Strain Name:
C57BL/6J-MtgxR6846Btlr/Mmmh
Stock Number:
044952-MU
Citation ID:
RRID:MMRRC_044952-MU
Other Names:
R6846 (G1)
Major Collection:

Strain Information

Cdh11
Name: cadherin 11
Synonyms: OB-cadherin, osteoblast-cadherin, Cad11
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12552
HGNC: HGNC:1750
Homologene: 1361
Strn
Name: striatin, calmodulin binding protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268980
Homologene: 2380
Bahcc1
Name: BAH domain and coiled-coil containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268515
Homologene: 129585
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, Gp330, Megalin, D230004K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Mthfd1l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Synonyms: 2410004L15Rik, Fthfsdc1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270685
Homologene: 56706
Nfya
Name: nuclear transcription factor-Y alpha
Synonyms: Cbf-b, Sez10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18044
HGNC: HGNC:7804
Homologene: 32114
Cep131
Name: centrosomal protein 131
Synonyms: AZ1, Azi1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12009
Homologene: 7638
Swap70
Name: SWA-70 protein
Synonyms: 70kDa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20947
Homologene: 7557
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, Skt, E330027G05Rik, 9430077C05Rik, Sickle tail, 6620402G01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208618
Homologene: 10477
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 3526402J09Rik, 5730590C14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77097
Homologene: 64680
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ankyrin-G, Ank-3, Ankyrin-3, 2900054D09Rik, AnkG
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Arhgap42
Name: Rho GTPase activating protein 42
Synonyms: 9030420J04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71544
Homologene: 28446
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: dgkd-2, DGKdelta
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230249
Homologene: 6056
Iws1
Name: IWS1, SUPT6 interacting protein
Synonyms: 1700069O15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 73473
Homologene: 134421
Ambn
Name: ameloblastin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11698
HGNC: HGNC:452
Homologene: 7625
Trim71
Name: tripartite motif-containing 71
Synonyms: LOC382112, 636931, 2610206G21Rik, mLin41, lin-41, Lin41, mlin-41
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 636931
Homologene: 9076
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Odz3, Ten-m3, 2610100B16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23965
Homologene: 22673
Limd2
Name: LIM domain containing 2
Synonyms: 0610025L06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67803
Homologene: 12731
Nlgn1
Name: neuroligin 1
Synonyms: NL1, Nlg1, 6330415N05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192167
Homologene: 56690
Zscan10
Name: zinc finger and SCAN domain containing 10
Synonyms: Zscan10, Zfp206
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 332221
Homologene: 13122
Mcc
Name: mutated in colorectal cancers
Synonyms: D18Ertd451e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328949
HGNC: HGNC:6935
Homologene: 20539
Ighg2c
Name: immunoglobulin heavy constant gamma 2C
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 404711
Vmn1r67
Name: vomeronasal 1 receptor 67
Synonyms: V1re10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171263
Homologene: 128344
Ahnak
Name: AHNAK nucleoprotein
Synonyms: 2310047C17Rik, 1110004P15Rik, DY6
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Htra4
Name: HtrA serine peptidase 4
Synonyms: B430206E18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330723
Homologene: 17801
Pitpnm2
Name: phosphatidylinositol transfer protein, membrane-associated 2
Synonyms: Rdgb2, RDGBA2, NIR3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19679
Homologene: 7915
Slc7a14
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241919
Homologene: 76320
Cd19
Name: CD19 antigen
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12478
HGNC: HGNC:1633
