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Strain Name:
C57BL/6J-MtgxR6834Btlr/Mmmh
Stock Number:
044943-MU
Citation ID:
RRID:MMRRC_044943-MU
Other Names:
R6834 (G1)
Major Collection:

Strain Information

Sf1
Name: splicing factor 1
Synonyms: WBP4, MZFM, CW17R, Zfp162
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22668
Homologene: 134065
Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Chrna6
Name: cholinergic receptor, nicotinic, alpha polypeptide 6
Synonyms: Acra6, alpha6 nAChR
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11440
Homologene: 20888
Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Sox9
Name: SRY (sex determining region Y)-box 9
Synonyms: 2010306G03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20682
Homologene: 294
Hsp90ab1
Name: heat shock protein 90 alpha (cytosolic), class B member 1
Synonyms: Hsp84, Hsp90, Hsp84-1, C81438, Hspcb
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15516
Homologene: 74306
Epb41l2
Name: erythrocyte membrane protein band 4.1 like 2
Synonyms: NBL2, 4.1G, D10Ertd398e, Epb4.1l2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13822
VEGA: 10
HGNC: HGNC:3379
Homologene: 37478
Lrrc41
Name: leucine rich repeat containing 41
Synonyms: D730026A16Rik, MUF1, D630045E04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230654
Homologene: 4645
Gatad2b
Name: GATA zinc finger domain containing 2B
Synonyms: C430014D17Rik, p66beta
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229542
Homologene: 32484
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Mcm3
Name: minichromosome maintenance complex component 3
Synonyms: p1.m, P1, Mcmd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17215
HGNC: HGNC:6945
Homologene: 1791
Ell
Name: elongation factor RNA polymerase II
Synonyms: Men, Ell1, eleven-nineteen lysine-rich leukemia gene
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13716
Homologene: 4762
Rnf40
Name: ring finger protein 40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233900
Homologene: 8856
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Cenpf
Name: centromere protein F
Synonyms: 6530404A22Rik, Lek1, mitosin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Ap5m1
Name: adaptor-related protein complex 5, mu 1 subunit
Synonyms: 4932432K03Rik, Mudeng
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74385
VEGA: 14
Homologene: 10081
Aco1
Name: aconitase 1
Synonyms: Irp1, Irebp, Aco-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11428
HGNC: HGNC:117
Homologene: 1657
Cdin1
Name: CDAN1 interacting nuclease 1
Synonyms: BC052040
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 399568
Homologene: 32780
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, A130030D10Rik, 1110059H15Rik, Zfp650
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Klk11
Name: kallikrein related-peptidase 11
Synonyms: TLSP, hippostasin, Prss20, 2310015I08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56538
HGNC: HGNC:6359
Homologene: 27048
Angptl1
Name: angiopoietin-like 1
Synonyms: ANGPT3, ANGY, ARP1, ANG3, 2810039D03Rik, ANG-3, ANG3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72713
HGNC: HGNC:489
Homologene: 128467
Klk12
Name: kallikrein related-peptidase 12
Synonyms: KLK-L5, 2310008B01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69511
HGNC: HGNC:6360
Homologene: 44690
Lrrc8a
Name: leucine rich repeat containing 8A VRAC subunit A
Synonyms: Lrrc8, ebo, SWELL1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241296
Homologene: 18617
Pamr1
Name: peptidase domain containing associated with muscle regeneration 1
Synonyms: RAMP, E430002G05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 210622
Homologene: 9134
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230676
Homologene: 49413
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20265
Homologene: 21375
Adam15
Name: ADAM metallopeptidase domain 15
Synonyms: metargidin, MDC15
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11490
HGNC: HGNC:193
