Strain Name:
C57BL/6J-MtgxR6866Btlr/Mmmh
Stock Number:
044965-MU
Citation ID:
RRID:MMRRC_044965-MU
Other Names:
R6866 (G1)
Major Collection:

Strain Information

Myo5a
Name: myosin VA
Synonyms: flail, MVa, 9630007J19Rik, MyoVA, Myo5, Dbv
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Il4i1
Name: interleukin 4 induced 1
Synonyms: H46, H-4, Fig1, H4, H-46, Fig1-ps
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14204
Homologene: 22567
Tjp2
Name: tight junction protein 2
Synonyms: ZO-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21873
VEGA: 19
Homologene: 3541
Strn4
Name: striatin, calmodulin binding protein 4
Synonyms: ZIN, zinedin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 97387
Homologene: 8378
Kif20a
Name: kinesin family member 20A
Synonyms: Rab6kifl, Rabkinesin-6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19348
VEGA: 18
HGNC: HGNC:9787
Homologene: 38093
Cdca2
Name: cell division cycle associated 2
Synonyms: 2610311M19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 108912
Homologene: 18444
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77011
Homologene: 67120
Bcl2l13
Name: BCL2 like 13
Synonyms: Mil-1, BCL-RAMBO, E430016C20Rik, Mil1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 94044
Homologene: 9111
Tango6
Name: transport and golgi organization 6
Synonyms: Tango6, Tmco7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 272538
Homologene: 52121
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Focad
Name: focadhesin
Synonyms: BC057079
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230393
Homologene: 9842
Als2
Name: alsin Rho guanine nucleotide exchange factor
Synonyms: Alsin, 3222402C23Rik, 9430073A21Rik, Als2cr6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74018
HGNC: HGNC:443
Homologene: 23264
Pvr
Name: poliovirus receptor
Synonyms: mE4, D7Ertd458e, 3830421F03Rik, necl-5, CD155, Tage4, Taa1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52118
HGNC: HGNC:9705
Homologene: 79541
Slc33a1
Name: solute carrier family 33 (acetyl-CoA transporter), member 1
Synonyms: Acatn, D630022N01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11416
HGNC: HGNC:95
Homologene: 3476
Cyfip2
Name: cytoplasmic FMR1 interacting protein 2
Synonyms: Pir121, 6430511D02Rik, 1500004I01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76884
Homologene: 7936
Eif3k
Name: eukaryotic translation initiation factor 3, subunit K
Synonyms: Eif3s12, eIF3K, 1200009C21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73830
Homologene: 8292
Nckap5l
Name: NCK-associated protein 5-like
Synonyms: C230021P08Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380969
Homologene: 18924
Pot1b
Name: protection of telomeres 1B
Synonyms: 2810458H16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72836
VEGA: 17
Homologene: 87058
Mmp16
Name: matrix metallopeptidase 16
Synonyms: Membrane type 3-MMP, MT3-MMP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17389
HGNC: HGNC:7162
Homologene: 55939
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Zfp148
Name: zinc finger protein 148
Synonyms: BFCOL1, ZBP-89, beta enolase repressor factor 1, 2210405J08Rik, BERF-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22661
VEGA: 16
Homologene: 8003
Timm50
Name: translocase of inner mitochondrial membrane 50
Synonyms: TIM50L, 2810403L02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66525
Homologene: 57031
Mgme1
Name: mitochondrial genome maintenance exonuclease 1
Synonyms: 8430406I07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74528
Homologene: 12573
Garnl3
Name: GTPase activating RANGAP domain-like 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99326
Homologene: 13003
Nptx1
Name: neuronal pentraxin 1
Synonyms: D11Bwg1004e, Np1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18164
HGNC: HGNC:7952
Homologene: 1891
Zfp534
Name: zinc finger protein 534
Synonyms: Gm13159
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100503584
Homologene: 133076
Apeh
Name: acylpeptide hydrolase
Synonyms: N-acylaminoacyl peptide hydrolase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235606
HGNC: HGNC:586
Homologene: 1240
