Strain Name:
C57BL/6J-MtgxR6889Btlr/Mmmh
Stock Number:
044983-MU
Citation ID:
RRID:MMRRC_044983-MU
Other Names:
R6889 (G1)
Major Collection:

Strain Information

Wasf2
Name: WASP family, member 2
Synonyms: D4Ertd13e, WAVE2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242687
Homologene: 86743
Gli2
Name: GLI-Kruppel family member GLI2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14633
HGNC: HGNC:4318
Homologene: 12725
Snx4
Name: sorting nexin 4
Synonyms: 1810036H14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69150
VEGA: 16
Homologene: 36143
Wasf1
Name: WASP family, member 1
Synonyms: WAVE-1, Scar, WAVE
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83767
Homologene: 2920
Zfp532
Name: zinc finger protein 532
Synonyms: C530030I18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328977
Homologene: 138627
Zfp462
Name: zinc finger protein 462
Synonyms: 9430078C22Rik, Zfpip, Gt4-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242466
Homologene: 41430
Ppfibp2
Name: PTPRF interacting protein, binding protein 2 (liprin beta 2)
Synonyms: Cclp1, liprin beta 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19024
HGNC: HGNC:9250
Homologene: 7486
Slc30a7
Name: solute carrier family 30 (zinc transporter), member 7
Synonyms: 2610034N15Rik, 4833428C12Rik, ZnT-7, ZnT7, 1810059J10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66500
Homologene: 11332
Opa1
Name: OPA1, mitochondrial dynamin like GTPase
Synonyms: optic atrophy 1, lilr3, 1200011N24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74143
HGNC: HGNC:8140
Homologene: 14618
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Syt9
Name: synaptotagmin IX
Synonyms: Sytv
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 60510
Homologene: 11062
Rars1
Name: arginyl-tRNA synthetase 1
Synonyms: 2610037E21Rik, 2610011N19Rik, Rars
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104458
HGNC: HGNC:9870
Homologene: 68281
Ehmt2
Name: euchromatic histone lysine N-methyltransferase 2
Synonyms: KMT1C, Bat8, D17Ertd710e, G9a, NG36
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110147
Homologene: 48460
Lrig1
Name: leucine-rich repeats and immunoglobulin-like domains 1
Synonyms: LIG-1, Img
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16206
Homologene: 7380
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: Zfp650, 1110059H15Rik, A130030D10Rik, 4833421P10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Zbtb14
Name: zinc finger and BTB domain containing 14
Synonyms: b2b1982Clo, Zfp161, ZF5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22666
Homologene: 2560
Igfl3
Name: IGF-like family member 3
Synonyms: Igfl, LOC232925
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232925
Homologene: 74410
Azi2
Name: 5-azacytidine induced gene 2
Synonyms: AZ2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 27215
Homologene: 8443
Dnaaf10
Name: dynein axonemal assembly factor 10
Synonyms: Wdr92
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103784
Homologene: 16321
Slc16a6
Name: solute carrier family 16 (monocarboxylic acid transporters), member 6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104681
Homologene: 20984
Eea1
Name: early endosome antigen 1
Synonyms: B230358H09Rik, A430109M19Rik, ZFYVE2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216238
VEGA: 10
HGNC: HGNC:3185
Homologene: 37822
Emc1
Name: ER membrane protein complex subunit 1
Synonyms: C230096C10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230866
Homologene: 9002
Pigt
Name: phosphatidylinositol glycan anchor biosynthesis, class T
Synonyms: Ndap7, 2510012P17Rik, NDAP, 4930534E15Rik, CGI-06
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78928
Homologene: 6134
Rai1
Name: retinoic acid induced 1
Synonyms: Gt1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19377
HGNC: HGNC:9834
Homologene: 7508
Sv2b
Name: synaptic vesicle glycoprotein 2b
Synonyms: A830038F04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64176
Homologene: 32236
Prrg2
Name: proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
