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Strain Name:
C57BL/6J-MtgxR6852Btlr/Mmmh
Stock Number:
045023-MU
Citation ID:
RRID:MMRRC_045023-MU
Other Names:
R6852 (G1)
Major Collection:

Strain Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: N-CoR, Rxrip13, A230020K14Rik, 5730405M06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Mindy3
Name: MINDY lysine 48 deubiquitinase 3
Synonyms: 1810041E18Rik, 5830410F13Rik, 2310047O13Rik, Fam188a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66960
Homologene: 11478
Lhx9
Name: LIM homeobox protein 9
Synonyms: LH2B, Lhx9 alpha, 3110009O07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16876
Homologene: 7816
Dgka
Name: diacylglycerol kinase, alpha
Synonyms: Dagk1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13139
VEGA: 10
HGNC: HGNC:2849
Homologene: 1028
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Efr3a
Name: EFR3 homolog A
Synonyms: A130089M23Rik, D030063F01Rik, C920006C10Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76740
Homologene: 44222
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Mtdh
Name: metadherin
Synonyms: D8Bwg1112e, 3D3/Lyric, Lyric, 2610103J23Rik, AEG-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67154
Homologene: 12089
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227648
Homologene: 10533
Tbcd
Name: tubulin-specific chaperone d
Synonyms: A030005L14Rik, 2310057L06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108903
Homologene: 4368
Relch
Name: RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms: 2310035C23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227446
Homologene: 10834
Ddx39a
Name: DEAD box helicase 39a
Synonyms: 2610307C23Rik, BAT1, Ddx39
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68278
Homologene: 68487
Rpl8
Name: ribosomal protein L8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 26961
VEGA: 15
Homologene: 32141
Zfp318
Name: zinc finger protein 318
Synonyms: TZF, 2610034E08Rik, D530032D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57908
Homologene: 22808
Cep128
Name: centrosomal protein 128
Synonyms: 5430424K18Rik, 4930534B04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75216
Homologene: 35315
Epg5
Name: ectopic P-granules 5 autophagy tethering factor
Synonyms: 5430411K18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
A630089N07Rik
Name: RIKEN cDNA A630089N07 gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320586
VEGA: 16
Elapor1
Name: endosome-lysosome associated apoptosis and autophagy regulator 1
Synonyms: Inceptor, Iir, 5330417C22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229722
Homologene: 23249
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, mSorLA, 2900010L19Rik, Sorla
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20660
Homologene: 2336
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: MOZ, Zfp220, 9930021N24Rik, Myst3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244349
Homologene: 4924
Raver2
Name: ribonucleoprotein, PTB-binding 2
Synonyms: A430091O22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242570
Homologene: 18829
Tor1aip1
Name: torsin A interacting protein 1
Synonyms: LAP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208263
Homologene: 9208
Bsph1
Name: binder of sperm protein homolog 1
Synonyms: LOC330470
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330470
Homologene: 86818
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213262
Homologene: 10584
Abca4
Name: ATP-binding cassette, sub-family A member 4
Synonyms: Rim protein, RmP, Abc10, D430003I15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Zfp560
Name: zinc finger protein 560
Synonyms: 2310030G09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434377
Homologene: 103820
Srgap3
Name: SLIT-ROBO Rho GTPase activating protein 3
Synonyms: Arhgap14, D130026O08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 259302
Homologene: 56686
Fer1l6
Name: fer-1 like family member 6
Synonyms: EG631797
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 631797
Homologene: 53396
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319482
Homologene: 130055
Ampd3
Name: adenosine monophosphate deaminase 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11717