Homologene: 2829
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Slc9a5
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 5
Synonyms: LOC277973
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 277973
Homologene: 31247
Lmod2
Name: leiomodin 2 (cardiac)
Synonyms: C-Lmod
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93677
HGNC: HGNC:6648
Homologene: 28302
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC381317, LOC269160, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Ankrd35
Name: ankyrin repeat domain 35
Synonyms: 4732436F15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213121
Homologene: 16977
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: 1700096C21Rik, sba
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240411
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Pcdhgb8
Name: protocadherin gamma subfamily B, 8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93705
Homologene: 81868
Il11ra1
Name: interleukin 11 receptor subunit alpha 1
Synonyms: NR1, Il11ra, Il-11ra-alpha, Il-11ra
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16157
HGNC: HGNC:5967
Homologene: 88705
Synpo2l
Name: synaptopodin 2-like
Synonyms: 1110054M18Rik, Chap
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68760
Homologene: 23499
AU018091
Name: expressed sequence AU018091
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 245128
Homologene: 106376
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210274
Homologene: 105965
Pam
Name: peptidylglycine alpha-amidating monooxygenase
Synonyms: PHM
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18484
HGNC: HGNC:8596
Homologene: 37369
Atf6b
Name: activating transcription factor 6 beta
Synonyms: Creb-rp, ATF6beta, Crebl1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12915
HGNC: HGNC:2349
Homologene: 31238
Zfp735
Name: zinc finger protein 735
Synonyms: 1700012C15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76390
Homologene: 88945
Prss39
Name: serine protease 39
Synonyms: Tesp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21755
Homologene: 84781
Ptar1
Name: protein prenyltransferase alpha subunit repeat containing 1
Synonyms: 2010013L17Rik, 1700084D09Rik, 4930428J16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72351
VEGA: 19
Homologene: 34254
Mrgprx1
Name: MAS-related GPR, member X1
Synonyms: MrgC11, Mrgprc11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404242
Homologene: 86184
Tmc1
Name: transmembrane channel-like gene family 1
Synonyms: Bth, Beethoven, 4933416G09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13409
VEGA: 19
Homologene: 23670
Mvb12a
Name: multivesicular body subunit 12A
Synonyms: 1110012M11Rik, Fam125a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73711
Homologene: 12509
Kcnip3
Name: Kv channel interacting protein 3, calsenilin
Synonyms: DREAM, 4933407H12Rik, KChIP3, R74849, Csen
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56461
Homologene: 8382
Or4k2
Name: olfactory receptor family 4 subfamily K member 2
Synonyms: GA_x6K02T2PMLR-5881670-5880717, MOR247-1, Olfr730
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258486
Homologene: 17269
Vmn1r85
Name: vomeronasal 1 receptor 85
Synonyms: V1rj3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252909
Homologene: 74338
Glb1l
Name: galactosidase, beta 1-like
Synonyms: 4833408P15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74577
Homologene: 75208
Zpld2
Name: zona pellucida like domain containing 2
Synonyms: Gm7534
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 665186
Homologene: 104039
Or4k15c
Name: olfactory receptor family 4 subfamily K member 15C
Synonyms: GA_x6K02T2PMLR-5775299-5774334, MOR246-4, Olfr726
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258313
Homologene: 44957
Poc1b
Name: POC1 centriolar protein B
Synonyms: 4933430F16Rik, Wdr51b
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 382406
Homologene: 41728
Vmn2r-ps158
Name: vomeronasal 2, receptor, pseudogene 158
Synonyms: Gm9268, Vmn2r126
