Strain Name:
C57BL/6J-MtgxR6833Btlr/Mmmh
Stock Number:
044942-MU
Citation ID:
RRID:MMRRC_044942-MU
Other Names:
R6833 (G1)
Major Collection:

Strain Information

Sema3b
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Synonyms: LUCA-1, SemA, sema5, SemA, semaV, Semaa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20347
Homologene: 20972
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22359
Homologene: 443
Hsp90ab1
Name: heat shock protein 90 alpha (cytosolic), class B member 1
Synonyms: Hspcb, Hsp90, C81438, Hsp84, Hsp84-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15516
Homologene: 74306
Efr3a
Name: EFR3 homolog A
Synonyms: A130089M23Rik, C920006C10Rik, D030063F01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76740
Homologene: 44222
Mcm3
Name: minichromosome maintenance complex component 3
Synonyms: Mcmd, p1.m, P1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17215
HGNC: HGNC:6945
Homologene: 1791
Nol10
Name: nucleolar protein 10
Synonyms: LOC217431
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217431
VEGA: 12
Homologene: 5998
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Sft2d1
Name: SFT2 domain containing 1
Synonyms: 5630401J11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106489
Homologene: 34525
Dnttip2
Name: deoxynucleotidyltransferase, terminal, interacting protein 2
Synonyms: 4930588M11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99480
Homologene: 124162
Syt7
Name: synaptotagmin VII
Synonyms: B230112P13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54525
VEGA: 19
Homologene: 20889
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: 2400004E04Rik, NMHC II-C
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71960
Homologene: 23480
Aco1
Name: aconitase 1
Synonyms: Aco-1, Irp1, Irebp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11428
HGNC: HGNC:117
Homologene: 1657
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218236
VEGA: 13
Homologene: 8752
Enpp3
Name: ectonucleotide pyrophosphatase/phosphodiesterase 3
Synonyms: CD203c
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209558
VEGA: 10
HGNC: HGNC:3358
Homologene: 3683
Prox1
Name: prospero homeobox 1
Synonyms: A230003G05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19130
HGNC: HGNC:9459
Homologene: 2069
Angptl1
Name: angiopoietin-like 1
Synonyms: ANG-3, 2810039D03Rik, ANG3, ANG3, ARP1, ANGY, ANGPT3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72713
HGNC: HGNC:489
Homologene: 128467
Lrrc8a
Name: leucine rich repeat containing 8A VRAC subunit A
Synonyms: ebo, SWELL1, Lrrc8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241296
Homologene: 18617
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Prap1
Name: proline-rich acidic protein 1
Synonyms: Upa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22264
Homologene: 130637
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Lgals7
Name: lectin, galactose binding, soluble 7
Synonyms: Galectin-7, Pig1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16858
Homologene: 100509
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC382129, 9430076A06Rik, LOC234973
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Mybpc3
Name: myosin binding protein C, cardiac
Synonyms: cardiac C-protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17868
HGNC: HGNC:7551
Homologene: 215
Pcdhgb8
Name: protocadherin gamma subfamily B, 8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93705
Homologene: 81868
Il11ra1
Name: interleukin 11 receptor subunit alpha 1
Synonyms: Il-11ra, Il11ra, NR1, Il-11ra-alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16157
HGNC: HGNC:5967
Homologene: 88705
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: 2310008C07Rik, myomaxin, mXin beta, A530024P18Rik, 2310003D02Rik, Cmya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: 1700016D22Rik, F77
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56523
Homologene: 23182
Astn1
Name: astrotactin 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11899
HGNC: HGNC:773
Homologene: 7233
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: E230025N21Rik, Kif16a, 4831403C07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Lpcat3
Name: lysophosphatidylcholine acyltransferase 3
Synonyms: Grcc3f, Oact5, Mboat5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14792
Homologene: 14678
Dcaf10
Name: DDB1 and CUL4 associated factor 10
Synonyms: Wdr32
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242418
Homologene: 32581
Ttc21a
Name: tetratricopeptide repeat domain 21A
Synonyms: Thm2, 4921538N17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74052
Homologene: 14728
Pam
Name: peptidylglycine alpha-amidating monooxygenase
Synonyms: PHM
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18484
HGNC: HGNC:8596
Homologene: 37369
Myo5b
Name: myosin VB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225638
Homologene: 50475
Atf6b
Name: activating transcription factor 6 beta
Synonyms: ATF6beta, Crebl1, Creb-rp
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12915
HGNC: HGNC:2349
Homologene: 31238
Zfp735
Name: zinc finger protein 735
Synonyms: 1700012C15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76390
Homologene: 88945
Prss39
Name: serine protease 39