Homologene: 1341
Evpl
Name: envoplakin
Synonyms: 210kDa protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14027
HGNC: HGNC:3503
Homologene: 1506
Or5ak22
Name: olfactory receptor family 5 subfamily AK member 22
Synonyms: MOR203-1, Olfr992, GA_x6K02T2Q125-46877170-46876241
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258865
Homologene: 121517
Fam120b
Name: family with sequence similarity 120, member B
Synonyms: 4932442K08Rik, CCPG
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67544
VEGA: 17
Homologene: 13033
Serpinb3b
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B
Synonyms: Scca2-rs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 383548
Homologene: 131278
Dnaaf1
Name: dynein, axonemal assembly factor 1
Synonyms: Lrrc50, 4930457P18Rik, m4Bei
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68270
Homologene: 12256
Hoxa6
Name: homeobox A6
Synonyms: Hox-1.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15403
HGNC: HGNC:5107
Homologene: 7765
Vnn3
Name: vanin 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 26464
Homologene: 48295
Or52r1c
Name: olfactory receptor family 52 subfamily R member 1C
Synonyms: GA_x6K02T2PBJ9-5796876-5797820, MOR30-2, Olfr584
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259056
Nat1
Name: N-acetyl transferase 1
Synonyms: Nat-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17960
Homologene: 115468
Fhit
Name: fragile histidine triad gene
Synonyms: Fra14A2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14198
HGNC: HGNC:3701
Homologene: 21661
Lats2
Name: large tumor suppressor 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50523
HGNC: HGNC:6515
Homologene: 56678
Slc16a13
Name: solute carrier family 16 (monocarboxylic acid transporters), member 13
Synonyms: 1700007D07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69309
Homologene: 71749
Myocos
Name: myocilin opposite strand
Synonyms: 7420461P10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100038657
Tmem176a
Name: transmembrane protein 176A
Synonyms: 0610011I04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66058
Homologene: 10224
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 87,925,691 bp
  • T to C, chromosome 1 at 107,154,673 bp
  • T to C, chromosome 1 at 162,657,096 bp
  • T to A, chromosome 2 at 20,744,108 bp
  • T to A, chromosome 2 at 69,518,443 bp
  • A to T, chromosome 2 at 85,400,517 bp
  • A to G, chromosome 3 at 25,436,342 bp
  • A to G, chromosome 3 at 31,224,223 bp
  • A to G, chromosome 4 at 58,814,081 bp
  • T to A, chromosome 5 at 88,461,715 bp
  • T to C, chromosome 5 at 124,131,171 bp
  • G to T, chromosome 6 at 48,843,825 bp
  • T to C, chromosome 6 at 52,206,543 bp
  • A to T, chromosome 7 at 10,446,913 bp
  • T to A, chromosome 7 at 103,086,058 bp
  • T to A, chromosome 7 at 110,255,749 bp
  • T to C, chromosome 7 at 126,410,853 bp
  • A to G, chromosome 8 at 25,030,545 bp
  • T to C, chromosome 8 at 48,276,738 bp
  • G to T, chromosome 8 at 67,491,343 bp
  • G to A, chromosome 8 at 102,664,644 bp
  • T to A, chromosome 8 at 119,582,662 bp
  • G to T, chromosome 9 at 9,006,445 bp
  • G to T, chromosome 9 at 114,525,047 bp
  • A to G, chromosome 10 at 4,047,898 bp
  • A to G, chromosome 10 at 23,851,722 bp
  • A to G, chromosome 10 at 69,824,349 bp
  • T to C, chromosome 11 at 70,217,835 bp
  • T to A, chromosome 11 at 105,798,653 bp
  • C to T, chromosome 11 at 106,159,387 bp
  • T to C, chromosome 11 at 116,223,807 bp
  • G to A, chromosome 11 at 120,065,691 bp
  • A to G, chromosome 11 at 120,271,596 bp
  • A to G, chromosome 12 at 113,288,310 bp
  • C to A, chromosome 14 at 9,763,762 bp
  • A to G, chromosome 14 at 57,696,134 bp
  • T to C, chromosome 17 at 15,414,829 bp
  • A to T, chromosome 17 at 23,605,607 bp
  • A to T, chromosome 17 at 48,395,687 bp
  • A to G, chromosome 17 at 78,736,457 bp
  • T to C, chromosome 18 at 32,086,273 bp
  • T to A, chromosome 18 at 44,473,640 bp
  • A to G, chromosome 19 at 9,011,857 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6846 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044952-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.