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Strain Name:
C57BL/6J-MtgxR6833Btlr/Mmmh
Stock Number:
044942-MU
Citation ID:
RRID:MMRRC_044942-MU
Other Names:
R6833 (G1)
Major Collection:

Strain Information

Sema3b
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Synonyms: SemA, semaV, sema5, SemA, LUCA-1, Semaa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20347
Homologene: 20972
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22359
Homologene: 443
Hsp90ab1
Name: heat shock protein 90 alpha (cytosolic), class B member 1
Synonyms: Hsp84, Hsp90, Hsp84-1, C81438, Hspcb
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15516
Homologene: 74306
Efr3a
Name: EFR3 homolog A
Synonyms: A130089M23Rik, D030063F01Rik, C920006C10Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76740
Homologene: 44222
Mcm3
Name: minichromosome maintenance complex component 3
Synonyms: p1.m, P1, Mcmd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17215
HGNC: HGNC:6945
Homologene: 1791
Nol10
Name: nucleolar protein 10
Synonyms: LOC217431
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217431
VEGA: 12
Homologene: 5998
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 11,588,509 bp
  • A to T, chromosome 1 at 20,810,096 bp
  • G to T, chromosome 1 at 34,498,616 bp
  • A to G, chromosome 1 at 75,201,753 bp
  • T to A, chromosome 1 at 97,837,992 bp
  • A to T, chromosome 1 at 156,844,693 bp
  • A to T, chromosome 1 at 158,664,122 bp
  • A to T, chromosome 1 at 166,494,578 bp
  • G to A, chromosome 1 at 190,160,778 bp
  • T to A, chromosome 2 at 30,255,647 bp
  • T to C, chromosome 2 at 67,509,950 bp
  • A to G, chromosome 2 at 91,125,428 bp
  • G to T, chromosome 2 at 120,701,259 bp
  • T to C, chromosome 3 at 122,276,803 bp
  • A to G, chromosome 4 at 40,164,747 bp
  • A to G, chromosome 4 at 41,765,454 bp
  • T to C, chromosome 4 at 45,373,043 bp
  • A to G, chromosome 6 at 124,700,011 bp
  • G to A, chromosome 7 at 28,865,662 bp
  • T to A, chromosome 7 at 44,624,379 bp
  • T to C, chromosome 7 at 66,779,671 bp
  • T to A, chromosome 7 at 105,703,373 bp
  • C to A, chromosome 7 at 140,095,082 bp
  • T to C, chromosome 8 at 109,538,675 bp
  • A to T, chromosome 8 at 120,084,924 bp
  • C to T, chromosome 9 at 15,915,061 bp
  • A to G, chromosome 9 at 53,392,008 bp
  • T to A, chromosome 9 at 107,603,316 bp
  • A to G, chromosome 9 at 119,942,635 bp
  • T to A, chromosome 10 at 24,809,870 bp
  • C to T, chromosome 10 at 41,488,446 bp
  • C to T, chromosome 10 at 99,192,804 bp
  • T to C, chromosome 11 at 4,919,804 bp
  • G to A, chromosome 11 at 73,710,608 bp
  • A to G, chromosome 11 at 120,726,091 bp
  • A to G, chromosome 12 at 17,352,727 bp
  • G to A, chromosome 12 at 33,928,538 bp
  • A to T, chromosome 12 at 98,887,024 bp
  • A to G, chromosome 13 at 48,934,041 bp
  • A to T, chromosome 14 at 55,681,580 bp
  • C to T, chromosome 14 at 68,618,127 bp
  • T to C, chromosome 14 at 72,434,416 bp
  • G to T, chromosome 14 at 77,088,931 bp
  • T to G, chromosome 15 at 65,842,686 bp
  • C to T, chromosome 17 at 8,318,875 bp
  • T to C, chromosome 17 at 34,027,217 bp
  • T to C, chromosome 17 at 34,649,157 bp
  • T to C, chromosome 17 at 45,570,467 bp
  • G to A, chromosome 18 at 12,491,548 bp
  • G to T, chromosome 18 at 37,762,089 bp
  • A to T, chromosome 18 at 49,955,823 bp
  • T to C, chromosome 18 at 65,306,409 bp
  • G to T, chromosome 18 at 73,863,932 bp
  • A to C, chromosome 18 at 74,770,325 bp
  • T to A, chromosome 19 at 10,444,144 bp
  • T to C, chromosome 19 at 27,240,574 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6833 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044942-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.