Strain Name:
C57BL/6J-MtgxR6890Btlr/Mmmh
Stock Number:
044984-MU
Citation ID:
RRID:MMRRC_044984-MU
Other Names:
R6890 (G1)
Major Collection:

Strain Information

Npr3
Name: natriuretic peptide receptor 3
Synonyms: Nppc receptor, lgj, longjohn, NPR-C, B430320C24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18162
VEGA: 15
HGNC: HGNC:7945
Homologene: 699
Snx2
Name: sorting nexin 2
Synonyms: 0610030A03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67804
VEGA: 18
Homologene: 2332
Mtss1
Name: MTSS I-BAR domain containing 1
Synonyms: MIM, D130001D01Rik, 2310003N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 211401
VEGA: 15
Homologene: 8841
Arhgef10
Name: Rho guanine nucleotide exchange factor 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234094
Homologene: 22827
Col18a1
Name: collagen, type XVIII, alpha 1
Synonyms: endostatin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12822
HGNC: HGNC:2195
Homologene: 7673
Eps8
Name: epidermal growth factor receptor pathway substrate 8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13860
HGNC: HGNC:3420
Homologene: 3272
Tex21
Name: testis expressed gene 21
Synonyms: tsec-2, 4931412D23Rik, 4931406F04Rik, 4931421K24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 80384
VEGA: 12
Homologene: 10510
Armh3
Name: armadillo-like helical domain containing 3
Synonyms: 9130011E15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71617
VEGA: 19
Homologene: 15843
Epb41
Name: erythrocyte membrane protein band 4.1
Synonyms: 4.1R, Elp-1, Elp1, D4Ertd442e, Epb4.1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269587
HGNC: HGNC:3377
Homologene: 44324
Npepps
Name: aminopeptidase puromycin sensitive
Synonyms: MP100, Psa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19155
HGNC: HGNC:7900
Homologene: 36199
Slitrk6
Name: SLIT and NTRK-like family, member 6
Synonyms: 4832410J21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239250
VEGA: 14
Homologene: 12986
Rad17
Name: RAD17 checkpoint clamp loader component
Synonyms: MmRad24, 9430035O09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19356
VEGA: 13
HGNC: HGNC:9807
Homologene: 32117
Zfp617
Name: zinc finger protein 617
Synonyms: Zfps11-6, Zinc finger protein s11-6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170938
Homologene: 135689
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: 6720464I07Rik, Solo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223435
VEGA: 15
Homologene: 20847
Cdhr1
Name: cadherin-related family member 1
Synonyms: Prcad, Pcdh21
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 170677
VEGA: 14
Homologene: 13215
Nsun6
Name: NOL1/NOP2/Sun domain family member 6
Synonyms: 4933403D21Rik, NOPD1, 4933414E04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74455
Homologene: 12564
Nphp3
Name: nephronophthisis 3 (adolescent)
Synonyms: D330020E01Rik, pcy, nephrocystin 3, 3632410F03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74025
HGNC: HGNC:7907
Homologene: 32697
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola2, Cola-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Klc4
Name: kinesin light chain 4
Synonyms: 1200014P03Rik, Knsl8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74764
VEGA: 17
Homologene: 12584
Fbxw16
Name: F-box and WD-40 domain protein 16
Synonyms: 7420402K12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320083
Homologene: 110776
Vpreb1b
Name: V-set pre-B cell surrogate light chain 1B
Synonyms: Vpreb-2, Vpreb2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22363
VEGA: 16
Homologene: 84741
Arhgef10l
Name: Rho guanine nucleotide exchange factor 10-like
Synonyms: 2810441C07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72754
Homologene: 10017
Pcnx1
Name: pecanex 1
Synonyms: 3526401J03Rik, 2900024E21Rik, Pcnx
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Or51ai2
Name: olfactory receptor family 51 subfamily AI member 2
Synonyms: GA_x6K02T2PBJ9-6671256-6672209, MOR2-1, Olfr632
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259123
Homologene: 64963
Cspg5