HGNC: HGNC:470
Homologene: 408
Zfp654
Name: zinc finger protein 654
Synonyms: 1810008K20Rik, 1600021C16Rik, Gm5488
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72020
Homologene: 10114
Zscan20
Name: zinc finger and SCAN domains 20
Synonyms: Zfp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269585
Homologene: 51463
Vmn2r78
Name: vomeronasal 2, receptor 78
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637896
Homologene: 115466
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MyHC-IIb, MHC2B, Myhsf, MM, MYH-2B, Minmus, Minimsc
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Aatk
Name: apoptosis-associated tyrosine kinase
Synonyms: AATYK1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11302
HGNC: HGNC:21
Homologene: 74861
Vmn2r53
Name: vomeronasal 2, receptor 53
Synonyms: EG637908
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637908
Homologene: 104040
Gmip
Name: Gem-interacting protein
Synonyms: 5031419I10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78816
Homologene: 9570
Prickle2
Name: prickle planar cell polarity protein 2
Synonyms: 6720451F06Rik, 6230400G14Rik, mpk2, Pk2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243548
Homologene: 17889
Kctd1
Name: potassium channel tetramerisation domain containing 1
Synonyms: 4933402K10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106931
VEGA: 18
Homologene: 65999
Smarcal1
Name: SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
Synonyms: Mharp, 6030401P21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54380
Homologene: 8558
Pcyt1a
Name: phosphate cytidylyltransferase 1, choline, alpha isoform
Synonyms: CTalpha, CTP:phosphocholine cytidylyltransferase alpha, Ctpct, Cttalpha, Cctalpha
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13026
HGNC: HGNC:8754
Homologene: 3680
Foxn1
Name: forkhead box N1
Synonyms: whn, Hfh11, D11Bhm185e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15218
Homologene: 2664
Zfp872
Name: zinc finger protein 872
Synonyms: 9530015I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 619310
Cfh
Name: complement component factor h
Synonyms: Mud-1, Sas-1, Sas1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Sptlc3
Name: serine palmitoyltransferase, long chain base subunit 3
Synonyms: C130053K05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228677
Homologene: 105590
Zdhhc1
Name: zinc finger, DHHC domain containing 1
Synonyms: 4432412D04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70796
Homologene: 36891
Hapln2
Name: hyaluronan and proteoglycan link protein 2
Synonyms: 4930401E20Rik, Bral1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73940
Homologene: 11045
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101100
Homologene: 134361
Tas2r117
Name: taste receptor, type 2, member 117
Synonyms: Tas2r17, mGR17, T2R17, mt2r54
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 353166
Homologene: 130073
Or5m9
Name: olfactory receptor family 5 subfamily M member 9
Synonyms: GA_x6K02T2Q125-47521463-47522395, MOR227-8P, MOR227-8P, MOR245-14P, Olfr1533-ps1, Olfr1034
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258216
Homologene: 51741
Vmn2r67
Name: vomeronasal 2, receptor 67
Synonyms: EG620672
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620672
Homologene: 115466
Cabyr
Name: calcium binding tyrosine phosphorylation regulated
Synonyms: FSP-2, CBP86, 4933421A18Rik, 1700016C01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71132
Homologene: 49299
Cdc14a
Name: CDC14 cell division cycle 14A
Synonyms: CDC14A2, CDC14a1, Cdc14, A830059A17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229776
HGNC: HGNC:1718
Homologene: 75343
Anks1b
Name: ankyrin repeat and sterile alpha motif domain containing 1B
Synonyms: LOC380650, C030032C09Rik, E530015N03Rik, AIDA-1b, Gm10937
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77531
Homologene: 51570
Vmn1r42
Name: vomeronasal 1 receptor 42
Synonyms: V1ra6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113848
Homologene: 130651
Micall2
Name: MICAL-like 2
Synonyms: Jrab, MICAL-L2, A930021H16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231830
Homologene: 85155
1700034E13Rik
