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Strain Name:
C57BL/6J-MtgxR6905Btlr/Mmmh
Stock Number:
044997-MU
Citation ID:
RRID:MMRRC_044997-MU
Other Names:
R6905 (G1)
Major Collection:

Strain Information

Traf4
Name: TNF receptor associated factor 4
Synonyms: CART1, A530032M13Rik, msp2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22032
Homologene: 3173
Pank3
Name: pantothenate kinase 3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 211347
Homologene: 56999
Nes
Name: nestin
Synonyms: RC2, Marc2, ESTM46, Ifaprc2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18008
HGNC: HGNC:7756
Homologene: 136487
Cdk11b
Name: cyclin dependent kinase 11B
Synonyms: CDK11-p110, PITSLRE proteins, CDK11-p46, CDK11-p58, Cdc2l2, Cdc2l1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12537
Homologene: 22416
Rps6ka2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: Rsk3, Rps6ka-rs1, 90kDa, p90rsk, pp90rsk, D17Wsu134e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20112
VEGA: 17
Homologene: 100680
Smg7
Name: SMG7 nonsense mediated mRNA decay factor
Synonyms: 9430023P16Rik, Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226517
Homologene: 32235
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77011
Homologene: 67120
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 54,792,494 bp
  • A to G, chromosome 1 at 87,044,839 bp
  • A to G, chromosome 1 at 87,935,375 bp
  • A to G, chromosome 1 at 135,827,880 bp
  • G to T, chromosome 1 at 151,980,438 bp
  • A to T, chromosome 1 at 152,850,006 bp
  • A to G, chromosome 2 at 25,220,479 bp
  • A to T, chromosome 2 at 89,881,708 bp
  • A to T, chromosome 2 at 112,110,358 bp
  • C to A, chromosome 2 at 112,479,556 bp
  • T to C, chromosome 3 at 57,294,909 bp
  • C to T, chromosome 3 at 87,978,678 bp
  • A to T, chromosome 4 at 24,503,107 bp
  • C to A, chromosome 4 at 61,833,103 bp
  • A to G, chromosome 4 at 139,306,441 bp
  • C to A, chromosome 4 at 152,009,727 bp
  • A to T, chromosome 4 at 155,641,608 bp
  • G to A, chromosome 5 at 86,090,922 bp
  • A to T, chromosome 6 at 3,375,387 bp
  • T to C, chromosome 6 at 13,205,927 bp
  • T to C, chromosome 6 at 50,351,882 bp
  • T to C, chromosome 7 at 12,925,858 bp
  • T to A, chromosome 7 at 25,337,932 bp
  • T to C, chromosome 7 at 79,665,850 bp
  • A to T, chromosome 7 at 103,604,367 bp
  • A to C, chromosome 7 at 114,253,890 bp
  • A to T, chromosome 9 at 90,062,766 bp
  • A to T, chromosome 9 at 106,060,318 bp
  • T to C, chromosome 9 at 107,587,890 bp
  • G to A, chromosome 10 at 39,817,327 bp
  • A to G, chromosome 10 at 81,108,867 bp
  • T to C, chromosome 11 at 35,776,412 bp
  • C to T, chromosome 11 at 78,160,442 bp
  • T to C, chromosome 12 at 44,283,553 bp
  • C to T, chromosome 12 at 71,061,544 bp
  • T to C, chromosome 12 at 115,648,085 bp
  • A to G, chromosome 13 at 34,027,990 bp
  • G to T, chromosome 14 at 52,770,313 bp
  • A to G, chromosome 15 at 78,905,030 bp
  • A to G, chromosome 16 at 56,574,517 bp
  • T to A, chromosome 17 at 7,227,941 bp
  • A to T, chromosome 17 at 68,777,888 bp
  • C to T, chromosome 18 at 37,474,695 bp
  • A to G, chromosome 19 at 4,803,236 bp
  • T to A, chromosome 19 at 7,095,392 bp
  • T to C, chromosome 19 at 34,619,590 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6905 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044997-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.