Name: chondroitin sulfate proteoglycan 5
Synonyms: NGC, neuroglycan C, CALEB
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 29873
HGNC: HGNC:2467
Homologene: 4795
Mapkbp1
Name: mitogen-activated protein kinase binding protein 1
Synonyms: Jnkbp1, 2810483F24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26390
Homologene: 69109
Slc26a4
Name: solute carrier family 26, member 4
Synonyms: Pds, pendrin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 23985
VEGA: 12
HGNC: HGNC:8818
Homologene: 20132
Dusp10
Name: dual specificity phosphatase 10
Synonyms: MKP-5, 2610306G15Rik, MKP5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 63953
HGNC: HGNC:3065
Homologene: 5215
Niban3
Name: niban apoptosis regulator 3
Synonyms: Bcnp1, Fam129c
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100037278
Homologene: 45462
Zgpat
Name: zinc finger, CCCH-type with G patch domain
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229007
Homologene: 41874
Or5b121
Name: olfactory receptor family 5 subfamily B member 121
Synonyms: GA_x6K02T2RE5P-3862389-3863336, MOR202-44, Olfr1480
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 404339
Homologene: 110492
Or13p4
Name: olfactory receptor family 13 subfamily P member 4
Synonyms: GA_x6K02T2QD9B-18856980-18857927, MOR258-3, Olfr1342
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258708
Homologene: 17357
Ambp
Name: alpha 1 microglobulin/bikunin precursor
Synonyms: ASPI, HI-30, ulinastatin, Urinary Trypsin Inhibitor, UTI, Itil, Intin4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11699
HGNC: HGNC:453
Homologene: 1234
Alg3
Name: ALG3 alpha-1,3- mannosyltransferase
Synonyms: D16Ertd36e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208624
Homologene: 4228
Gsg1
Name: germ cell associated 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14840
Homologene: 7745
Malsu1
Name: mitochondrial assembly of ribosomal large subunit 1
Synonyms: 2410003K15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75593
Homologene: 16317
Iglc3
Name: immunoglobulin lambda constant 3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110787
HGNC: HGNC:5855
Gm49368
Name: predicted gene, 49368
Type: Gene
Species: Mouse
Chromosome: 7
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 184,069,196 bp
  • A to G, chromosome 2 at 15,048,977 bp
  • T to C, chromosome 2 at 120,015,802 bp
  • T to A, chromosome 2 at 181,378,511 bp
  • G to C, chromosome 4 at 63,150,359 bp
  • A to G, chromosome 4 at 118,689,531 bp
  • A to T, chromosome 4 at 131,935,829 bp
  • A to G, chromosome 4 at 140,544,419 bp
  • T to A, chromosome 6 at 4,539,587 bp
  • A to G, chromosome 6 at 49,075,251 bp
  • C to T, chromosome 6 at 135,237,420 bp
  • A to G, chromosome 6 at 137,512,257 bp
  • A to T, chromosome 7 at 103,937,859 bp
  • A to G, chromosome 7 at 128,081,729 bp
  • T to C, chromosome 8 at 14,928,786 bp
  • T to A, chromosome 8 at 71,605,671 bp
  • T to G, chromosome 8 at 71,932,166 bp
  • A to C, chromosome 9 at 104,041,954 bp
  • A to T, chromosome 9 at 109,436,742 bp
  • T to C, chromosome 9 at 110,246,784 bp
  • T to A, chromosome 10 at 77,113,484 bp
  • A to T, chromosome 11 at 97,267,644 bp
  • G to A, chromosome 12 at 31,549,951 bp
  • A to G, chromosome 12 at 76,239,455 bp
  • A to G, chromosome 12 at 81,971,376 bp
  • A to C, chromosome 13 at 100,162,041 bp
  • T to C, chromosome 13 at 100,637,084 bp
  • T to C, chromosome 14 at 37,085,645 bp
  • A to T, chromosome 14 at 110,751,096 bp
  • A to G, chromosome 15 at 11,883,392 bp
  • A to T, chromosome 15 at 27,919,288 bp
  • G to T, chromosome 15 at 58,951,659 bp
  • T to C, chromosome 16 at 17,980,956 bp
  • T to A, chromosome 16 at 19,065,508 bp
  • T to C, chromosome 16 at 20,605,986 bp
  • A to T, chromosome 17 at 46,631,843 bp
  • A to G, chromosome 18 at 53,212,879 bp
  • C to T, chromosome 19 at 13,530,081 bp
  • A to G, chromosome 19 at 45,960,357 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6890 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044984-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.