Name: RIKEN cDNA 1700034E13 gene
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 78414
Homologene: 19041
Samd14
Name: sterile alpha motif domain containing 14
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217125
Homologene: 17130
Rgs19
Name: regulator of G-protein signaling 19
Synonyms: 2610042F04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56470
Homologene: 23320
Slc46a3
Name: solute carrier family 46, member 3
Synonyms: 1200006F02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71706
Homologene: 41733
Fbxo48
Name: F-box protein 48
Synonyms: A630050E13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319701
Homologene: 18541
Trbv23
Name: T cell receptor beta, variable V23
Synonyms: VB20, Tcrb-V20
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100124688
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 30,804,630 bp
  • A to G, chromosome 1 at 72,591,173 bp
  • T to C, chromosome 1 at 105,753,595 bp
  • ACC to ACCC, chromosome 1 at 138,841,806 bp
  • T to A, chromosome 1 at 140,147,749 bp
  • A to T, chromosome 1 at 156,035,820 bp
  • T to A, chromosome 2 at 12,419,252 bp
  • C to T, chromosome 2 at 26,441,419 bp
  • A to T, chromosome 2 at 86,046,604 bp
  • T to C, chromosome 2 at 139,566,586 bp
  • A to G, chromosome 2 at 181,689,148 bp
  • A to G, chromosome 3 at 76,707,855 bp
  • G to A, chromosome 3 at 88,022,651 bp
  • T to C, chromosome 3 at 108,482,338 bp
  • G to A, chromosome 3 at 116,328,676 bp
  • A to T, chromosome 3 at 122,135,195 bp
  • C to T, chromosome 3 at 138,065,169 bp
  • T to C, chromosome 4 at 101,133,590 bp
  • T to C, chromosome 4 at 128,589,722 bp
  • C to T, chromosome 4 at 132,493,802 bp
  • C to A, chromosome 4 at 143,439,109 bp
  • G to T, chromosome 5 at 139,715,793 bp
  • A to T, chromosome 5 at 147,886,160 bp
  • T to C, chromosome 6 at 41,216,247 bp
  • T to G, chromosome 6 at 89,844,787 bp
  • T to C, chromosome 6 at 92,376,544 bp
  • T to C, chromosome 6 at 112,816,661 bp
  • GGCAAAG to GGCAAAGCAAAG, chromosome 6 at 113,399,155 bp
  • CAAAGTAA to CAAAGTAAAGTAA, chromosome 6 at 113,399,157 bp
  • AAGTA to AAGTATAGTA, chromosome 6 at 113,399,159 bp
  • T to A, chromosome 6 at 132,802,929 bp
  • C to A, chromosome 7 at 12,606,514 bp
  • T to A, chromosome 7 at 13,470,330 bp
  • T to A, chromosome 7 at 28,147,135 bp
  • T to C, chromosome 7 at 85,152,153 bp
  • T to C, chromosome 7 at 86,954,603 bp
  • T to C, chromosome 7 at 110,802,546 bp
  • G to A, chromosome 7 at 141,816,907 bp
  • T to A, chromosome 8 at 22,938,660 bp
  • T to C, chromosome 8 at 45,035,598 bp
  • C to T, chromosome 8 at 69,817,991 bp
  • T to C, chromosome 8 at 83,723,017 bp
  • C to T, chromosome 8 at 105,477,072 bp
  • A to G, chromosome 9 at 20,348,043 bp
  • A to T, chromosome 9 at 22,200,059 bp
  • T to A, chromosome 9 at 42,024,398 bp
  • A to G, chromosome 9 at 53,482,430 bp
  • A to G, chromosome 10 at 90,260,654 bp
  • T to A, chromosome 10 at 128,722,539 bp
  • T to A, chromosome 11 at 16,953,402 bp
  • A to G, chromosome 11 at 62,343,245 bp
  • A to G, chromosome 11 at 67,252,968 bp
  • G to T, chromosome 11 at 78,360,960 bp
  • G to A, chromosome 11 at 95,021,454 bp
  • T to A, chromosome 11 at 120,010,468 bp
  • A to G, chromosome 11 at 121,609,380 bp
  • C to A, chromosome 12 at 91,366,342 bp
  • T to A, chromosome 14 at 61,179,288 bp
  • A to G, chromosome 15 at 34,136,721 bp
  • A to T, chromosome 15 at 58,594,878 bp
  • G to A, chromosome 15 at 65,829,830 bp
  • G to T, chromosome 15 at 76,905,949 bp
  • T to C, chromosome 16 at 32,470,120 bp
  • G to A, chromosome 16 at 64,786,598 bp
  • A to G, chromosome 16 at 98,065,655 bp
  • T to C, chromosome 17 at 36,168,073 bp
  • GAAGAA to GAAGAAAAAGAA, chromosome 17 at 46,412,533 bp
  • AAGAAG to AAGAAGTAGAAG, chromosome 17 at 46,412,534 bp
  • AGAAG to AGAAGAGGAAG, chromosome 17 at 46,412,538 bp
  • C to T, chromosome 18 at 12,754,097 bp
  • C to T, chromosome 18 at 14,986,344 bp
  • T to C, chromosome 18 at 52,663,633 bp
  • C to T, chromosome 18 at 78,012,891 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6852 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045023-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.