Strain Name:
C57BL/6J-MtgxR6815Btlr/Mmmh
Stock Number:
044927-MU
Citation ID:
RRID:MMRRC_044927-MU
Other Names:
R6815 (G1)
Major Collection:

Strain Information

Dst
Name: dystonin
Synonyms: A830042E19Rik, nmf339, bullous pemphigoid antigen 1, Bpag1, 2310001O04Rik, Bpag, Macf2, BPAG1, BPAG1-n, athetoid, bullous pemphigoid antigen 1, ah, nmf203
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Dnajc21
Name: DnaJ heat shock protein family (Hsp40) member C21
Synonyms: 9930116P15Rik, 4930461P20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78244
Homologene: 6752
Prkd2
Name: protein kinase D2
Synonyms: PKD2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101540
Homologene: 9516
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, MCPH5, D330028K02Rik, Aspm, Calmbp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12316
Homologene: 7650
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320487
VEGA: 12
Homologene: 19635
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Sin3a
Name: transcriptional regulator, SIN3A (yeast)
Synonyms: mSin3A, Sin3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20466
Homologene: 32124
Arid4a
Name: AT-rich interaction domain 4A
Synonyms: Rbbp1, A630067N03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238247
HGNC: HGNC:9885
Homologene: 11303
Abcc5
Name: ATP-binding cassette, sub-family C member 5
Synonyms: 2900011L11Rik, Mrp5, Abcc5b, Abcc5a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27416
HGNC: HGNC:56
Homologene: 21164
Ttll4
Name: tubulin tyrosine ligase-like family, member 4
Synonyms: 4632407P03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67534
Homologene: 8764
Aip
Name: aryl-hydrocarbon receptor-interacting protein
Synonyms: Ara9, D19Bwg1412e, Xap2, Fkbp16
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11632
HGNC: HGNC:358
Homologene: 2959
Gpr4
Name: G protein-coupled receptor 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319197
HGNC: HGNC:4497
Homologene: 3867
Hipk2
Name: homeodomain interacting protein kinase 2
Synonyms: B230339E18Rik, Stank, 1110014O20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15258
Homologene: 68766
Lrig1
Name: leucine-rich repeats and immunoglobulin-like domains 1
Synonyms: LIG-1, Img
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16206
Homologene: 7380
Trmt6
Name: tRNA methyltransferase 6
Synonyms: 3300001M20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66926
Homologene: 6816
Cntrl
Name: centriolin
Synonyms: b2b1468Clo, Ma2a8, 6720467O09Rik, IB3/5, Cep110, Cep1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Rag2
Name: recombination activating gene 2
Synonyms: Rag-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19374
HGNC: HGNC:9832
Homologene: 7507
Cd180
Name: CD180 antigen
Synonyms: RP105, Ly78
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17079
HGNC: HGNC:6726
Homologene: 4077
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: fibrocystin L, PKHDL1, D86 mRNA
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Pde5a
Name: phosphodiesterase 5A, cGMP-specific
Synonyms: PDE5A1, Pde5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242202
HGNC: HGNC:8784
Homologene: 842
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Dock10
Name: dedicator of cytokinesis 10
Synonyms: Jr4, Zizimin3, ZIZ3, Jr5, A630054M16Rik, 9330153B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210293
Homologene: 45952
Zfp652
Name: zinc finger protein 652
Synonyms: 9530033F24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268469
Homologene: 54768
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242627
Homologene: 135888
Wdr41
Name: WD repeat domain 41
Synonyms: B830029I03Rik, MSTP048
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218460
Homologene: 23087
Ttc21b
Name: tetratricopeptide repeat domain 21B
Synonyms: 2410066K11Rik, aln, line 158, Thm1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73668
Homologene: 57006
Ccdc110
Name: coiled-coil domain containing 110
Synonyms: LOC212392
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212392
Homologene: 17668
Stox2
Name: storkhead box 2
Synonyms: 4933409N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71069
Homologene: 18414
Acad11
Name: acyl-Coenzyme A dehydrogenase family, member 11
Synonyms: 5730439E10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102632
Homologene: 49896
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mar, Mor1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Gucy2e
Name: guanylate cyclase 2e
Synonyms: ROS-GC1, GC1, GC-E
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14919
HGNC: HGNC:4689
Homologene: 55442
Igsf11
Name: immunoglobulin superfamily, member 11
Synonyms: BT-IgSF, 1700025L02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207683
Homologene: 17613
Dpy19l3
Name: dpy-19 like C-mannosyltransferase 3
Synonyms: 9330164H19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233115
Homologene: 18692
Ercc4
Name: excision repair cross-complementing rodent repair deficiency, complementation group 4
Synonyms: Xpf
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50505
HGNC: HGNC:3436
Homologene: 3836
Trim54
Name: tripartite motif-containing 54