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668612
Homologene: 104832
Zfp358
Name: zinc finger protein 358
Synonyms: Zfend
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 140482
Homologene: 9996
Pacsin3
Name: protein kinase C and casein kinase substrate in neurons 3
Synonyms: 4921507A02Rik, 6330413E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 80708
HGNC: HGNC:8572
Homologene: 41117
Med24
Name: mediator complex subunit 24
Synonyms: Trap100, D11Ertd307e, R75526, 100kDa, DRIP100, Gse2, Pparb2, Thrap4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23989
Homologene: 40795
Hsd17b8
Name: hydroxysteroid 17-beta dehydrogenase 8
Synonyms: Ring2, H-2Ke6, H2-Ke6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14979
HGNC: HGNC:3554
Homologene: 56588
Gng11
Name: guanine nucleotide binding protein (G protein), gamma 11
Synonyms: 0610037B21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66066
HGNC: HGNC:4403
Homologene: 3045
Igkv4-79
Name: immunoglobulin kappa variable 4-79
Synonyms: LOC213684, IgVk ae4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213684
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 20,810,096 bp
  • G to T, chromosome 1 at 34,498,616 bp
  • A to G, chromosome 1 at 75,201,753 bp
  • T to A, chromosome 1 at 97,837,992 bp
  • A to T, chromosome 1 at 156,844,693 bp
  • A to T, chromosome 1 at 158,664,122 bp
  • A to T, chromosome 1 at 166,494,578 bp
  • T to C, chromosome 1 at 188,356,792 bp
  • T to C, chromosome 1 at 189,659,446 bp
  • T to A, chromosome 2 at 30,255,647 bp
  • T to A, chromosome 2 at 66,327,742 bp
  • T to C, chromosome 2 at 70,000,481 bp
  • T to A, chromosome 2 at 91,262,835 bp
  • C to T, chromosome 2 at 102,614,931 bp
  • T to C, chromosome 2 at 115,674,784 bp
  • A to T, chromosome 2 at 127,458,358 bp
  • C to T, chromosome 3 at 86,350,286 bp
  • C to T, chromosome 3 at 89,340,083 bp
  • T to A, chromosome 3 at 90,348,643 bp
  • A to G, chromosome 3 at 96,683,283 bp
  • A to G, chromosome 4 at 40,164,747 bp
  • A to G, chromosome 4 at 41,765,454 bp
  • T to C, chromosome 4 at 116,096,529 bp
  • A to G, chromosome 4 at 118,388,325 bp
  • A to C, chromosome 4 at 134,193,165 bp
  • A to G, chromosome 6 at 4,008,068 bp
  • A to G, chromosome 6 at 22,999,633 bp
  • A to T, chromosome 6 at 24,597,783 bp
  • A to G, chromosome 6 at 69,043,272 bp
  • T to A, chromosome 7 at 3,157,955 bp
  • T to C, chromosome 7 at 13,084,644 bp
  • G to C, chromosome 7 at 43,023,580 bp
  • T to C, chromosome 7 at 43,773,348 bp
  • T to C, chromosome 7 at 43,778,912 bp
  • T to C, chromosome 7 at 48,021,637 bp
  • G to A, chromosome 7 at 127,596,406 bp
  • A to T, chromosome 7 at 144,409,894 bp
  • A to G, chromosome 8 at 3,495,613 bp
  • C to T, chromosome 8 at 27,408,310 bp
  • A to G, chromosome 8 at 70,579,134 bp
  • G to A, chromosome 8 at 71,545,252 bp
  • G to T, chromosome 8 at 105,364,684 bp
  • T to A, chromosome 10 at 25,493,604 bp
  • C to T, chromosome 10 at 99,192,804 bp
  • T to A, chromosome 11 at 9,275,110 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • G to A, chromosome 11 at 73,710,608 bp
  • A to T, chromosome 11 at 98,705,024 bp
  • A to T, chromosome 11 at 112,784,000 bp
  • A to T, chromosome 12 at 98,887,024 bp
  • A to T, chromosome 14 at 20,660,634 bp
  • T to A, chromosome 14 at 49,073,737 bp
  • A to G, chromosome 14 at 50,084,228 bp
  • T to C, chromosome 14 at 50,186,483 bp
  • T to C, chromosome 17 at 34,027,217 bp
  • T to C, chromosome 17 at 34,649,157 bp
  • T to C, chromosome 17 at 45,570,467 bp
  • G to A, chromosome 18 at 12,491,548 bp
  • G to T, chromosome 18 at 37,762,089 bp
  • A to T, chromosome 18 at 49,955,823 bp
  • T to A, chromosome 18 at 77,441,526 bp
  • G to T, chromosome 19 at 6,374,097 bp
  • C to A, chromosome 19 at 20,795,610 bp
  • A to G, chromosome 19 at 23,717,924 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6834 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044943-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.