Strain Name:
C57BL/6J-MtgxR6910Btlr/Mmmh
Stock Number:
045002-MU
Citation ID:
RRID:MMRRC_045002-MU
Other Names:
R6910 (G1)
Major Collection:

Strain Information

Epha2
Name: Eph receptor A2
Synonyms: Eck, Sek2, Myk2, Sek-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13836
HGNC: HGNC:3386
Homologene: 20929
Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20370
Homologene: 10948
Nms
Name: neuromedin S
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 433292
Homologene: 67775
Mrpl39
Name: mitochondrial ribosomal protein L39
Synonyms: MRP-L5, Rpml5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27393
Homologene: 9679
Ncoa7
Name: nuclear receptor coactivator 7
Synonyms: 9030406N13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 211329
VEGA: 10
Homologene: 65245
Map3k8
Name: mitogen-activated protein kinase kinase kinase 8
Synonyms: Tpl2, Cot, Cot/Tpl2, Tpl-2, c-COT
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26410
HGNC: HGNC:6860
Homologene: 3812
Micu1
Name: mitochondrial calcium uptake 1
Synonyms: Cbara1, C730016L05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216001
HGNC: HGNC:1530
Homologene: 4431
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: G431004K08Rik, GCN1L, Gcn1l1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Hdac4
Name: histone deacetylase 4
Synonyms: 4932408F19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208727
Homologene: 55946
Gpatch2l
Name: G patch domain containing 2 like
Synonyms: 1700020O03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70373
VEGA: 12
Homologene: 9942
Tcof1
Name: treacle ribosome biogenesis factor 1
Synonyms: treacle
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21453
Homologene: 68049
Scp2
Name: sterol carrier protein 2, liver
Synonyms: SCPx, SCP-2, ns-LTP, NSL-TP, nonspecific lipid transfer protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20280
Homologene: 37717
Ift80
Name: intraflagellar transport 80
Synonyms: Wdr56, 4921524P20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68259
Homologene: 12253
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Nrip1
Name: nuclear receptor interacting protein 1
Synonyms: 8430438I05Rik, 6030458L20Rik, RIP140
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268903
HGNC: HGNC:8001
Homologene: 2606
Tpm1
Name: tropomyosin 1, alpha
Synonyms: Tm3, alpha-TM, Tpm-1, TM2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22003
Homologene: 128637
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Rsrc1
Name: arginine/serine-rich coiled-coil 1
Synonyms: 1200013F24Rik, SRrp53
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66880
Homologene: 41147
Glp2r
Name: glucagon-like peptide 2 receptor
Synonyms: GLP-2, 9530092J08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 93896
HGNC: HGNC:4325
Homologene: 3132
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Zfp1001
Name: zinc finger protein 1001
Synonyms: Gm10130
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 102633750
VEGA: 2
Or11g27
Name: olfactory receptor family 11 subfamily G member 27
Synonyms: Olfr743-ps1, Olfr264, Olfr265, GA_x6K02T2N6FY-2320-2039, GA_x6K02T2N6FY-3870-3385, MOR106-14, Olfr743, GA_x6K02T2PMLR-6243196-6244132, MOR106-8P
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219019
Homologene: 74163
Or10ak9
Name: olfactory receptor family 10 subfamily AK member 9
Synonyms: Olfr1331, MOR259-3P, GA_x6K02T2QD9B-18670866-18669913
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258159
Homologene: 134082
Gnptab
Name: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Synonyms: EG432486
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432486
Homologene: 32576
Dennd3
Name: DENN domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105841
Homologene: 28254
Sanbr
Name: SANT and BTB domain regulator of CSR
Synonyms: 0610010F05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71675
Homologene: 19038
Zfp616
Name: zinc finger protein 616
Synonyms: Gm12330
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327963
Homologene: 88945
Chil5
Name: chitinase-like 5
Synonyms: Bclp1, Chi3l7, Bclp2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229687
Homologene: 132668
Tnfrsf11a
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Synonyms: Rank, TRANCE-R
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21934
Homologene: 2848
Hapln2
Name: hyaluronan and proteoglycan link protein 2
Synonyms: 4930401E20Rik, Bral1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73940
Homologene: 11045
Vmn2r-ps158
Name: vomeronasal 2, receptor, pseudogene 158
Synonyms: Gm9268, Vmn2r126
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668612
Homologene: 104832
Try5
Name: trypsin 5
Synonyms: 1810049H19Rik, Tc
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 103964
Homologene: 106639
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: 4930485B16Rik, Gm872, LOC380653
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
R3hcc1
Name: R3H domain and coiled-coil containing 1
Synonyms: 1700020M16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71843
Homologene: 136250
Pcdhga10
Name: protocadherin gamma subfamily A, 10
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93722
HGNC: HGNC:8697
Homologene: 49567
Gm17655
Name: predicted gene, 17655
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100504130
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 38,941,895 bp
  • G to T, chromosome 1 at 91,982,153 bp
  • A to G, chromosome 1 at 105,844,546 bp
  • T to C, chromosome 2 at 112,958,175 bp
  • A to T, chromosome 2 at 150,324,067 bp
  • C to T, chromosome 3 at 66,994,649 bp
  • A to C, chromosome 3 at 68,927,735 bp
  • A to G, chromosome 3 at 88,023,828 bp
  • A to G, chromosome 3 at 106,019,661 bp
  • C to A, chromosome 4 at 108,105,086 bp
  • T to A, chromosome 4 at 118,869,138 bp
  • A to G, chromosome 4 at 141,321,513 bp
  • T to A, chromosome 5 at 110,047,173 bp
  • A to G, chromosome 5 at 115,606,538 bp
  • T to C, chromosome 5 at 137,419,080 bp
  • T to C, chromosome 6 at 41,311,799 bp
  • T to C, chromosome 7 at 43,024,051 bp
  • A to G, chromosome 9 at 67,031,974 bp
  • T to C, chromosome 10 at 5,048,887 bp
  • T to G, chromosome 10 at 30,694,121 bp
  • A to G, chromosome 10 at 59,740,667 bp
  • G to A, chromosome 10 at 88,431,396 bp
  • A to G, chromosome 10 at 92,836,512 bp
  • A to G, chromosome 11 at 23,620,447 bp
  • A to G, chromosome 11 at 67,730,671 bp
  • A to T, chromosome 11 at 74,085,002 bp
  • A to G, chromosome 11 at 77,953,869 bp
  • G to A, chromosome 12 at 86,244,184 bp
  • G to A, chromosome 14 at 50,533,873 bp
  • G to A, chromosome 14 at 69,697,575 bp
  • A to G, chromosome 15 at 73,555,116 bp
  • G to A, chromosome 16 at 76,294,417 bp
  • A to G, chromosome 16 at 84,735,192 bp
  • A to G, chromosome 17 at 67,791,464 bp
  • A to G, chromosome 18 at 4,340,801 bp
  • T to A, chromosome 18 at 37,748,232 bp
  • G to C, chromosome 18 at 60,829,051 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6910 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045002-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.