Strain Name:
C57BL/6J-MtgxR6905Btlr/Mmmh
Stock Number:
044997-MU
Citation ID:
RRID:MMRRC_044997-MU
Other Names:
R6905 (G1)
Major Collection:

Strain Information

Traf4
Name: TNF receptor associated factor 4
Synonyms: CART1, A530032M13Rik, msp2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22032
Homologene: 3173
Pank3
Name: pantothenate kinase 3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 211347
Homologene: 56999
Nes
Name: nestin
Synonyms: RC2, Marc2, ESTM46, Ifaprc2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18008
HGNC: HGNC:7756
Homologene: 136487
Cdk11b
Name: cyclin dependent kinase 11B
Synonyms: CDK11-p110, PITSLRE proteins, CDK11-p46, CDK11-p58, Cdc2l2, Cdc2l1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12537
Homologene: 22416
Rps6ka2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: Rsk3, 90kDa, Rps6ka-rs1, p90rsk, pp90rsk, D17Wsu134e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20112
VEGA: 17
Homologene: 100680
Smg7
Name: SMG7 nonsense mediated mRNA decay factor
Synonyms: 9430023P16Rik, Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226517
Homologene: 32235
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77011
Homologene: 67120
Copb1
Name: coatomer protein complex, subunit beta 1
Synonyms: Copb1, 2610019B04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70349
HGNC: HGNC:2231
Homologene: 5664
Dis3l2
Name: DIS3 like 3'-5' exoribonuclease 2
Synonyms: 8030493P09Rik, 4930429A22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208718
Homologene: 62417
Map2k2
Name: mitogen-activated protein kinase kinase 2
Synonyms: MEK2, MAP kinase/Erk kinase, Prkmk2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 26396
HGNC: HGNC:6842
Homologene: 48591
Arid4a
Name: AT-rich interaction domain 4A
Synonyms: A630067N03Rik, Rbbp1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238247
HGNC: HGNC:9885
Homologene: 11303
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: DGKdelta, dgkd-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Ripk1
Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
Synonyms: Rinp, Rip1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19766
Homologene: 2820
Mms22l
Name: MMS22-like, DNA repair protein
Synonyms: F730047E07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212377
Homologene: 18874
Flrt1
Name: fibronectin leucine rich transmembrane protein 1
Synonyms: D630040I23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 396184
VEGA: 19
HGNC: HGNC:3760
Homologene: 40864
Rps5
Name: ribosomal protein S5
Synonyms: S5 ribosomal protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20103
Homologene: 783
Ifrd2
Name: interferon-related developmental regulator 2
Synonyms: SKMc15, 1810034A24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15983
HGNC: HGNC:5457
Homologene: 21341
Rbm14
Name: RNA binding motif protein 14
Synonyms: p16, 1300007E16Rik, PSP2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56275
Homologene: 4614
Chrm5
Name: cholinergic receptor, muscarinic 5
Synonyms: muscarinic acetylcholine receptor 5, M5R
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 213788
HGNC: HGNC:1954
Homologene: 22697
Slc66a1
Name: solute carrier family 66 member 1
Synonyms: Pqlc2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212555
Homologene: 56784
Ifit1bl2
Name: interferon induced protein with tetratricopeptide repeats 1B like 2
Synonyms: 2010002M12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 112419
Homologene: 78213
Pnpla8
Name: patatin-like phospholipase domain containing 8
Synonyms: 1200006O19Rik, iPLA2 gamma
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67452
Homologene: 12136
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Megf8
Name: multiple EGF-like-domains 8
Synonyms: Egfl4, b2b288Clo, b2b1702Clo, m687Ddg
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
Vwde
Name: von Willebrand factor D and EGF domains
Synonyms: LOC232585
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232585
Homologene: 35456
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: EG235580, 1110001D15Rik, Dvwa, Vwa6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
L3mbtl4
Name: L3MBTL4 histone methyl-lysine binding protein
Synonyms: D930040M24Rik, A730037L19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320858
Homologene: 114383
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Mup5
Name: major urinary protein 5
Synonyms: Mup V
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17844
Homologene: 74304
Tm4sf1
Name: transmembrane 4 superfamily member 1
Synonyms: 12A8 target antigen, L6 antigen, L6, M3s1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17112
