Strain Name:
C57BL/6J-MtgxR6886Btlr/Mmmh
Stock Number:
044980-MU
Citation ID:
RRID:MMRRC_044980-MU
Other Names:
R6886 (G1)
Major Collection:

Strain Information

Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: SNF2beta, SW1/SNF, Brg1, b2b692Clo, b2b508.1Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20586
Homologene: 135927
Slc12a5
Name: solute carrier family 12, member 5
Synonyms: KCC2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57138
Homologene: 10665
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: CAGH26, Tnrc6, D130023A07Rik, 3110054G10Rik, 2010321I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233833
Homologene: 41399
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108989
Homologene: 37753
Rnf2
Name: ring finger protein 2
Synonyms: dinG, Ring1B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19821
Homologene: 2199
Zfp516
Name: zinc finger protein 516
Synonyms: Zfp26l, C330029B10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329003
VEGA: 18
Homologene: 37122
Kif18a
Name: kinesin family member 18A
Synonyms: B130001M12Rik, N-8 kinesin, gcd2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228421
Homologene: 41820
Fanci
Name: Fanconi anemia, complementation group I
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 208836
Homologene: 49530
Rad50
Name: RAD50 double strand break repair protein
Synonyms: Rad50l, Mrell
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19360
HGNC: HGNC:9816
Homologene: 38092
Trp53bp2
Name: transformation related protein 53 binding protein 2
Synonyms: 53BP2, ASPP2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 209456
Homologene: 3959
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: Doc4, l7Rn3, ELM2, Odz4, l(7)-3Rn, Ten-m4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Ctsl
Name: cathepsin L
Synonyms: major excreted protein, 1190035F06Rik, Cat L, MEP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13039
VEGA: 13
Homologene: 76699
Bcr
Name: BCR activator of RhoGEF and GTPase
Synonyms: 5133400C09Rik, breakpoint cluster region
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110279
VEGA: 10
HGNC: HGNC:1014
Homologene: 3192
Rab4b
Name: RAB4B, member RAS oncogene family
Synonyms: 1500031G17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19342
HGNC: HGNC:9782
Homologene: 100632
Zfp644
Name: zinc finger protein 644
Synonyms: 1110068L01Rik, BM-005, Zep-2, D5Ertd689e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52397
Homologene: 12971
Tax1bp1
Name: Tax1 (human T cell leukemia virus type I) binding protein 1
Synonyms: 1200003J11Rik, D6Ertd772e, T6BP, TXBP151, D6Ertd404e, 1700069J21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52440
Homologene: 4395
Exosc7
Name: exosome component 7
Synonyms: 2610002K22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66446
Homologene: 8994
Med6
Name: mediator complex subunit 6
Synonyms: 1500012F11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69792
Homologene: 3990
Lonrf1
Name: LON peptidase N-terminal domain and ring finger 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244421
Homologene: 34980
Man1a2
Name: mannosidase, alpha, class 1A, member 2
Synonyms: Man1b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17156
HGNC: HGNC:6822
Homologene: 55982
Ccdc181
Name: coiled-coil domain containing 181
Synonyms: 4930455F23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74895
Homologene: 10912
Rel
Name: reticuloendotheliosis oncogene
Synonyms: c-Rel
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19696
HGNC: HGNC:9954
Homologene: 2182
Unc13b
Name: unc-13 homolog B
Synonyms: Munc13-2, Unc13h2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, Crsh, Adgrc1, crash
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Tesk1
Name: testis specific protein kinase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21754
Homologene: 4577
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Vmn2r3
Name: vomeronasal 2, receptor 3
Synonyms: EG637004
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 637004
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: Atp7a, Wilson protein, WND
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Gm10801
Name: predicted gene 10801
Type: Gene
Species: Mouse
Chromosome: 2
Nlrp12
Name: NLR family, pyrin domain containing 12
Synonyms: Nalp12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 378425
Homologene: 16972
Zfp329
Name: zinc finger protein 329
Synonyms: 2810439M05Rik, 4632409L22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67230
Homologene: 23459
Col9a1
Name: collagen, type IX, alpha 1
Synonyms: Col9a-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12839
HGNC: HGNC:2217
Homologene: 1393
Serpinb9c
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9c
Synonyms: NK9, 3830421J05Rik, Spi11, ovalbumin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20707
HGNC: HGNC:8955
Fam20b
Name: FAM20B, glycosaminoglycan xylosylkinase
Synonyms: C530043G21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215015
Homologene: 8909
Snx19
Name: sorting nexin 19
Synonyms: 3526401K03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102607
VEGA: 9
Homologene: 8846
Serpina3m
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3M
Synonyms: Spi-2rs1, contrapsin-like, 3e46, MMCM7, alpha-1 antiproteinase, Spi2-rs1, Spi2.4, MMSPi2.4, antitrypsin, Spi-2l
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20717
HGNC: HGNC:16
Homologene: 111129
Kif26b
Name: kinesin family member 26B