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213262
Homologene: 10584
Cntnap5c
Name: contactin associated protein-like 5C
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 620292
VEGA: 17
Homologene: 128806
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Or5p76
Name: olfactory receptor family 5 subfamily P member 76
Synonyms: MOR204-8, Olfr502, GA_x6K02T2PBJ9-10853935-10852991
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258734
Homologene: 72021
Cnga4
Name: cyclic nucleotide gated channel alpha 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233649
HGNC: HGNC:2152
Homologene: 13579
Myh1
Name: myosin, heavy polypeptide 1, skeletal muscle, adult
Synonyms: MyHC-IId/x, IId, IId/x, A530084A17Rik, MYHC-IIX, Myhs-f, Myhs-f2, myosin heavy chain 2X, Myhsf2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17879
HGNC: HGNC:7567
Homologene: 133718
Tsbp1
Name: testis expressed basic protein 1
Synonyms: BC051142
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 407788
Homologene: 128168
Sult1e1
Name: sulfotransferase family 1E, member 1
Synonyms: EST, Ste
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20860
Homologene: 101388
Kcnj6
Name: potassium inwardly-rectifying channel, subfamily J, member 6
Synonyms: KCNJ7, GIRK2, Kir3.2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16522
VEGA: 16
HGNC: HGNC:6267
Homologene: 1688
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: bapa, Mll4, C430014K11Rik, Mll2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Serping1
Name: serine (or cysteine) peptidase inhibitor, clade G, member 1
Synonyms: C1nh, C1 inhibitor, C1INH
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12258
HGNC: HGNC:1228
Homologene: 44
Tecrl
Name: trans-2,3-enoyl-CoA reductase-like
Synonyms: D330017N19Rik, Srd5a2l2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243078
Homologene: 27549
Kynu
Name: kynureninase
Synonyms: 4432411A05Rik, L-kynurenine hydrolase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70789
HGNC: HGNC:6469
Homologene: 2925
Psg21
Name: pregnancy-specific beta-1-glycoprotein 21
Synonyms: 1600019C01Rik, cea8, 1600026N13Rik, 1600025N01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72242
Homologene: 110989
Rbm17
Name: RNA binding motif protein 17
Synonyms: 2700027J02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76938
Homologene: 13162
Cryba1
Name: crystallin, beta A1
Synonyms: BA3/A1, Cryb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12957
HGNC: HGNC:2394
Homologene: 3815
Sting1
Name: stimulator of interferon response cGAMP interactor 1
Synonyms: 2610307O08Rik, MPYS, ERIS, Sting, Tmem173
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72512
VEGA: 18
Homologene: 18868
Tmem45a2
Name: transmembrane protein 45A2
Synonyms: 2310005G13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69457
VEGA: 16
Homologene: 131266
Rnf207
Name: ring finger protein 207
Synonyms: D330010C22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433809
Homologene: 19234
Cr2
Name: complement receptor 2
Synonyms: Cr-1, Cr1, CD35, CD21, Cr-2, C3DR
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12902
HGNC: HGNC:2336
Homologene: 55611
Extl2
Name: exostosin-like glycosyltransferase 2
Synonyms: 3000001D04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 58193
HGNC: HGNC:3516
Homologene: 1102
Or56a42-ps1
Name: olfactory receptor family 56 subfamily A member 42, pseudogene 1
Synonyms: GA_x6K02T2PBJ9-7755919-7755070, Olfr682-ps1, GA_x6K02SYW8DF-188-1037, Olfr217-ps1, MOR40-6P, MOR40-19_p
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258187
Brsk1
Name: BR serine/threonine kinase 1
Synonyms: SAD-B, LOC381979
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381979
Homologene: 57169
Ly9
Name: lymphocyte antigen 9
Synonyms: T100, Lgp100, CD229, SLAMF3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17085
HGNC: HGNC:6730
Homologene: 1759
Rnf138
Name: ring finger protein 138
Synonyms: 2810480D20Rik, Trif-d, 2410015A17Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 56515
VEGA: 18
Homologene: 9446
Slc26a8
Name: solute carrier family 26, member 8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224661
