C to T, chromosome 10 at 58,457,737 bp
  • T to A, chromosome 10 at 76,501,314 bp
  • A to G, chromosome 11 at 51,275,574 bp
  • T to C, chromosome 11 at 61,265,262 bp
  • T to A, chromosome 12 at 3,984,613 bp
  • A to G, chromosome 12 at 8,011,049 bp
  • A to G, chromosome 12 at 11,457,144 bp
  • T to A, chromosome 12 at 71,318,137 bp
  • T to A, chromosome 12 at 76,204,312 bp
  • A to T, chromosome 12 at 84,787,410 bp
  • G to A, chromosome 14 at 56,620,490 bp
  • T to A, chromosome 14 at 67,795,996 bp
  • A to G, chromosome 15 at 67,111,346 bp
  • T to A, chromosome 15 at 88,863,093 bp
  • C to T, chromosome 17 at 23,176,536 bp
  • T to A, chromosome 17 at 23,666,744 bp
  • T to A, chromosome 17 at 30,663,292 bp
  • A to G, chromosome 17 at 32,057,089 bp
  • G to A, chromosome 17 at 64,625,388 bp
  • G to T, chromosome 18 at 34,695,873 bp
  • T to A, chromosome 18 at 64,546,090 bp
  • T to C, chromosome 19 at 20,699,956 bp
  • C to A, chromosome 19 at 25,127,484 bp
  • G to T, chromosome Y at 1,174,735 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6759 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044875-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.