Synonyms: N-11 kinesin, D230039L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269152
Homologene: 18623
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226438
Homologene: 130054
Vmn2r54
Name: vomeronasal 2, receptor 54
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 666085
Homologene: 104040
Ube4a
Name: ubiquitination factor E4A
Synonyms: UFD2b, 9930123J21Rik, 4732444G18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 140630
Homologene: 3517
Pramel26
Name: PRAME like 26
Synonyms: Gm13084
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381569
Homologene: 77858
Washc1
Name: WASH complex subunit 1
Synonyms: Wash, Wash1, 1110049F14Rik, ORF19
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68767
VEGA: 17
Homologene: 45706
Bbs12
Name: Bardet-Biedl syndrome 12
Synonyms: LOC386537, LOC241950, LOC241950
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241950
Homologene: 17634
Ssrp1
Name: structure specific recognition protein 1
Synonyms: Hmgi-rs3, Hmgox, Hmg1-rs1, T160
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20833
Homologene: 110735
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: very-kind, VKIND, 2410012C07Rik, B830014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Carf
Name: calcium response factor
Synonyms: Als2cr8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241066
Homologene: 11689
Vmn2r81
Name: vomeronasal 2, receptor 81
Synonyms: EC1-VR2, V2rf2, pheromone recepter
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216144
Homologene: 83483
Fstl4
Name: follistatin-like 4
Synonyms: SPIG1, B230374F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320027
Homologene: 18543
Or8k22
Name: olfactory receptor family 8 subfamily K member 22
Synonyms: MOR188-2, Olfr1054, GA_x6K02T2Q125-47811880-47810942
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259021
Homologene: 133882
Or7e173
Name: olfactory receptor family 7 subfamily E member 173
Synonyms: MOR145-5, GA_x6K02T2PVTD-13768406-13767468, Olfr866
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258551
HGNC: HGNC:8396
Homologene: 133687
Khdc1c
Name: KH domain containing 1C
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 433278
Homologene: 134524
Krtap4-21
Name: keratin associated protein 4-21
Synonyms: Gm11569
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 670472
Homologene: 124486
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240427
Homologene: 9192
Il6
Name: interleukin 6
Synonyms: Il-6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16193
HGNC: HGNC:6018
Homologene: 502
Nhlrc1
Name: NHL repeat containing 1
Synonyms: B230309E09Rik, EPM2B, Malin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105193
VEGA: 13
Homologene: 18439
Bad
Name: BCL2-associated agonist of cell death
Synonyms: Bbc2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12015
HGNC: HGNC:936
Homologene: 3189
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 20,347,280 bp
  • T to C, chromosome 1 at 21,369,525 bp
  • T to A, chromosome 1 at 24,185,345 bp
  • C to A, chromosome 1 at 60,136,254 bp
  • G to A, chromosome 1 at 135,973,460 bp
  • A to G, chromosome 1 at 150,423,965 bp
  • G to T, chromosome 1 at 151,473,266 bp
  • A to T, chromosome 1 at 156,690,511 bp
  • A to G, chromosome 1 at 164,280,096 bp
  • A to C, chromosome 1 at 178,874,138 bp
  • T to C, chromosome 1 at 182,429,043 bp
  • T to C, chromosome 2 at 52,220,224 bp
  • T to A, chromosome 2 at 85,039,936 bp
  • A to T, chromosome 2 at 86,333,064 bp
  • TC to TCGGC, chromosome 2 at 98,663,806 bp
  • G to A, chromosome 2 at 109,296,663 bp
  • T to A, chromosome 2 at 164,982,905 bp
  • A to G, chromosome 3 at 37,319,241 bp
  • T to C, chromosome 3 at 64,259,506 bp
  • C to T, chromosome 3 at 100,656,071 bp
  • A to G, chromosome 4 at 43,170,156 bp
  • A to G, chromosome 4 at 43,443,592 bp
  • A to G, chromosome 4 at 143,812,762 bp
  • C to T, chromosome 5 at 30,018,203 bp
  • T to C, chromosome 5 at 106,637,911 bp
  • A to T, chromosome 6 at 52,733,223 bp
  • T to C, chromosome 7 at 3,240,683 bp
  • A to G, chromosome 7 at 12,632,153 bp
  • T to A, chromosome 7 at 12,810,098 bp
  • A to C, chromosome 7 at 27,172,956 bp
  • A to T, chromosome 7 at 79,420,342 bp
  • T to A, chromosome 7 at 96,797,392 bp
  • T to A, chromosome 7 at 123,187,445 bp
  • A to G, chromosome 7 at 139,913,569 bp
  • A to T, chromosome 8 at 22,028,690 bp
  • T to C, chromosome 8 at 36,229,037 bp
  • G to T, chromosome 9 at 20,027,132 bp
  • C to T, chromosome 9 at 21,658,831 bp
  • C to A, chromosome 9 at 30,428,935 bp
  • A to T, chromosome 9 at 44,948,843 bp
  • A to T, chromosome 9 at 123,135,958 bp
  • C to T, chromosome 10 at 75,153,937 bp
  • T to G, chromosome 10 at 79,268,154 bp
  • T to C, chromosome 11 at 23,744,304 bp
  • A to G, chromosome 11 at 53,186,450 bp
  • T to C, chromosome 11 at 53,686,184 bp
  • T to A, chromosome 11 at 99,798,421 bp
  • G to T, chromosome 12 at 81,591,385 bp
  • G to T, chromosome 12 at 104,389,127 bp
  • T to C, chromosome 13 at 33,150,327 bp
  • T to A, chromosome 13 at 47,013,776 bp
  • T to C, chromosome 13 at 64,365,147 bp
  • A to G, chromosome 15 at 86,031,654 bp
  • A to G, chromosome 17 at 66,119,066 bp
  • T to A, chromosome 18 at 78,857,500 bp
  • A to G, chromosome 18 at 82,957,000 bp
  • T to C, chromosome 19 at 6,951,334 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6886 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044980-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.