Homologene: 27095
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Or5k16
Name: olfactory receptor family 5 subfamily K member 16
Synonyms: MOR184-11P, MOR184-9, MOR184-11P, Olfr180, Olfr1563-ps1, GA_x54KRFPKG5P-55134972-55134019
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258178
Homologene: 79337
Slc25a3
Name: solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
Synonyms: Phc, 5730556H19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18674
Homologene: 37649
Phc3
Name: polyhomeotic 3
Synonyms: HPH3, E030046K01Rik, EDR3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241915
Homologene: 69390
Mtres1
Name: mitochondrial transcription rescue factor 1
Synonyms: 1700021F05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67851
Homologene: 41137
Slc27a5
Name: solute carrier family 27 (fatty acid transporter), member 5
Synonyms: VLCS-H2, FACVL3, FATP5, VLCSH2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26459
Homologene: 7596
Caly
Name: calcyon neuron-specific vesicular protein
Synonyms: 0710001P07Rik, Calcyon, 1110004A22Rik, Drd1ip
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68566
Homologene: 9256
Gm3633
Name: predicted gene 3633
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 118568142
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 46,657,243 bp
  • T to A, chromosome 1 at 59,211,133 bp
  • T to C, chromosome 1 at 171,605,279 bp
  • T to A, chromosome 1 at 195,151,691 bp
  • T to G, chromosome 2 at 11,598,090 bp
  • A to G, chromosome 2 at 33,002,773 bp
  • T to A, chromosome 2 at 43,563,110 bp
  • A to C, chromosome 2 at 84,770,233 bp
  • T to C, chromosome 2 at 144,276,519 bp
  • T to A, chromosome 3 at 30,914,531 bp
  • A to T, chromosome 3 at 63,943,323 bp
  • A to T, chromosome 3 at 76,322,225 bp
  • A to G, chromosome 3 at 116,027,352 bp
  • T to A, chromosome 3 at 116,027,353 bp
  • T to A, chromosome 4 at 17,853,800 bp
  • T to C, chromosome 4 at 88,403,386 bp
  • T to A, chromosome 4 at 88,627,740 bp
  • T to C, chromosome 4 at 147,674,481 bp
  • C to T, chromosome 4 at 152,312,532 bp
  • G to T, chromosome 5 at 83,313,314 bp
  • G to A, chromosome 5 at 87,586,766 bp
  • A to G, chromosome 6 at 85,621,098 bp
  • T to A, chromosome 6 at 120,862,889 bp
  • T to C, chromosome 7 at 4,706,407 bp
  • T to A, chromosome 7 at 12,997,516 bp
  • A to T, chromosome 7 at 16,828,785 bp
  • A to T, chromosome 7 at 18,652,284 bp
  • A to C, chromosome 7 at 19,918,630 bp
  • C to T, chromosome 7 at 28,305,945 bp
  • T to C, chromosome 7 at 28,977,226 bp
  • T to A, chromosome 7 at 44,836,539 bp
  • T to C, chromosome 7 at 79,693,957 bp
  • T to A, chromosome 7 at 105,126,618 bp
  • A to G, chromosome 7 at 105,407,745 bp
  • A to G, chromosome 7 at 108,523,170 bp
  • T to C, chromosome 7 at 140,070,619 bp
  • G to A, chromosome 8 at 106,742,472 bp
  • G to A, chromosome 9 at 75,140,688 bp
  • G to A, chromosome 9 at 108,092,679 bp
  • ACTGCACCACCT to ACT, chromosome 10 at 43,532,725 bp
  • A to T, chromosome 10 at 91,119,705 bp
  • G to A, chromosome 11 at 46,242,459 bp
  • A to C, chromosome 11 at 67,224,393 bp
  • T to C, chromosome 11 at 77,719,529 bp
  • T to C, chromosome 11 at 107,073,580 bp
  • A to G, chromosome 11 at 119,546,650 bp
  • T to A, chromosome 14 at 42,640,622 bp
  • T to C, chromosome 14 at 67,693,666 bp
  • A to T, chromosome 15 at 85,820,881 bp
  • T to G, chromosome 15 at 98,857,393 bp
  • A to G, chromosome 15 at 99,426,468 bp
  • T to A, chromosome 16 at 33,468,126 bp
  • T to A, chromosome 16 at 57,047,023 bp
  • A to G, chromosome 16 at 58,915,988 bp
  • A to T, chromosome 16 at 94,762,677 bp
  • T to C, chromosome 17 at 28,638,481 bp
  • T to A, chromosome 17 at 34,459,961 bp
  • T to A, chromosome 17 at 55,653,474 bp
  • A to C, chromosome 17 at 58,092,294 bp
  • C to T, chromosome 18 at 21,002,142 bp
  • A to T, chromosome 18 at 34,628,493 bp
  • T to C, chromosome 18 at 35,739,429 bp
  • A to G, chromosome 19 at 24,101,991 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6866 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044965-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.