Synonyms: Tesp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21755
Homologene: 84781
Adam28
Name: a disintegrin and metallopeptidase domain 28
Synonyms: MDC-L, D430033C21Rik, C130072N01Rik, Dtgn1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13522
VEGA: 14
HGNC: HGNC:206
Homologene: 40705
A830018L16Rik
Name: RIKEN cDNA A830018L16 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320492
Homologene: 14194
Zdhhc7
Name: zinc finger, DHHC domain containing 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102193
Homologene: 41193
Thoc5
Name: THO complex 5
Synonyms: Fmip, 1700060C24Rik, PK1.3, A430085L24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107829
Homologene: 37836
Cers3
Name: ceramide synthase 3
Synonyms: CerS3, T3L, LOC233330, Lass3, 4930550L11Rik, related to TRH3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545975
Homologene: 18719
Glb1l
Name: galactosidase, beta 1-like
Synonyms: 4833408P15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74577
Homologene: 75208
Mro
Name: maestro
Synonyms: 4930507C04Rik, 4933435E20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71263
Homologene: 41729
Gm4846
Name: predicted gene 4846
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226601
Homologene: 136281
Poc1b
Name: POC1 centriolar protein B
Synonyms: 4933430F16Rik, Wdr51b
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 382406
Homologene: 41728
Ccdc122
Name: coiled-coil domain containing 122
Synonyms: 4933415L06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 108811
Homologene: 51651
Tinf2
Name: Terf1 (TRF1)-interacting nuclear factor 2
Synonyms: TIN2, D14Wsu146e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 28113
VEGA: 14
Homologene: 8264
Dcxr
Name: dicarbonyl L-xylulose reductase
Synonyms: 1810027P18Rik, 0610038K04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67880
Homologene: 22964
Smpd2
Name: sphingomyelin phosphodiesterase 2, neutral
Synonyms: nSMase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20598
Homologene: 31129
Poglut3
Name: protein O-glucosyltransferase 3
Synonyms: 4833410J10Rik, Kdelc2, 2010004J24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68304
VEGA: 9
Homologene: 17805
Hsd17b8
Name: hydroxysteroid 17-beta dehydrogenase 8
Synonyms: H2-Ke6, H-2Ke6, Ring2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14979
HGNC: HGNC:3554
Homologene: 56588
Ferd3l
Name: Fer3 like bHLH transcription factor
Synonyms: N-twist, Nato3, Mnato3, fer3, bHLHa31
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 114712
VEGA: 12
Homologene: 14136
Gm9195
Name: predicted gene 9195
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 675947
Homologene: 139067
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 11,588,509 bp
  • A to T, chromosome 1 at 20,810,096 bp
  • G to T, chromosome 1 at 34,498,616 bp
  • A to G, chromosome 1 at 75,201,753 bp
  • T to A, chromosome 1 at 97,837,992 bp
  • A to T, chromosome 1 at 156,844,693 bp
  • A to T, chromosome 1 at 158,664,122 bp
  • A to T, chromosome 1 at 166,494,578 bp
  • G to A, chromosome 1 at 190,160,778 bp
  • T to A, chromosome 2 at 30,255,647 bp
  • T to C, chromosome 2 at 67,509,950 bp
  • A to G, chromosome 2 at 91,125,428 bp
  • G to T, chromosome 2 at 120,701,259 bp
  • T to C, chromosome 3 at 122,276,803 bp
  • A to G, chromosome 4 at 40,164,747 bp
  • A to G, chromosome 4 at 41,765,454 bp
  • T to C, chromosome 4 at 45,373,043 bp
  • A to G, chromosome 6 at 124,700,011 bp
  • G to A, chromosome 7 at 28,865,662 bp
  • T to A, chromosome 7 at 44,624,379 bp
  • T to C, chromosome 7 at 66,779,671 bp
  • T to A, chromosome 7 at 105,703,373 bp
  • C to A, chromosome 7 at 140,095,082 bp
  • T to C, chromosome 8 at 109,538,675 bp
  • A to T, chromosome 8 at 120,084,924 bp
  • C to T, chromosome 9 at 15,915,061 bp
  • A to G, chromosome 9 at 53,392,008 bp
  • T to A, chromosome 9 at 107,603,316 bp
  • A to G, chromosome 9 at 119,942,635 bp
  • T to A, chromosome 10 at 24,809,870 bp
  • C to T, chromosome 10 at 41,488,446 bp
  • C to T, chromosome 10 at 99,192,804 bp
  • T to C, chromosome 11 at 4,919,804 bp
  • G to A, chromosome 11 at 73,710,608 bp
  • A to G, chromosome 11 at 120,726,091 bp
  • A to G, chromosome 12 at 17,352,727 bp
  • G to A, chromosome 12 at 33,928,538 bp
  • A to T, chromosome 12 at 98,887,024 bp
  • A to G, chromosome 13 at 48,934,041 bp
  • A to T, chromosome 14 at 55,681,580 bp
  • C to T, chromosome 14 at 68,618,127 bp
  • T to C, chromosome 14 at 72,434,416 bp
  • G to T, chromosome 14 at 77,088,931 bp
  • T to G, chromosome 15 at 65,842,686 bp
  • C to T, chromosome 17 at 8,318,875 bp
  • T to C, chromosome 17 at 34,027,217 bp
  • T to C, chromosome 17 at 34,649,157 bp
  • T to C, chromosome 17 at 45,570,467 bp
  • G to A, chromosome 18 at 12,491,548 bp
  • G to T, chromosome 18 at 37,762,089 bp
  • A to T, chromosome 18 at 49,955,823 bp
  • T to C, chromosome 18 at 65,306,409 bp
  • G to T, chromosome 18 at 73,863,932 bp
  • A to C, chromosome 18 at 74,770,325 bp
  • T to A, chromosome 19 at 10,444,144 bp
  • T to C, chromosome 19 at 27,240,574 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6833 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044942-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.