Synonyms: 2510041M06Rik, N4WBP1, 1600014G02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 65116
HGNC: HGNC:9470
Homologene: 735
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Cd8a
Name: CD8 subunit alpha
Synonyms: Lyt-2, Ly-B, Ly-35, Ly-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12525
HGNC: HGNC:1706
Homologene: 133777
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy3, hyrh, hy-3, 1700034M11Rik, 4930545D19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Cspg4b
Name: chondroitin sulfate proteoglycan 4B
Synonyms: BC067074
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408066
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Ush2a
Name: usherin
Synonyms: Ushrn, A930037M10Rik, MUSH2A, LOC269160, A930011D15Rik, LOC381317, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: 6330444M21Rik, Wdr52, D16Ertd642e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212517
Homologene: 75085
Kctd7
Name: potassium channel tetramerisation domain containing 7
Synonyms: 9430010P06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212919
Homologene: 17687
Vmn2r2
Name: vomeronasal 2, receptor 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100125586
Homologene: 129753
Nrp1
Name: neuropilin 1
Synonyms: NP-1, Npn1, NPN-1, Neuropilin-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Or10ak14
Name: olfactory receptor family 10 subfamily AK member 14
Synonyms: GA_x6K02T2QD9B-18795136-18796077, Olfr1524-ps1, MOR259-4P, MOR259-9, MOR259-4P, Olfr1338
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258259
Homologene: 115537
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: Adlican2, CMF608, 6530405F15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Nod1
Name: nucleotide-binding oligomerization domain containing 1
Synonyms: F830007N14Rik, Card4, Nlrc1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107607
Homologene: 4440
Smc1b
Name: structural maintenance of chromosomes 1B
Synonyms: Smc1l2, SMC1beta
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 140557
VEGA: 15
Homologene: 13786
Cacnb2
Name: calcium channel, voltage-dependent, beta 2 subunit
Synonyms: Cavbeta2, Cchb2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12296
HGNC: HGNC:1402
Homologene: 75191
Vmn2r53
Name: vomeronasal 2, receptor 53
Synonyms: EG637908
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637908
Homologene: 104040
Atp6v0a1
Name: ATPase, H+ transporting, lysosomal V0 subunit A1
Synonyms: Atp6n1a, Atp6n1, V-ATPase a1, Vpp1, Vpp-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11975
HGNC: HGNC:865
Homologene: 3795
Kctd1
Name: potassium channel tetramerisation domain containing 1
Synonyms: 4933402K10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106931
VEGA: 18
Homologene: 65999
Or5p63
Name: olfactory receptor family 5 subfamily P member 63
Synonyms: Olfr487, MOR204-31P, GA_x6K02T2PBJ9-10541702-10540758, MOR204-31P, MOR204-29P, Olfr1538-ps1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258042
Homologene: 110483
Gpr108
Name: G protein-coupled receptor 108
Synonyms: 1810015L19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78308
VEGA: 17
Homologene: 32495
Abcc3
Name: ATP-binding cassette, sub-family C member 3
Synonyms: 1700019L09Rik, MRP3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76408
HGNC: HGNC:54
Homologene: 68364
Eme1
Name: essential meiotic structure-specific endonuclease 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268465
Homologene: 16123
Hmgcl
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A lyase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15356
HGNC: HGNC:5005
Homologene: 159
Ttbk2
Name: tau tubulin kinase 2
Synonyms: TTK, 2610507N02Rik, B930008N24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140810
Homologene: 62795
Vill
Name: villin-like
Synonyms: Villp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22351
Homologene: 22650
Pdia2
Name: protein disulfide isomerase associated 2
Synonyms: Pdip, Pdipl, 1810041F13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69191
Homologene: 55994
Qars1
Name: glutaminyl-tRNA synthetase 1