Homologene: 7409
Osbpl3
Name: oxysterol binding protein-like 3
Synonyms: OSBP3, ORP3, 1200014M06Rik, 6720421I08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71720
Homologene: 49422
Sh3bp1
Name: SH3-domain binding protein 1
Synonyms: 3BP-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20401
Homologene: 7534
Pcdhb15
Name: protocadherin beta 15
Synonyms: Pcdhb7, PcdhbO
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93886
HGNC: HGNC:8692
Homologene: 32429
Stap1
Name: signal transducing adaptor family member 1
Synonyms: STAP-1, Brdg1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56792
Homologene: 8103
Ctsh
Name: cathepsin H
Synonyms: Cat H
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13036
HGNC: HGNC:2535
Homologene: 36159
Cimip2a
Name: ciliary microtubule inner protein 2A
Synonyms: Fam166a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68222
Homologene: 12247
Abi3bp
Name: ABI family member 3 binding protein
Synonyms: 5033411B22Rik, D930038M13Rik, eratin, TARSH
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320712
VEGA: 16
Homologene: 134172
Ankrd44
Name: ankyrin repeat domain 44
Synonyms: E130014H08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329154
Homologene: 27547
Klhl21
Name: kelch-like 21
Synonyms: 1810045K06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242785
Homologene: 8902
Or4c10b
Name: olfactory receptor family 4 subfamily C member 10B
Synonyms: GA_x6K02T2Q125-51319458-51320387, MOR232-1, Olfr1257
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258984
Homologene: 115501
1700025G04Rik
Name: RIKEN cDNA 1700025G04 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69399
Homologene: 12776
Or52z14
Name: olfactory receptor family 52 subfamily Z member 14
Synonyms: GA_x6K02T2PBJ9-6326488-6327450, MOR31-5, Olfr619
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259080
Homologene: 45095
Ighv8-12
Name: immunoglobulin heavy variable V8-12
Synonyms: ENSMUSG00000062479
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 780960
Lad1
Name: ladinin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16763
HGNC: HGNC:6472
Homologene: 4059
Trav7d-4
Name: T cell receptor alpha variable 7D-4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 382180
Or4f14c
Name: olfactory receptor family 4 subfamily F member 14C
Synonyms: GA_x6K02T2Q125-73157028-73156524, MOR245-1, Olfr1315
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404497
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 54,792,494 bp
  • A to G, chromosome 1 at 87,044,839 bp
  • A to G, chromosome 1 at 87,935,375 bp
  • A to G, chromosome 1 at 135,827,880 bp
  • G to T, chromosome 1 at 151,980,438 bp
  • A to T, chromosome 1 at 152,850,006 bp
  • A to G, chromosome 2 at 25,220,479 bp
  • A to T, chromosome 2 at 89,881,708 bp
  • A to T, chromosome 2 at 112,110,358 bp
  • C to A, chromosome 2 at 112,479,556 bp
  • T to C, chromosome 3 at 57,294,909 bp
  • C to T, chromosome 3 at 87,978,678 bp
  • A to T, chromosome 4 at 24,503,107 bp
  • C to A, chromosome 4 at 61,833,103 bp
  • A to G, chromosome 4 at 139,306,441 bp
  • C to A, chromosome 4 at 152,009,727 bp
  • A to T, chromosome 4 at 155,641,608 bp
  • G to A, chromosome 5 at 86,090,922 bp
  • A to T, chromosome 6 at 3,375,387 bp
  • T to C, chromosome 6 at 13,205,927 bp
  • T to C, chromosome 6 at 50,351,882 bp
  • T to C, chromosome 7 at 12,925,858 bp
  • T to A, chromosome 7 at 25,337,932 bp
  • T to C, chromosome 7 at 79,665,850 bp
  • A to T, chromosome 7 at 103,604,367 bp
  • A to C, chromosome 7 at 114,253,890 bp
  • A to T, chromosome 9 at 90,062,766 bp
  • A to T, chromosome 9 at 106,060,318 bp
  • T to C, chromosome 9 at 107,587,890 bp
  • G to A, chromosome 10 at 39,817,327 bp
  • A to G, chromosome 10 at 81,108,867 bp
  • T to C, chromosome 11 at 35,776,412 bp
  • C to T, chromosome 11 at 78,160,442 bp
  • T to C, chromosome 12 at 44,283,553 bp
  • C to T, chromosome 12 at 71,061,544 bp
  • T to C, chromosome 12 at 115,648,085 bp
  • A to G, chromosome 13 at 34,027,990 bp
  • G to T, chromosome 14 at 52,770,313 bp
  • A to G, chromosome 15 at 78,905,030 bp
  • A to G, chromosome 16 at 56,574,517 bp
  • T to A, chromosome 17 at 7,227,941 bp
  • A to T, chromosome 17 at 68,777,888 bp
  • C to T, chromosome 18 at 37,474,695 bp
  • A to G, chromosome 19 at 4,803,236 bp
  • T to A, chromosome 19 at 7,095,392 bp
  • T to C, chromosome 19 at 34,619,590 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6905 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044997-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.