Synonyms: MuRF3, Rnf30, 4930486E09Rik, 4930566I02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 58522
Homologene: 10983
Ccdc158
Name: coiled-coil domain containing 158
Synonyms: 4932413O14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320696
Homologene: 18560
Armh1
Name: armadillo-like helical domain containing 1
Synonyms: LOC381544, LOC381543, Ncrna00082, Gm1661
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381544
Homologene: 28727
Or7g31
Name: olfactory receptor family 7 subfamily G member 31
Synonyms: GA_x6K02T2PVTD-13214162-13213224, MOR147-2, Olfr850
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258516
HGNC: HGNC:8466
Homologene: 121552
Cyp2u1
Name: cytochrome P450, family 2, subfamily u, polypeptide 1
Synonyms: 8430436A10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71519
Homologene: 77704
Prr15l
Name: proline rich 15-like
Synonyms: E230006A12Rik, Atad4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217138
Homologene: 11522
Akr1b7
Name: aldo-keto reductase family 1, member B7
Synonyms: Avdp, MVDP
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11997
Homologene: 122176
Bco1
Name: beta-carotene oxygenase 1
Synonyms: Cmoi, Bcdo1, Bcdo, betaCMOOX, Bcmo1, beta-CD
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 63857
Homologene: 41172
6820408C15Rik
Name: RIKEN cDNA 6820408C15 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228778
Homologene: 51916
4931414P19Rik
Name: RIKEN cDNA 4931414P19 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74359
VEGA: 14
Homologene: 11078
Septin14
Name: septin 14
Synonyms: Sept14, 1700016K13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74222
Homologene: 87501
Heatr4
Name: HEAT repeat containing 4
Synonyms: Gm17673
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 101055670
Homologene: 45728
Tpm3-rs7
Name: tropomyosin 3, related sequence 7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 621054
VEGA: 14
Hdhd5
Name: haloacid dehalogenase like hydrolase domain containing 5
Synonyms: A930002G03Rik, Cecr5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214932
HGNC: HGNC:1843
Homologene: 32816
Ace3
Name: angiotensin I converting enzyme 3
Synonyms: EG217246
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217246
Homologene: 80337
Or10p22
Name: olfactory receptor family 10 subfamily P member 22
Synonyms: Olfr9, GA_x6K02T2PULF-10675610-10676548, MOR269-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18373
Homologene: 85121
Pcdha7
Name: protocadherin alpha 7
Synonyms: Cnr4, Crnr4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12939
HGNC: HGNC:8673
Homologene: 117962
Tmem52b
Name: transmembrane protein 52B
Synonyms: D630042F21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330428
Homologene: 27407
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 34,228,369 bp
  • C to A, chromosome 1 at 74,679,349 bp
  • C to T, chromosome 1 at 80,538,859 bp
  • A to G, chromosome 1 at 139,480,142 bp
  • T to C, chromosome 2 at 35,149,491 bp
  • T to C, chromosome 2 at 66,226,790 bp
  • T to A, chromosome 2 at 101,630,555 bp
  • A to C, chromosome 2 at 132,809,858 bp
  • A to G, chromosome 2 at 152,441,055 bp
  • A to G, chromosome 3 at 122,824,924 bp
  • A to C, chromosome 3 at 131,298,010 bp
  • T to A, chromosome 4 at 113,717,127 bp
  • T to A, chromosome 4 at 117,229,937 bp
  • G to T, chromosome 5 at 31,134,080 bp
  • T to A, chromosome 5 at 92,612,486 bp
  • T to C, chromosome 5 at 129,692,987 bp
  • A to T, chromosome 6 at 34,412,334 bp
  • G to T, chromosome 6 at 38,818,842 bp
  • A to G, chromosome 6 at 94,625,029 bp
  • A to G, chromosome 6 at 120,521,209 bp
  • G to A, chromosome 6 at 129,516,742 bp
  • T to C, chromosome 7 at 16,843,793 bp
  • T to A, chromosome 7 at 19,222,635 bp
  • T to A, chromosome 7 at 35,749,847 bp
  • C to T, chromosome 7 at 80,766,884 bp
  • ATGGCG to ATGGCGACGGTGGCG, chromosome 7 at 97,579,904 bp
  • C to T, chromosome 7 at 119,971,727 bp
  • A to G, chromosome 8 at 45,941,987 bp
  • A to T, chromosome 8 at 47,193,101 bp
  • A to T, chromosome 8 at 117,113,522 bp
  • G to T, chromosome 9 at 19,477,765 bp
  • T to A, chromosome 9 at 57,117,540 bp
  • A to G, chromosome 9 at 104,081,327 bp
  • A to G, chromosome 10 at 128,990,322 bp
  • A to C, chromosome 11 at 69,232,001 bp
  • A to T, chromosome 11 at 95,749,404 bp
  • T to C, chromosome 11 at 96,934,607 bp
  • C to T, chromosome 11 at 105,997,258 bp
  • T to G, chromosome 12 at 51,955,508 bp
  • T to A, chromosome 12 at 71,017,082 bp
  • T to A, chromosome 12 at 83,979,727 bp
  • C to A, chromosome 12 at 109,594,503 bp
  • A to T, chromosome 13 at 95,018,174 bp
  • C to T, chromosome 13 at 102,705,429 bp
  • T to G, chromosome 14 at 54,591,153 bp
  • A to G, chromosome 14 at 113,314,860 bp
  • C to T, chromosome 15 at 10,447,691 bp
  • A to G, chromosome 15 at 44,562,655 bp
  • T to C, chromosome 16 at 13,123,435 bp
  • T to C, chromosome 16 at 20,333,630 bp
  • A to G, chromosome 16 at 39,008,881 bp
  • A to G, chromosome 18 at 36,975,121 bp
  • A to T, chromosome 19 at 4,116,066 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6815 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044927-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.