Synonyms: 1110018N24Rik, Qars, 1200016L19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 97541
HGNC: HGNC:9751
Homologene: 133975
Pdpr
Name: pyruvate dehydrogenase phosphatase regulatory subunit
Synonyms: 4930402E16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319518
Homologene: 9948
Or51t4
Name: olfactory receptor family 51 subfamily T member 4
Synonyms: GA_x6K02T2PBJ9-5659738-5660748, MOR14-9, Olfr574
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258357
Homologene: 27137
2310002L09Rik
Name: RIKEN cDNA 2310002L09 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71886
Homologene: 36448
Vmn2r32
Name: vomeronasal 2, receptor 32
Synonyms: V2r5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22311
Homologene: 113703
Or6c74
Name: olfactory receptor family 6 subfamily C member 74
Synonyms: GA_x6K02T2PULF-11704843-11705775, Olfr821, MOR109-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258772
Homologene: 27260
Pcdha6
Name: protocadherin alpha 6
Synonyms: Crnr2, Cnr2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12937
Homologene: 75098
Vmn1r41
Name: vomeronasal 1 receptor 41
Synonyms: V1rb9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113857
Homologene: 113975
Gm43302
Name: predicted gene 43302
Type: Gene
Species: Mouse
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 118,844,416 bp
  • T to A, chromosome 1 at 188,797,871 bp
  • T to A, chromosome 2 at 14,986,015 bp
  • A to T, chromosome 2 at 69,944,300 bp
  • T to C, chromosome 2 at 120,773,353 bp
  • T to A, chromosome 2 at 164,507,331 bp
  • A to C, chromosome 3 at 59,331,933 bp
  • A to T, chromosome 3 at 64,117,267 bp
  • T to C, chromosome 3 at 115,954,153 bp
  • G to T, chromosome 4 at 55,007,671 bp
  • A to T, chromosome 4 at 73,943,053 bp
  • G to A, chromosome 4 at 118,754,307 bp
  • G to T, chromosome 4 at 133,194,730 bp
  • C to A, chromosome 4 at 135,955,642 bp
  • T to C, chromosome 4 at 139,365,350 bp
  • T to C, chromosome 5 at 105,280,138 bp
  • A to T, chromosome 5 at 130,152,501 bp
  • A to G, chromosome 6 at 54,944,109 bp
  • A to C, chromosome 6 at 71,374,562 bp
  • A to T, chromosome 6 at 89,747,370 bp
  • A to G, chromosome 6 at 94,625,063 bp
  • A to G, chromosome 7 at 7,472,574 bp
  • A to G, chromosome 7 at 12,601,142 bp
  • G to T, chromosome 7 at 18,179,800 bp
  • G to A, chromosome 7 at 45,059,989 bp
  • A to C, chromosome 7 at 75,125,767 bp
  • GCGGCGGCG to GCGGCGGCGTCGGCGGCG, chromosome 7 at 97,579,925 bp
  • A to T, chromosome 7 at 102,948,768 bp
  • A to T, chromosome 7 at 107,425,286 bp
  • A to C, chromosome 7 at 107,737,981 bp
  • A to T, chromosome 7 at 108,211,918 bp
  • C to T, chromosome 7 at 141,809,744 bp
  • G to A, chromosome 8 at 110,532,856 bp
  • G to T, chromosome 8 at 111,124,613 bp
  • T to C, chromosome 8 at 128,493,057 bp
  • A to G, chromosome 9 at 108,513,183 bp
  • A to G, chromosome 9 at 118,049,895 bp
  • A to G, chromosome 9 at 119,065,882 bp
  • A to T, chromosome 10 at 40,920,369 bp
  • G to T, chromosome 10 at 96,037,478 bp
  • T to C, chromosome 10 at 130,034,532 bp
  • G to A, chromosome 11 at 17,222,309 bp
  • A to T, chromosome 11 at 35,808,486 bp
  • T to C, chromosome 11 at 60,185,715 bp
  • A to T, chromosome 11 at 94,375,555 bp
  • G to A, chromosome 11 at 94,650,477 bp
  • A to G, chromosome 11 at 101,029,183 bp
  • A to C, chromosome 11 at 109,455,040 bp
  • C to A, chromosome 13 at 113,318,378 bp
  • A to T, chromosome 15 at 85,067,759 bp
  • G to T, chromosome 16 at 29,620,868 bp
  • G to T, chromosome 16 at 33,251,470 bp
  • G to A, chromosome 16 at 44,404,132 bp
  • A to G, chromosome 16 at 49,153,111 bp
  • A to T, chromosome 17 at 26,196,970 bp
  • T to G, chromosome 17 at 34,912,772 bp
  • A to T, chromosome 17 at 57,236,990 bp
  • G to A, chromosome 17 at 69,387,679 bp
  • A to G, chromosome 18 at 14,973,988 bp
  • G to T, chromosome 18 at 36,968,343 bp
  • A to G, chromosome 18 at 65,686,990 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6889 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044983-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.